Putative leucine-rich repeat protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat protein, putative

Species:

Leishmania major

UniProt:

Q4QHK2_LEIMA

TriTrypDb:

LmjF.10.0180 , LMJLV39_100006600 , LMJSD75_100006700

Length:

238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	12
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0120025	plasma membrane bounded cell projection	3	10

Expansion

Sequence features

Q4QHK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHK2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	151	155	PF00082	0.361
DEG_APCC_DBOX_1	53	61	PF00400	0.340
DOC_CDC14_PxL_1	144	152	PF14671	0.329
DOC_CYCLIN_RxL_1	148	156	PF00134	0.405
DOC_MAPK_gen_1	100	109	PF00069	0.361
DOC_MAPK_gen_1	189	197	PF00069	0.454
DOC_MAPK_MEF2A_6	191	199	PF00069	0.466
DOC_PP2B_LxvP_1	145	148	PF13499	0.285
DOC_WW_Pin1_4	69	74	PF00397	0.473
LIG_14-3-3_CanoR_1	106	110	PF00244	0.351
LIG_14-3-3_CanoR_1	151	156	PF00244	0.405
LIG_14-3-3_CanoR_1	74	81	PF00244	0.448
LIG_Actin_WH2_2	77	94	PF00022	0.426
LIG_BIR_II_1	1	5	PF00653	0.643
LIG_BRCT_BRCA1_1	37	41	PF00533	0.458
LIG_CSL_BTD_1	115	118	PF09270	0.405
LIG_FHA_2	160	166	PF00498	0.557
LIG_LIR_Gen_1	198	203	PF02991	0.428
LIG_LIR_Gen_1	207	214	PF02991	0.433
LIG_LIR_Gen_1	87	94	PF02991	0.334
LIG_LIR_Nem_3	115	119	PF02991	0.390
LIG_LIR_Nem_3	173	177	PF02991	0.426
LIG_LIR_Nem_3	190	196	PF02991	0.490
LIG_LIR_Nem_3	198	202	PF02991	0.366
LIG_LIR_Nem_3	207	213	PF02991	0.252
LIG_LIR_Nem_3	87	91	PF02991	0.321
LIG_MAD2	151	159	PF02301	0.384
LIG_PCNA_yPIPBox_3	103	117	PF02747	0.414
LIG_Pex14_2	37	41	PF04695	0.458
LIG_PTB_Apo_2	155	162	PF02174	0.405
LIG_PTB_Phospho_1	155	161	PF10480	0.384
LIG_SH2_CRK	88	92	PF00017	0.337
LIG_SH2_NCK_1	43	47	PF00017	0.339
LIG_SH2_PTP2	174	177	PF00017	0.552
LIG_SH2_SRC	174	177	PF00017	0.633
LIG_SH2_STAT5	161	164	PF00017	0.657
LIG_SH2_STAT5	174	177	PF00017	0.561
LIG_SH2_STAT5	36	39	PF00017	0.439
LIG_SH2_STAT5	43	46	PF00017	0.422
LIG_SH2_STAT5	88	91	PF00017	0.345
LIG_SUMO_SIM_anti_2	55	61	PF11976	0.358
LIG_SUMO_SIM_par_1	151	156	PF11976	0.304
LIG_TRAF2_1	126	129	PF00917	0.304
LIG_TRAF2_1	162	165	PF00917	0.618
LIG_WRC_WIRS_1	196	201	PF05994	0.417
MOD_CDK_SPK_2	69	74	PF00069	0.473
MOD_CK1_1	87	93	PF00069	0.485
MOD_CK1_1	96	102	PF00069	0.357
MOD_CK2_1	10	16	PF00069	0.527
MOD_CK2_1	159	165	PF00069	0.546
MOD_CK2_1	222	228	PF00069	0.515
MOD_CK2_1	99	105	PF00069	0.368
MOD_GlcNHglycan	182	186	PF01048	0.571
MOD_GSK3_1	177	184	PF00069	0.546
MOD_GSK3_1	31	38	PF00069	0.370
MOD_GSK3_1	69	76	PF00069	0.463
MOD_GSK3_1	90	97	PF00069	0.468
MOD_N-GLC_1	41	46	PF02516	0.466
MOD_N-GLC_1	84	89	PF02516	0.390
MOD_NEK2_1	3	8	PF00069	0.687
MOD_NEK2_1	35	40	PF00069	0.371
MOD_NEK2_1	84	89	PF00069	0.319
MOD_NEK2_2	31	36	PF00069	0.482
MOD_PKA_2	73	79	PF00069	0.452
MOD_PKA_2	99	105	PF00069	0.391
MOD_PKB_1	149	157	PF00069	0.384
MOD_Plk_1	84	90	PF00069	0.409
MOD_Plk_1	94	100	PF00069	0.353
MOD_Plk_4	10	16	PF00069	0.678
MOD_Plk_4	112	118	PF00069	0.384
MOD_Plk_4	170	176	PF00069	0.552
MOD_Plk_4	198	204	PF00069	0.519
MOD_Plk_4	31	37	PF00069	0.399
MOD_ProDKin_1	69	75	PF00069	0.467
TRG_ENDOCYTIC_2	174	177	PF00928	0.429
TRG_ENDOCYTIC_2	193	196	PF00928	0.438
TRG_ENDOCYTIC_2	43	46	PF00928	0.345
TRG_ENDOCYTIC_2	88	91	PF00928	0.309
TRG_ER_diArg_1	148	151	PF00400	0.384
TRG_ER_diArg_1	188	191	PF00400	0.484
TRG_ER_diArg_1	223	226	PF00400	0.534
TRG_NES_CRM1_1	123	133	PF08389	0.279
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.269
TRG_Pf-PMV_PEXEL_1	151	156	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7B1	Leptomonas seymouri	61%	100%
A0A0S4J897	Bodo saltans	46%	83%
A0A1X0NQ44	Trypanosomatidae	54%	100%
A0A3S7WQZ4	Leishmania donovani	94%	100%
A0A422NRS7	Trypanosoma rangeli	54%	100%
A4H5Z9	Leishmania braziliensis	81%	100%
A4HUC5	Leishmania infantum	95%	100%
C9ZVG5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AN24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q5FVI3	Rattus norvegicus	28%	100%
Q8N456	Homo sapiens	27%	91%
Q8N9N7	Homo sapiens	28%	100%
Q9D1G5	Mus musculus	28%	100%
V5BIH6	Trypanosoma cruzi	53%	100%