Putative folate/biopterin transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

folate/biopterin transporter, putative

Species:

Leishmania major

UniProt:

Q4QHH9_LEIMA

TriTrypDb:

LmjF.10.0385 , LMJLV39_100009200 , LMJSD75_100009400

Length:

708

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 70
NetGPI	no	yes: 0, no: 70

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0016020	membrane	2	71
GO:0110165	cellular anatomical entity	1	71
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

Q4QHH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHH9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	669	673	PF00656	0.803
CLV_MEL_PAP_1	442	448	PF00089	0.285
CLV_NRD_NRD_1	275	277	PF00675	0.372
CLV_NRD_NRD_1	52	54	PF00675	0.454
CLV_PCSK_KEX2_1	137	139	PF00082	0.331
CLV_PCSK_KEX2_1	52	54	PF00082	0.488
CLV_PCSK_KEX2_1	523	525	PF00082	0.556
CLV_PCSK_KEX2_1	9	11	PF00082	0.455
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.331
CLV_PCSK_PC1ET2_1	523	525	PF00082	0.556
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.455
CLV_PCSK_SKI1_1	120	124	PF00082	0.388
CLV_PCSK_SKI1_1	320	324	PF00082	0.383
DEG_APCC_DBOX_1	280	288	PF00400	0.460
DEG_SPOP_SBC_1	667	671	PF00917	0.636
DOC_CDC14_PxL_1	613	621	PF14671	0.366
DOC_CKS1_1	625	630	PF01111	0.467
DOC_CYCLIN_yCln2_LP_2	630	636	PF00134	0.412
DOC_MAPK_gen_1	137	143	PF00069	0.540
DOC_MAPK_gen_1	261	271	PF00069	0.583
DOC_MAPK_gen_1	276	284	PF00069	0.575
DOC_MAPK_gen_1	523	531	PF00069	0.357
DOC_MAPK_gen_1	641	650	PF00069	0.622
DOC_MAPK_MEF2A_6	231	238	PF00069	0.363
DOC_MAPK_MEF2A_6	523	531	PF00069	0.391
DOC_PP1_RVXF_1	499	505	PF00149	0.554
DOC_PP2B_LxvP_1	630	633	PF13499	0.399
DOC_PP2B_PxIxI_1	231	237	PF00149	0.322
DOC_USP7_MATH_1	203	207	PF00917	0.357
DOC_USP7_MATH_1	306	310	PF00917	0.594
DOC_USP7_MATH_1	565	569	PF00917	0.520
DOC_USP7_MATH_1	667	671	PF00917	0.675
DOC_USP7_MATH_1	703	707	PF00917	0.810
DOC_WW_Pin1_4	302	307	PF00397	0.624
DOC_WW_Pin1_4	624	629	PF00397	0.449
LIG_14-3-3_CanoR_1	108	113	PF00244	0.525
LIG_14-3-3_CanoR_1	261	271	PF00244	0.620
LIG_14-3-3_CanoR_1	501	505	PF00244	0.525
LIG_14-3-3_CanoR_1	581	590	PF00244	0.533
LIG_Actin_WH2_2	54	69	PF00022	0.655
LIG_APCC_ABBA_1	54	59	PF00400	0.670
LIG_APCC_ABBAyCdc20_2	53	59	PF00400	0.542
LIG_BIR_II_1	1	5	PF00653	0.801
LIG_BIR_III_4	17	21	PF00653	0.852
LIG_Clathr_ClatBox_1	269	273	PF01394	0.482
LIG_EH1_1	503	511	PF00400	0.375
LIG_eIF4E_1	613	619	PF01652	0.265
LIG_FHA_1	121	127	PF00498	0.604
LIG_FHA_1	212	218	PF00498	0.372
LIG_FHA_1	369	375	PF00498	0.625
LIG_FHA_1	386	392	PF00498	0.391
LIG_FHA_1	401	407	PF00498	0.293
LIG_FHA_1	485	491	PF00498	0.429
LIG_FHA_1	501	507	PF00498	0.526
