Amastin surface glycofamily protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amastin surface glycoprotein, putative

Species:

Leishmania major

UniProt:

Q4QHJ4_LEIMA

TriTrypDb:

LmjF.10.0220 , LMJLV39_100007300 , LMJSD75_100007400

Length:

490

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

Q4QHJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHJ4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.496
CLV_NRD_NRD_1	344	346	PF00675	0.539
CLV_NRD_NRD_1	35	37	PF00675	0.360
CLV_NRD_NRD_1	52	54	PF00675	0.301
CLV_NRD_NRD_1	58	60	PF00675	0.392
CLV_NRD_NRD_1	76	78	PF00675	0.345
CLV_PCSK_FUR_1	74	78	PF00082	0.368
CLV_PCSK_KEX2_1	35	37	PF00082	0.370
CLV_PCSK_KEX2_1	65	67	PF00082	0.430
CLV_PCSK_KEX2_1	74	76	PF00082	0.390
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.329
CLV_PCSK_SKI1_1	61	65	PF00082	0.401
DEG_MDM2_SWIB_1	284	292	PF02201	0.488
DOC_MAPK_gen_1	296	305	PF00069	0.461
DOC_MAPK_gen_1	74	82	PF00069	0.706
DOC_MAPK_MEF2A_6	298	307	PF00069	0.461
DOC_MAPK_MEF2A_6	394	402	PF00069	0.543
DOC_MAPK_RevD_3	333	346	PF00069	0.243
DOC_PP1_RVXF_1	296	303	PF00149	0.461
DOC_USP7_MATH_1	190	194	PF00917	0.293
DOC_USP7_MATH_1	333	337	PF00917	0.248
DOC_USP7_MATH_1	431	435	PF00917	0.227
DOC_USP7_MATH_1	5	9	PF00917	0.650
DOC_USP7_UBL2_3	61	65	PF12436	0.612
DOC_WW_Pin1_4	11	16	PF00397	0.675
DOC_WW_Pin1_4	429	434	PF00397	0.264
LIG_14-3-3_CanoR_1	24	30	PF00244	0.690
LIG_14-3-3_CanoR_1	348	353	PF00244	0.416
LIG_14-3-3_CanoR_1	355	359	PF00244	0.369
LIG_14-3-3_CanoR_1	4	13	PF00244	0.648
LIG_BIR_II_1	1	5	PF00653	0.726
LIG_BRCT_BRCA1_1	226	230	PF00533	0.299
LIG_BRCT_BRCA1_1	400	404	PF00533	0.359
LIG_BRCT_BRCA1_1	407	411	PF00533	0.367
LIG_EH1_1	372	380	PF00400	0.259
LIG_FHA_1	287	293	PF00498	0.583
LIG_FHA_1	295	301	PF00498	0.565
LIG_FHA_1	309	315	PF00498	0.292
LIG_FHA_1	412	418	PF00498	0.370
LIG_FHA_1	476	482	PF00498	0.353
LIG_FHA_2	113	119	PF00498	0.573
LIG_FHA_2	28	34	PF00498	0.587
LIG_LIR_Apic_2	356	361	PF02991	0.275
LIG_LIR_Gen_1	224	233	PF02991	0.320
LIG_LIR_Gen_1	234	242	PF02991	0.361
LIG_LIR_Gen_1	377	387	PF02991	0.328
LIG_LIR_Gen_1	395	404	PF02991	0.590
LIG_LIR_Gen_1	414	421	PF02991	0.401
LIG_LIR_Gen_1	437	447	PF02991	0.304
LIG_LIR_LC3C_4	234	239	PF02991	0.353
LIG_LIR_Nem_3	224	229	PF02991	0.336
LIG_LIR_Nem_3	234	238	PF02991	0.386
LIG_LIR_Nem_3	377	383	PF02991	0.328
LIG_LIR_Nem_3	395	400	PF02991	0.519
LIG_LIR_Nem_3	414	419	PF02991	0.324
LIG_LIR_Nem_3	441	447	PF02991	0.301
LIG_LIR_Nem_3	465	470	PF02991	0.311
LIG_MLH1_MIPbox_1	226	230	PF16413	0.228
LIG_Pex14_1	324	328	PF04695	0.300
LIG_Pex14_2	221	225	PF04695	0.295
LIG_Pex14_2	284	288	PF04695	0.468
LIG_SH2_CRK	129	133	PF00017	0.353
LIG_SH2_CRK	358	362	PF00017	0.305
LIG_SH2_CRK	444	448	PF00017	0.356
LIG_SH2_PTP2	304	307	PF00017	0.293
LIG_SH2_PTP2	397	400	PF00017	0.514
LIG_SH2_STAP1	226	230	PF00017	0.267
LIG_SH2_STAP1	406	410	PF00017	0.438
LIG_SH2_STAT3	181	184	PF00017	0.261
LIG_SH2_STAT3	393	396	PF00017	0.452
LIG_SH2_STAT5	129	132	PF00017	0.353
LIG_SH2_STAT5	304	307	PF00017	0.353
LIG_SH2_STAT5	321	324	PF00017	0.227
LIG_SH2_STAT5	397	400	PF00017	0.541
LIG_SUMO_SIM_anti_2	477	483	PF11976	0.349
LIG_SUMO_SIM_par_1	417	422	PF11976	0.317
LIG_SUMO_SIM_par_1	78	83	PF11976	0.555
LIG_TRAF2_1	14	17	PF00917	0.700
LIG_TYR_ITIM	127	132	PF00017	0.353
LIG_WRC_WIRS_1	198	203	PF05994	0.354
LIG_WRC_WIRS_1	222	227	PF05994	0.353
LIG_WRC_WIRS_1	242	247	PF05994	0.183
