Putative folate/biopterin transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

folate/biopterin transporter, putative

Species:

Leishmania major

UniProt:

Q4QHI0_LEIMA

TriTrypDb:

LmjF.10.0380 , LMJLV39_100009300 , LMJSD75_100009300

Length:

691

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 70
NetGPI	no	yes: 0, no: 70

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0016020	membrane	2	71
GO:0110165	cellular anatomical entity	1	71
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

Q4QHI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHI0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	658	662	PF00656	0.833
CLV_MEL_PAP_1	431	437	PF00089	0.318
CLV_NRD_NRD_1	264	266	PF00675	0.405
CLV_NRD_NRD_1	41	43	PF00675	0.486
CLV_PCSK_KEX2_1	126	128	PF00082	0.364
CLV_PCSK_KEX2_1	41	43	PF00082	0.520
CLV_PCSK_KEX2_1	512	514	PF00082	0.589
CLV_PCSK_KEX2_1	9	11	PF00082	0.499
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.364
CLV_PCSK_PC1ET2_1	512	514	PF00082	0.589
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.499
CLV_PCSK_SKI1_1	109	113	PF00082	0.422
CLV_PCSK_SKI1_1	309	313	PF00082	0.416
DEG_SPOP_SBC_1	656	660	PF00917	0.669
DOC_CDC14_PxL_1	602	610	PF14671	0.399
DOC_CKS1_1	614	619	PF01111	0.500
DOC_CYCLIN_yCln2_LP_2	619	625	PF00134	0.445
DOC_MAPK_gen_1	126	132	PF00069	0.574
DOC_MAPK_gen_1	250	260	PF00069	0.616
DOC_MAPK_gen_1	512	520	PF00069	0.391
DOC_MAPK_gen_1	630	639	PF00069	0.655
DOC_MAPK_MEF2A_6	220	227	PF00069	0.396
DOC_MAPK_MEF2A_6	512	520	PF00069	0.424
DOC_PP1_RVXF_1	488	494	PF00149	0.587
DOC_PP2B_LxvP_1	619	622	PF13499	0.432
DOC_PP2B_PxIxI_1	220	226	PF00149	0.355
DOC_USP7_MATH_1	100	104	PF00917	0.660
DOC_USP7_MATH_1	189	193	PF00917	0.547
DOC_USP7_MATH_1	295	299	PF00917	0.627
DOC_USP7_MATH_1	554	558	PF00917	0.553
DOC_USP7_MATH_1	656	660	PF00917	0.707
DOC_USP7_MATH_1	681	685	PF00917	0.840
DOC_WW_Pin1_4	291	296	PF00397	0.657
DOC_WW_Pin1_4	434	439	PF00397	0.399
DOC_WW_Pin1_4	613	618	PF00397	0.482
DOC_WW_Pin1_4	96	101	PF00397	0.480
LIG_14-3-3_CanoR_1	250	260	PF00244	0.653
LIG_14-3-3_CanoR_1	434	438	PF00244	0.480
LIG_14-3-3_CanoR_1	490	494	PF00244	0.558
LIG_14-3-3_CanoR_1	77	82	PF00244	0.494
LIG_APCC_ABBA_1	43	48	PF00400	0.706
LIG_APCC_ABBAyCdc20_2	42	48	PF00400	0.577
LIG_BIR_II_1	1	5	PF00653	0.860
LIG_BIR_III_4	17	21	PF00653	0.659
LIG_Clathr_ClatBox_1	258	262	PF01394	0.515
LIG_EH1_1	492	500	PF00400	0.409
LIG_eIF4E_1	602	608	PF01652	0.298
LIG_FHA_1	110	116	PF00498	0.637
LIG_FHA_1	201	207	PF00498	0.405
LIG_FHA_1	358	364	PF00498	0.658