LIG_FHA_1	625	631	PF00498	0.452
LIG_FHA_2	273	279	PF00498	0.605
LIG_FHA_2	602	608	PF00498	0.262
LIG_GBD_Chelix_1	482	490	PF00786	0.267
LIG_GBD_Chelix_1	505	513	PF00786	0.509
LIG_GBD_Chelix_1	543	551	PF00786	0.538
LIG_LIR_Apic_2	33	39	PF02991	0.656
LIG_LIR_Apic_2	352	358	PF02991	0.564
LIG_LIR_Apic_2	420	426	PF02991	0.452
LIG_LIR_Apic_2	457	461	PF02991	0.366
LIG_LIR_Apic_2	596	600	PF02991	0.336
LIG_LIR_Gen_1	128	135	PF02991	0.554
LIG_LIR_Gen_1	206	217	PF02991	0.538
LIG_LIR_Gen_1	470	479	PF02991	0.365
LIG_LIR_Gen_1	489	496	PF02991	0.428
LIG_LIR_Gen_1	570	580	PF02991	0.551
LIG_LIR_Gen_1	91	99	PF02991	0.573
LIG_LIR_Nem_3	128	133	PF02991	0.529
LIG_LIR_Nem_3	136	142	PF02991	0.529
LIG_LIR_Nem_3	2	6	PF02991	0.620
LIG_LIR_Nem_3	206	212	PF02991	0.327
LIG_LIR_Nem_3	246	252	PF02991	0.379
LIG_LIR_Nem_3	375	381	PF02991	0.533
LIG_LIR_Nem_3	419	425	PF02991	0.407
LIG_LIR_Nem_3	468	472	PF02991	0.335
LIG_LIR_Nem_3	489	494	PF02991	0.376
LIG_Pex14_2	173	177	PF04695	0.400
LIG_Pex14_2	467	471	PF04695	0.345
LIG_Pex14_2	491	495	PF04695	0.406
LIG_PTB_Apo_2	463	470	PF02174	0.407
LIG_PTB_Apo_2	489	496	PF02174	0.474
LIG_PTB_Phospho_1	463	469	PF10480	0.440
LIG_SH2_CRK	106	110	PF00017	0.546
LIG_SH2_CRK	140	144	PF00017	0.410
LIG_SH2_CRK	155	159	PF00017	0.361
LIG_SH2_CRK	190	194	PF00017	0.549
LIG_SH2_CRK	355	359	PF00017	0.653
LIG_SH2_CRK	383	387	PF00017	0.380
LIG_SH2_CRK	458	462	PF00017	0.362
LIG_SH2_CRK	472	476	PF00017	0.337
LIG_SH2_CRK	597	601	PF00017	0.359
LIG_SH2_CRK	613	617	PF00017	0.392
LIG_SH2_GRB2like	454	457	PF00017	0.392
LIG_SH2_GRB2like	613	616	PF00017	0.385
LIG_SH2_NCK_1	338	342	PF00017	0.471
LIG_SH2_NCK_1	472	476	PF00017	0.335
LIG_SH2_PTP2	36	39	PF00017	0.650
LIG_SH2_PTP2	528	531	PF00017	0.434
LIG_SH2_SRC	338	341	PF00017	0.474
LIG_SH2_SRC	342	345	PF00017	0.462
LIG_SH2_SRC	36	39	PF00017	0.656
LIG_SH2_STAP1	135	139	PF00017	0.535
LIG_SH2_STAP1	190	194	PF00017	0.524
LIG_SH2_STAP1	338	342	PF00017	0.466
LIG_SH2_STAP1	383	387	PF00017	0.428
LIG_SH2_STAP1	573	577	PF00017	0.374
LIG_SH2_STAP1	92	96	PF00017	0.571
LIG_SH2_STAT5	135	138	PF00017	0.536
LIG_SH2_STAT5	250	253	PF00017	0.474
LIG_SH2_STAT5	36	39	PF00017	0.645
LIG_SH2_STAT5	437	440	PF00017	0.389
LIG_SH2_STAT5	454	457	PF00017	0.321
LIG_SH2_STAT5	469	472	PF00017	0.297
LIG_SH2_STAT5	528	531	PF00017	0.337
LIG_SH2_STAT5	537	540	PF00017	0.328
LIG_SH3_1	355	361	PF00018	0.620
LIG_SH3_3	355	361	PF00018	0.631
LIG_SH3_3	443	449	PF00018	0.394
LIG_SUMO_SIM_anti_2	518	523	PF11976	0.355
LIG_SUMO_SIM_par_1	484	489	PF11976	0.270
LIG_SUMO_SIM_par_1	556	561	PF11976	0.363
LIG_TRFH_1	155	159	PF08558	0.396
LIG_TYR_ITIM	153	158	PF00017	0.416
LIG_TYR_ITSM	468	475	PF00017	0.439
LIG_UBA3_1	153	161	PF00899	0.393
