Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QHJ6_LEIMA

TriTrypDb:

LmjF.10.0218 , LMJLV39_100007100 , LMJSD75_100007200

Length:

712

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHJ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.571
CLV_C14_Caspase3-7	206	210	PF00656	0.698
CLV_C14_Caspase3-7	342	346	PF00656	0.559
CLV_C14_Caspase3-7	365	369	PF00656	0.471
CLV_NRD_NRD_1	529	531	PF00675	0.390
CLV_NRD_NRD_1	548	550	PF00675	0.465
CLV_NRD_NRD_1	663	665	PF00675	0.461
CLV_PCSK_KEX2_1	529	531	PF00082	0.390
CLV_PCSK_KEX2_1	547	549	PF00082	0.459
CLV_PCSK_KEX2_1	662	664	PF00082	0.445
CLV_PCSK_PC7_1	658	664	PF00082	0.432
CLV_PCSK_SKI1_1	585	589	PF00082	0.394
CLV_PCSK_SKI1_1	62	66	PF00082	0.630
DEG_APCC_DBOX_1	151	159	PF00400	0.530
DEG_Nend_Nbox_1	1	3	PF02207	0.602
DEG_SPOP_SBC_1	71	75	PF00917	0.556
DOC_MAPK_gen_1	152	161	PF00069	0.621
DOC_MAPK_gen_1	294	303	PF00069	0.615
DOC_MAPK_gen_1	441	449	PF00069	0.440
DOC_MAPK_gen_1	529	536	PF00069	0.390
DOC_MAPK_MEF2A_6	297	305	PF00069	0.617
DOC_MAPK_MEF2A_6	529	536	PF00069	0.390
DOC_PP1_RVXF_1	625	631	PF00149	0.444
DOC_PP2B_LxvP_1	192	195	PF13499	0.630
DOC_PP4_FxxP_1	58	61	PF00568	0.459
DOC_PP4_MxPP_1	708	711	PF00568	0.544
DOC_USP7_MATH_1	150	154	PF00917	0.555
DOC_USP7_MATH_1	195	199	PF00917	0.648
DOC_USP7_MATH_1	287	291	PF00917	0.581
DOC_USP7_MATH_1	310	314	PF00917	0.582
DOC_USP7_MATH_1	373	377	PF00917	0.421
DOC_USP7_MATH_1	381	385	PF00917	0.445
DOC_USP7_MATH_1	420	424	PF00917	0.639
DOC_USP7_MATH_1	457	461	PF00917	0.547
DOC_USP7_MATH_1	505	509	PF00917	0.684
DOC_USP7_MATH_1	510	514	PF00917	0.613
DOC_USP7_MATH_1	537	541	PF00917	0.474
DOC_USP7_MATH_1	595	599	PF00917	0.535
DOC_USP7_MATH_1	608	612	PF00917	0.434
DOC_USP7_MATH_1	639	643	PF00917	0.517
DOC_USP7_MATH_1	70	74	PF00917	0.686
DOC_USP7_MATH_2	21	27	PF00917	0.650
DOC_USP7_MATH_2	96	102	PF00917	0.650
DOC_WW_Pin1_4	133	138	PF00397	0.622
DOC_WW_Pin1_4	193	198	PF00397	0.587
DOC_WW_Pin1_4	283	288	PF00397	0.579
DOC_WW_Pin1_4	306	311	PF00397	0.593
DOC_WW_Pin1_4	31	36	PF00397	0.586
DOC_WW_Pin1_4	516	521	PF00397	0.485
DOC_WW_Pin1_4	563	568	PF00397	0.496
DOC_WW_Pin1_4	63	68	PF00397	0.578
DOC_WW_Pin1_4	680	685	PF00397	0.576
DOC_WW_Pin1_4	72	77	PF00397	0.593
DOC_WW_Pin1_4	89	94	PF00397	0.670
LIG_14-3-3_CanoR_1	152	162	PF00244	0.653
LIG_14-3-3_CanoR_1	187	195	PF00244	0.640
LIG_14-3-3_CanoR_1	280	288	PF00244	0.798
LIG_14-3-3_CanoR_1	3	7	PF00244	0.684
LIG_14-3-3_CanoR_1	414	422	PF00244	0.559
LIG_14-3-3_CanoR_1	441	446	PF00244	0.527
LIG_14-3-3_CanoR_1	492	496	PF00244	0.530
LIG_14-3-3_CanoR_1	663	669	PF00244	0.403
