PDZ domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QHK0_LEIMA

TriTrypDb:

LmjF.10.0190 , LMJLV39_100006700 , LMJSD75_100006800

Length:

667

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHK0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHK0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	209	211	PF00675	0.648
CLV_NRD_NRD_1	243	245	PF00675	0.440
CLV_NRD_NRD_1	278	280	PF00675	0.649
CLV_PCSK_KEX2_1	242	244	PF00082	0.440
CLV_PCSK_PC7_1	239	245	PF00082	0.436
CLV_PCSK_SKI1_1	211	215	PF00082	0.475
CLV_PCSK_SKI1_1	402	406	PF00082	0.766
CLV_PCSK_SKI1_1	432	436	PF00082	0.835
CLV_PCSK_SKI1_1	96	100	PF00082	0.637
DEG_APCC_DBOX_1	154	162	PF00400	0.821
DEG_APCC_DBOX_1	284	292	PF00400	0.706
DEG_SPOP_SBC_1	132	136	PF00917	0.756
DEG_SPOP_SBC_1	524	528	PF00917	0.640
DOC_CYCLIN_yClb5_NLxxxL_5	5	14	PF00134	0.621
DOC_CYCLIN_yCln2_LP_2	295	298	PF00134	0.703
DOC_MAPK_MEF2A_6	642	650	PF00069	0.335
DOC_PP2B_LxvP_1	295	298	PF13499	0.703
DOC_PP2B_LxvP_1	451	454	PF13499	0.607
DOC_USP7_MATH_1	133	137	PF00917	0.620
DOC_USP7_MATH_1	165	169	PF00917	0.842
DOC_USP7_MATH_1	180	184	PF00917	0.702
DOC_USP7_MATH_1	343	347	PF00917	0.840
DOC_USP7_MATH_1	386	390	PF00917	0.838
DOC_USP7_MATH_1	430	434	PF00917	0.838
DOC_USP7_MATH_1	48	52	PF00917	0.654
DOC_USP7_MATH_1	484	488	PF00917	0.672
DOC_USP7_MATH_1	518	522	PF00917	0.700
DOC_USP7_MATH_1	55	59	PF00917	0.611
DOC_USP7_MATH_1	551	555	PF00917	0.794
DOC_USP7_MATH_1	627	631	PF00917	0.452
DOC_USP7_MATH_1	81	85	PF00917	0.779
DOC_USP7_UBL2_3	33	37	PF12436	0.667
DOC_WW_Pin1_4	109	114	PF00397	0.486
DOC_WW_Pin1_4	161	166	PF00397	0.684
DOC_WW_Pin1_4	167	172	PF00397	0.704
DOC_WW_Pin1_4	173	178	PF00397	0.562
DOC_WW_Pin1_4	181	186	PF00397	0.735
DOC_WW_Pin1_4	255	260	PF00397	0.649
DOC_WW_Pin1_4	261	266	PF00397	0.657
DOC_WW_Pin1_4	318	323	PF00397	0.809
DOC_WW_Pin1_4	348	353	PF00397	0.758
DOC_WW_Pin1_4	366	371	PF00397	0.547
DOC_WW_Pin1_4	394	399	PF00397	0.637
DOC_WW_Pin1_4	549	554	PF00397	0.636
DOC_WW_Pin1_4	601	606	PF00397	0.452
DOC_WW_Pin1_4	72	77	PF00397	0.656
DOC_WW_Pin1_4	86	91	PF00397	0.637
LIG_14-3-3_CanoR_1	121	127	PF00244	0.493
LIG_14-3-3_CanoR_1	402	407	PF00244	0.729
LIG_14-3-3_CanoR_1	543	547	PF00244	0.672
LIG_14-3-3_CanoR_1	642	646	PF00244	0.452
LIG_14-3-3_CanoR_1	70	76	PF00244	0.745
LIG_BIR_II_1	1	5	PF00653	0.776
LIG_BIR_III_4	63	67	PF00653	0.727
LIG_BRCT_BRCA1_1	43	47	PF00533	0.619
LIG_deltaCOP1_diTrp_1	93	98	PF00928	0.724
LIG_EH1_1	654	662	PF00400	0.512
LIG_EVH1_1	158	162	PF00568	0.811
