Kinetoplastid kinetochore protein 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinetoplastid kinetochore protein 4, putative

Species:

Leishmania major

UniProt:

Q4QHI6_LEIMA

TriTrypDb:

LmjF.10.0300 , LMJLV39_100008100 , LMJSD75_100008200

Length:

765

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000776	kinetochore	3	2
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0099080	supramolecular complex	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QHI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHI6

PDB structure(s): 6zpj_A , 6zpj_B

Function

Biological processes
Term	Name	Level	Count
GO:0007059	chromosome segregation	2	2
GO:0009987	cellular process	1	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	160	162	PF00675	0.746
CLV_NRD_NRD_1	193	195	PF00675	0.564
CLV_NRD_NRD_1	246	248	PF00675	0.570
CLV_NRD_NRD_1	411	413	PF00675	0.833
CLV_NRD_NRD_1	449	451	PF00675	0.703
CLV_NRD_NRD_1	452	454	PF00675	0.670
CLV_NRD_NRD_1	602	604	PF00675	0.489
CLV_NRD_NRD_1	82	84	PF00675	0.821
CLV_PCSK_FUR_1	450	454	PF00082	0.745
CLV_PCSK_KEX2_1	160	162	PF00082	0.746
CLV_PCSK_KEX2_1	193	195	PF00082	0.564
CLV_PCSK_KEX2_1	352	354	PF00082	0.712
CLV_PCSK_KEX2_1	391	393	PF00082	0.745
CLV_PCSK_KEX2_1	411	413	PF00082	0.503
CLV_PCSK_KEX2_1	451	453	PF00082	0.695
CLV_PCSK_KEX2_1	595	597	PF00082	0.507
CLV_PCSK_KEX2_1	602	604	PF00082	0.412
CLV_PCSK_KEX2_1	734	736	PF00082	0.690
CLV_PCSK_KEX2_1	82	84	PF00082	0.737
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.712
CLV_PCSK_PC1ET2_1	391	393	PF00082	0.745
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.851
CLV_PCSK_PC1ET2_1	595	597	PF00082	0.507
CLV_PCSK_PC1ET2_1	734	736	PF00082	0.690
CLV_PCSK_PC7_1	156	162	PF00082	0.728
CLV_PCSK_PC7_1	387	393	PF00082	0.795
CLV_PCSK_PC7_1	447	453	PF00082	0.737
CLV_PCSK_SKI1_1	10	14	PF00082	0.614
CLV_PCSK_SKI1_1	172	176	PF00082	0.691
CLV_PCSK_SKI1_1	257	261	PF00082	0.555
CLV_PCSK_SKI1_1	349	353	PF00082	0.594
CLV_PCSK_SKI1_1	504	508	PF00082	0.743
CLV_PCSK_SKI1_1	603	607	PF00082	0.490
CLV_PCSK_SKI1_1	653	657	PF00082	0.482
CLV_PCSK_SKI1_1	702	706	PF00082	0.451
CLV_PCSK_SKI1_1	758	762	PF00082	0.507
CLV_Separin_Metazoa	7	11	PF03568	0.722
DEG_APCC_DBOX_1	712	720	PF00400	0.483
DEG_APCC_KENBOX_2	287	291	PF00400	0.704
DEG_SCF_FBW7_1	455	461	PF00400	0.721
DEG_SCF_FBW7_1	492	497	PF00400	0.709
DEG_SPOP_SBC_1	482	486	PF00917	0.765
DEG_SPOP_SBC_1	639	643	PF00917	0.542
DOC_CKS1_1	426	431	PF01111	0.821
DOC_CKS1_1	455	460	PF01111	0.724
