Exonuclease domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

exonuclease, putative

Species:

Leishmania major

UniProt:

Q4QHI9_LEIMA

TriTrypDb:

LmjF.10.0270 , LMJLV39_100007800 , LMJSD75_100007900

Length:

931

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QHI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHI9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	4
GO:0004518	nuclease activity	4	4
GO:0004527	exonuclease activity	5	4
GO:0005488	binding	1	12
GO:0016787	hydrolase activity	2	4
GO:0016788	hydrolase activity, acting on ester bonds	3	4
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	501	505	PF00656	0.513
CLV_C14_Caspase3-7	590	594	PF00656	0.503
CLV_C14_Caspase3-7	629	633	PF00656	0.691
CLV_MEL_PAP_1	70	76	PF00089	0.614
CLV_NRD_NRD_1	2	4	PF00675	0.790
CLV_NRD_NRD_1	261	263	PF00675	0.708
CLV_NRD_NRD_1	29	31	PF00675	0.733
CLV_NRD_NRD_1	581	583	PF00675	0.280
CLV_NRD_NRD_1	712	714	PF00675	0.517
CLV_NRD_NRD_1	721	723	PF00675	0.500
CLV_NRD_NRD_1	810	812	PF00675	0.594
CLV_NRD_NRD_1	817	819	PF00675	0.449
CLV_PCSK_KEX2_1	2	4	PF00082	0.791
CLV_PCSK_KEX2_1	261	263	PF00082	0.654
CLV_PCSK_KEX2_1	28	30	PF00082	0.701
CLV_PCSK_KEX2_1	581	583	PF00082	0.262
CLV_PCSK_KEX2_1	721	723	PF00082	0.510
CLV_PCSK_KEX2_1	810	812	PF00082	0.594
CLV_PCSK_KEX2_1	817	819	PF00082	0.449
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.696
CLV_PCSK_PC7_1	577	583	PF00082	0.278
CLV_PCSK_PC7_1	717	723	PF00082	0.582
CLV_PCSK_SKI1_1	117	121	PF00082	0.570
CLV_PCSK_SKI1_1	23	27	PF00082	0.600
CLV_PCSK_SKI1_1	364	368	PF00082	0.435
CLV_PCSK_SKI1_1	42	46	PF00082	0.577
CLV_PCSK_SKI1_1	480	484	PF00082	0.321
CLV_PCSK_SKI1_1	568	572	PF00082	0.288
CLV_PCSK_SKI1_1	817	821	PF00082	0.563
CLV_PCSK_SKI1_1	90	94	PF00082	0.693
DEG_APCC_DBOX_1	469	477	PF00400	0.436
DEG_APCC_DBOX_1	816	824	PF00400	0.552
DEG_MDM2_SWIB_1	749	756	PF02201	0.586
DEG_Nend_UBRbox_1	1	4	PF02207	0.585
DEG_SCF_FBW7_2	770	776	PF00400	0.541
DEG_SPOP_SBC_1	268	272	PF00917	0.759
DEG_SPOP_SBC_1	432	436	PF00917	0.578
DEG_SPOP_SBC_1	510	514	PF00917	0.503
DEG_SPOP_SBC_1	690	694	PF00917	0.623
DOC_CKS1_1	770	775	PF01111	0.563
DOC_CKS1_1	8	13	PF01111	0.656
DOC_CYCLIN_yClb1_LxF_4	568	574	PF00134	0.478
DOC_MAPK_gen_1	124	133	PF00069	0.552
DOC_MAPK_gen_1	614	622	PF00069	0.516
DOC_MAPK_MEF2A_6	126	135	PF00069	0.567
DOC_MAPK_MEF2A_6	480	487	PF00069	0.397
DOC_MAPK_MEF2A_6	73	81	PF00069	0.626