LIG_BIR_III_4	509	513	PF00653	0.552
LIG_BRCT_BRCA1_1	259	263	PF00533	0.607
LIG_CSL_BTD_1	681	684	PF09270	0.535
LIG_CtBP_PxDLS_1	96	100	PF00389	0.558
LIG_deltaCOP1_diTrp_1	39	44	PF00928	0.584
LIG_eIF4E_1	448	454	PF01652	0.597
LIG_FHA_1	187	193	PF00498	0.561
LIG_FHA_1	2	8	PF00498	0.647
LIG_FHA_1	20	26	PF00498	0.735
LIG_FHA_1	219	225	PF00498	0.552
LIG_FHA_1	323	329	PF00498	0.491
LIG_FHA_1	391	397	PF00498	0.501
LIG_FHA_1	681	687	PF00498	0.557
LIG_FHA_1	700	706	PF00498	0.326
LIG_FHA_2	204	210	PF00498	0.704
LIG_FHA_2	363	369	PF00498	0.462
LIG_FHA_2	407	413	PF00498	0.523
LIG_FHA_2	552	558	PF00498	0.465
LIG_FHA_2	683	689	PF00498	0.470
LIG_FHA_2	9	15	PF00498	0.686
LIG_GSK3_LRP6_1	193	198	PF00069	0.609
LIG_LIR_Gen_1	121	131	PF02991	0.522
LIG_LIR_Gen_1	344	351	PF02991	0.476
LIG_LIR_Nem_3	121	126	PF02991	0.532
LIG_LIR_Nem_3	344	350	PF02991	0.449
LIG_LIR_Nem_3	695	701	PF02991	0.430
LIG_LRP6_Inhibitor_1	328	334	PF00058	0.380
LIG_NRBOX	154	160	PF00104	0.542
LIG_SH2_CRK	298	302	PF00017	0.665
LIG_SH2_GRB2like	329	332	PF00017	0.385
LIG_SH2_GRB2like	448	451	PF00017	0.527
LIG_SH2_NCK_1	112	116	PF00017	0.632
LIG_SH2_NCK_1	636	640	PF00017	0.503
LIG_SH2_SRC	329	332	PF00017	0.485
LIG_SH2_STAT5	185	188	PF00017	0.614
LIG_SH2_STAT5	29	32	PF00017	0.673
LIG_SH2_STAT5	329	332	PF00017	0.535
LIG_SH2_STAT5	448	451	PF00017	0.537
LIG_SH2_STAT5	526	529	PF00017	0.394
LIG_SH2_STAT5	57	60	PF00017	0.569
LIG_SH2_STAT5	6	9	PF00017	0.644
LIG_SH3_1	90	96	PF00018	0.676
LIG_SH3_3	191	197	PF00018	0.627
LIG_SH3_3	233	239	PF00018	0.608
LIG_SH3_3	354	360	PF00018	0.544
LIG_SH3_3	39	45	PF00018	0.585
LIG_SH3_3	423	429	PF00018	0.642
LIG_SH3_3	64	70	PF00018	0.581
LIG_SH3_3	90	96	PF00018	0.679
LIG_Sin3_3	493	500	PF02671	0.502
LIG_SUMO_SIM_anti_2	177	183	PF11976	0.605
LIG_SUMO_SIM_par_1	358	365	PF11976	0.483
LIG_SUMO_SIM_par_1	406	413	PF11976	0.546
LIG_TRAF2_1	614	617	PF00917	0.488
LIG_TRFH_1	6	10	PF08558	0.642
MOD_CDK_SPK_2	72	77	PF00069	0.561
MOD_CDK_SPxxK_3	133	140	PF00069	0.614
MOD_CK1_1	153	159	PF00069	0.590
MOD_CK1_1	362	368	PF00069	0.446
MOD_CK1_1	397	403	PF00069	0.605
MOD_CK1_1	92	98	PF00069	0.579
MOD_CK2_1	287	293	PF00069	0.621
MOD_CK2_1	406	412	PF00069	0.524
MOD_CK2_1	551	557	PF00069	0.446
MOD_CK2_1	92	98	PF00069	0.587
MOD_CMANNOS	41	44	PF00535	0.584
MOD_Cter_Amidation	545	548	PF01082	0.511
MOD_GlcNHglycan	100	103	PF01048	0.619
MOD_GlcNHglycan	118	121	PF01048	0.480
MOD_GlcNHglycan	171	174	PF01048	0.623
MOD_GlcNHglycan	176	179	PF01048	0.707
MOD_GlcNHglycan	197	200	PF01048	0.585
MOD_GlcNHglycan	289	292	PF01048	0.594
