4a-hydroxytetrahydrobiopterin dehydratase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pterin 4 alpha carbinolamine dehydratase, putative

Species:

Leishmania major

UniProt:

Q4QHJ1_LEIMA

TriTrypDb:

LmjF.10.0250 , LMJLV39_100007600 , LMJSD75_100007700

Length:

259

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHJ1

Function

Biological processes
Term	Name	Level	Count
GO:0006066	alcohol metabolic process	3	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006729	tetrahydrobiopterin biosynthetic process	6	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009987	cellular process	1	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0019751	polyol metabolic process	4	11
GO:0034311	diol metabolic process	5	11
GO:0034312	diol biosynthetic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0042558	pteridine-containing compound metabolic process	4	11
GO:0042559	pteridine-containing compound biosynthetic process	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0044281	small molecule metabolic process	2	11
GO:0044283	small molecule biosynthetic process	3	11
GO:0046146	tetrahydrobiopterin metabolic process	5	11
GO:0046165	alcohol biosynthetic process	4	11
GO:0046173	polyol biosynthetic process	5	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:1901615	organic hydroxy compound metabolic process	3	11
GO:1901617	organic hydroxy compound biosynthetic process	4	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008124	4-alpha-hydroxytetrahydrobiopterin dehydratase activity	5	11
GO:0016829	lyase activity	2	11
GO:0016835	carbon-oxygen lyase activity	3	11
GO:0016836	hydro-lyase activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	224	228	PF00656	0.555
CLV_C14_Caspase3-7	245	249	PF00656	0.594
CLV_C14_Caspase3-7	74	78	PF00656	0.592
CLV_NRD_NRD_1	179	181	PF00675	0.455
CLV_NRD_NRD_1	187	189	PF00675	0.475
CLV_NRD_NRD_1	51	53	PF00675	0.417
CLV_PCSK_KEX2_1	163	165	PF00082	0.289
CLV_PCSK_KEX2_1	187	189	PF00082	0.441
CLV_PCSK_KEX2_1	51	53	PF00082	0.417
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.289
CLV_PCSK_PC7_1	159	165	PF00082	0.289
CLV_PCSK_SKI1_1	63	67	PF00082	0.422
DEG_Nend_UBRbox_1	1	4	PF02207	0.529
DEG_SPOP_SBC_1	84	88	PF00917	0.723
DOC_ANK_TNKS_1	186	193	PF00023	0.508
DOC_USP7_MATH_1	250	254	PF00917	0.596
DOC_USP7_MATH_1	84	88	PF00917	0.723
DOC_USP7_MATH_1	9	13	PF00917	0.543
DOC_WW_Pin1_4	235	240	PF00397	0.616
LIG_14-3-3_CanoR_1	195	203	PF00244	0.441
LIG_14-3-3_CanoR_1	2	8	PF00244	0.669
LIG_14-3-3_CanoR_1	230	240	PF00244	0.553
LIG_Actin_WH2_2	165	182	PF00022	0.351
LIG_Actin_WH2_2	204	220	PF00022	0.494
LIG_BRCT_BRCA1_1	154	158	PF00533	0.271
LIG_FHA_1	148	154	PF00498	0.289
LIG_FHA_1	217	223	PF00498	0.619
LIG_FHA_2	116	122	PF00498	0.299
