Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHJ2_LEIMA

TriTrypDb:

LmjF.10.0240 , LMJLV39_100007500 , LMJSD75_100007600

Length:

726

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHJ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHJ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	207	211	PF00656	0.824
CLV_C14_Caspase3-7	655	659	PF00656	0.743
CLV_NRD_NRD_1	112	114	PF00675	0.687
CLV_NRD_NRD_1	143	145	PF00675	0.794
CLV_NRD_NRD_1	295	297	PF00675	0.692
CLV_NRD_NRD_1	44	46	PF00675	0.728
CLV_NRD_NRD_1	462	464	PF00675	0.694
CLV_NRD_NRD_1	494	496	PF00675	0.713
CLV_NRD_NRD_1	573	575	PF00675	0.673
CLV_PCSK_KEX2_1	112	114	PF00082	0.687
CLV_PCSK_KEX2_1	143	145	PF00082	0.728
CLV_PCSK_KEX2_1	44	46	PF00082	0.728
CLV_PCSK_KEX2_1	462	464	PF00082	0.694
CLV_PCSK_KEX2_1	494	496	PF00082	0.713
CLV_PCSK_SKI1_1	112	116	PF00082	0.690
CLV_PCSK_SKI1_1	233	237	PF00082	0.653
CLV_PCSK_SKI1_1	463	467	PF00082	0.692
CLV_PCSK_SKI1_1	57	61	PF00082	0.485
CLV_PCSK_SKI1_1	721	725	PF00082	0.666
CLV_PCSK_SKI1_1	78	82	PF00082	0.684
CLV_Separin_Metazoa	445	449	PF03568	0.526
CLV_Separin_Metazoa	668	672	PF03568	0.739
DEG_APCC_DBOX_1	447	455	PF00400	0.667
DEG_SIAH_1	9	17	PF03145	0.636
DEG_SPOP_SBC_1	349	353	PF00917	0.762
DEG_SPOP_SBC_1	377	381	PF00917	0.771
DEG_SPOP_SBC_1	612	616	PF00917	0.617
DOC_CKS1_1	603	608	PF01111	0.728
DOC_CKS1_1	629	634	PF01111	0.719
DOC_CYCLIN_RxL_1	231	242	PF00134	0.658
DOC_CYCLIN_RxL_1	457	468	PF00134	0.689
DOC_MAPK_FxFP_2	69	72	PF00069	0.719
DOC_MAPK_gen_1	232	238	PF00069	0.657
DOC_MAPK_gen_1	296	304	PF00069	0.694
DOC_PP2B_LxvP_1	361	364	PF13499	0.747
DOC_PP2B_LxvP_1	375	378	PF13499	0.581
DOC_PP4_FxxP_1	69	72	PF00568	0.719
DOC_USP7_MATH_1	151	155	PF00917	0.735
DOC_USP7_MATH_1	172	176	PF00917	0.747
DOC_USP7_MATH_1	177	181	PF00917	0.678
DOC_USP7_MATH_1	187	191	PF00917	0.584
DOC_USP7_MATH_1	335	339	PF00917	0.810
DOC_USP7_MATH_1	376	380	PF00917	0.825
DOC_USP7_MATH_1	598	602	PF00917	0.729
DOC_USP7_MATH_1	611	615	PF00917	0.636
DOC_USP7_MATH_1	625	629	PF00917	0.658
DOC_USP7_MATH_1	72	76	PF00917	0.735
DOC_WW_Pin1_4	161	166	PF00397	0.814
DOC_WW_Pin1_4	183	188	PF00397	0.846
DOC_WW_Pin1_4	191	196	PF00397	0.714
DOC_WW_Pin1_4	350	355	PF00397	0.843
DOC_WW_Pin1_4	359	364	PF00397	0.677
DOC_WW_Pin1_4	577	582	PF00397	0.834
DOC_WW_Pin1_4	588	593	PF00397	0.649
DOC_WW_Pin1_4	602	607	PF00397	0.613
DOC_WW_Pin1_4	628	633	PF00397	0.710
LIG_14-3-3_CanoR_1	475	483	PF00244	0.688
LIG_14-3-3_CanoR_1	494	500	PF00244	0.403
LIG_14-3-3_CanoR_1	527	531	PF00244	0.524
LIG_APCC_ABBA_1	14	19	PF00400	0.620
LIG_CaM_IQ_9	91	107	PF13499	0.618
LIG_FHA_1	280	286	PF00498	0.689
LIG_FHA_1	299	305	PF00498	0.374
LIG_FHA_1	488	494	PF00498	0.470
LIG_FHA_1	580	586	PF00498	0.608
LIG_FHA_1	75	81	PF00498	0.700
LIG_FHA_1	99	105	PF00498	0.571
LIG_FHA_2	279	285	PF00498	0.571
LIG_FHA_2	83	89	PF00498	0.423
LIG_LIR_Apic_2	626	632	PF02991	0.714
LIG_LIR_Apic_2	68	72	PF02991	0.719
