Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHK4_LEIMA

TriTrypDb:

LmjF.10.0160 , LMJLV39_100006400 , LMJSD75_100006500

Length:

505

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHK4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	177	181	PF00656	0.702
CLV_NRD_NRD_1	140	142	PF00675	0.569
CLV_NRD_NRD_1	148	150	PF00675	0.556
CLV_NRD_NRD_1	282	284	PF00675	0.560
CLV_NRD_NRD_1	72	74	PF00675	0.518
CLV_NRD_NRD_1	83	85	PF00675	0.443
CLV_NRD_NRD_1	91	93	PF00675	0.354
CLV_PCSK_KEX2_1	140	142	PF00082	0.588
CLV_PCSK_KEX2_1	282	284	PF00082	0.560
CLV_PCSK_KEX2_1	290	292	PF00082	0.555
CLV_PCSK_KEX2_1	72	74	PF00082	0.518
CLV_PCSK_KEX2_1	83	85	PF00082	0.443
CLV_PCSK_KEX2_1	89	91	PF00082	0.391
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.574
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.557
CLV_PCSK_PC7_1	286	292	PF00082	0.492
CLV_PCSK_SKI1_1	125	129	PF00082	0.543
CLV_PCSK_SKI1_1	469	473	PF00082	0.751
CLV_PCSK_SKI1_1	482	486	PF00082	0.640
CLV_PCSK_SKI1_1	53	57	PF00082	0.398
DEG_APCC_DBOX_1	52	60	PF00400	0.500
DEG_SPOP_SBC_1	229	233	PF00917	0.722
DEG_SPOP_SBC_1	402	406	PF00917	0.706
DOC_CKS1_1	483	488	PF01111	0.660
DOC_CYCLIN_RxL_1	466	476	PF00134	0.646
DOC_PP2B_LxvP_1	449	452	PF13499	0.668
DOC_PP4_FxxP_1	390	393	PF00568	0.621
DOC_USP7_MATH_1	182	186	PF00917	0.700
DOC_USP7_MATH_1	190	194	PF00917	0.586
DOC_USP7_MATH_1	195	199	PF00917	0.684
DOC_USP7_MATH_1	203	207	PF00917	0.685
DOC_USP7_MATH_1	229	233	PF00917	0.598
DOC_USP7_MATH_1	258	262	PF00917	0.542
DOC_USP7_MATH_1	358	362	PF00917	0.704
DOC_USP7_MATH_1	393	397	PF00917	0.670
DOC_USP7_MATH_1	400	404	PF00917	0.634
DOC_USP7_MATH_1	419	423	PF00917	0.691
DOC_USP7_MATH_1	492	496	PF00917	0.748
DOC_USP7_MATH_1	8	12	PF00917	0.681
DOC_WW_Pin1_4	207	212	PF00397	0.590
DOC_WW_Pin1_4	347	352	PF00397	0.671
DOC_WW_Pin1_4	364	369	PF00397	0.448
DOC_WW_Pin1_4	444	449	PF00397	0.801
DOC_WW_Pin1_4	482	487	PF00397	0.591
LIG_14-3-3_CanoR_1	114	123	PF00244	0.621
LIG_14-3-3_CanoR_1	362	370	PF00244	0.719
LIG_14-3-3_CanoR_1	442	448	PF00244	0.703
LIG_AP2alpha_2	388	390	PF02296	0.682
LIG_BRCT_BRCA1_1	212	216	PF00533	0.616
LIG_BRCT_BRCA1_1	332	336	PF00533	0.685
LIG_FHA_1	115	121	PF00498	0.569
LIG_FHA_1	158	164	PF00498	0.575
LIG_FHA_1	195	201	PF00498	0.711
LIG_FHA_1	236	242	PF00498	0.721
LIG_FHA_1	244	250	PF00498	0.610
LIG_FHA_1	262	268	PF00498	0.320