LIG_FHA_1	375	381	PF00498	0.424
LIG_FHA_1	390	396	PF00498	0.326
LIG_FHA_1	474	480	PF00498	0.462
LIG_FHA_1	490	496	PF00498	0.559
LIG_FHA_1	614	620	PF00498	0.485
LIG_FHA_2	262	268	PF00498	0.638
LIG_FHA_2	591	597	PF00498	0.295
LIG_GBD_Chelix_1	471	479	PF00786	0.300
LIG_GBD_Chelix_1	494	502	PF00786	0.542
LIG_GBD_Chelix_1	532	540	PF00786	0.572
LIG_LIR_Apic_2	22	28	PF02991	0.701
LIG_LIR_Apic_2	341	347	PF02991	0.597
LIG_LIR_Apic_2	409	415	PF02991	0.486
LIG_LIR_Apic_2	585	589	PF02991	0.370
LIG_LIR_Gen_1	117	124	PF02991	0.588
LIG_LIR_Gen_1	195	202	PF02991	0.572
LIG_LIR_Gen_1	478	485	PF02991	0.462
LIG_LIR_Gen_1	559	568	PF02991	0.584
LIG_LIR_Gen_1	80	88	PF02991	0.606
LIG_LIR_Nem_3	117	122	PF02991	0.562
LIG_LIR_Nem_3	125	131	PF02991	0.562
LIG_LIR_Nem_3	195	201	PF02991	0.360
LIG_LIR_Nem_3	235	241	PF02991	0.412
LIG_LIR_Nem_3	364	370	PF02991	0.566
LIG_LIR_Nem_3	409	414	PF02991	0.448
LIG_LIR_Nem_3	457	461	PF02991	0.368
LIG_LIR_Nem_3	478	483	PF02991	0.410
LIG_Pex14_2	162	166	PF04695	0.433
LIG_Pex14_2	456	460	PF04695	0.378
LIG_Pex14_2	480	484	PF04695	0.440
LIG_PTB_Apo_2	452	459	PF02174	0.440
LIG_PTB_Apo_2	478	485	PF02174	0.507
LIG_PTB_Phospho_1	452	458	PF10480	0.473
LIG_SH2_CRK	129	133	PF00017	0.443
LIG_SH2_CRK	144	148	PF00017	0.395
LIG_SH2_CRK	179	183	PF00017	0.582
LIG_SH2_CRK	344	348	PF00017	0.686
LIG_SH2_CRK	372	376	PF00017	0.413
LIG_SH2_CRK	447	451	PF00017	0.396
LIG_SH2_CRK	461	465	PF00017	0.370
LIG_SH2_CRK	586	590	PF00017	0.393
LIG_SH2_CRK	602	606	PF00017	0.425
LIG_SH2_CRK	95	99	PF00017	0.580
LIG_SH2_GRB2like	602	605	PF00017	0.419
LIG_SH2_NCK_1	327	331	PF00017	0.504
LIG_SH2_PTP2	25	28	PF00017	0.693
LIG_SH2_SRC	25	28	PF00017	0.699
LIG_SH2_SRC	327	330	PF00017	0.507
LIG_SH2_SRC	331	334	PF00017	0.495
LIG_SH2_STAP1	124	128	PF00017	0.568
LIG_SH2_STAP1	179	183	PF00017	0.558
LIG_SH2_STAP1	327	331	PF00017	0.500
LIG_SH2_STAP1	372	376	PF00017	0.461
LIG_SH2_STAP1	562	566	PF00017	0.407
LIG_SH2_STAP1	81	85	PF00017	0.604
LIG_SH2_STAT5	124	127	PF00017	0.569
LIG_SH2_STAT5	239	242	PF00017	0.507
LIG_SH2_STAT5	25	28	PF00017	0.688
LIG_SH2_STAT5	426	429	PF00017	0.423
LIG_SH2_STAT5	458	461	PF00017	0.330
LIG_SH2_STAT5	526	529	PF00017	0.361
LIG_SH2_STAT5	65	68	PF00017	0.595
LIG_SH3_1	344	350	PF00018	0.653
LIG_SH3_3	344	350	PF00018	0.664
LIG_SH3_3	432	438	PF00018	0.427
LIG_SUMO_SIM_anti_2	507	512	PF11976	0.388
LIG_SUMO_SIM_anti_2	616	622	PF11976	0.522
LIG_SUMO_SIM_par_1	473	478	PF11976	0.304
LIG_SUMO_SIM_par_1	544	550	PF11976	0.397
LIG_TRFH_1	144	148	PF08558	0.429
LIG_TYR_ITIM	142	147	PF00017	0.449