LIG_EVH1_1	451	455	PF00568	0.609
LIG_FHA_1	173	179	PF00498	0.752
LIG_FHA_1	373	379	PF00498	0.725
LIG_FHA_2	458	464	PF00498	0.767
LIG_FHA_2	654	660	PF00498	0.517
LIG_GBD_Chelix_1	288	296	PF00786	0.726
LIG_Integrin_RGD_1	364	366	PF01839	0.751
LIG_LIR_Gen_1	544	555	PF02991	0.715
LIG_LIR_Nem_3	544	550	PF02991	0.710
LIG_MYND_1	159	163	PF01753	0.812
LIG_MYND_1	322	326	PF01753	0.679
LIG_PCNA_yPIPBox_3	228	242	PF02747	0.672
LIG_PDZ_Class_2	662	667	PF00595	0.500
LIG_Pex14_1	94	98	PF04695	0.722
LIG_SH2_CRK	547	551	PF00017	0.715
LIG_SH2_NCK_1	52	56	PF00017	0.496
LIG_SH2_STAP1	17	21	PF00017	0.624
LIG_SH2_STAP1	52	56	PF00017	0.459
LIG_SH2_STAT3	342	345	PF00017	0.607
LIG_SH2_STAT5	247	250	PF00017	0.527
LIG_SH3_3	156	162	PF00018	0.807
LIG_SH3_3	296	302	PF00018	0.741
LIG_SH3_3	375	381	PF00018	0.777
LIG_SH3_3	449	455	PF00018	0.776
LIG_SH3_3	464	470	PF00018	0.720
LIG_SH3_3	483	489	PF00018	0.518
LIG_SH3_3	547	553	PF00018	0.630
LIG_SH3_3	578	584	PF00018	0.503
LIG_TRAF2_1	656	659	PF00917	0.571
LIG_TRAF2_2	352	357	PF00917	0.754
LIG_WRC_WIRS_1	95	100	PF05994	0.714
LIG_WW_2	159	162	PF00397	0.810
LIG_WW_2	467	470	PF00397	0.743
MOD_CDK_SPK_2	161	166	PF00069	0.708
MOD_CDK_SPxxK_3	181	188	PF00069	0.731
MOD_CK1_1	134	140	PF00069	0.678
MOD_CK1_1	193	199	PF00069	0.561
MOD_CK1_1	320	326	PF00069	0.729
MOD_CK1_1	335	341	PF00069	0.642
MOD_CK1_1	393	399	PF00069	0.698
MOD_CK1_1	400	406	PF00069	0.729
MOD_CK1_1	433	439	PF00069	0.835
MOD_CK1_1	520	526	PF00069	0.775
MOD_CK1_1	549	555	PF00069	0.789
MOD_CK1_1	557	563	PF00069	0.683
MOD_CK1_1	58	64	PF00069	0.717
MOD_CK1_1	75	81	PF00069	0.573
MOD_CK1_1	84	90	PF00069	0.682
MOD_CK2_1	16	22	PF00069	0.625
MOD_CK2_1	180	186	PF00069	0.646
MOD_CK2_1	457	463	PF00069	0.767
MOD_CK2_1	497	503	PF00069	0.819
MOD_CK2_1	557	563	PF00069	0.730
MOD_CK2_1	653	659	PF00069	0.509
MOD_GlcNHglycan	1	4	PF01048	0.781
MOD_GlcNHglycan	11	14	PF01048	0.509
MOD_GlcNHglycan	128	131	PF01048	0.758
MOD_GlcNHglycan	136	139	PF01048	0.618
MOD_GlcNHglycan	199	202	PF01048	0.598
MOD_GlcNHglycan	303	306	PF01048	0.765
MOD_GlcNHglycan	332	335	PF01048	0.806
MOD_GlcNHglycan	346	349	PF01048	0.616
MOD_GlcNHglycan	388	391	PF01048	0.761
MOD_GlcNHglycan	399	402	PF01048	0.668
MOD_GlcNHglycan	411	415	PF01048	0.555
MOD_GlcNHglycan	441	444	PF01048	0.768
MOD_GlcNHglycan	455	458	PF01048	0.597
MOD_GlcNHglycan	519	523	PF01048	0.684
MOD_GlcNHglycan	60	63	PF01048	0.705
MOD_GSK3_1	105	112	PF00069	0.490
MOD_GSK3_1	122	129	PF00069	0.585
MOD_GSK3_1	132	139	PF00069	0.699