LIG_FHA_1	296	302	PF00498	0.587
LIG_FHA_1	348	354	PF00498	0.731
LIG_FHA_1	45	51	PF00498	0.513
LIG_FHA_1	473	479	PF00498	0.691
LIG_FHA_2	105	111	PF00498	0.366
LIG_FHA_2	235	241	PF00498	0.672
LIG_FHA_2	483	489	PF00498	0.633
LIG_FHA_2	56	62	PF00498	0.502
LIG_GBD_Chelix_1	134	142	PF00786	0.525
LIG_GBD_Chelix_1	77	85	PF00786	0.497
LIG_LIR_Apic_2	388	393	PF02991	0.619
LIG_LIR_Nem_3	213	219	PF02991	0.682
LIG_PCNA_yPIPBox_3	72	81	PF02747	0.560
LIG_RPA_C_Fungi	79	91	PF08784	0.544
LIG_SH2_STAP1	17	21	PF00017	0.654
LIG_SH2_STAT5	251	254	PF00017	0.569
LIG_SH2_STAT5	273	276	PF00017	0.568
LIG_SH3_3	383	389	PF00018	0.620
LIG_SH3_3	475	481	PF00018	0.778
LIG_TRAF2_1	107	110	PF00917	0.546
LIG_TRAF2_1	155	158	PF00917	0.569
LIG_TRAF2_1	58	61	PF00917	0.597
LIG_TYR_ITIM	65	70	PF00017	0.482
LIG_UBA3_1	81	89	PF00899	0.522
LIG_WW_1	14	17	PF00397	0.700
MOD_CDK_SPxxK_3	347	354	PF00069	0.689
MOD_CDK_SPxxK_3	482	489	PF00069	0.495
MOD_CK1_1	108	114	PF00069	0.526
MOD_CK1_1	198	204	PF00069	0.731
MOD_CK1_1	206	212	PF00069	0.683
MOD_CK1_1	225	231	PF00069	0.562
MOD_CK1_1	261	267	PF00069	0.543
MOD_CK1_1	342	348	PF00069	0.623
MOD_CK1_1	396	402	PF00069	0.690
MOD_CK1_1	403	409	PF00069	0.743
MOD_CK1_1	415	421	PF00069	0.546
MOD_CK1_1	422	428	PF00069	0.766
MOD_CK1_1	444	450	PF00069	0.751
MOD_CK1_1	462	468	PF00069	0.636
MOD_CK1_1	493	499	PF00069	0.753
MOD_CK2_1	104	110	PF00069	0.415
MOD_CK2_1	265	271	PF00069	0.618
MOD_CK2_1	451	457	PF00069	0.733
MOD_CK2_1	482	488	PF00069	0.629
MOD_CK2_1	55	61	PF00069	0.545
MOD_DYRK1A_RPxSP_1	482	486	PF00069	0.488
MOD_GlcNHglycan	10	13	PF01048	0.725
MOD_GlcNHglycan	183	187	PF01048	0.715
MOD_GlcNHglycan	192	195	PF01048	0.687
MOD_GlcNHglycan	197	200	PF01048	0.635
MOD_GlcNHglycan	206	209	PF01048	0.709
MOD_GlcNHglycan	212	215	PF01048	0.641
MOD_GlcNHglycan	227	230	PF01048	0.643
MOD_GlcNHglycan	342	345	PF01048	0.652
MOD_GlcNHglycan	356	359	PF01048	0.674
MOD_GlcNHglycan	364	367	PF01048	0.735
MOD_GlcNHglycan	395	398	PF01048	0.728
MOD_GlcNHglycan	414	417	PF01048	0.664
MOD_GlcNHglycan	421	424	PF01048	0.653
MOD_GlcNHglycan	492	495	PF01048	0.683
MOD_GlcNHglycan	6	9	PF01048	0.741
MOD_GSK3_1	104	111	PF00069	0.533
MOD_GSK3_1	190	197	PF00069	0.686
MOD_GSK3_1	203	210	PF00069	0.747
MOD_GSK3_1	221	228	PF00069	0.557
MOD_GSK3_1	229	236	PF00069	0.637
MOD_GSK3_1	261	268	PF00069	0.613
MOD_GSK3_1	339	346	PF00069	0.632
