Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QHJ5_LEIMA

TriTrypDb:

LmjF.10.0219 , LMJLV39_100007200 , LMJSD75_100007300

Length:

276

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 7, no: 0
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QHJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHJ5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	44	48	PF00656	0.389
CLV_NRD_NRD_1	230	232	PF00675	0.486
CLV_NRD_NRD_1	234	236	PF00675	0.528
CLV_PCSK_KEX2_1	230	232	PF00082	0.484
CLV_PCSK_KEX2_1	234	236	PF00082	0.528
CLV_PCSK_PC7_1	230	236	PF00082	0.483
CLV_PCSK_SKI1_1	120	124	PF00082	0.643
DEG_SCF_FBW7_1	62	69	PF00400	0.382
DOC_CKS1_1	123	128	PF01111	0.446
DOC_PP4_FxxP_1	123	126	PF00568	0.447
DOC_USP7_MATH_1	161	165	PF00917	0.496
DOC_USP7_MATH_1	214	218	PF00917	0.628
DOC_USP7_MATH_1	39	43	PF00917	0.403
DOC_WW_Pin1_4	122	127	PF00397	0.442
DOC_WW_Pin1_4	164	169	PF00397	0.521
DOC_WW_Pin1_4	212	217	PF00397	0.633
DOC_WW_Pin1_4	62	67	PF00397	0.510
LIG_14-3-3_CanoR_1	131	135	PF00244	0.466
LIG_14-3-3_CanoR_1	144	148	PF00244	0.387
LIG_14-3-3_CanoR_1	183	190	PF00244	0.481
LIG_14-3-3_CanoR_1	57	63	PF00244	0.342
LIG_FHA_1	107	113	PF00498	0.481
LIG_FHA_1	15	21	PF00498	0.647
LIG_FHA_1	185	191	PF00498	0.473
LIG_FHA_1	200	206	PF00498	0.379
LIG_FHA_1	35	41	PF00498	0.375
LIG_FHA_1	57	63	PF00498	0.363
LIG_FHA_1	86	92	PF00498	0.380
LIG_FHA_2	218	224	PF00498	0.655
LIG_LIR_Apic_2	121	126	PF02991	0.445
LIG_LIR_Gen_1	220	226	PF02991	0.651
LIG_LIR_Nem_3	146	151	PF02991	0.386
LIG_LIR_Nem_3	90	96	PF02991	0.409
LIG_PTAP_UEV_1	167	172	PF05743	0.522
LIG_PTB_Apo_2	246	253	PF02174	0.686
LIG_PTB_Phospho_1	246	252	PF10480	0.688
LIG_SH2_CRK	97	101	PF00017	0.346
LIG_SH2_NCK_1	45	49	PF00017	0.364
LIG_SH2_STAP1	222	226	PF00017	0.622
LIG_SH2_STAP1	45	49	PF00017	0.412
LIG_SH2_STAP1	97	101	PF00017	0.360
LIG_SH3_2	126	131	PF14604	0.459
LIG_SH3_3	123	129	PF00018	0.460
LIG_SH3_3	165	171	PF00018	0.573
LIG_SH3_3	33	39	PF00018	0.449
MOD_CDK_SPxxK_3	212	219	PF00069	0.634
MOD_CK1_1	150	156	PF00069	0.416
MOD_CK1_1	164	170	PF00069	0.450
MOD_CK1_1	217	223	PF00069	0.623
MOD_CK1_1	34	40	PF00069	0.446
MOD_CK1_1	80	86	PF00069	0.486
MOD_CK2_1	217	223	PF00069	0.652
MOD_GlcNHglycan	168	171	PF01048	0.694
MOD_GSK3_1	143	150	PF00069	0.423
MOD_GSK3_1	162	169	PF00069	0.413
MOD_GSK3_1	184	191	PF00069	0.450
MOD_GSK3_1	214	221	PF00069	0.631
MOD_GSK3_1	39	46	PF00069	0.394
MOD_GSK3_1	58	65	PF00069	0.464
MOD_GSK3_1	76	83	PF00069	0.436
MOD_N-GLC_1	107	112	PF02516	0.611
MOD_N-GLC_1	156	161	PF02516	0.694
MOD_N-GLC_1	23	28	PF02516	0.593
MOD_N-GLC_1	62	67	PF02516	0.593
MOD_N-GLC_2	249	251	PF02516	0.487
MOD_NEK2_1	104	109	PF00069	0.397
MOD_NEK2_1	184	189	PF00069	0.455
MOD_NEK2_1	20	25	PF00069	0.688
MOD_NEK2_2	143	148	PF00069	0.411
MOD_OFUCOSY	155	160	PF10250	0.632
MOD_PIKK_1	162	168	PF00454	0.499
MOD_PKA_2	130	136	PF00069	0.499
MOD_PKA_2	143	149	PF00069	0.368
MOD_PKA_2	56	62	PF00069	0.341
MOD_Plk_1	23	29	PF00069	0.463
MOD_Plk_1	80	86	PF00069	0.373
MOD_Plk_4	130	136	PF00069	0.504
MOD_Plk_4	14	20	PF00069	0.496
MOD_Plk_4	143	149	PF00069	0.363
MOD_Plk_4	5	11	PF00069	0.509
MOD_ProDKin_1	122	128	PF00069	0.443
MOD_ProDKin_1	164	170	PF00069	0.521
MOD_ProDKin_1	212	218	PF00069	0.633
MOD_ProDKin_1	62	68	PF00069	0.511
MOD_SUMO_for_1	237	240	PF00179	0.668
TRG_DiLeu_BaEn_2	270	276	PF01217	0.662
TRG_ENDOCYTIC_2	222	225	PF00928	0.679
TRG_ENDOCYTIC_2	97	100	PF00928	0.359
TRG_NLS_MonoExtC_3	230	235	PF00514	0.678
TRG_NLS_MonoExtN_4	230	235	PF00514	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYT1	Leptomonas seymouri	55%	87%
A0A3S7WR08	Leishmania donovani	91%	99%
A4H604	Leishmania braziliensis	71%	100%
A4HUD1	Leishmania infantum	92%	99%
E9AN31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	97%
Q4QIC3	Leishmania major	24%	100%