MOD_GSK3_1	161	168	PF00069	0.676
MOD_GSK3_1	193	200	PF00069	0.624
MOD_GSK3_1	297	304	PF00069	0.665
MOD_GSK3_1	314	321	PF00069	0.712
MOD_GSK3_1	332	339	PF00069	0.514
MOD_GSK3_1	344	351	PF00069	0.750
MOD_GSK3_1	386	393	PF00069	0.636
MOD_GSK3_1	432	439	PF00069	0.759
MOD_GSK3_1	453	460	PF00069	0.787
MOD_GSK3_1	506	513	PF00069	0.794
MOD_GSK3_1	520	527	PF00069	0.618
MOD_GSK3_1	542	549	PF00069	0.672
MOD_GSK3_1	553	560	PF00069	0.663
MOD_GSK3_1	66	73	PF00069	0.751
MOD_GSK3_1	77	84	PF00069	0.673
MOD_N-GLC_1	126	131	PF02516	0.666
MOD_N-GLC_1	394	399	PF02516	0.619
MOD_N-GLC_1	461	466	PF02516	0.715
MOD_N-GLC_2	539	541	PF02516	0.608
MOD_NEK2_1	197	202	PF00069	0.632
MOD_NEK2_1	248	253	PF00069	0.567
MOD_NEK2_1	332	337	PF00069	0.733
MOD_NEK2_1	356	361	PF00069	0.635
MOD_NEK2_1	372	377	PF00069	0.644
MOD_NEK2_1	517	522	PF00069	0.720
MOD_NEK2_1	542	547	PF00069	0.705
MOD_PIKK_1	136	142	PF00454	0.593
MOD_PIKK_1	641	647	PF00454	0.530
MOD_PK_1	599	605	PF00069	0.530
MOD_PKA_2	165	171	PF00069	0.801
MOD_PKA_2	238	244	PF00069	0.670
MOD_PKA_2	357	363	PF00069	0.668
MOD_PKA_2	436	442	PF00069	0.838
MOD_PKA_2	506	512	PF00069	0.837
MOD_PKA_2	542	548	PF00069	0.675
MOD_PKA_2	641	647	PF00069	0.483
MOD_PKA_2	653	659	PF00069	0.474
MOD_Plk_1	143	149	PF00069	0.750
MOD_Plk_1	193	199	PF00069	0.731
MOD_Plk_1	497	503	PF00069	0.605
MOD_Plk_4	193	199	PF00069	0.653
MOD_Plk_4	542	548	PF00069	0.718
MOD_ProDKin_1	109	115	PF00069	0.483
MOD_ProDKin_1	161	167	PF00069	0.687
MOD_ProDKin_1	173	179	PF00069	0.646
MOD_ProDKin_1	181	187	PF00069	0.731
MOD_ProDKin_1	255	261	PF00069	0.651
MOD_ProDKin_1	318	324	PF00069	0.808
MOD_ProDKin_1	348	354	PF00069	0.761
MOD_ProDKin_1	366	372	PF00069	0.550
MOD_ProDKin_1	394	400	PF00069	0.637
MOD_ProDKin_1	549	555	PF00069	0.637
MOD_ProDKin_1	601	607	PF00069	0.452
MOD_ProDKin_1	72	78	PF00069	0.659
MOD_ProDKin_1	86	92	PF00069	0.628
MOD_SUMO_rev_2	273	281	PF00179	0.594
MOD_SUMO_rev_2	28	34	PF00179	0.663
TRG_DiLeu_BaLyEn_6	327	332	PF01217	0.721
TRG_ENDOCYTIC_2	547	550	PF00928	0.716
TRG_ER_diArg_1	207	210	PF00400	0.669
TRG_ER_diArg_1	242	244	PF00400	0.673
TRG_ER_diArg_1	284	287	PF00400	0.706
TRG_ER_diArg_1	477	480	PF00400	0.722
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.698
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.663

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WQZ0	Leishmania donovani	89%	100%
A4H600	Leishmania braziliensis	58%	100%
A4HUC6	Leishmania infantum	89%	100%
E9AN26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%