LIG_LIR_Gen_1	273	283	PF02991	0.683
LIG_LIR_Gen_1	543	553	PF02991	0.654
LIG_LIR_Gen_1	665	673	PF02991	0.747
LIG_LIR_LC3C_4	282	287	PF02991	0.693
LIG_LIR_Nem_3	273	279	PF02991	0.682
LIG_LIR_Nem_3	543	549	PF02991	0.636
LIG_LIR_Nem_3	665	670	PF02991	0.756
LIG_MYND_1	359	363	PF01753	0.750
LIG_NRBOX	536	542	PF00104	0.699
LIG_NRBOX	719	725	PF00104	0.742
LIG_Pex14_2	318	322	PF04695	0.616
LIG_SH2_STAT3	461	464	PF00017	0.578
LIG_SH2_STAT3	530	533	PF00017	0.741
LIG_SH2_STAT5	170	173	PF00017	0.742
LIG_SH2_STAT5	240	243	PF00017	0.653
LIG_SH2_STAT5	366	369	PF00017	0.727
LIG_SH2_STAT5	51	54	PF00017	0.663
LIG_SH2_STAT5	552	555	PF00017	0.764
LIG_SH3_1	147	153	PF00018	0.582
LIG_SH3_3	147	153	PF00018	0.582
LIG_SH3_3	353	359	PF00018	0.839
LIG_SH3_3	393	399	PF00018	0.628
LIG_SH3_3	619	625	PF00018	0.643
LIG_SH3_3	691	697	PF00018	0.736
LIG_SUMO_SIM_anti_2	683	689	PF11976	0.719
LIG_SUMO_SIM_anti_2	79	85	PF11976	0.670
LIG_SUMO_SIM_par_1	299	307	PF11976	0.683
LIG_SUMO_SIM_par_1	79	85	PF11976	0.437
LIG_TRAF2_1	213	216	PF00917	0.573
LIG_TRAF2_1	281	284	PF00917	0.573
LIG_TRAF2_1	312	315	PF00917	0.654
LIG_TRAF2_1	409	412	PF00917	0.748
LIG_TRAF2_1	569	572	PF00917	0.769
LIG_TRAF2_1	716	719	PF00917	0.697
LIG_TRAF2_2	197	202	PF00917	0.804
LIG_WW_1	363	366	PF00397	0.710
MOD_CDK_SPK_2	191	196	PF00069	0.846
MOD_CDK_SPK_2	350	355	PF00069	0.765
MOD_CDK_SPxK_1	183	189	PF00069	0.772
MOD_CDK_SPxK_1	588	594	PF00069	0.769
MOD_CDK_SPxK_1	628	634	PF00069	0.834
MOD_CK1_1	160	166	PF00069	0.781
MOD_CK1_1	190	196	PF00069	0.652
MOD_CK1_1	362	368	PF00069	0.832
MOD_CK1_1	379	385	PF00069	0.575
MOD_CK1_1	428	434	PF00069	0.809
MOD_CK1_1	521	527	PF00069	0.773
MOD_CK1_1	545	551	PF00069	0.731
MOD_CK1_1	580	586	PF00069	0.795
MOD_CK1_1	601	607	PF00069	0.758
MOD_CK1_1	615	621	PF00069	0.595
MOD_CK1_1	628	634	PF00069	0.609
MOD_CK1_1	638	644	PF00069	0.649
MOD_CK1_1	648	654	PF00069	0.555
MOD_CK1_1	656	662	PF00069	0.576
MOD_CK2_1	278	284	PF00069	0.569
MOD_CK2_1	335	341	PF00069	0.821
MOD_CK2_1	513	519	PF00069	0.597
MOD_CK2_1	526	532	PF00069	0.504
MOD_CK2_1	565	571	PF00069	0.772
MOD_CK2_1	662	668	PF00069	0.741
MOD_CK2_1	82	88	PF00069	0.424
MOD_GlcNHglycan	122	125	PF01048	0.780
MOD_GlcNHglycan	134	137	PF01048	0.583
MOD_GlcNHglycan	153	156	PF01048	0.722
MOD_GlcNHglycan	174	177	PF01048	0.737
MOD_GlcNHglycan	189	192	PF01048	0.694
MOD_GlcNHglycan	210	214	PF01048	0.738
MOD_GlcNHglycan	218	221	PF01048	0.622
MOD_GlcNHglycan	241	244	PF01048	0.533
MOD_GlcNHglycan	368	371	PF01048	0.816
MOD_GlcNHglycan	385	388	PF01048	0.566
MOD_GlcNHglycan	412	416	PF01048	0.808
MOD_GlcNHglycan	422	425	PF01048	0.732
MOD_GlcNHglycan	427	430	PF01048	0.636
MOD_GlcNHglycan	519	523	PF01048	0.647
MOD_GlcNHglycan	566	570	PF01048	0.775
MOD_GlcNHglycan	596	599	PF01048	0.792
MOD_GlcNHglycan	609	612	PF01048	0.639
MOD_GlcNHglycan	625	628	PF01048	0.545
MOD_GlcNHglycan	648	651	PF01048	0.824
MOD_GlcNHglycan	698	701	PF01048	0.824