DOC_MAPK_NFAT4_5	480	488	PF00069	0.389
DOC_PP1_RVXF_1	115	121	PF00149	0.611
DOC_PP1_RVXF_1	249	256	PF00149	0.610
DOC_PP2B_LxvP_1	240	243	PF13499	0.682
DOC_PP2B_LxvP_1	372	375	PF13499	0.508
DOC_PP2B_LxvP_1	665	668	PF13499	0.664
DOC_PP4_FxxP_1	430	433	PF00568	0.433
DOC_PP4_FxxP_1	559	562	PF00568	0.436
DOC_USP7_MATH_1	16	20	PF00917	0.709
DOC_USP7_MATH_1	189	193	PF00917	0.640
DOC_USP7_MATH_1	263	267	PF00917	0.738
DOC_USP7_MATH_1	268	272	PF00917	0.724
DOC_USP7_MATH_1	279	283	PF00917	0.676
DOC_USP7_MATH_1	320	324	PF00917	0.750
DOC_USP7_MATH_1	391	395	PF00917	0.668
DOC_USP7_MATH_1	400	404	PF00917	0.671
DOC_USP7_MATH_1	431	435	PF00917	0.483
DOC_USP7_MATH_1	594	598	PF00917	0.462
DOC_USP7_MATH_1	615	619	PF00917	0.558
DOC_USP7_MATH_1	626	630	PF00917	0.630
DOC_USP7_MATH_1	65	69	PF00917	0.669
DOC_USP7_MATH_1	679	683	PF00917	0.732
DOC_USP7_MATH_1	690	694	PF00917	0.688
DOC_USP7_MATH_1	771	775	PF00917	0.753
DOC_USP7_MATH_1	88	92	PF00917	0.706
DOC_USP7_MATH_1	885	889	PF00917	0.742
DOC_USP7_UBL2_3	23	27	PF12436	0.531
DOC_USP7_UBL2_3	28	32	PF12436	0.711
DOC_WW_Pin1_4	112	117	PF00397	0.670
DOC_WW_Pin1_4	167	172	PF00397	0.760
DOC_WW_Pin1_4	211	216	PF00397	0.529
DOC_WW_Pin1_4	296	301	PF00397	0.716
DOC_WW_Pin1_4	3	8	PF00397	0.681
DOC_WW_Pin1_4	332	337	PF00397	0.643
DOC_WW_Pin1_4	343	348	PF00397	0.556
DOC_WW_Pin1_4	443	448	PF00397	0.683
DOC_WW_Pin1_4	769	774	PF00397	0.776
DOC_WW_Pin1_4	921	926	PF00397	0.592
LIG_14-3-3_CanoR_1	126	132	PF00244	0.536
LIG_14-3-3_CanoR_1	2	7	PF00244	0.772
LIG_14-3-3_CanoR_1	207	216	PF00244	0.622
LIG_14-3-3_CanoR_1	470	474	PF00244	0.458
LIG_14-3-3_CanoR_1	492	500	PF00244	0.478
LIG_14-3-3_CanoR_1	614	620	PF00244	0.537
LIG_14-3-3_CanoR_1	691	700	PF00244	0.594
LIG_14-3-3_CanoR_1	721	730	PF00244	0.426
LIG_14-3-3_CanoR_1	73	81	PF00244	0.725
LIG_14-3-3_CanoR_1	746	752	PF00244	0.551
LIG_14-3-3_CanoR_1	87	95	PF00244	0.631
LIG_14-3-3_CanoR_1	886	894	PF00244	0.561
LIG_Actin_WH2_2	588	606	PF00022	0.460
LIG_Actin_WH2_2	805	823	PF00022	0.622
LIG_APCC_ABBA_1	652	657	PF00400	0.494
LIG_BIR_III_2	701	705	PF00653	0.725
LIG_BIR_III_4	174	178	PF00653	0.622
LIG_BIR_III_4	304	308	PF00653	0.551
LIG_BRCT_BRCA1_1	350	354	PF00533	0.621
LIG_CaM_NSCaTE_8	204	211	PF13499	0.667
LIG_CtBP_PxDLS_1	869	873	PF00389	0.588
LIG_deltaCOP1_diTrp_1	425	430	PF00928	0.434
LIG_deltaCOP1_diTrp_1	554	559	PF00928	0.529
LIG_FHA_1	128	134	PF00498	0.544
LIG_FHA_1	15	21	PF00498	0.722
