Putative folate/biopterin transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

folate/biopterin transporter, putative

Species:

Leishmania major

UniProt:

Q4QHI1_LEIMA

TriTrypDb:

LmjF.10.0370 , LMJLV39_100008900 , LMJSD75_100009300

Length:

595

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 70
NetGPI	no	yes: 0, no: 70

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0016020	membrane	2	71
GO:0110165	cellular anatomical entity	1	71
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

Q4QHI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHI1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	182	184	PF00675	0.372
CLV_PCSK_KEX2_1	430	432	PF00082	0.556
CLV_PCSK_KEX2_1	44	46	PF00082	0.331
CLV_PCSK_PC1ET2_1	430	432	PF00082	0.556
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.331
CLV_PCSK_SKI1_1	227	231	PF00082	0.383
CLV_PCSK_SKI1_1	27	31	PF00082	0.388
DEG_APCC_DBOX_1	187	195	PF00400	0.460
DOC_CDC14_PxL_1	517	525	PF14671	0.366
DOC_CKS1_1	529	534	PF01111	0.467
DOC_CYCLIN_yCln2_LP_2	534	540	PF00134	0.412
DOC_MAPK_gen_1	168	178	PF00069	0.583
DOC_MAPK_gen_1	183	191	PF00069	0.575
DOC_MAPK_gen_1	430	438	PF00069	0.357
DOC_MAPK_gen_1	44	50	PF00069	0.540
DOC_MAPK_gen_1	559	567	PF00069	0.733
DOC_MAPK_MEF2A_6	138	145	PF00069	0.363
DOC_MAPK_MEF2A_6	430	438	PF00069	0.391
DOC_MAPK_MEF2A_6	561	569	PF00069	0.571
DOC_PP2B_LxvP_1	534	537	PF13499	0.399
DOC_PP2B_PxIxI_1	138	144	PF00149	0.322
DOC_USP7_MATH_1	107	111	PF00917	0.514
DOC_USP7_MATH_1	213	217	PF00917	0.594
DOC_USP7_MATH_1	472	476	PF00917	0.520
DOC_USP7_MATH_1	582	586	PF00917	0.810
DOC_WW_Pin1_4	209	214	PF00397	0.624
DOC_WW_Pin1_4	352	357	PF00397	0.365
DOC_WW_Pin1_4	528	533	PF00397	0.449
LIG_14-3-3_CanoR_1	15	20	PF00244	0.525
LIG_14-3-3_CanoR_1	168	178	PF00244	0.620
LIG_14-3-3_CanoR_1	352	356	PF00244	0.447
LIG_14-3-3_CanoR_1	5	11	PF00244	0.490
LIG_Clathr_ClatBox_1	176	180	PF01394	0.482
LIG_deltaCOP1_diTrp_1	503	509	PF00928	0.277
LIG_eIF4E_1	517	523	PF01652	0.265
LIG_FHA_1	276	282	PF00498	0.625
LIG_FHA_1	28	34	PF00498	0.604
LIG_FHA_1	293	299	PF00498	0.391
LIG_FHA_1	308	314	PF00498	0.293
LIG_FHA_1	529	535	PF00498	0.452
LIG_FHA_2	180	186	PF00498	0.605
LIG_GBD_Chelix_1	412	420	PF00786	0.509
LIG_GBD_Chelix_1	450	458	PF00786	0.538
LIG_HP1_1	462	466	PF01393	0.434
LIG_LIR_Apic_2	259	265	PF02991	0.564
LIG_LIR_Apic_2	327	333	PF02991	0.452
LIG_LIR_Apic_2	503	507	PF02991	0.336
LIG_LIR_Apic_2	539	543	PF02991	0.372
LIG_LIR_Gen_1	113	121	PF02991	0.538
