Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHI3_LEIMA

TriTrypDb:

LmjF.10.0330 , LMJLV39_100008400 , LMJSD75_100008500

Length:

434

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHI3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.654
CLV_C14_Caspase3-7	203	207	PF00656	0.628
CLV_C14_Caspase3-7	263	267	PF00656	0.607
CLV_NRD_NRD_1	252	254	PF00675	0.444
CLV_PCSK_FUR_1	418	422	PF00082	0.652
CLV_PCSK_KEX2_1	252	254	PF00082	0.444
CLV_PCSK_KEX2_1	420	422	PF00082	0.605
CLV_PCSK_PC1ET2_1	420	422	PF00082	0.677
CLV_PCSK_SKI1_1	122	126	PF00082	0.664
CLV_PCSK_SKI1_1	167	171	PF00082	0.563
CLV_PCSK_SKI1_1	22	26	PF00082	0.536
CLV_Separin_Metazoa	320	324	PF03568	0.496
DEG_APCC_DBOX_1	73	81	PF00400	0.536
DEG_SPOP_SBC_1	10	14	PF00917	0.587
DOC_MAPK_FxFP_2	32	35	PF00069	0.373
DOC_MAPK_MEF2A_6	295	304	PF00069	0.537
DOC_PP2B_LxvP_1	197	200	PF13499	0.448
DOC_PP4_FxxP_1	32	35	PF00568	0.464
DOC_USP7_MATH_1	390	394	PF00917	0.644
DOC_USP7_MATH_1	406	410	PF00917	0.553
DOC_WW_Pin1_4	183	188	PF00397	0.622
DOC_WW_Pin1_4	205	210	PF00397	0.612
DOC_WW_Pin1_4	307	312	PF00397	0.596
DOC_WW_Pin1_4	394	399	PF00397	0.608
LIG_14-3-3_CanoR_1	147	153	PF00244	0.488
LIG_14-3-3_CanoR_1	22	32	PF00244	0.509
LIG_14-3-3_CanoR_1	252	260	PF00244	0.513
LIG_14-3-3_CanoR_1	323	333	PF00244	0.490
LIG_14-3-3_CanoR_1	37	46	PF00244	0.467
LIG_14-3-3_CanoR_1	97	104	PF00244	0.504
LIG_Actin_WH2_2	131	149	PF00022	0.522
LIG_Actin_WH2_2	315	332	PF00022	0.574
LIG_BIR_III_2	206	210	PF00653	0.578
LIG_BRCT_BRCA1_1	30	34	PF00533	0.396
LIG_FHA_1	147	153	PF00498	0.501
LIG_FHA_1	155	161	PF00498	0.415
LIG_FHA_1	208	214	PF00498	0.694
LIG_FHA_1	23	29	PF00498	0.467
LIG_FHA_1	39	45	PF00498	0.565
LIG_FHA_2	201	207	PF00498	0.543
LIG_FHA_2	312	318	PF00498	0.589
LIG_GBD_Chelix_1	290	298	PF00786	0.523
LIG_LIR_Apic_2	31	35	PF02991	0.466
LIG_LIR_Gen_1	157	165	PF02991	0.419
LIG_LIR_Gen_1	219	230	PF02991	0.626
LIG_LIR_Nem_3	157	162	PF02991	0.419
LIG_LIR_Nem_3	219	225	PF02991	0.517
LIG_PDZ_Wminus1_1	432	434	PF00595	0.539
LIG_SH2_SRC	198	201	PF00017	0.463
LIG_SH2_STAP1	165	169	PF00017	0.528
LIG_SH2_STAT5	198	201	PF00017	0.625
LIG_SH2_STAT5	259	262	PF00017	0.580
LIG_SH2_STAT5	90	93	PF00017	0.424
LIG_SH3_3	178	184	PF00018	0.704
LIG_SH3_3	331	337	PF00018	0.588
LIG_SH3_3	338	344	PF00018	0.663
LIG_SH3_3	400	406	PF00018	0.653
LIG_SUMO_SIM_anti_2	317	324	PF11976	0.663
LIG_SUMO_SIM_par_1	160	166	PF11976	0.401
LIG_SUMO_SIM_par_1	357	363	PF11976	0.484
LIG_TRAF2_1	209	212	PF00917	0.618
LIG_TRAF2_1	286	289	PF00917	0.551
LIG_TRAF2_1	351	354	PF00917	0.582
LIG_WW_2	405	408	PF00397	0.550
MOD_CDK_SPK_2	394	399	PF00069	0.676
MOD_CK1_1	113	119	PF00069	0.491
MOD_CK1_1	13	19	PF00069	0.520