LIG_FHA_1	443	449	PF00498	0.538
LIG_FHA_1	476	482	PF00498	0.519
LIG_FHA_1	528	534	PF00498	0.520
LIG_FHA_1	553	559	PF00498	0.473
LIG_FHA_1	660	666	PF00498	0.575
LIG_FHA_1	8	14	PF00498	0.731
LIG_FHA_1	828	834	PF00498	0.581
LIG_FHA_1	905	911	PF00498	0.603
LIG_FHA_1	916	922	PF00498	0.524
LIG_FHA_2	192	198	PF00498	0.542
LIG_FHA_2	243	249	PF00498	0.684
LIG_FHA_2	470	476	PF00498	0.446
LIG_FHA_2	512	518	PF00498	0.436
LIG_LIR_Apic_2	429	433	PF02991	0.463
LIG_LIR_Apic_2	554	560	PF02991	0.479
LIG_LIR_Gen_1	139	148	PF02991	0.598
LIG_LIR_Gen_1	425	433	PF02991	0.438
LIG_LIR_Gen_1	748	756	PF02991	0.479
LIG_LIR_Gen_1	854	864	PF02991	0.551
LIG_LIR_Nem_3	425	430	PF02991	0.398
LIG_LIR_Nem_3	498	503	PF02991	0.436
LIG_LIR_Nem_3	748	752	PF02991	0.473
LIG_LIR_Nem_3	854	859	PF02991	0.540
LIG_LYPXL_SIV_4	566	574	PF13949	0.503
LIG_Pex14_2	749	753	PF04695	0.591
LIG_REV1ctd_RIR_1	117	126	PF16727	0.573
LIG_SH2_CRK	237	241	PF00017	0.688
LIG_SH2_GRB2like	134	137	PF00017	0.564
LIG_SH2_NCK_1	671	675	PF00017	0.704
LIG_SH2_SRC	134	137	PF00017	0.564
LIG_SH2_STAP1	140	144	PF00017	0.586
LIG_SH2_STAP1	370	374	PF00017	0.354
LIG_SH2_STAT5	134	137	PF00017	0.550
LIG_SH2_STAT5	237	240	PF00017	0.616
LIG_SH2_STAT5	551	554	PF00017	0.465
LIG_SH2_STAT5	578	581	PF00017	0.444
LIG_SH3_1	46	52	PF00018	0.756
LIG_SH3_3	103	109	PF00018	0.578
LIG_SH3_3	145	151	PF00018	0.715
LIG_SH3_3	257	263	PF00018	0.613
LIG_SH3_3	385	391	PF00018	0.419
LIG_SH3_3	46	52	PF00018	0.770
LIG_SH3_3	5	11	PF00018	0.732
LIG_SH3_3	61	67	PF00018	0.603
LIG_SH3_3	760	766	PF00018	0.778
LIG_SH3_3	767	773	PF00018	0.742
LIG_SUMO_SIM_anti_2	472	478	PF11976	0.470
LIG_SUMO_SIM_anti_2	828	836	PF11976	0.451
LIG_SUMO_SIM_par_1	450	455	PF11976	0.352
LIG_SUMO_SIM_par_1	457	462	PF11976	0.445
LIG_SUMO_SIM_par_1	472	478	PF11976	0.488
LIG_TRAF2_1	390	393	PF00917	0.623
LIG_TRAF2_1	779	782	PF00917	0.679
LIG_TYR_ITIM	235	240	PF00017	0.689
LIG_UBA3_1	118	124	PF00899	0.615
LIG_UBA3_1	473	480	PF00899	0.389
MOD_CDC14_SPxK_1	214	217	PF00782	0.535
MOD_CDK_SPK_2	112	117	PF00069	0.670
MOD_CDK_SPK_2	332	337	PF00069	0.631
MOD_CDK_SPxK_1	211	217	PF00069	0.533
MOD_CDK_SPxxK_3	296	303	PF00069	0.647
MOD_CK1_1	19	25	PF00069	0.712
MOD_CK1_1	192	198	PF00069	0.711
MOD_CK1_1	267	273	PF00069	0.752
MOD_CK1_1	441	447	PF00069	0.549
MOD_CK1_1	587	593	PF00069	0.472
MOD_CK1_1	682	688	PF00069	0.773
MOD_CK1_1	693	699	PF00069	0.666
MOD_CK1_1	797	803	PF00069	0.681
