Putative folate/biopterin transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

folate/biopterin transporter, putative

Species:

Leishmania major

UniProt:

Q4QHI2_LEIMA

TriTrypDb:

LmjF.10.0360 , LMJLV39_100009300 , LMJSD75_100009400

Length:

665

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 70
NetGPI	no	yes: 0, no: 70

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0016020	membrane	2	71
GO:0110165	cellular anatomical entity	1	71
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

Q4QHI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHI2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	22	24	PF00675	0.443
CLV_NRD_NRD_1	245	247	PF00675	0.372
CLV_NRD_NRD_1	4	6	PF00675	0.468
CLV_NRD_NRD_1	625	627	PF00675	0.314
CLV_PCSK_FUR_1	2	6	PF00082	0.369
CLV_PCSK_KEX2_1	107	109	PF00082	0.331
CLV_PCSK_KEX2_1	22	24	PF00082	0.477
CLV_PCSK_KEX2_1	4	6	PF00082	0.517
CLV_PCSK_KEX2_1	493	495	PF00082	0.556
CLV_PCSK_KEX2_1	625	627	PF00082	0.325
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.331
CLV_PCSK_PC1ET2_1	493	495	PF00082	0.556
CLV_PCSK_SKI1_1	290	294	PF00082	0.383
CLV_PCSK_SKI1_1	55	59	PF00082	0.405
CLV_PCSK_SKI1_1	90	94	PF00082	0.388
DEG_APCC_DBOX_1	250	258	PF00400	0.460
DOC_AGCK_PIF_1	434	439	PF00069	0.226
DOC_CYCLIN_yCln2_LP_2	600	606	PF00134	0.412
DOC_MAPK_gen_1	107	113	PF00069	0.540
DOC_MAPK_gen_1	231	241	PF00069	0.583
DOC_MAPK_gen_1	246	254	PF00069	0.575
DOC_MAPK_gen_1	493	501	PF00069	0.357
DOC_MAPK_gen_1	610	619	PF00069	0.622
DOC_MAPK_MEF2A_6	201	208	PF00069	0.363
DOC_MAPK_MEF2A_6	493	501	PF00069	0.391
DOC_PP1_RVXF_1	469	475	PF00149	0.554
DOC_PP2B_LxvP_1	600	603	PF13499	0.399
DOC_PP2B_LxvP_1	606	609	PF13499	0.365
DOC_PP2B_PxIxI_1	201	207	PF00149	0.322
DOC_PP4_FxxP_1	6	9	PF00568	0.593
DOC_USP7_MATH_1	170	174	PF00917	0.514
DOC_USP7_MATH_1	276	280	PF00917	0.594
DOC_USP7_MATH_1	456	460	PF00917	0.411
DOC_USP7_MATH_1	512	516	PF00917	0.349
DOC_USP7_MATH_1	535	539	PF00917	0.520
DOC_WW_Pin1_4	272	277	PF00397	0.624
DOC_WW_Pin1_4	415	420	PF00397	0.365
DOC_WW_Pin1_4	639	644	PF00397	0.671
LIG_14-3-3_CanoR_1	231	241	PF00244	0.620
LIG_14-3-3_CanoR_1	471	475	PF00244	0.525
LIG_14-3-3_CanoR_1	554	563	PF00244	0.510
LIG_14-3-3_CanoR_1	68	74	PF00244	0.490
LIG_14-3-3_CanoR_1	78	85	PF00244	0.525
LIG_APCC_ABBA_1	24	29	PF00400	0.668
LIG_APCC_ABBAyCdc20_2	23	29	PF00400	0.539
LIG_APCC_ABBAyCdc20_2	4	10	PF00400	0.545
LIG_BRCT_BRCA1_1	437	441	PF00533	0.352
LIG_Clathr_ClatBox_1	239	243	PF01394	0.482
LIG_Clathr_ClatBox_1	632	636	PF01394	0.573
LIG_FHA_1	339	345	PF00498	0.625
LIG_FHA_1	356	362	PF00498	0.391
LIG_FHA_1	371	377	PF00498	0.293
LIG_FHA_1	420	426	PF00498	0.412
LIG_FHA_1	43	49	PF00498	0.594
LIG_FHA_1	471	477	PF00498	0.526
LIG_FHA_1	485	491	PF00498	0.393