MOD_GSK3_1	354	361	PF00069	0.643
MOD_GSK3_1	364	371	PF00069	0.647
MOD_GSK3_1	392	399	PF00069	0.591
MOD_GSK3_1	4	11	PF00069	0.726
MOD_GSK3_1	415	422	PF00069	0.784
MOD_GSK3_1	451	458	PF00069	0.755
MOD_LATS_1	220	226	PF00433	0.715
MOD_LATS_1	410	416	PF00433	0.656
MOD_N-GLC_1	114	119	PF02516	0.605
MOD_N-GLC_1	331	336	PF02516	0.538
MOD_NEK2_1	113	118	PF00069	0.555
MOD_NEK2_1	204	209	PF00069	0.672
MOD_NEK2_1	331	336	PF00069	0.641
MOD_NEK2_1	340	345	PF00069	0.615
MOD_NEK2_1	443	448	PF00069	0.736
MOD_NEK2_1	45	50	PF00069	0.448
MOD_NEK2_1	472	477	PF00069	0.689
MOD_NEK2_1	55	60	PF00069	0.439
MOD_NEK2_1	85	90	PF00069	0.538
MOD_NEK2_2	258	263	PF00069	0.544
MOD_PIKK_1	105	111	PF00454	0.575
MOD_PIKK_1	114	120	PF00454	0.580
MOD_PIKK_1	295	301	PF00454	0.661
MOD_PIKK_1	368	374	PF00454	0.554
MOD_PIKK_1	462	468	PF00454	0.664
MOD_PK_1	73	79	PF00069	0.526
MOD_PKA_1	90	96	PF00069	0.455
MOD_PKA_2	113	119	PF00069	0.625
MOD_PKA_2	221	227	PF00069	0.710
MOD_PKA_2	441	447	PF00069	0.702
MOD_PKA_2	90	96	PF00069	0.455
MOD_Plk_1	331	337	PF00069	0.638
MOD_Plk_1	455	461	PF00069	0.823
MOD_Plk_1	473	479	PF00069	0.492
MOD_Plk_1	487	493	PF00069	0.740
MOD_Plk_4	244	250	PF00069	0.357
MOD_Plk_4	45	51	PF00069	0.474
MOD_ProDKin_1	207	213	PF00069	0.592
MOD_ProDKin_1	347	353	PF00069	0.673
MOD_ProDKin_1	364	370	PF00069	0.452
MOD_ProDKin_1	444	450	PF00069	0.803
MOD_ProDKin_1	482	488	PF00069	0.594
MOD_SUMO_for_1	127	130	PF00179	0.575
MOD_SUMO_rev_2	105	113	PF00179	0.555
TRG_DiLeu_BaLyEn_6	466	471	PF01217	0.696
TRG_ENDOCYTIC_2	67	70	PF00928	0.528
TRG_ER_diArg_1	140	142	PF00400	0.553
TRG_ER_diArg_1	282	284	PF00400	0.591
TRG_ER_diArg_1	50	53	PF00400	0.485
TRG_ER_diArg_1	82	84	PF00400	0.497
TRG_ER_diArg_1	90	92	PF00400	0.497
TRG_NES_CRM1_1	54	69	PF08389	0.321
TRG_NLS_Bipartite_1	72	93	PF00514	0.550
TRG_NLS_MonoCore_2	88	93	PF00514	0.550
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.522
TRG_Pf-PMV_PEXEL_1	282	287	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	469	473	PF00026	0.687

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6X5	Leptomonas seymouri	55%	67%
A0A0S4JC19	Bodo saltans	27%	100%
A0A3R7MLU6	Trypanosoma rangeli	30%	100%
A0A3S7WR07	Leishmania donovani	92%	100%
A4H5Z7	Leishmania braziliensis	75%	100%
A4HUC3	Leishmania infantum	91%	100%
E9AN22	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%