Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

conserved protein, unknown function

Species:

Leishmania major

UniProt:

Q4QHK5_LEIMA

TriTrypDb:

LmjF.10.0150 , LMJLV39_100006300 , LMJSD75_100006400

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0010494	cytoplasmic stress granule	5	2
GO:0035770	ribonucleoprotein granule	3	2
GO:0036464	cytoplasmic ribonucleoprotein granule	4	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0099080	supramolecular complex	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QHK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHK5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DEG_SCF_FBW7_1	262	267	PF00400	0.607
DEG_SPOP_SBC_1	270	274	PF00917	0.772
DOC_CDC14_PxL_1	183	191	PF14671	0.683
DOC_CKS1_1	168	173	PF01111	0.713
DOC_CKS1_1	265	270	PF01111	0.616
DOC_CYCLIN_yCln2_LP_2	115	121	PF00134	0.617
DOC_PP2B_LxvP_1	152	155	PF13499	0.682
DOC_USP7_MATH_1	23	27	PF00917	0.700
DOC_USP7_MATH_1	269	273	PF00917	0.772
DOC_USP7_MATH_1	288	292	PF00917	0.517
DOC_USP7_MATH_1	311	315	PF00917	0.713
DOC_USP7_MATH_1	82	86	PF00917	0.680
DOC_WW_Pin1_4	167	172	PF00397	0.630
DOC_WW_Pin1_4	174	179	PF00397	0.587
DOC_WW_Pin1_4	189	194	PF00397	0.720
DOC_WW_Pin1_4	209	214	PF00397	0.440
DOC_WW_Pin1_4	224	229	PF00397	0.671
DOC_WW_Pin1_4	260	265	PF00397	0.604
DOC_WW_Pin1_4	271	276	PF00397	0.645
DOC_WW_Pin1_4	328	333	PF00397	0.678
DOC_WW_Pin1_4	347	352	PF00397	0.713
LIG_14-3-3_CanoR_1	282	286	PF00244	0.693
LIG_14-3-3_CanoR_1	312	320	PF00244	0.713
LIG_14-3-3_CterR_2	366	371	PF00244	0.646
LIG_BIR_II_1	1	5	PF00653	0.684
LIG_BRCT_BRCA1_1	20	24	PF00533	0.773
LIG_BRCT_BRCA1_1	50	54	PF00533	0.750
LIG_CtBP_PxDLS_1	112	117	PF00389	0.618
LIG_EVH1_1	152	156	PF00568	0.678
LIG_EVH1_2	198	202	PF00568	0.620
LIG_FHA_1	14	20	PF00498	0.717
LIG_FHA_1	242	248	PF00498	0.590
LIG_FHA_1	315	321	PF00498	0.654
LIG_FHA_1	348	354	PF00498	0.708
LIG_FHA_1	42	48	PF00498	0.623
LIG_FHA_2	30	36	PF00498	0.681
LIG_LIR_Apic_2	263	269	PF02991	0.609
LIG_LIR_Gen_1	51	60	PF02991	0.748
LIG_LIR_Nem_3	51	57	PF02991	0.670
LIG_NRBOX	72	78	PF00104	0.549
LIG_PCNA_yPIPBox_3	70	81	PF02747	0.613
LIG_PROFILIN_1	153	159	PF00235	0.666
LIG_PROFILIN_1	160	166	PF00235	0.664
LIG_PTB_Apo_2	9	16	PF02174	0.646
LIG_PTB_Phospho_1	9	15	PF10480	0.644
LIG_SH2_CRK	119	123	PF00017	0.763
LIG_SH2_CRK	168	172	PF00017	0.662
LIG_SH2_CRK	183	187	PF00017	0.642
LIG_SH2_CRK	266	270	PF00017	0.618
LIG_SH2_CRK	283	287	PF00017	0.638
LIG_SH2_GRB2like	179	182	PF00017	0.767
LIG_SH2_NCK_1	123	127	PF00017	0.771
LIG_SH2_NCK_1	146	150	PF00017	0.716
LIG_SH2_NCK_1	168	172	PF00017	0.787
LIG_SH2_NCK_1	266	270	PF00017	0.618
LIG_SH2_NCK_1	283	287	PF00017	0.638
LIG_SH2_PTP2	233	236	PF00017	0.674
LIG_SH2_SRC	233	236	PF00017	0.620
LIG_SH2_STAP1	146	150	PF00017	0.697
LIG_SH2_STAP1	179	183	PF00017	0.699
LIG_SH2_STAP1	340	344	PF00017	0.708
LIG_SH2_STAT5	123	126	PF00017	0.760