DOC_CYCLIN_RxL_1	254	262	PF00134	0.540
DOC_CYCLIN_RxL_1	699	708	PF00134	0.596
DOC_MAPK_gen_1	699	707	PF00069	0.589
DOC_PP2B_LxvP_1	165	168	PF13499	0.578
DOC_PP4_FxxP_1	694	697	PF00568	0.494
DOC_USP7_MATH_1	159	163	PF00917	0.685
DOC_USP7_MATH_1	331	335	PF00917	0.832
DOC_USP7_MATH_1	494	498	PF00917	0.710
DOC_USP7_MATH_1	502	506	PF00917	0.740
DOC_USP7_MATH_1	630	634	PF00917	0.646
DOC_USP7_MATH_1	729	733	PF00917	0.621
DOC_WW_Pin1_4	131	136	PF00397	0.735
DOC_WW_Pin1_4	419	424	PF00397	0.724
DOC_WW_Pin1_4	425	430	PF00397	0.725
DOC_WW_Pin1_4	451	456	PF00397	0.737
DOC_WW_Pin1_4	488	493	PF00397	0.727
DOC_WW_Pin1_4	508	513	PF00397	0.513
DOC_WW_Pin1_4	585	590	PF00397	0.633
DOC_WW_Pin1_4	648	653	PF00397	0.532
DOC_WW_Pin1_4	666	671	PF00397	0.456
LIG_14-3-3_CanoR_1	10	19	PF00244	0.608
LIG_14-3-3_CanoR_1	119	123	PF00244	0.831
LIG_14-3-3_CanoR_1	160	165	PF00244	0.823
LIG_14-3-3_CanoR_1	172	177	PF00244	0.695
LIG_14-3-3_CanoR_1	204	212	PF00244	0.527
LIG_14-3-3_CanoR_1	229	233	PF00244	0.450
LIG_14-3-3_CanoR_1	238	242	PF00244	0.503
LIG_14-3-3_CanoR_1	332	338	PF00244	0.718
LIG_14-3-3_CanoR_1	392	396	PF00244	0.651
LIG_14-3-3_CanoR_1	474	482	PF00244	0.780
LIG_14-3-3_CanoR_1	616	624	PF00244	0.539
LIG_14-3-3_CanoR_1	702	708	PF00244	0.487
LIG_14-3-3_CanoR_1	758	765	PF00244	0.549
LIG_Actin_WH2_2	743	760	PF00022	0.511
LIG_BIR_II_1	1	5	PF00653	0.572
LIG_Clathr_ClatBox_1	704	708	PF01394	0.494
LIG_eIF4E_1	543	549	PF01652	0.599
LIG_EVH1_1	556	560	PF00568	0.738
LIG_FHA_1	204	210	PF00498	0.663
LIG_FHA_1	395	401	PF00498	0.732
LIG_FHA_1	435	441	PF00498	0.803
LIG_FHA_1	482	488	PF00498	0.700
LIG_FHA_1	491	497	PF00498	0.685
LIG_FHA_1	575	581	PF00498	0.735
LIG_FHA_1	641	647	PF00498	0.531
LIG_FHA_2	173	179	PF00498	0.619
LIG_FHA_2	290	296	PF00498	0.758
LIG_FHA_2	391	397	PF00498	0.681
LIG_FHA_2	415	421	PF00498	0.759
LIG_FHA_2	459	465	PF00498	0.718
LIG_FHA_2	519	525	PF00498	0.769
LIG_FHA_2	68	74	PF00498	0.663
LIG_FHA_2	749	755	PF00498	0.488
LIG_LIR_Gen_1	240	245	PF02991	0.494
LIG_LIR_Nem_3	240	244	PF02991	0.494
LIG_MYND_1	320	324	PF01753	0.760
LIG_NRBOX	255	261	PF00104	0.656
LIG_PDZ_Class_3	760	765	PF00595	0.665
LIG_RPA_C_Fungi	407	419	PF08784	0.750
LIG_SH2_CRK	241	245	PF00017	0.567
LIG_SH2_CRK	543	547	PF00017	0.598
LIG_SH2_NCK_1	543	547	PF00017	0.598
LIG_SH2_STAP1	272	276	PF00017	0.650
LIG_SH2_STAT3	674	677	PF00017	0.474
LIG_SH2_STAT3	759	762	PF00017	0.608
LIG_SH2_STAT5	425	428	PF00017	0.740
LIG_SH2_STAT5	543	546	PF00017	0.606