MOD_GlcNHglycan	711	714	PF01048	0.549
MOD_GlcNHglycan	74	77	PF01048	0.718
MOD_GSK3_1	116	123	PF00069	0.715
MOD_GSK3_1	153	160	PF00069	0.772
MOD_GSK3_1	183	190	PF00069	0.849
MOD_GSK3_1	239	246	PF00069	0.648
MOD_GSK3_1	298	305	PF00069	0.690
MOD_GSK3_1	362	369	PF00069	0.770
MOD_GSK3_1	377	384	PF00069	0.604
MOD_GSK3_1	398	405	PF00069	0.843
MOD_GSK3_1	425	432	PF00069	0.791
MOD_GSK3_1	509	516	PF00069	0.552
MOD_GSK3_1	521	528	PF00069	0.495
MOD_GSK3_1	577	584	PF00069	0.736
MOD_GSK3_1	594	601	PF00069	0.659
MOD_GSK3_1	607	614	PF00069	0.636
MOD_GSK3_1	648	655	PF00069	0.818
MOD_GSK3_1	698	705	PF00069	0.826
MOD_GSK3_1	70	77	PF00069	0.652
MOD_N-GLC_1	601	606	PF02516	0.723
MOD_N-GLC_1	638	643	PF02516	0.748
MOD_NEK2_1	120	125	PF00069	0.767
MOD_NEK2_1	476	481	PF00069	0.688
MOD_NEK2_1	493	498	PF00069	0.435
MOD_NEK2_1	511	516	PF00069	0.400
MOD_NEK2_1	518	523	PF00069	0.641
MOD_PIKK_1	245	251	PF00454	0.639
MOD_PIKK_1	476	482	PF00454	0.686
MOD_PIKK_1	91	97	PF00454	0.611
MOD_PKA_2	449	455	PF00069	0.653
MOD_PKA_2	456	462	PF00069	0.534
MOD_PKA_2	493	499	PF00069	0.652
MOD_PKA_2	526	532	PF00069	0.526
MOD_PKA_2	98	104	PF00069	0.702
MOD_Plk_1	116	122	PF00069	0.721
MOD_Plk_1	298	304	PF00069	0.692
MOD_Plk_1	542	548	PF00069	0.691
MOD_Plk_2-3	203	209	PF00069	0.751
MOD_Plk_4	298	304	PF00069	0.692
MOD_Plk_4	362	368	PF00069	0.715
MOD_Plk_4	506	512	PF00069	0.694
MOD_Plk_4	82	88	PF00069	0.424
MOD_ProDKin_1	161	167	PF00069	0.814
MOD_ProDKin_1	183	189	PF00069	0.849
MOD_ProDKin_1	191	197	PF00069	0.712
MOD_ProDKin_1	350	356	PF00069	0.840
MOD_ProDKin_1	359	365	PF00069	0.678
MOD_ProDKin_1	577	583	PF00069	0.835
MOD_ProDKin_1	588	594	PF00069	0.651
MOD_ProDKin_1	602	608	PF00069	0.613
MOD_ProDKin_1	628	634	PF00069	0.712
MOD_SUMO_rev_2	123	131	PF00179	0.591
TRG_DiLeu_BaEn_1	299	304	PF01217	0.691
TRG_DiLeu_BaEn_1	560	565	PF01217	0.649
TRG_DiLeu_BaEn_1	719	724	PF01217	0.739
TRG_DiLeu_BaEn_4	299	305	PF01217	0.688
TRG_DiLeu_BaEn_4	571	577	PF01217	0.793
TRG_DiLeu_BaLyEn_6	261	266	PF01217	0.696
TRG_ENDOCYTIC_2	170	173	PF00928	0.820
TRG_ENDOCYTIC_2	276	279	PF00928	0.688
TRG_ENDOCYTIC_2	546	549	PF00928	0.644
TRG_ENDOCYTIC_2	667	670	PF00928	0.750
TRG_ENDOCYTIC_2	717	720	PF00928	0.741
TRG_ER_diArg_1	111	113	PF00400	0.706
TRG_ER_diArg_1	447	450	PF00400	0.714
TRG_ER_diArg_1	461	463	PF00400	0.466
TRG_ER_diArg_1	493	495	PF00400	0.724
TRG_ER_diArg_1	664	667	PF00400	0.777
TRG_NLS_MonoExtN_4	143	148	PF00514	0.737
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.685
TRG_Pf-PMV_PEXEL_1	264	268	PF00026	0.689
TRG_Pf-PMV_PEXEL_1	383	388	PF00026	0.733
TRG_Pf-PMV_PEXEL_1	463	468	PF00026	0.690
TRG_Pf-PMV_PEXEL_1	475	480	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	721	726	PF00026	0.670

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I8Q7	Leishmania donovani	91%	99%
A4H607	Leishmania braziliensis	68%	99%
A4HUD4	Leishmania infantum	91%	99%
E9AN34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	97%