LIG_TYR_ITSM	457	464	PF00017	0.472
LIG_UBA3_1	142	150	PF00899	0.427
LIG_UBA3_1	258	266	PF00899	0.589
LIG_UBA3_1	479	486	PF00899	0.484
LIG_UBA3_1	625	630	PF00899	0.303
LIG_Vh1_VBS_1	370	388	PF01044	0.476
LIG_Vh1_VBS_1	460	478	PF01044	0.454
MOD_CK1_1	192	198	PF00069	0.415
MOD_CK1_1	613	619	PF00069	0.314
MOD_CK1_1	659	665	PF00069	0.686
MOD_CK1_1	99	105	PF00069	0.430
MOD_CK2_1	261	267	PF00069	0.500
MOD_Cter_Amidation	290	293	PF01082	0.538
MOD_DYRK1A_RPxSP_1	434	438	PF00069	0.484
MOD_GlcNHglycan	151	155	PF01048	0.427
MOD_GlcNHglycan	227	230	PF01048	0.440
MOD_GlcNHglycan	683	686	PF01048	0.595
MOD_GSK3_1	202	209	PF00069	0.387
MOD_GSK3_1	221	228	PF00069	0.510
MOD_GSK3_1	291	298	PF00069	0.489
MOD_GSK3_1	357	364	PF00069	0.548
MOD_GSK3_1	370	377	PF00069	0.442
MOD_GSK3_1	429	436	PF00069	0.317
MOD_GSK3_1	456	463	PF00069	0.447
MOD_GSK3_1	489	496	PF00069	0.432
MOD_GSK3_1	571	578	PF00069	0.442
MOD_GSK3_1	655	662	PF00069	0.702
MOD_GSK3_1	96	103	PF00069	0.475
MOD_N-GLC_1	454	459	PF02516	0.424
MOD_NEK2_1	104	109	PF00069	0.444
MOD_NEK2_1	122	127	PF00069	0.351
MOD_NEK2_1	130	135	PF00069	0.406
MOD_NEK2_1	202	207	PF00069	0.394
MOD_NEK2_1	261	266	PF00069	0.478
MOD_NEK2_1	370	375	PF00069	0.440
MOD_NEK2_1	389	394	PF00069	0.366
MOD_NEK2_1	429	434	PF00069	0.521
MOD_NEK2_1	456	461	PF00069	0.431
MOD_NEK2_1	493	498	PF00069	0.435
MOD_NEK2_1	571	576	PF00069	0.423
MOD_NEK2_1	610	615	PF00069	0.517
MOD_NEK2_2	221	226	PF00069	0.537
MOD_OFUCOSY	158	165	PF10250	0.280
MOD_PIKK_1	172	178	PF00454	0.395
MOD_PIKK_1	590	596	PF00454	0.575
MOD_PKA_2	433	439	PF00069	0.527
MOD_PKA_2	489	495	PF00069	0.417
MOD_PKA_2	554	560	PF00069	0.402
MOD_PKB_1	268	276	PF00069	0.282
MOD_Plk_1	454	460	PF00069	0.441
MOD_Plk_4	189	195	PF00069	0.414
MOD_Plk_4	202	208	PF00069	0.405
MOD_Plk_4	29	35	PF00069	0.585
MOD_Plk_4	370	376	PF00069	0.423
MOD_Plk_4	407	413	PF00069	0.462
MOD_Plk_4	456	462	PF00069	0.531
MOD_Plk_4	467	473	PF00069	0.394
MOD_Plk_4	475	481	PF00069	0.274
MOD_Plk_4	489	495	PF00069	0.413
MOD_Plk_4	556	562	PF00069	0.449
MOD_Plk_4	621	627	PF00069	0.449
MOD_ProDKin_1	291	297	PF00069	0.542
MOD_ProDKin_1	434	440	PF00069	0.399
MOD_ProDKin_1	613	619	PF00069	0.482
MOD_ProDKin_1	96	102	PF00069	0.295
MOD_SUMO_for_1	8	11	PF00179	0.597
MOD_SUMO_rev_2	16	26	PF00179	0.651
MOD_SUMO_rev_2	635	644	PF00179	0.476
TRG_DiLeu_BaEn_2	254	260	PF01217	0.383
TRG_DiLeu_BaLyEn_6	603	608	PF01217	0.449
TRG_DiLeu_BaLyEn_6	614	619	PF01217	0.388
TRG_ENDOCYTIC_2	129	132	PF00928	0.421
TRG_ENDOCYTIC_2	144	147	PF00928	0.408
TRG_ENDOCYTIC_2	179	182	PF00928	0.412
