Amastin surface glycofamily protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amastin surface glycoprotein, putative

Species:

Leishmania major

UniProt:

Q4QHJ3_LEIMA

TriTrypDb:

LmjF.10.0230 , LMJLV39_100007400 , LMJSD75_100007500

Length:

418

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

Q4QHJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHJ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	36	40	PF00656	0.579
CLV_NRD_NRD_1	93	95	PF00675	0.506
CLV_PCSK_KEX2_1	115	117	PF00082	0.519
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.496
CLV_PCSK_SKI1_1	116	120	PF00082	0.472
CLV_PCSK_SKI1_1	333	337	PF00082	0.318
DEG_APCC_DBOX_1	146	154	PF00400	0.434
DOC_CYCLIN_RxL_1	113	123	PF00134	0.239
DOC_MAPK_FxFP_2	315	318	PF00069	0.209
DOC_MAPK_gen_1	330	339	PF00069	0.489
DOC_MAPK_HePTP_8	327	339	PF00069	0.496
DOC_MAPK_MEF2A_6	147	154	PF00069	0.450
DOC_MAPK_MEF2A_6	330	339	PF00069	0.548
DOC_PP1_RVXF_1	383	389	PF00149	0.296
DOC_PP2B_LxvP_1	83	86	PF13499	0.257
DOC_PP4_FxxP_1	315	318	PF00568	0.300
DOC_USP7_MATH_1	236	240	PF00917	0.374
DOC_USP7_MATH_1	289	293	PF00917	0.389
DOC_WW_Pin1_4	102	107	PF00397	0.243
DOC_WW_Pin1_4	22	27	PF00397	0.574
LIG_14-3-3_CanoR_1	264	269	PF00244	0.253
LIG_14-3-3_CanoR_1	358	363	PF00244	0.309
LIG_14-3-3_CanoR_1	94	99	PF00244	0.331
LIG_Actin_WH2_2	76	91	PF00022	0.245
LIG_BIR_II_1	1	5	PF00653	0.624
LIG_BRCT_BRCA1_1	311	315	PF00533	0.363
LIG_BRCT_BRCA1_1	71	75	PF00533	0.393
LIG_eIF4E_1	232	238	PF01652	0.478
LIG_FHA_1	11	17	PF00498	0.720
LIG_FHA_1	158	164	PF00498	0.328
LIG_FHA_1	203	209	PF00498	0.300
LIG_FHA_1	263	269	PF00498	0.270
LIG_FHA_1	343	349	PF00498	0.361
LIG_FHA_1	392	398	PF00498	0.298
LIG_FHA_1	406	412	PF00498	0.319
LIG_LIR_Apic_2	291	296	PF02991	0.264
LIG_LIR_Apic_2	312	318	PF02991	0.209
LIG_LIR_Apic_2	372	378	PF02991	0.243
LIG_LIR_Gen_1	105	113	PF02991	0.243
LIG_LIR_Gen_1	123	132	PF02991	0.398
LIG_LIR_Gen_1	166	175	PF02991	0.371
LIG_LIR_Gen_1	203	212	PF02991	0.355
LIG_LIR_Gen_1	343	352	PF02991	0.427
LIG_LIR_Gen_1	66	75	PF02991	0.284
LIG_LIR_Nem_3	105	110	PF02991	0.270
LIG_LIR_Nem_3	123	128	PF02991	0.451
LIG_LIR_Nem_3	166	171	PF02991	0.395
LIG_LIR_Nem_3	194	200	PF02991	0.339
LIG_LIR_Nem_3	271	275	PF02991	0.377
LIG_LIR_Nem_3	336	342	PF02991	0.362
LIG_LIR_Nem_3	343	347	PF02991	0.349
LIG_LIR_Nem_3	66	70	PF02991	0.284
LIG_LIR_Nem_3	97	102	PF02991	0.294
LIG_Pex14_2	197	201	PF04695	0.297
LIG_SH2_CRK	293	297	PF00017	0.292
LIG_SH2_CRK	328	332	PF00017	0.426
LIG_SH2_CRK	375	379	PF00017	0.365
LIG_SH2_STAT5	413	416	PF00017	0.367
LIG_SH3_3	364	370	PF00018	0.390
LIG_SUMO_SIM_par_1	130	136	PF11976	0.305
LIG_SUMO_SIM_par_1	159	164	PF11976	0.321
LIG_SUMO_SIM_par_1	245	251	PF11976	0.367
LIG_SUMO_SIM_par_1	306	313	PF11976	0.225
LIG_TYR_ITIM	270	275	PF00017	0.252
LIG_TYR_ITIM	411	416	PF00017	0.367
LIG_UBA3_1	411	417	PF00899	0.257
LIG_WRC_WIRS_1	201	206	PF05994	0.359
LIG_WRC_WIRS_1	238	243	PF05994	0.277
LIG_WRC_WIRS_1	317	322	PF05994	0.281
LIG_WRC_WIRS_1	359	364	PF05994	0.296