LIG_SH2_STAT5	672	675	PF00017	0.398
LIG_SH3_1	452	458	PF00018	0.730
LIG_SH3_2	455	460	PF14604	0.748
LIG_SH3_2	557	562	PF14604	0.742
LIG_SH3_2	591	596	PF14604	0.611
LIG_SH3_3	452	458	PF00018	0.730
LIG_SH3_3	511	517	PF00018	0.656
LIG_SH3_3	554	560	PF00018	0.708
LIG_SH3_3	561	567	PF00018	0.710
LIG_SH3_3	58	64	PF00018	0.762
LIG_SH3_3	588	594	PF00018	0.640
LIG_SH3_3	704	710	PF00018	0.602
LIG_SUMO_SIM_anti_2	746	752	PF11976	0.502
LIG_SUMO_SIM_par_1	703	708	PF11976	0.486
LIG_SUMO_SIM_par_1	746	752	PF11976	0.502
LIG_UBA3_1	605	610	PF00899	0.619
LIG_WW_3	32	36	PF00397	0.715
LIG_WW_3	62	66	PF00397	0.727
MOD_CDK_SPK_2	451	456	PF00069	0.737
MOD_CDK_SPK_2	648	653	PF00069	0.532
MOD_CDK_SPxK_1	454	460	PF00069	0.748
MOD_CDK_SPxxK_3	427	434	PF00069	0.700
MOD_CK1_1	109	115	PF00069	0.647
MOD_CK1_1	133	139	PF00069	0.810
MOD_CK1_1	163	169	PF00069	0.696
MOD_CK1_1	325	331	PF00069	0.767
MOD_CK1_1	341	347	PF00069	0.591
MOD_CK1_1	37	43	PF00069	0.714
MOD_CK1_1	575	581	PF00069	0.735
MOD_CK1_1	641	647	PF00069	0.633
MOD_CK1_1	676	682	PF00069	0.490
MOD_CK1_1	88	94	PF00069	0.738
MOD_CK1_1	99	105	PF00069	0.707
MOD_CK2_1	414	420	PF00069	0.688
MOD_CK2_1	458	464	PF00069	0.741
MOD_CK2_1	466	472	PF00069	0.664
MOD_CK2_1	518	524	PF00069	0.760
MOD_Cter_Amidation	409	412	PF01082	0.832
MOD_DYRK1A_RPxSP_1	587	591	PF00069	0.663
MOD_GlcNHglycan	122	125	PF01048	0.723
MOD_GlcNHglycan	165	168	PF01048	0.642
MOD_GlcNHglycan	182	185	PF01048	0.502
MOD_GlcNHglycan	267	270	PF01048	0.497
MOD_GlcNHglycan	299	302	PF01048	0.724
MOD_GlcNHglycan	340	343	PF01048	0.747
MOD_GlcNHglycan	36	39	PF01048	0.686
MOD_GlcNHglycan	369	372	PF01048	0.594
MOD_GlcNHglycan	402	405	PF01048	0.770
MOD_GlcNHglycan	447	450	PF01048	0.817
MOD_GlcNHglycan	574	577	PF01048	0.733
MOD_GlcNHglycan	581	584	PF01048	0.735
MOD_GlcNHglycan	618	621	PF01048	0.613
MOD_GlcNHglycan	662	665	PF01048	0.543
MOD_GlcNHglycan	678	681	PF01048	0.376
MOD_GlcNHglycan	729	732	PF01048	0.568
MOD_GlcNHglycan	737	740	PF01048	0.606
MOD_GlcNHglycan	751	754	PF01048	0.392
MOD_GlcNHglycan	93	96	PF01048	0.827
MOD_GlcNHglycan	98	101	PF01048	0.746
MOD_GSK3_1	126	133	PF00069	0.790
MOD_GSK3_1	135	142	PF00069	0.663
MOD_GSK3_1	159	166	PF00069	0.726
MOD_GSK3_1	390	397	PF00069	0.737
MOD_GSK3_1	414	421	PF00069	0.755
MOD_GSK3_1	441	448	PF00069	0.791
MOD_GSK3_1	454	461	PF00069	0.816
MOD_GSK3_1	490	497	PF00069	0.699
MOD_GSK3_1	498	505	PF00069	0.674
MOD_GSK3_1	508	515	PF00069	0.565
MOD_GSK3_1	520	527	PF00069	0.774
MOD_GSK3_1	570	577	PF00069	0.697