LIG_FHA_1	603	609	PF00498	0.451
LIG_FHA_1	635	641	PF00498	0.687
LIG_FHA_1	91	97	PF00498	0.604
LIG_FHA_2	243	249	PF00498	0.605
LIG_FHA_2	572	578	PF00498	0.262
LIG_HP1_1	525	529	PF01393	0.434
LIG_LIR_Apic_2	322	328	PF02991	0.564
LIG_LIR_Apic_2	390	396	PF02991	0.452
LIG_LIR_Apic_2	566	570	PF02991	0.336
LIG_LIR_Gen_1	106	116	PF02991	0.552
LIG_LIR_Gen_1	157	168	PF02991	0.563
LIG_LIR_Gen_1	176	184	PF02991	0.538
LIG_LIR_Gen_1	440	449	PF02991	0.365
LIG_LIR_Gen_1	459	465	PF02991	0.428
LIG_LIR_Gen_1	477	486	PF02991	0.324
LIG_LIR_Gen_1	540	550	PF02991	0.551
LIG_LIR_Gen_1	61	69	PF02991	0.573
LIG_LIR_Gen_1	98	105	PF02991	0.554
LIG_LIR_Nem_3	106	112	PF02991	0.529
LIG_LIR_Nem_3	140	144	PF02991	0.330
LIG_LIR_Nem_3	157	163	PF02991	0.571
LIG_LIR_Nem_3	16	21	PF02991	0.632
LIG_LIR_Nem_3	176	182	PF02991	0.327
LIG_LIR_Nem_3	216	222	PF02991	0.379
LIG_LIR_Nem_3	345	351	PF02991	0.533
LIG_LIR_Nem_3	390	395	PF02991	0.415
LIG_LIR_Nem_3	431	437	PF02991	0.330
LIG_LIR_Nem_3	438	442	PF02991	0.335
LIG_LIR_Nem_3	459	464	PF02991	0.376
LIG_LIR_Nem_3	477	482	PF02991	0.361
LIG_LIR_Nem_3	98	103	PF02991	0.529
LIG_NRBOX	585	591	PF00104	0.261
LIG_PDZ_Class_3	660	665	PF00595	0.640
LIG_Pex14_2	143	147	PF04695	0.400
LIG_Pex14_2	437	441	PF04695	0.345
LIG_Pex14_2	461	465	PF04695	0.406
LIG_PTB_Apo_2	433	440	PF02174	0.407
LIG_PTB_Phospho_1	433	439	PF10480	0.440
LIG_SH2_CRK	125	129	PF00017	0.361
LIG_SH2_CRK	160	164	PF00017	0.549
LIG_SH2_CRK	325	329	PF00017	0.653
LIG_SH2_CRK	353	357	PF00017	0.380
LIG_SH2_CRK	442	446	PF00017	0.337
LIG_SH2_CRK	567	571	PF00017	0.359
LIG_SH2_CRK	76	80	PF00017	0.546
LIG_SH2_GRB2like	413	416	PF00017	0.440
LIG_SH2_GRB2like	424	427	PF00017	0.392
LIG_SH2_NCK_1	308	312	PF00017	0.471
LIG_SH2_NCK_1	442	446	PF00017	0.335
LIG_SH2_PTP2	413	416	PF00017	0.384
LIG_SH2_PTP2	498	501	PF00017	0.434
LIG_SH2_SRC	308	311	PF00017	0.474
LIG_SH2_SRC	312	315	PF00017	0.462
LIG_SH2_SRC	413	416	PF00017	0.516
LIG_SH2_SRC	424	427	PF00017	0.379
LIG_SH2_STAP1	105	109	PF00017	0.535
LIG_SH2_STAP1	160	164	PF00017	0.524
LIG_SH2_STAP1	308	312	PF00017	0.466
LIG_SH2_STAP1	353	357	PF00017	0.428
LIG_SH2_STAP1	543	547	PF00017	0.374
LIG_SH2_STAP1	62	66	PF00017	0.571
LIG_SH2_STAT3	407	410	PF00017	0.243
LIG_SH2_STAT5	105	108	PF00017	0.536
LIG_SH2_STAT5	220	223	PF00017	0.474
LIG_SH2_STAT5	407	410	PF00017	0.389
LIG_SH2_STAT5	413	416	PF00017	0.382
LIG_SH2_STAT5	424	427	PF00017	0.321
LIG_SH2_STAT5	498	501	PF00017	0.337
LIG_SH2_STAT5	507	510	PF00017	0.328
LIG_SH3_1	325	331	PF00018	0.620
LIG_SH3_3	325	331	PF00018	0.631
LIG_SH3_3	592	598	PF00018	0.374
LIG_SUMO_SIM_anti_2	487	493	PF11976	0.354
LIG_SUMO_SIM_par_1	525	531	PF11976	0.363
LIG_TRFH_1	125	129	PF08558	0.396
LIG_TYR_ITIM	123	128	PF00017	0.416
LIG_UBA3_1	123	131	PF00899	0.393