LIG_LIR_Gen_1	35	42	PF02991	0.554
LIG_LIR_Gen_1	396	403	PF02991	0.428
LIG_LIR_Gen_1	477	487	PF02991	0.551
LIG_LIR_Gen_1	94	105	PF02991	0.563
LIG_LIR_Nem_3	113	119	PF02991	0.327
LIG_LIR_Nem_3	153	159	PF02991	0.379
LIG_LIR_Nem_3	282	288	PF02991	0.533
LIG_LIR_Nem_3	327	332	PF02991	0.415
LIG_LIR_Nem_3	35	40	PF02991	0.529
LIG_LIR_Nem_3	355	361	PF02991	0.458
LIG_LIR_Nem_3	375	379	PF02991	0.335
LIG_LIR_Nem_3	396	401	PF02991	0.376
LIG_LIR_Nem_3	43	49	PF02991	0.529
LIG_LIR_Nem_3	503	509	PF02991	0.326
LIG_LIR_Nem_3	94	100	PF02991	0.571
LIG_PCNA_PIPBox_1	417	426	PF02747	0.236
LIG_PDZ_Class_3	590	595	PF00595	0.615
LIG_Pex14_2	374	378	PF04695	0.345
LIG_Pex14_2	398	402	PF04695	0.406
LIG_Pex14_2	80	84	PF04695	0.400
LIG_PTB_Apo_2	370	377	PF02174	0.407
LIG_PTB_Apo_2	396	403	PF02174	0.474
LIG_PTB_Phospho_1	370	376	PF10480	0.440
LIG_Rb_pABgroove_1	418	426	PF01858	0.368
LIG_SH2_CRK	13	17	PF00017	0.546
LIG_SH2_CRK	262	266	PF00017	0.653
LIG_SH2_CRK	290	294	PF00017	0.380
LIG_SH2_CRK	379	383	PF00017	0.337
LIG_SH2_CRK	47	51	PF00017	0.410
LIG_SH2_CRK	517	521	PF00017	0.392
LIG_SH2_CRK	62	66	PF00017	0.361
LIG_SH2_CRK	97	101	PF00017	0.549
LIG_SH2_GRB2like	361	364	PF00017	0.392
LIG_SH2_GRB2like	517	520	PF00017	0.385
LIG_SH2_NCK_1	245	249	PF00017	0.471
LIG_SH2_SRC	245	248	PF00017	0.474
LIG_SH2_SRC	249	252	PF00017	0.462
LIG_SH2_SRC	361	364	PF00017	0.379
LIG_SH2_STAP1	245	249	PF00017	0.466
LIG_SH2_STAP1	290	294	PF00017	0.428
LIG_SH2_STAP1	358	362	PF00017	0.369
LIG_SH2_STAP1	42	46	PF00017	0.535
LIG_SH2_STAP1	480	484	PF00017	0.374
LIG_SH2_STAP1	97	101	PF00017	0.524
LIG_SH2_STAT5	157	160	PF00017	0.474
LIG_SH2_STAT5	344	347	PF00017	0.389
LIG_SH2_STAT5	350	353	PF00017	0.382
LIG_SH2_STAT5	361	364	PF00017	0.321
LIG_SH2_STAT5	376	379	PF00017	0.297
LIG_SH2_STAT5	42	45	PF00017	0.536
LIG_SH2_STAT5	444	447	PF00017	0.328
LIG_SH2_STAT5	540	543	PF00017	0.546
LIG_SH3_1	262	268	PF00018	0.620
LIG_SH3_3	262	268	PF00018	0.631
LIG_SH3_3	526	532	PF00018	0.374
LIG_SUMO_SIM_anti_2	425	430	PF11976	0.355
LIG_SUMO_SIM_anti_2	531	537	PF11976	0.489
LIG_SUMO_SIM_par_1	463	468	PF11976	0.363
LIG_TRAF2_1	572	575	PF00917	0.590
LIG_TRFH_1	62	66	PF08558	0.396
LIG_TYR_ITIM	60	65	PF00017	0.416
LIG_TYR_ITSM	375	382	PF00017	0.439
LIG_UBA3_1	176	184	PF00899	0.556
LIG_UBA3_1	397	404	PF00899	0.450
LIG_UBA3_1	423	430	PF00899	0.358
LIG_UBA3_1	60	68	PF00899	0.393
LIG_Vh1_VBS_1	288	306	PF01044	0.442
MOD_CK1_1	110	116	PF00069	0.382
MOD_CK1_1	17	23	PF00069	0.397
MOD_CK1_1	528	534	PF00069	0.280
MOD_CK1_1	578	584	PF00069	0.603