MOD_CK1_1	154	160	PF00069	0.463
MOD_CK1_1	205	211	PF00069	0.516
MOD_CK1_1	237	243	PF00069	0.582
MOD_CK1_1	307	313	PF00069	0.676
MOD_CK1_1	335	341	PF00069	0.679
MOD_CK1_1	383	389	PF00069	0.566
MOD_CK1_1	96	102	PF00069	0.620
MOD_CK2_1	205	211	PF00069	0.549
MOD_CK2_1	215	221	PF00069	0.451
MOD_CK2_1	411	417	PF00069	0.657
MOD_GlcNHglycan	15	18	PF01048	0.650
MOD_GlcNHglycan	170	173	PF01048	0.613
MOD_GlcNHglycan	242	245	PF01048	0.735
MOD_GlcNHglycan	255	258	PF01048	0.406
MOD_GlcNHglycan	356	359	PF01048	0.525
MOD_GlcNHglycan	385	388	PF01048	0.536
MOD_GlcNHglycan	408	411	PF01048	0.588
MOD_GlcNHglycan	421	424	PF01048	0.684
MOD_GlcNHglycan	50	53	PF01048	0.619
MOD_GlcNHglycan	6	9	PF01048	0.604
MOD_GlcNHglycan	77	80	PF01048	0.497
MOD_GSK3_1	147	154	PF00069	0.472
MOD_GSK3_1	207	214	PF00069	0.670
MOD_GSK3_1	234	241	PF00069	0.593
MOD_GSK3_1	24	31	PF00069	0.465
MOD_GSK3_1	273	280	PF00069	0.709
MOD_GSK3_1	305	312	PF00069	0.578
MOD_GSK3_1	345	352	PF00069	0.586
MOD_GSK3_1	379	386	PF00069	0.559
MOD_GSK3_1	390	397	PF00069	0.724
MOD_GSK3_1	419	426	PF00069	0.679
MOD_GSK3_1	48	55	PF00069	0.611
MOD_GSK3_1	9	16	PF00069	0.516
MOD_GSK3_1	92	99	PF00069	0.517
MOD_LATS_1	369	375	PF00433	0.509
MOD_N-GLC_1	226	231	PF02516	0.511
MOD_NEK2_1	1	6	PF00069	0.611
MOD_NEK2_1	146	151	PF00069	0.490
MOD_NEK2_1	278	283	PF00069	0.576
MOD_NEK2_1	290	295	PF00069	0.404
MOD_NEK2_1	304	309	PF00069	0.556
MOD_NEK2_1	321	326	PF00069	0.672
MOD_NEK2_1	380	385	PF00069	0.607
MOD_NMyristoyl	1	7	PF02799	0.535
MOD_PIKK_1	110	116	PF00454	0.553
MOD_PIKK_1	270	276	PF00454	0.606
MOD_PIKK_1	278	284	PF00454	0.479
MOD_PIKK_1	335	341	PF00454	0.633
MOD_PK_1	147	153	PF00069	0.464
MOD_PKA_2	146	152	PF00069	0.487
MOD_PKA_2	4	10	PF00069	0.460
MOD_PKA_2	96	102	PF00069	0.620
MOD_Plk_1	211	217	PF00069	0.536
MOD_Plk_1	226	232	PF00069	0.465
MOD_Plk_1	52	58	PF00069	0.466
MOD_Plk_2-3	349	355	PF00069	0.496
MOD_Plk_4	147	153	PF00069	0.515
MOD_Plk_4	226	232	PF00069	0.515
MOD_Plk_4	52	58	PF00069	0.483
MOD_ProDKin_1	183	189	PF00069	0.616
MOD_ProDKin_1	205	211	PF00069	0.612
MOD_ProDKin_1	307	313	PF00069	0.597
MOD_ProDKin_1	394	400	PF00069	0.609
MOD_SUMO_for_1	124	127	PF00179	0.656
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.451
TRG_ER_diArg_1	251	253	PF00400	0.449
TRG_NES_CRM1_1	288	303	PF08389	0.485
TRG_NES_CRM1_1	353	365	PF08389	0.565
TRG_NLS_MonoExtC_3	121	127	PF00514	0.592
TRG_Pf-PMV_PEXEL_1	299	303	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYC0	Leptomonas seymouri	35%	80%
A0A3Q8I7N0	Leishmania donovani	91%	100%
A4H616	Leishmania braziliensis	68%	92%
A4HUE3	Leishmania infantum	91%	100%
E9AN43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%