Putative nucleoside phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

guanosine diphosphatase, putative

Species:

Leishmania major

UniProt:

Q4QHK3_LEIMA

TriTrypDb:

LmjF.10.0170 , LMJLV39_100006500 , LMJSD75_100006600

Length:

674

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 5
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QHK3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHK3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006753	nucleoside phosphate metabolic process	4	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009132	nucleoside diphosphate metabolic process	5	2
GO:0009134	nucleoside diphosphate catabolic process	6	2
GO:0009987	cellular process	1	2
GO:0019439	aromatic compound catabolic process	4	2
GO:0019637	organophosphate metabolic process	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034655	nucleobase-containing compound catabolic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044270	cellular nitrogen compound catabolic process	4	2
GO:0044281	small molecule metabolic process	2	2
GO:0046434	organophosphate catabolic process	4	2
GO:0046483	heterocycle metabolic process	3	2
GO:0046700	heterocycle catabolic process	4	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901292	nucleoside phosphate catabolic process	5	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901361	organic cyclic compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	10
GO:0004382	GDP phosphatase activity	7	5
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016462	pyrophosphatase activity	5	5
GO:0016787	hydrolase activity	2	10
GO:0016817	hydrolase activity, acting on acid anhydrides	3	5
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	5
GO:0017076	purine nucleotide binding	4	9
GO:0017110	nucleoside diphosphate phosphatase activity	6	5
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	251	255	PF00656	0.232
CLV_C14_Caspase3-7	348	352	PF00656	0.189
CLV_NRD_NRD_1	132	134	PF00675	0.508
CLV_NRD_NRD_1	76	78	PF00675	0.523
CLV_PCSK_KEX2_1	132	134	PF00082	0.522
CLV_PCSK_KEX2_1	472	474	PF00082	0.276
CLV_PCSK_KEX2_1	505	507	PF00082	0.254
CLV_PCSK_KEX2_1	76	78	PF00082	0.541
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.501
CLV_PCSK_PC1ET2_1	472	474	PF00082	0.276
CLV_PCSK_PC1ET2_1	505	507	PF00082	0.254
CLV_PCSK_SKI1_1	3	7	PF00082	0.474
CLV_PCSK_SKI1_1	345	349	PF00082	0.239
CLV_PCSK_SKI1_1	410	414	PF00082	0.432
CLV_PCSK_SKI1_1	502	506	PF00082	0.464
CLV_PCSK_SKI1_1	528	532	PF00082	0.397
CLV_PCSK_SKI1_1	97	101	PF00082	0.630
DEG_APCC_DBOX_1	132	140	PF00400	0.431
DEG_APCC_DBOX_1	78	86	PF00400	0.477
DEG_SPOP_SBC_1	433	437	PF00917	0.276
DOC_CYCLIN_yCln2_LP_2	529	535	PF00134	0.298
DOC_MAPK_DCC_7	526	535	PF00069	0.298
DOC_MAPK_gen_1	526	535	PF00069	0.320
DOC_MAPK_gen_1	585	592	PF00069	0.446
DOC_MAPK_gen_1	76	85	PF00069	0.627
DOC_PP4_MxPP_1	477	480	PF00568	0.265
DOC_PP4_MxPP_1	548	551	PF00568	0.276
DOC_USP7_MATH_1	188	192	PF00917	0.189
DOC_USP7_MATH_1	223	227	PF00917	0.291
DOC_USP7_MATH_1	30	34	PF00917	0.555
DOC_USP7_MATH_1	349	353	PF00917	0.320