MOD_CK2_1	179	185	PF00069	0.467
MOD_Cter_Amidation	208	211	PF01082	0.505
MOD_DYRK1A_RPxSP_1	352	356	PF00069	0.450
MOD_GlcNHglycan	145	148	PF01048	0.406
MOD_GlcNHglycan	579	583	PF01048	0.703
MOD_GlcNHglycan	584	587	PF01048	0.723
MOD_GlcNHglycan	69	73	PF01048	0.394
MOD_GSK3_1	139	146	PF00069	0.476
MOD_GSK3_1	14	21	PF00069	0.442
MOD_GSK3_1	209	216	PF00069	0.456
MOD_GSK3_1	275	282	PF00069	0.515
MOD_GSK3_1	288	295	PF00069	0.409
MOD_GSK3_1	374	381	PF00069	0.414
MOD_GSK3_1	407	414	PF00069	0.399
MOD_GSK3_1	489	496	PF00069	0.409
MOD_GSK3_1	524	531	PF00069	0.419
MOD_GSK3_1	574	581	PF00069	0.662
MOD_N-GLC_1	372	377	PF02516	0.390
MOD_N-GLC_1	575	580	PF02516	0.536
MOD_N-GLC_2	365	367	PF02516	0.234
MOD_NEK2_1	179	184	PF00069	0.445
MOD_NEK2_1	22	27	PF00069	0.411
MOD_NEK2_1	288	293	PF00069	0.407
MOD_NEK2_1	307	312	PF00069	0.333
MOD_NEK2_1	374	379	PF00069	0.397
MOD_NEK2_1	40	45	PF00069	0.317
MOD_NEK2_1	411	416	PF00069	0.401
MOD_NEK2_1	48	53	PF00069	0.372
MOD_NEK2_1	489	494	PF00069	0.390
MOD_NEK2_1	524	529	PF00069	0.488
MOD_NEK2_1	80	85	PF00069	0.379
MOD_NEK2_2	139	144	PF00069	0.503
MOD_PKA_2	14	20	PF00069	0.411
MOD_PKA_2	351	357	PF00069	0.494
MOD_PKA_2	472	478	PF00069	0.369
MOD_Plk_1	372	378	PF00069	0.408
MOD_Plk_4	107	113	PF00069	0.381
MOD_Plk_4	124	130	PF00069	0.366
MOD_Plk_4	288	294	PF00069	0.390
MOD_Plk_4	325	331	PF00069	0.429
MOD_Plk_4	374	380	PF00069	0.498
MOD_Plk_4	393	399	PF00069	0.241
MOD_Plk_4	407	413	PF00069	0.380
MOD_Plk_4	474	480	PF00069	0.416
MOD_Plk_4	536	542	PF00069	0.416
MOD_ProDKin_1	209	215	PF00069	0.509
MOD_ProDKin_1	352	358	PF00069	0.365
MOD_ProDKin_1	528	534	PF00069	0.449
MOD_SUMO_rev_2	549	558	PF00179	0.442
TRG_DiLeu_BaEn_2	172	178	PF01217	0.350
TRG_DiLeu_BaLyEn_6	518	523	PF01217	0.415
TRG_DiLeu_BaLyEn_6	529	534	PF01217	0.355
TRG_ENDOCYTIC_2	13	16	PF00928	0.360
TRG_ENDOCYTIC_2	290	293	PF00928	0.382
TRG_ENDOCYTIC_2	344	347	PF00928	0.393
TRG_ENDOCYTIC_2	379	382	PF00928	0.391
TRG_ENDOCYTIC_2	47	50	PF00928	0.387
TRG_ENDOCYTIC_2	480	483	PF00928	0.375
TRG_ENDOCYTIC_2	517	520	PF00928	0.459
TRG_ENDOCYTIC_2	62	65	PF00928	0.375
TRG_ENDOCYTIC_2	97	100	PF00928	0.379
TRG_Pf-PMV_PEXEL_1	168	173	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	47%	85%
A0A0N1HY49	Leptomonas seymouri	46%	88%
A0A0N1HZ06	Leptomonas seymouri	36%	100%
A0A0N1IHL1	Leptomonas seymouri	41%	83%
A0A0N1PAY4	Leptomonas seymouri	47%	68%
A0A0N1PB77	Leptomonas seymouri	36%	92%
A0A0N1PBZ2	Leptomonas seymouri	71%	88%
A0A0N1PCC1	Leptomonas seymouri	44%	89%