LIG_SH2_STAT5	15	18	PF00017	0.691
LIG_SH2_STAT5	233	236	PF00017	0.674
LIG_SH2_STAT5	266	269	PF00017	0.613
LIG_SH2_STAT5	333	336	PF00017	0.735
LIG_SH3_3	115	121	PF00018	0.683
LIG_SH3_3	150	156	PF00018	0.690
LIG_SH3_3	157	163	PF00018	0.642
LIG_SH3_3	172	178	PF00018	0.522
LIG_SH3_3	194	200	PF00018	0.762
LIG_SH3_3	232	238	PF00018	0.625
LIG_SH3_3	259	265	PF00018	0.604
LIG_SH3_3	273	279	PF00018	0.636
LIG_SH3_3	321	327	PF00018	0.765
LIG_SH3_3	362	368	PF00018	0.735
LIG_TRAF2_1	222	225	PF00917	0.695
LIG_TRAF2_1	240	243	PF00917	0.663
LIG_TRFH_1	254	258	PF08558	0.558
LIG_TRFH_1	283	287	PF08558	0.638
LIG_UBA3_1	255	261	PF00899	0.583
LIG_WW_1	165	168	PF00397	0.637
LIG_WW_1	357	360	PF00397	0.631
MOD_CDK_SPxxK_3	189	196	PF00069	0.782
MOD_CDK_SPxxK_3	275	282	PF00069	0.687
MOD_CK1_1	145	151	PF00069	0.698
MOD_CK1_1	169	175	PF00069	0.701
MOD_CK1_1	220	226	PF00069	0.738
MOD_CK1_1	260	266	PF00069	0.629
MOD_CK1_1	314	320	PF00069	0.714
MOD_CK1_1	352	358	PF00069	0.654
MOD_CK2_1	14	20	PF00069	0.707
MOD_CK2_1	198	204	PF00069	0.621
MOD_CK2_1	312	318	PF00069	0.738
MOD_CK2_1	82	88	PF00069	0.525
MOD_GlcNHglycan	147	150	PF01048	0.721
MOD_GlcNHglycan	16	19	PF01048	0.735
MOD_GlcNHglycan	183	186	PF01048	0.696
MOD_GlcNHglycan	20	23	PF01048	0.667
MOD_GSK3_1	14	21	PF00069	0.764
MOD_GSK3_1	144	151	PF00069	0.725
MOD_GSK3_1	188	195	PF00069	0.787
MOD_GSK3_1	205	212	PF00069	0.623
MOD_GSK3_1	220	227	PF00069	0.635
MOD_GSK3_1	260	267	PF00069	0.605
MOD_GSK3_1	271	278	PF00069	0.641
MOD_GSK3_1	288	295	PF00069	0.677
MOD_GSK3_1	328	335	PF00069	0.706
MOD_GSK3_1	343	350	PF00069	0.722
MOD_N-GLC_1	142	147	PF02516	0.684
MOD_NEK2_1	217	222	PF00069	0.753
MOD_NEK2_1	247	252	PF00069	0.595
MOD_NEK2_1	301	306	PF00069	0.637
MOD_NEK2_1	334	339	PF00069	0.699
MOD_NEK2_2	49	54	PF00069	0.751
MOD_PIKK_1	220	226	PF00454	0.697
MOD_PK_1	312	318	PF00069	0.702
MOD_PKA_2	247	253	PF00069	0.610
MOD_PKA_2	281	287	PF00069	0.692
MOD_PKA_2	311	317	PF00069	0.710
MOD_Plk_1	142	148	PF00069	0.691
MOD_Plk_2-3	96	102	PF00069	0.707
MOD_Plk_4	212	218	PF00069	0.788
MOD_Plk_4	241	247	PF00069	0.627
MOD_Plk_4	302	308	PF00069	0.718
MOD_Plk_4	49	55	PF00069	0.689
MOD_ProDKin_1	167	173	PF00069	0.629
MOD_ProDKin_1	174	180	PF00069	0.588
MOD_ProDKin_1	189	195	PF00069	0.720
MOD_ProDKin_1	209	215	PF00069	0.442
MOD_ProDKin_1	224	230	PF00069	0.671
MOD_ProDKin_1	260	266	PF00069	0.606
MOD_ProDKin_1	271	277	PF00069	0.644
MOD_ProDKin_1	328	334	PF00069	0.678
MOD_ProDKin_1	347	353	PF00069	0.712
TRG_DiLeu_BaLyEn_6	72	77	PF01217	0.600
TRG_ENDOCYTIC_2	123	126	PF00928	0.775
TRG_ENDOCYTIC_2	183	186	PF00928	0.703
TRG_ENDOCYTIC_2	322	325	PF00928	0.693
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCX5	Leptomonas seymouri	56%	100%
A0A3Q8IAY2	Leishmania donovani	96%	100%
A4H5Z6	Leishmania braziliensis	78%	100%
A4HUC2	Leishmania infantum	95%	100%
E9AN21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BE36	Trypanosoma cruzi	37%	100%