MOD_CK1_1	903	909	PF00069	0.632
MOD_CK2_1	136	142	PF00069	0.536
MOD_CK2_1	242	248	PF00069	0.638
MOD_CK2_1	400	406	PF00069	0.749
MOD_CK2_1	632	638	PF00069	0.567
MOD_CK2_1	72	78	PF00069	0.610
MOD_DYRK1A_RPxSP_1	3	7	PF00069	0.598
MOD_GlcNHglycan	185	188	PF01048	0.794
MOD_GlcNHglycan	191	194	PF01048	0.747
MOD_GlcNHglycan	197	202	PF01048	0.616
MOD_GlcNHglycan	209	212	PF01048	0.696
MOD_GlcNHglycan	266	269	PF01048	0.756
MOD_GlcNHglycan	271	274	PF01048	0.729
MOD_GlcNHglycan	322	325	PF01048	0.704
MOD_GlcNHglycan	330	333	PF01048	0.722
MOD_GlcNHglycan	339	342	PF01048	0.772
MOD_GlcNHglycan	393	396	PF01048	0.739
MOD_GlcNHglycan	403	406	PF01048	0.729
MOD_GlcNHglycan	465	468	PF01048	0.237
MOD_GlcNHglycan	500	503	PF01048	0.236
MOD_GlcNHglycan	596	599	PF01048	0.264
MOD_GlcNHglycan	628	631	PF01048	0.628
MOD_GlcNHglycan	634	637	PF01048	0.710
MOD_GlcNHglycan	674	677	PF01048	0.669
MOD_GlcNHglycan	680	684	PF01048	0.674
MOD_GlcNHglycan	686	689	PF01048	0.734
MOD_GlcNHglycan	693	696	PF01048	0.623
MOD_GlcNHglycan	773	776	PF01048	0.780
MOD_GlcNHglycan	801	804	PF01048	0.695
MOD_GlcNHglycan	861	865	PF01048	0.675
MOD_GlcNHglycan	881	884	PF01048	0.769
MOD_GlcNHglycan	887	890	PF01048	0.613
MOD_GlcNHglycan	90	93	PF01048	0.738
MOD_GlcNHglycan	901	905	PF01048	0.753
MOD_GSK3_1	207	214	PF00069	0.597
MOD_GSK3_1	263	270	PF00069	0.724
MOD_GSK3_1	3	10	PF00069	0.708
MOD_GSK3_1	328	335	PF00069	0.736
MOD_GSK3_1	431	438	PF00069	0.578
MOD_GSK3_1	439	446	PF00069	0.624
MOD_GSK3_1	491	498	PF00069	0.564
MOD_GSK3_1	594	601	PF00069	0.532
MOD_GSK3_1	689	696	PF00069	0.708
MOD_GSK3_1	741	748	PF00069	0.531
MOD_GSK3_1	900	907	PF00069	0.679
MOD_N-GLC_1	122	127	PF02516	0.573
MOD_N-GLC_1	177	182	PF02516	0.669
MOD_N-GLC_1	279	284	PF02516	0.752
MOD_N-GLC_1	879	884	PF02516	0.510
MOD_NEK2_1	143	148	PF00069	0.582
MOD_NEK2_1	295	300	PF00069	0.622
MOD_NEK2_1	384	389	PF00069	0.553
MOD_NEK2_1	553	558	PF00069	0.477
MOD_NEK2_2	307	312	PF00069	0.654
MOD_NEK2_2	747	752	PF00069	0.542
MOD_NEK2_2	851	856	PF00069	0.564
MOD_PIKK_1	598	604	PF00454	0.515
MOD_PIKK_1	721	727	PF00454	0.630
MOD_PIKK_1	741	747	PF00454	0.641
MOD_PIKK_1	754	760	PF00454	0.461
MOD_PKA_1	2	8	PF00069	0.642
MOD_PKA_1	721	727	PF00069	0.531
MOD_PKA_2	127	133	PF00069	0.721
MOD_PKA_2	2	8	PF00069	0.736
MOD_PKA_2	226	232	PF00069	0.678
MOD_PKA_2	469	475	PF00069	0.458
MOD_PKA_2	491	497	PF00069	0.462
MOD_PKA_2	498	504	PF00069	0.412
MOD_PKA_2	615	621	PF00069	0.539