DOC_USP7_MATH_1	370	374	PF00917	0.368
DOC_USP7_MATH_1	572	576	PF00917	0.417
DOC_USP7_MATH_1	581	585	PF00917	0.327
DOC_USP7_UBL2_3	189	193	PF12436	0.276
DOC_USP7_UBL2_3	419	423	PF12436	0.404
DOC_USP7_UBL2_3	587	591	PF12436	0.466
LIG_14-3-3_CanoR_1	125	130	PF00244	0.601
LIG_14-3-3_CanoR_1	154	162	PF00244	0.443
LIG_14-3-3_CanoR_1	315	321	PF00244	0.189
LIG_14-3-3_CanoR_1	345	354	PF00244	0.307
LIG_14-3-3_CanoR_1	383	389	PF00244	0.435
LIG_14-3-3_CanoR_1	92	100	PF00244	0.569
LIG_AP2alpha_2	146	148	PF02296	0.419
LIG_BIR_II_1	1	5	PF00653	0.619
LIG_BRCT_BRCA1_1	111	115	PF00533	0.479
LIG_BRCT_BRCA1_1	194	198	PF00533	0.255
LIG_BRCT_BRCA1_1	562	566	PF00533	0.320
LIG_deltaCOP1_diTrp_1	257	263	PF00928	0.320
LIG_FHA_1	121	127	PF00498	0.625
LIG_FHA_1	283	289	PF00498	0.255
LIG_FHA_1	309	315	PF00498	0.352
LIG_FHA_1	351	357	PF00498	0.264
LIG_FHA_1	362	368	PF00498	0.283
LIG_FHA_1	407	413	PF00498	0.372
LIG_FHA_1	554	560	PF00498	0.279
LIG_FHA_2	17	23	PF00498	0.606
LIG_FHA_2	276	282	PF00498	0.372
LIG_FHA_2	346	352	PF00498	0.230
LIG_Integrin_RGD_1	466	468	PF01839	0.189
LIG_LIR_Gen_1	191	200	PF02991	0.293
LIG_LIR_Gen_1	257	266	PF02991	0.423
LIG_LIR_Gen_1	563	572	PF02991	0.255
LIG_LIR_Gen_1	626	635	PF02991	0.311
LIG_LIR_Nem_3	145	151	PF02991	0.675
LIG_LIR_Nem_3	191	197	PF02991	0.293
LIG_LIR_Nem_3	257	263	PF02991	0.410
LIG_LIR_Nem_3	399	403	PF02991	0.331
LIG_LIR_Nem_3	486	491	PF02991	0.305
LIG_LIR_Nem_3	563	569	PF02991	0.255
LIG_LIR_Nem_3	628	634	PF02991	0.289
LIG_Pex14_2	562	566	PF04695	0.320
LIG_PTB_Apo_2	306	313	PF02174	0.276
LIG_RPA_C_Fungi	65	77	PF08784	0.397
LIG_SH2_CRK	194	198	PF00017	0.279
LIG_SH2_CRK	632	636	PF00017	0.381
LIG_SH2_NCK_1	194	198	PF00017	0.279
LIG_SH2_NCK_1	643	647	PF00017	0.309
LIG_SH2_SRC	396	399	PF00017	0.255
LIG_SH2_SRC	495	498	PF00017	0.351
LIG_SH2_SRC	634	637	PF00017	0.351
LIG_SH2_STAP1	194	198	PF00017	0.276
LIG_SH2_STAP1	384	388	PF00017	0.276
LIG_SH2_STAP1	560	564	PF00017	0.277
LIG_SH2_STAP1	627	631	PF00017	0.367
LIG_SH2_STAP1	632	636	PF00017	0.344
LIG_SH2_STAP1	660	664	PF00017	0.295
LIG_SH2_STAT3	414	417	PF00017	0.189
LIG_SH2_STAT5	338	341	PF00017	0.291
LIG_SH2_STAT5	634	637	PF00017	0.309
LIG_SH3_1	472	478	PF00018	0.275
LIG_SH3_3	364	370	PF00018	0.279
LIG_SH3_3	472	478	PF00018	0.378
LIG_SH3_3	509	515	PF00018	0.359
LIG_SH3_3	544	550	PF00018	0.256
LIG_SH3_3	587	593	PF00018	0.309
LIG_SUMO_SIM_anti_2	109	115	PF11976	0.471
LIG_SUMO_SIM_anti_2	229	236	PF11976	0.298
LIG_SUMO_SIM_anti_2	350	358	PF11976	0.369
LIG_SUMO_SIM_anti_2	567	572	PF11976	0.210
LIG_SUMO_SIM_par_1	350	358	PF11976	0.354
LIG_SUMO_SIM_par_1	669	674	PF11976	0.338
LIG_SUMO_SIM_par_1	84	89	PF11976	0.607
LIG_TRAF2_1	325	328	PF00917	0.320
LIG_TYR_ITIM	192	197	PF00017	0.189
LIG_UBA3_1	166	175	PF00899	0.551
LIG_UBA3_1	237	243	PF00899	0.410
LIG_UBA3_1	290	295	PF00899	0.441
LIG_UBA3_1	412	419	PF00899	0.362
MOD_CK1_1	109	115	PF00069	0.593
MOD_CK1_1	226	232	PF00069	0.276
MOD_CK1_1	95	101	PF00069	0.517
MOD_CK2_1	152	158	PF00069	0.538
MOD_CK2_1	16	22	PF00069	0.586
MOD_CK2_1	243	249	PF00069	0.189
MOD_CK2_1	275	281	PF00069	0.372
MOD_GlcNHglycan	182	185	PF01048	0.465