LIG_UBA3_1	239	247	PF00899	0.556
LIG_Vh1_VBS_1	351	369	PF01044	0.442
LIG_WRC_WIRS_1	420	425	PF05994	0.370
LIG_WRC_WIRS_1	476	481	PF05994	0.340
MOD_CK1_1	173	179	PF00069	0.382
MOD_CK1_1	466	472	PF00069	0.386
MOD_CK1_1	642	648	PF00069	0.663
MOD_CK2_1	242	248	PF00069	0.467
MOD_CK2_1	642	648	PF00069	0.737
MOD_Cter_Amidation	271	274	PF01082	0.505
MOD_GlcNHglycan	132	136	PF01048	0.394
MOD_GlcNHglycan	208	211	PF01048	0.406
MOD_GlcNHglycan	458	461	PF01048	0.381
MOD_GlcNHglycan	556	559	PF01048	0.426
MOD_GlcNHglycan	645	648	PF01048	0.755
MOD_GSK3_1	202	209	PF00069	0.476
MOD_GSK3_1	272	279	PF00069	0.456
MOD_GSK3_1	338	345	PF00069	0.515
MOD_GSK3_1	351	358	PF00069	0.409
MOD_GSK3_1	415	422	PF00069	0.275
MOD_GSK3_1	437	444	PF00069	0.414
MOD_GSK3_1	466	473	PF00069	0.398
MOD_GSK3_1	548	555	PF00069	0.410
MOD_GSK3_1	639	646	PF00069	0.719
MOD_GSK3_1	77	84	PF00069	0.442
MOD_N-GLC_1	435	440	PF02516	0.390
MOD_N-GLC_2	594	596	PF02516	0.522
MOD_NEK2_1	103	108	PF00069	0.317
MOD_NEK2_1	111	116	PF00069	0.372
MOD_NEK2_1	143	148	PF00069	0.379
MOD_NEK2_1	242	247	PF00069	0.445
MOD_NEK2_1	351	356	PF00069	0.407
MOD_NEK2_1	370	375	PF00069	0.333
MOD_NEK2_1	42	47	PF00069	0.490
MOD_NEK2_1	437	442	PF00069	0.397
MOD_NEK2_1	474	479	PF00069	0.401
MOD_NEK2_1	552	557	PF00069	0.390
MOD_NEK2_1	85	90	PF00069	0.411
MOD_NEK2_2	202	207	PF00069	0.503
MOD_NEK2_2	419	424	PF00069	0.371
MOD_OFUCOSY	110	115	PF10250	0.217
MOD_PIKK_1	571	577	PF00454	0.542
MOD_PKA_2	470	476	PF00069	0.384
MOD_PKA_2	535	541	PF00069	0.369
MOD_PKA_2	553	559	PF00069	0.369
MOD_PKA_2	650	656	PF00069	0.813
MOD_PKA_2	77	83	PF00069	0.411
MOD_Plk_1	435	441	PF00069	0.408
MOD_Plk_4	10	16	PF00069	0.533
MOD_Plk_4	137	143	PF00069	0.227
MOD_Plk_4	170	176	PF00069	0.381
MOD_Plk_4	187	193	PF00069	0.366
MOD_Plk_4	351	357	PF00069	0.390
MOD_Plk_4	388	394	PF00069	0.429
MOD_Plk_4	419	425	PF00069	0.373
MOD_Plk_4	437	443	PF00069	0.498
MOD_Plk_4	537	543	PF00069	0.416
MOD_Plk_4	602	608	PF00069	0.416
MOD_ProDKin_1	272	278	PF00069	0.509
MOD_ProDKin_1	415	421	PF00069	0.365
MOD_ProDKin_1	639	645	PF00069	0.573
MOD_SUMO_rev_2	615	624	PF00179	0.442
TRG_DiLeu_BaEn_2	235	241	PF01217	0.350
TRG_ENDOCYTIC_2	125	128	PF00928	0.375
TRG_ENDOCYTIC_2	160	163	PF00928	0.379
TRG_ENDOCYTIC_2	353	356	PF00928	0.382
TRG_ENDOCYTIC_2	413	416	PF00928	0.395
TRG_ENDOCYTIC_2	442	445	PF00928	0.391
TRG_ENDOCYTIC_2	498	501	PF00928	0.516
TRG_ENDOCYTIC_2	523	526	PF00928	0.339
TRG_ENDOCYTIC_2	543	546	PF00928	0.375
TRG_ENDOCYTIC_2	62	65	PF00928	0.387
TRG_ENDOCYTIC_2	76	79	PF00928	0.360
TRG_ER_diArg_1	1	4	PF00400	0.486
TRG_ER_diArg_1	21	23	PF00400	0.596
TRG_ER_diArg_1	624	626	PF00400	0.334
TRG_Pf-PMV_PEXEL_1	231	236	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.235
TRG_Pf-PMV_PEXEL_1	55	60	PF00026	0.239