MOD_GSK3_1	579	586	PF00069	0.747
MOD_GSK3_1	735	742	PF00069	0.740
MOD_GSK3_1	84	91	PF00069	0.744
MOD_GSK3_1	94	101	PF00069	0.716
MOD_N-GLC_1	289	294	PF02516	0.719
MOD_NEK2_1	139	144	PF00069	0.835
MOD_NEK2_1	202	207	PF00069	0.560
MOD_NEK2_1	234	239	PF00069	0.509
MOD_NEK2_1	259	264	PF00069	0.549
MOD_NEK2_1	265	270	PF00069	0.511
MOD_NEK2_1	390	395	PF00069	0.756
MOD_NEK2_1	466	471	PF00069	0.804
MOD_NEK2_1	506	511	PF00069	0.689
MOD_NEK2_1	604	609	PF00069	0.502
MOD_NEK2_1	98	103	PF00069	0.747
MOD_NEK2_2	483	488	PF00069	0.744
MOD_PIKK_1	101	107	PF00454	0.819
MOD_PIKK_1	203	209	PF00454	0.552
MOD_PIKK_1	322	328	PF00454	0.762
MOD_PIKK_1	441	447	PF00454	0.719
MOD_PIKK_1	474	480	PF00454	0.768
MOD_PIKK_1	673	679	PF00454	0.584
MOD_PIKK_1	758	764	PF00454	0.637
MOD_PKA_1	160	166	PF00069	0.741
MOD_PKA_1	391	397	PF00069	0.726
MOD_PKA_2	118	124	PF00069	0.831
MOD_PKA_2	159	165	PF00069	0.729
MOD_PKA_2	203	209	PF00069	0.540
MOD_PKA_2	228	234	PF00069	0.448
MOD_PKA_2	237	243	PF00069	0.500
MOD_PKA_2	331	337	PF00069	0.710
MOD_PKA_2	34	40	PF00069	0.752
MOD_PKA_2	391	397	PF00069	0.726
MOD_Plk_1	395	401	PF00069	0.760
MOD_Plk_1	502	508	PF00069	0.844
MOD_Plk_2-3	228	234	PF00069	0.475
MOD_Plk_4	106	112	PF00069	0.818
MOD_Plk_4	160	166	PF00069	0.741
MOD_ProDKin_1	131	137	PF00069	0.731
MOD_ProDKin_1	419	425	PF00069	0.726
MOD_ProDKin_1	427	433	PF00069	0.719
MOD_ProDKin_1	451	457	PF00069	0.735
MOD_ProDKin_1	488	494	PF00069	0.719
MOD_ProDKin_1	508	514	PF00069	0.509
MOD_ProDKin_1	585	591	PF00069	0.632
MOD_ProDKin_1	648	654	PF00069	0.527
MOD_ProDKin_1	666	672	PF00069	0.453
MOD_SUMO_for_1	270	273	PF00179	0.609
MOD_SUMO_for_1	487	490	PF00179	0.842
TRG_DiLeu_BaEn_1	613	618	PF01217	0.490
TRG_ENDOCYTIC_2	241	244	PF00928	0.567
TRG_ENDOCYTIC_2	272	275	PF00928	0.651
TRG_ER_diArg_1	159	161	PF00400	0.712
TRG_ER_diArg_1	193	195	PF00400	0.564
TRG_ER_diArg_1	450	453	PF00400	0.696
TRG_ER_diArg_1	601	603	PF00400	0.511
TRG_NLS_MonoCore_2	449	454	PF00514	0.845
TRG_NLS_MonoExtC_3	450	455	PF00514	0.842
TRG_NLS_MonoExtN_4	447	454	PF00514	0.839
TRG_Pf-PMV_PEXEL_1	10	14	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	193	197	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	349	354	PF00026	0.735

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8R5	Leptomonas seymouri	51%	100%
A0A3S7WR22	Leishmania donovani	94%	100%
A4H613	Leishmania braziliensis	78%	100%
A4HUE0	Leishmania infantum	94%	100%
E9AN40	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%