LIG_LIR_Gen_1	113	124	PF02991	0.259
LIG_LIR_Gen_1	29	40	PF02991	0.519
LIG_LIR_Gen_1	5	15	PF02991	0.557
LIG_LIR_Nem_3	113	119	PF02991	0.253
LIG_LIR_Nem_3	136	142	PF02991	0.252
LIG_LIR_Nem_3	155	161	PF02991	0.410
LIG_LIR_Nem_3	174	179	PF02991	0.377
LIG_LIR_Nem_3	29	35	PF02991	0.521
LIG_LIR_Nem_3	5	10	PF02991	0.619
LIG_LYPXL_yS_3	139	142	PF13949	0.306
LIG_PCNA_yPIPBox_3	195	203	PF02747	0.512
LIG_Pex14_1	130	134	PF04695	0.288
LIG_PTB_Apo_2	170	177	PF02174	0.362
LIG_PTB_Phospho_1	170	176	PF10480	0.289
LIG_SH2_CRK	176	180	PF00017	0.383
LIG_SH2_SRC	152	155	PF00017	0.289
LIG_SH2_STAP1	154	158	PF00017	0.261
LIG_SH2_STAT5	123	126	PF00017	0.278
LIG_SH2_STAT5	152	155	PF00017	0.288
LIG_SH3_3	94	100	PF00018	0.700
LIG_TRAF2_1	198	201	PF00917	0.441
LIG_TRAF2_1	221	224	PF00917	0.560
LIG_ULM_U2AF65_1	180	185	PF00076	0.453
LIG_WRC_WIRS_1	111	116	PF05994	0.315
MOD_CDC14_SPxK_1	238	241	PF00782	0.538
MOD_CDK_SPxK_1	235	241	PF00069	0.523
MOD_CK1_1	231	237	PF00069	0.677
MOD_CK1_1	242	248	PF00069	0.658
MOD_CK1_1	5	11	PF00069	0.662
MOD_CK1_1	86	92	PF00069	0.732
MOD_CK2_1	115	121	PF00069	0.349
MOD_CK2_1	159	165	PF00069	0.280
MOD_CK2_1	194	200	PF00069	0.443
MOD_GlcNHglycan	11	14	PF01048	0.640
MOD_GlcNHglycan	196	199	PF01048	0.473
MOD_GlcNHglycan	233	236	PF01048	0.561
MOD_GlcNHglycan	244	247	PF01048	0.615
MOD_GlcNHglycan	7	10	PF01048	0.649
MOD_GlcNHglycan	90	93	PF01048	0.736
MOD_GSK3_1	140	147	PF00069	0.361
MOD_GSK3_1	231	238	PF00069	0.609
MOD_GSK3_1	5	12	PF00069	0.627
MOD_GSK3_1	83	90	PF00069	0.746
MOD_NEK2_1	153	158	PF00069	0.261
MOD_NEK2_1	16	21	PF00069	0.532
MOD_NEK2_1	179	184	PF00069	0.385
MOD_NEK2_1	35	40	PF00069	0.547
MOD_NEK2_1	61	66	PF00069	0.389
MOD_NEK2_2	154	159	PF00069	0.204
MOD_PIKK_1	19	25	PF00454	0.584
MOD_PKA_2	179	185	PF00069	0.459
MOD_PKA_2	194	200	PF00069	0.491
MOD_PKA_2	213	219	PF00069	0.551
MOD_PKA_2	3	9	PF00069	0.633
MOD_Plk_4	147	153	PF00069	0.332
MOD_ProDKin_1	235	241	PF00069	0.622
TRG_DiLeu_BaEn_2	120	126	PF01217	0.404
TRG_DiLeu_BaEn_2	56	62	PF01217	0.400
TRG_ENDOCYTIC_2	123	126	PF00928	0.295
TRG_ENDOCYTIC_2	139	142	PF00928	0.397
TRG_ENDOCYTIC_2	176	179	PF00928	0.374
TRG_ER_diArg_1	1	4	PF00400	0.548
TRG_ER_diArg_1	187	189	PF00400	0.530
TRG_ER_diArg_1	51	54	PF00400	0.419
TRG_NLS_Bipartite_1	163	184	PF00514	0.374
TRG_Pf-PMV_PEXEL_1	187	191	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W5	Leptomonas seymouri	63%	97%
A0A0S4IXY6	Bodo saltans	41%	100%
A0A1X0NQ34	Trypanosomatidae	55%	100%
A0A3S7WR02	Leishmania donovani	94%	100%
A4H608	Leishmania braziliensis	77%	92%
A4HUD5	Leishmania infantum	94%	100%
C9ZVG1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	81%
E9AN35	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5BIH1	Trypanosoma cruzi	62%	100%