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	47%	94%
A0A0N1HY49	Leptomonas seymouri	46%	99%
A0A0N1HZ06	Leptomonas seymouri	35%	100%
A0A0N1IHL1	Leptomonas seymouri	40%	93%
A0A0N1PAY4	Leptomonas seymouri	46%	76%
A0A0N1PB77	Leptomonas seymouri	34%	100%
A0A0N1PBZ2	Leptomonas seymouri	66%	99%
A0A0N1PCC1	Leptomonas seymouri	42%	100%
A0A381MBI0	Leishmania infantum	43%	100%
A0A3Q8I8X7	Leishmania donovani	43%	100%
A0A3Q8IAZ0	Leishmania donovani	79%	95%
A0A3Q8IH50	Leishmania donovani	58%	92%
A0A3Q8IVN0	Leishmania donovani	37%	100%
A0A3R7M4J1	Trypanosoma rangeli	40%	100%
A0A3S5H5P4	Leishmania donovani	44%	98%
A0A3S5H5V2	Leishmania donovani	42%	100%
A0A3S5H6F6	Leishmania donovani	79%	95%
A0A3S5H763	Leishmania donovani	53%	99%
A0A3S7WR10	Leishmania donovani	43%	89%
A0A3S7WR14	Leishmania donovani	82%	97%
A0A3S7WR15	Leishmania donovani	87%	78%
A0A3S7WR24	Leishmania donovani	78%	94%
A4H4T8	Leishmania braziliensis	41%	100%
A4H5Y4	Leishmania braziliensis	44%	100%
A4H617	Leishmania braziliensis	72%	95%
A4H618	Leishmania braziliensis	70%	97%
A4H619	Leishmania braziliensis	72%	95%
A4H620	Leishmania braziliensis	62%	94%
A4H6C3	Leishmania braziliensis	44%	100%
A4HNH7	Leishmania braziliensis	35%	100%
A4HSS2	Leishmania infantum	44%	98%
A4HUE4	Leishmania infantum	43%	89%
A4HUE5	Leishmania infantum	87%	96%
A4HUE6	Leishmania infantum	82%	97%
A4HUE7	Leishmania infantum	79%	95%
A4HUE8	Leishmania infantum	78%	94%
A4HUF4	Leishmania infantum	79%	95%
A4HUF5	Leishmania infantum	57%	100%
A4HYA9	Leishmania infantum	53%	99%
A4IC33	Leishmania infantum	36%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	95%
E9AG72	Leishmania infantum	42%	100%
E9AI40	Leishmania braziliensis	79%	98%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	98%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	89%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	93%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	99%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
Q4QDC4	Leishmania major	52%	100%
Q4QH81	Leishmania major	43%	100%
Q4QHH7	Leishmania major	59%	100%
Q4QHH8	Leishmania major	78%	100%
Q4QHH9	Leishmania major	78%	100%
Q4QHI0	Leishmania major	79%	100%
Q4QHI1	Leishmania major	82%	99%
Q4QIU9	Leishmania major	43%	100%
Q4QJ48	Leishmania major	44%	98%
Q7KIP2	Leishmania major	36%	98%