TRG_ENDOCYTIC_2	372	375	PF00928	0.415
TRG_ENDOCYTIC_2	426	429	PF00928	0.426
TRG_ENDOCYTIC_2	461	464	PF00928	0.424
TRG_ENDOCYTIC_2	562	565	PF00928	0.408
TRG_ENDOCYTIC_2	602	605	PF00928	0.493
TRG_ENDOCYTIC_2	81	84	PF00928	0.420
TRG_ENDOCYTIC_2	95	98	PF00928	0.393
TRG_ER_diArg_1	41	43	PF00400	0.657
TRG_Pf-PMV_PEXEL_1	250	255	PF00026	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	47%	98%
A0A0N1HY49	Leptomonas seymouri	46%	100%
A0A0N1HZ06	Leptomonas seymouri	34%	100%
A0A0N1IHL1	Leptomonas seymouri	37%	97%
A0A0N1PAY4	Leptomonas seymouri	45%	79%
A0A0N1PB77	Leptomonas seymouri	34%	100%
A0A0N1PBZ2	Leptomonas seymouri	67%	100%
A0A0N1PCC1	Leptomonas seymouri	42%	100%
A0A381MBI0	Leishmania infantum	44%	100%
A0A3Q8I8X7	Leishmania donovani	44%	100%
A0A3Q8IAZ0	Leishmania donovani	95%	99%
A0A3Q8IH50	Leishmania donovani	59%	96%
A0A3Q8IVN0	Leishmania donovani	37%	100%
A0A3R7M4J1	Trypanosoma rangeli	42%	100%
A0A3S5H5P4	Leishmania donovani	43%	100%
A0A3S5H5V2	Leishmania donovani	44%	100%
A0A3S5H6F6	Leishmania donovani	91%	99%
A0A3S5H763	Leishmania donovani	52%	100%
A0A3S7WR10	Leishmania donovani	43%	93%
A0A3S7WR14	Leishmania donovani	82%	100%
A0A3S7WR15	Leishmania donovani	71%	81%
A0A3S7WR24	Leishmania donovani	88%	98%
A4H4T8	Leishmania braziliensis	42%	100%
A4H5Y4	Leishmania braziliensis	44%	100%
A4H617	Leishmania braziliensis	79%	99%
A4H618	Leishmania braziliensis	80%	100%
A4H619	Leishmania braziliensis	80%	99%
A4H620	Leishmania braziliensis	57%	98%
A4H6C3	Leishmania braziliensis	42%	100%
A4HNH7	Leishmania braziliensis	35%	100%
A4HSS2	Leishmania infantum	43%	100%
A4HUE4	Leishmania infantum	43%	93%
A4HUE5	Leishmania infantum	71%	100%
A4HUE6	Leishmania infantum	83%	100%
A4HUE7	Leishmania infantum	95%	99%
A4HUE8	Leishmania infantum	88%	98%
A4HUF4	Leishmania infantum	89%	99%
A4HUF5	Leishmania infantum	59%	100%
A4HYA9	Leishmania infantum	52%	100%
A4IC33	Leishmania infantum	35%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%
E9AG72	Leishmania infantum	44%	100%
E9AI40	Leishmania braziliensis	74%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	93%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	97%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
Q4QDC4	Leishmania major	51%	99%
Q4QH81	Leishmania major	44%	100%
Q4QHH7	Leishmania major	59%	100%
Q4QHH8	Leishmania major	91%	100%
Q4QHH9	Leishmania major	90%	100%
Q4QHI1	Leishmania major	88%	100%
Q4QHI2	Leishmania major	79%	100%
Q4QIU9	Leishmania major	44%	100%
Q4QJ48	Leishmania major	42%	100%
Q7KIP2	Leishmania major	36%	98%