MOD_GlcNHglycan	61	64	PF01048	0.536
MOD_GlcNHglycan	94	97	PF01048	0.643
MOD_GSK3_1	138	145	PF00069	0.546
MOD_GSK3_1	188	195	PF00069	0.351
MOD_GSK3_1	341	348	PF00069	0.226
MOD_GSK3_1	425	432	PF00069	0.392
MOD_GSK3_1	55	62	PF00069	0.461
MOD_GSK3_1	662	669	PF00069	0.303
MOD_N-GLC_1	120	125	PF02516	0.584
MOD_N-GLC_1	308	313	PF02516	0.254
MOD_N-GLC_1	316	321	PF02516	0.206
MOD_N-GLC_1	553	558	PF02516	0.388
MOD_N-GLC_1	572	577	PF02516	0.320
MOD_NEK2_1	170	175	PF00069	0.531
MOD_NEK2_1	248	253	PF00069	0.167
MOD_NEK2_1	282	287	PF00069	0.255
MOD_NEK2_1	36	41	PF00069	0.508
MOD_NEK2_1	434	439	PF00069	0.261
MOD_NEK2_1	571	576	PF00069	0.347
MOD_NEK2_1	606	611	PF00069	0.309
MOD_NEK2_1	630	635	PF00069	0.251
MOD_NEK2_1	666	671	PF00069	0.261
MOD_NEK2_2	188	193	PF00069	0.189
MOD_NEK2_2	316	321	PF00069	0.189
MOD_NEK2_2	371	376	PF00069	0.232
MOD_NEK2_2	389	394	PF00069	0.254
MOD_NEK2_2	619	624	PF00069	0.384
MOD_PIKK_1	36	42	PF00454	0.634
MOD_PIKK_1	361	367	PF00454	0.255
MOD_PIKK_1	417	423	PF00454	0.340
MOD_PKA_2	153	159	PF00069	0.489
MOD_PKA_2	170	176	PF00069	0.438
MOD_PKB_1	306	314	PF00069	0.298
MOD_PKB_1	90	98	PF00069	0.517
MOD_Plk_1	109	115	PF00069	0.656
MOD_Plk_1	248	254	PF00069	0.167
MOD_Plk_1	308	314	PF00069	0.254
MOD_Plk_1	316	322	PF00069	0.206
MOD_Plk_1	350	356	PF00069	0.268
MOD_Plk_1	371	377	PF00069	0.232
MOD_Plk_1	572	578	PF00069	0.320
MOD_Plk_4	109	115	PF00069	0.473
MOD_Plk_4	138	144	PF00069	0.468
MOD_Plk_4	192	198	PF00069	0.268
MOD_Plk_4	308	314	PF00069	0.298
MOD_Plk_4	572	578	PF00069	0.422
MOD_Plk_4	630	636	PF00069	0.257
MOD_Plk_4	666	672	PF00069	0.274
MOD_SUMO_for_1	623	626	PF00179	0.367
MOD_SUMO_rev_2	584	593	PF00179	0.309
TRG_DiLeu_BaEn_3	80	86	PF01217	0.479
TRG_DiLeu_BaEn_4	235	241	PF01217	0.276
TRG_DiLeu_BaLyEn_6	525	530	PF01217	0.320
TRG_ENDOCYTIC_2	194	197	PF00928	0.279
TRG_ENDOCYTIC_2	627	630	PF00928	0.367
TRG_ENDOCYTIC_2	632	635	PF00928	0.367
TRG_ENDOCYTIC_2	636	639	PF00928	0.367
TRG_ER_diArg_1	303	306	PF00400	0.315
TRG_ER_diArg_1	75	77	PF00400	0.615
TRG_NES_CRM1_1	105	119	PF08389	0.469
TRG_NLS_MonoExtC_3	131	137	PF00514	0.346
TRG_NLS_MonoExtN_4	131	136	PF00514	0.345
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	289	294	PF00026	0.372
TRG_Pf-PMV_PEXEL_1	456	461	PF00026	0.189
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0E8	Leptomonas seymouri	46%	99%
A0A0S4IR76	Bodo saltans	30%	100%
A0A1X0NQR7	Trypanosomatidae	33%	100%
A0A3R7NV38	Trypanosoma rangeli	33%	100%
A0A3S7WR18	Leishmania donovani	90%	100%
A4H5Z8	Leishmania braziliensis	69%	98%
A4HUC4	Leishmania infantum	90%	100%
C9ZVG6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AN23	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
P32621	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P40009	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	100%
P55772	Mus musculus	25%	100%
Q28CF8	Xenopus tropicalis	21%	100%
Q5MY95	Homo sapiens	23%	100%
Q8TGH6	Candida albicans (strain SC5314 / ATCC MYA-2876)	29%	100%
Q9HEM6	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	31%	100%
Q9Y227	Homo sapiens	21%	100%