MOD_CDK_SPxxK_3	102	109	PF00069	0.226
MOD_CK1_1	133	139	PF00069	0.438
MOD_CK1_1	240	246	PF00069	0.385
MOD_CK1_1	309	315	PF00069	0.387
MOD_CK1_1	32	38	PF00069	0.637
MOD_CK1_1	351	357	PF00069	0.340
MOD_CK1_1	71	77	PF00069	0.367
MOD_CK2_1	105	111	PF00069	0.307
MOD_CK2_1	220	226	PF00069	0.522
MOD_CK2_1	280	286	PF00069	0.286
MOD_CMANNOS	96	99	PF00535	0.513
MOD_Cter_Amidation	92	95	PF01082	0.505
MOD_GlcNHglycan	234	237	PF01048	0.377
MOD_GlcNHglycan	242	245	PF01048	0.385
MOD_GlcNHglycan	350	353	PF01048	0.452
MOD_GlcNHglycan	364	367	PF01048	0.550
MOD_GlcNHglycan	401	404	PF01048	0.401
MOD_GlcNHglycan	56	61	PF01048	0.404
MOD_GSK3_1	157	164	PF00069	0.337
MOD_GSK3_1	218	225	PF00069	0.666
MOD_GSK3_1	227	234	PF00069	0.584
MOD_GSK3_1	236	243	PF00069	0.240
MOD_GSK3_1	264	271	PF00069	0.402
MOD_GSK3_1	29	36	PF00069	0.663
MOD_GSK3_1	316	323	PF00069	0.493
MOD_GSK3_1	358	365	PF00069	0.358
MOD_LATS_1	92	98	PF00433	0.200
MOD_N-GLC_1	102	107	PF02516	0.467
MOD_N-GLC_1	218	223	PF02516	0.390
MOD_N-GLC_1	280	285	PF02516	0.539
MOD_N-GLC_1	29	34	PF02516	0.414
MOD_NEK2_1	1	6	PF00069	0.616
MOD_NEK2_1	218	223	PF00069	0.638
MOD_NEK2_1	227	232	PF00069	0.587
MOD_NEK2_1	237	242	PF00069	0.322
MOD_NEK2_1	268	273	PF00069	0.231
MOD_NEK2_1	320	325	PF00069	0.324
MOD_NEK2_1	33	38	PF00069	0.692
MOD_NEK2_1	348	353	PF00069	0.481
MOD_NEK2_1	399	404	PF00069	0.375
MOD_NEK2_1	69	74	PF00069	0.269
MOD_NEK2_1	79	84	PF00069	0.368
MOD_NEK2_2	296	301	PF00069	0.226
MOD_PIKK_1	33	39	PF00454	0.612
MOD_PKA_1	94	100	PF00069	0.256
MOD_PKA_2	263	269	PF00069	0.244
MOD_Plk_1	218	224	PF00069	0.482
MOD_Plk_1	280	286	PF00069	0.274
MOD_Plk_1	29	35	PF00069	0.646
MOD_Plk_2-3	220	226	PF00069	0.509
MOD_Plk_4	133	139	PF00069	0.477
MOD_Plk_4	157	163	PF00069	0.335
MOD_Plk_4	237	243	PF00069	0.385
MOD_Plk_4	306	312	PF00069	0.370
MOD_Plk_4	316	322	PF00069	0.373
MOD_Plk_4	71	77	PF00069	0.405
MOD_ProDKin_1	102	108	PF00069	0.243
MOD_ProDKin_1	22	28	PF00069	0.573
MOD_SUMO_rev_2	35	43	PF00179	0.641
TRG_ENDOCYTIC_2	272	275	PF00928	0.389
TRG_ENDOCYTIC_2	359	362	PF00928	0.307
TRG_ENDOCYTIC_2	413	416	PF00928	0.367
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.434
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.453

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6X2	Leptomonas seymouri	28%	82%
A0A0N1PC74	Leptomonas seymouri	24%	83%
A0A0N1PCA2	Leptomonas seymouri	54%	100%
A0A0S4IH58	Bodo saltans	24%	71%
A0A3Q8I8Q6	Leishmania donovani	27%	85%
A0A3S7WR28	Leishmania donovani	95%	100%
A0A3S7X1E1	Leishmania donovani	25%	81%
A4H605	Leishmania braziliensis	27%	82%
A4H606	Leishmania braziliensis	67%	100%
A4HGF8	Leishmania braziliensis	27%	80%
A4HUD2	Leishmania infantum	28%	85%
A4HUD3	Leishmania infantum	95%	100%
A4I3I9	Leishmania infantum	25%	81%
E9AN32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	88%
E9AN33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AZT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	80%
Q4Q8F3	Leishmania major	25%	100%
Q4QHJ4	Leishmania major	27%	85%