MOD_GlcNHglycan	334	337	PF01048	0.501
MOD_GlcNHglycan	379	382	PF01048	0.577
MOD_GlcNHglycan	399	402	PF01048	0.400
MOD_GlcNHglycan	443	446	PF01048	0.668
MOD_GlcNHglycan	567	570	PF01048	0.532
MOD_GlcNHglycan	610	613	PF01048	0.501
MOD_GlcNHglycan	641	644	PF01048	0.597
MOD_GSK3_1	19	26	PF00069	0.693
MOD_GSK3_1	278	285	PF00069	0.619
MOD_GSK3_1	299	306	PF00069	0.660
MOD_GSK3_1	355	362	PF00069	0.682
MOD_GSK3_1	373	380	PF00069	0.335
MOD_GSK3_1	390	397	PF00069	0.570
MOD_GSK3_1	491	498	PF00069	0.409
MOD_GSK3_1	512	519	PF00069	0.521
MOD_GSK3_1	600	607	PF00069	0.573
MOD_GSK3_1	699	706	PF00069	0.455
MOD_GSK3_1	88	95	PF00069	0.584
MOD_N-GLC_1	537	542	PF02516	0.473
MOD_NEK2_1	1	6	PF00069	0.606
MOD_NEK2_1	174	179	PF00069	0.524
MOD_NEK2_1	30	35	PF00069	0.609
MOD_NEK2_1	495	500	PF00069	0.502
MOD_NEK2_1	51	56	PF00069	0.572
MOD_NEK2_1	551	556	PF00069	0.453
MOD_OFUCOSY	592	599	PF10250	0.562
MOD_PIKK_1	381	387	PF00454	0.472
MOD_PIKK_1	510	516	PF00454	0.493
MOD_PIKK_1	537	543	PF00454	0.472
MOD_PKA_2	153	159	PF00069	0.590
MOD_PKA_2	186	192	PF00069	0.563
MOD_PKA_2	2	8	PF00069	0.684
MOD_PKA_2	491	497	PF00069	0.534
MOD_PKA_2	657	663	PF00069	0.427
MOD_PKB_1	662	670	PF00069	0.400
MOD_Plk_1	278	284	PF00069	0.525
MOD_Plk_1	322	328	PF00069	0.510
MOD_Plk_1	394	400	PF00069	0.616
MOD_Plk_1	537	543	PF00069	0.321
MOD_Plk_1	677	683	PF00069	0.494
MOD_Plk_1	703	709	PF00069	0.498
MOD_Plk_4	2	8	PF00069	0.634
MOD_Plk_4	491	497	PF00069	0.484
MOD_Plk_4	704	710	PF00069	0.517
MOD_ProDKin_1	133	139	PF00069	0.619
MOD_ProDKin_1	193	199	PF00069	0.589
MOD_ProDKin_1	283	289	PF00069	0.579
MOD_ProDKin_1	306	312	PF00069	0.591
MOD_ProDKin_1	31	37	PF00069	0.586
MOD_ProDKin_1	516	522	PF00069	0.479
MOD_ProDKin_1	563	569	PF00069	0.492
MOD_ProDKin_1	63	69	PF00069	0.584
MOD_ProDKin_1	680	686	PF00069	0.569
MOD_ProDKin_1	72	78	PF00069	0.595
MOD_ProDKin_1	89	95	PF00069	0.666
MOD_SUMO_rev_2	136	142	PF00179	0.540
TRG_ENDOCYTIC_2	298	301	PF00928	0.666
TRG_ER_diArg_1	151	154	PF00400	0.604
TRG_ER_diArg_1	213	216	PF00400	0.563
TRG_ER_diArg_1	440	443	PF00400	0.510
TRG_ER_diArg_1	547	549	PF00400	0.643
TRG_ER_diArg_1	662	664	PF00400	0.475
TRG_NES_CRM1_1	255	270	PF08389	0.617
TRG_Pf-PMV_PEXEL_1	571	575	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	650	655	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	666	671	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILE3	Leptomonas seymouri	38%	100%
A0A3S7WR11	Leishmania donovani	90%	100%
A4H603	Leishmania braziliensis	70%	100%
A4HUD0	Leishmania infantum	90%	100%
E9AN30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%