MOD_PKA_2	690	696	PF00069	0.665
MOD_PKA_2	72	78	PF00069	0.759
MOD_PKA_2	721	727	PF00069	0.630
MOD_PKA_2	745	751	PF00069	0.604
MOD_PKA_2	797	803	PF00069	0.770
MOD_PKA_2	885	891	PF00069	0.628
MOD_PKA_2	915	921	PF00069	0.686
MOD_Plk_1	122	128	PF00069	0.506
MOD_Plk_1	362	368	PF00069	0.418
MOD_Plk_1	553	559	PF00069	0.538
MOD_Plk_1	598	604	PF00069	0.498
MOD_Plk_1	827	833	PF00069	0.519
MOD_Plk_1	879	885	PF00069	0.532
MOD_Plk_1	900	906	PF00069	0.582
MOD_Plk_4	127	133	PF00069	0.645
MOD_Plk_4	16	22	PF00069	0.515
MOD_Plk_4	307	313	PF00069	0.638
MOD_Plk_4	447	453	PF00069	0.306
MOD_Plk_4	469	475	PF00069	0.460
MOD_Plk_4	527	533	PF00069	0.446
MOD_Plk_4	553	559	PF00069	0.469
MOD_Plk_4	587	593	PF00069	0.533
MOD_Plk_4	615	621	PF00069	0.530
MOD_Plk_4	65	71	PF00069	0.635
MOD_Plk_4	660	666	PF00069	0.668
MOD_Plk_4	827	833	PF00069	0.425
MOD_ProDKin_1	112	118	PF00069	0.668
MOD_ProDKin_1	167	173	PF00069	0.757
MOD_ProDKin_1	211	217	PF00069	0.533
MOD_ProDKin_1	296	302	PF00069	0.715
MOD_ProDKin_1	3	9	PF00069	0.683
MOD_ProDKin_1	332	338	PF00069	0.643
MOD_ProDKin_1	343	349	PF00069	0.545
MOD_ProDKin_1	443	449	PF00069	0.659
MOD_ProDKin_1	769	775	PF00069	0.777
MOD_ProDKin_1	921	927	PF00069	0.591
MOD_SUMO_rev_2	403	412	PF00179	0.773
MOD_SUMO_rev_2	536	543	PF00179	0.477
TRG_DiLeu_BaEn_4	870	876	PF01217	0.584
TRG_ENDOCYTIC_2	140	143	PF00928	0.585
TRG_ENDOCYTIC_2	237	240	PF00928	0.687
TRG_ER_diArg_1	1	3	PF00400	0.817
TRG_ER_diArg_1	260	262	PF00400	0.700
TRG_ER_diArg_1	496	499	PF00400	0.453
TRG_ER_diArg_1	581	583	PF00400	0.480
TRG_ER_diArg_1	613	616	PF00400	0.522
TRG_ER_diArg_1	809	811	PF00400	0.611
TRG_ER_diArg_1	817	819	PF00400	0.443
TRG_NES_CRM1_1	475	491	PF08389	0.470
TRG_NLS_MonoCore_2	25	30	PF00514	0.772
TRG_NLS_MonoExtC_3	25	30	PF00514	0.769
TRG_NLS_MonoExtC_3	31	37	PF00514	0.761
TRG_NLS_MonoExtN_4	23	30	PF00514	0.540
TRG_Pf-PMV_PEXEL_1	364	368	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	572	576	PF00026	0.288

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCK4	Leptomonas seymouri	55%	95%
A0A0S4JVL6	Bodo saltans	34%	100%
A0A1X0NQ48	Trypanosomatidae	37%	100%
A0A3Q8I8M2	Leishmania donovani	89%	100%
A0A422NRV3	Trypanosoma rangeli	38%	100%
A4H610	Leishmania braziliensis	72%	100%
A4HUD7	Leishmania infantum	90%	100%
C9ZVF8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AN37	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5DA05	Trypanosoma cruzi	37%	100%