LIG_WRC_WIRS_1	349	354	PF05994	0.304
MOD_CK1_1	111	117	PF00069	0.571
MOD_CK1_1	224	230	PF00069	0.399
MOD_CK1_1	231	237	PF00069	0.318
MOD_CK1_1	291	297	PF00069	0.627
MOD_CK1_1	354	360	PF00069	0.339
MOD_CK1_1	434	440	PF00069	0.245
MOD_CK1_1	459	465	PF00069	0.251
MOD_CK2_1	11	17	PF00069	0.832
MOD_CK2_1	112	118	PF00069	0.575
MOD_CK2_1	459	465	PF00069	0.302
MOD_CK2_1	49	55	PF00069	0.593
MOD_CK2_1	91	97	PF00069	0.771
MOD_Cter_Amidation	154	157	PF01082	0.496
MOD_GlcNHglycan	132	135	PF01048	0.443
MOD_GlcNHglycan	153	156	PF01048	0.622
MOD_GlcNHglycan	205	208	PF01048	0.359
MOD_GlcNHglycan	25	28	PF01048	0.479
MOD_GlcNHglycan	293	296	PF01048	0.459
MOD_GlcNHglycan	433	436	PF01048	0.534
MOD_GlcNHglycan	448	451	PF01048	0.576
MOD_GlcNHglycan	458	461	PF01048	0.533
MOD_GSK3_1	108	115	PF00069	0.701
MOD_GSK3_1	19	26	PF00069	0.731
MOD_GSK3_1	190	197	PF00069	0.348
MOD_GSK3_1	217	224	PF00069	0.489
MOD_GSK3_1	344	351	PF00069	0.295
MOD_GSK3_1	411	418	PF00069	0.378
MOD_GSK3_1	422	429	PF00069	0.347
MOD_GSK3_1	431	438	PF00069	0.378
MOD_LATS_1	47	53	PF00433	0.550
MOD_N-GLC_1	11	16	PF02516	0.461
MOD_N-GLC_1	22	27	PF02516	0.471
MOD_N-GLC_1	456	461	PF02516	0.434
MOD_NEK2_1	141	146	PF00069	0.340
MOD_NEK2_1	217	222	PF00069	0.470
MOD_NEK2_1	228	233	PF00069	0.335
MOD_NEK2_1	241	246	PF00069	0.216
MOD_NEK2_1	313	318	PF00069	0.468
MOD_NEK2_1	353	358	PF00069	0.380
MOD_NEK2_1	374	379	PF00069	0.388
MOD_NEK2_1	411	416	PF00069	0.466
MOD_NEK2_1	419	424	PF00069	0.502
MOD_NEK2_2	308	313	PF00069	0.254
MOD_OFUCOSY	139	145	PF10250	0.215
MOD_PIKK_1	112	118	PF00454	0.575
MOD_PIKK_1	392	398	PF00454	0.443
MOD_PIKK_1	98	104	PF00454	0.669
MOD_PKA_2	161	167	PF00069	0.234
MOD_PKA_2	23	29	PF00069	0.699
MOD_PKA_2	344	350	PF00069	0.324
MOD_PKA_2	354	360	PF00069	0.352
MOD_PKA_2	5	11	PF00069	0.646
MOD_Plk_1	177	183	PF00069	0.270
MOD_Plk_1	331	337	PF00069	0.314
MOD_Plk_1	47	53	PF00069	0.627
MOD_Plk_4	127	133	PF00069	0.361
MOD_Plk_4	190	196	PF00069	0.370
MOD_Plk_4	217	223	PF00069	0.472
MOD_Plk_4	224	230	PF00069	0.350
MOD_Plk_4	308	314	PF00069	0.414
MOD_Plk_4	319	325	PF00069	0.324
MOD_Plk_4	333	339	PF00069	0.256
MOD_Plk_4	348	354	PF00069	0.377
MOD_Plk_4	374	380	PF00069	0.349
MOD_Plk_4	482	488	PF00069	0.360
MOD_ProDKin_1	11	17	PF00069	0.677
MOD_ProDKin_1	429	435	PF00069	0.264
TRG_DiLeu_BaEn_1	465	470	PF01217	0.353
TRG_ENDOCYTIC_2	129	132	PF00928	0.353
TRG_ENDOCYTIC_2	226	229	PF00928	0.322
TRG_ENDOCYTIC_2	242	245	PF00928	0.384
TRG_ENDOCYTIC_2	304	307	PF00928	0.416
TRG_ENDOCYTIC_2	397	400	PF00928	0.453
TRG_ENDOCYTIC_2	444	447	PF00928	0.304
TRG_ER_diArg_1	3	6	PF00400	0.658
TRG_ER_diArg_1	34	36	PF00400	0.543
TRG_ER_diArg_1	74	77	PF00400	0.534

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6X2	Leptomonas seymouri	63%	97%
A0A0N1PC74	Leptomonas seymouri	26%	97%
A0A0N1PCA2	Leptomonas seymouri	29%	100%
A0A3Q8I8Q6	Leishmania donovani	92%	100%
A0A3S7WR28	Leishmania donovani	27%	100%
A0A3S7X1E1	Leishmania donovani	27%	94%
A4H605	Leishmania braziliensis	70%	96%
A4H606	Leishmania braziliensis	26%	100%
A4HGF8	Leishmania braziliensis	29%	94%
A4HUD2	Leishmania infantum	92%	100%
A4HUD3	Leishmania infantum	27%	100%
A4I3I9	Leishmania infantum	28%	94%
E9AN32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9AN33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AZT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	94%
Q4Q8F3	Leishmania major	28%	100%
Q4QHJ3	Leishmania major	27%	97%