A0A381MBI0	Leishmania infantum	46%	90%
A0A3Q8I8X7	Leishmania donovani	46%	90%
A0A3Q8IAZ0	Leishmania donovani	85%	85%
A0A3Q8IH50	Leishmania donovani	60%	82%
A0A3Q8IVN0	Leishmania donovani	37%	95%
A0A3R7M4J1	Trypanosoma rangeli	42%	93%
A0A3S5H5P4	Leishmania donovani	44%	88%
A0A3S5H5V2	Leishmania donovani	46%	91%
A0A3S5H6F6	Leishmania donovani	84%	85%
A0A3S5H763	Leishmania donovani	56%	88%
A0A3S7WR10	Leishmania donovani	43%	80%
A0A3S7WR14	Leishmania donovani	93%	87%
A0A3S7WR15	Leishmania donovani	73%	70%
A0A3S7WR24	Leishmania donovani	85%	85%
A4H4T8	Leishmania braziliensis	43%	91%
A4H5Y4	Leishmania braziliensis	46%	91%
A4H617	Leishmania braziliensis	75%	85%
A4H618	Leishmania braziliensis	73%	87%
A4H619	Leishmania braziliensis	75%	85%
A4H620	Leishmania braziliensis	61%	84%
A4H6C3	Leishmania braziliensis	45%	91%
A4HNH7	Leishmania braziliensis	37%	95%
A4HSS2	Leishmania infantum	45%	88%
A4HUE4	Leishmania infantum	43%	80%
A4HUE5	Leishmania infantum	72%	86%
A4HUE6	Leishmania infantum	93%	87%
A4HUE7	Leishmania infantum	85%	85%
A4HUE8	Leishmania infantum	85%	85%
A4HUF4	Leishmania infantum	84%	85%
A4HUF5	Leishmania infantum	59%	90%
A4HYA9	Leishmania infantum	56%	88%
A4IC33	Leishmania infantum	36%	94%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	91%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	91%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	94%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	94%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	94%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	93%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	85%
E9AG72	Leishmania infantum	46%	91%
E9AI40	Leishmania braziliensis	74%	88%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	88%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	91%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	80%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	91%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	84%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	90%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	89%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	94%
Q4QDC4	Leishmania major	55%	100%
Q4QH81	Leishmania major	46%	100%
Q4QHH7	Leishmania major	61%	100%
Q4QHH8	Leishmania major	87%	100%
Q4QHH9	Leishmania major	87%	100%
Q4QHI0	Leishmania major	88%	100%
Q4QHI2	Leishmania major	82%	89%
Q4QIU9	Leishmania major	46%	91%
Q4QJ48	Leishmania major	45%	88%
Q7KIP2	Leishmania major	37%	100%