LIG_UBA3_1	269	277	PF00899	0.556
LIG_UBA3_1	490	497	PF00899	0.450
LIG_UBA3_1	636	641	PF00899	0.270
LIG_Vh1_VBS_1	381	399	PF01044	0.442
LIG_Vh1_VBS_1	471	489	PF01044	0.421
MOD_CK1_1	110	116	PF00069	0.397
MOD_CK1_1	624	630	PF00069	0.280
MOD_CK1_1	670	676	PF00069	0.657
MOD_CK2_1	272	278	PF00069	0.467
MOD_Cter_Amidation	301	304	PF01082	0.505
MOD_GlcNHglycan	162	166	PF01048	0.394
MOD_GlcNHglycan	238	241	PF01048	0.406
MOD_GSK3_1	107	114	PF00069	0.442
MOD_GSK3_1	213	220	PF00069	0.354
MOD_GSK3_1	232	239	PF00069	0.476
MOD_GSK3_1	302	309	PF00069	0.456
MOD_GSK3_1	368	375	PF00069	0.515
MOD_GSK3_1	381	388	PF00069	0.409
MOD_GSK3_1	412	419	PF00069	0.309
MOD_GSK3_1	467	474	PF00069	0.414
MOD_GSK3_1	500	507	PF00069	0.399
MOD_GSK3_1	582	589	PF00069	0.409
MOD_GSK3_1	620	627	PF00069	0.419
MOD_GSK3_1	666	673	PF00069	0.669
MOD_N-GLC_1	465	470	PF02516	0.390
MOD_NEK2_1	115	120	PF00069	0.411
MOD_NEK2_1	133	138	PF00069	0.317
MOD_NEK2_1	141	146	PF00069	0.372
MOD_NEK2_1	213	218	PF00069	0.361
MOD_NEK2_1	272	277	PF00069	0.445
MOD_NEK2_1	381	386	PF00069	0.407
MOD_NEK2_1	400	405	PF00069	0.333
MOD_NEK2_1	467	472	PF00069	0.397
MOD_NEK2_1	504	509	PF00069	0.401
MOD_NEK2_1	582	587	PF00069	0.390
MOD_NEK2_1	620	625	PF00069	0.488
MOD_NEK2_1	72	77	PF00069	0.488
MOD_NEK2_2	232	237	PF00069	0.503
MOD_OFUCOSY	169	176	PF10250	0.247
MOD_PIKK_1	183	189	PF00454	0.361
MOD_PIKK_1	601	607	PF00454	0.542
MOD_PK_1	440	446	PF00069	0.423
MOD_PKA_2	107	113	PF00069	0.411
MOD_PKA_2	500	506	PF00069	0.384
MOD_PKA_2	565	571	PF00069	0.369
MOD_PKA_2	583	589	PF00069	0.369
MOD_Plk_1	465	471	PF00069	0.408
MOD_Plk_4	203	209	PF00069	0.380
MOD_Plk_4	213	219	PF00069	0.371
MOD_Plk_4	381	387	PF00069	0.390
MOD_Plk_4	40	46	PF00069	0.544
MOD_Plk_4	418	424	PF00069	0.429
MOD_Plk_4	467	473	PF00069	0.498
MOD_Plk_4	478	484	PF00069	0.361
MOD_Plk_4	486	492	PF00069	0.241
MOD_Plk_4	500	506	PF00069	0.380
MOD_Plk_4	567	573	PF00069	0.416
MOD_Plk_4	632	638	PF00069	0.416
MOD_ProDKin_1	302	308	PF00069	0.509
MOD_ProDKin_1	624	630	PF00069	0.449
MOD_SUMO_for_1	8	11	PF00179	0.549
MOD_SUMO_rev_2	646	655	PF00179	0.442
TRG_DiLeu_BaEn_2	265	271	PF01217	0.350
TRG_DiLeu_BaLyEn_6	614	619	PF01217	0.415
TRG_DiLeu_BaLyEn_6	625	630	PF01217	0.355
TRG_ENDOCYTIC_2	106	109	PF00928	0.360
TRG_ENDOCYTIC_2	140	143	PF00928	0.387
TRG_ENDOCYTIC_2	155	158	PF00928	0.375
TRG_ENDOCYTIC_2	190	193	PF00928	0.379
TRG_ENDOCYTIC_2	3	6	PF00928	0.505
TRG_ENDOCYTIC_2	383	386	PF00928	0.382
TRG_ENDOCYTIC_2	472	475	PF00928	0.391
TRG_ENDOCYTIC_2	528	531	PF00928	0.516
TRG_ENDOCYTIC_2	573	576	PF00928	0.375
TRG_ENDOCYTIC_2	613	616	PF00928	0.459
TRG_ENDOCYTIC_2	92	95	PF00928	0.387
TRG_ER_diArg_1	52	54	PF00400	0.627
TRG_Pf-PMV_PEXEL_1	261	266	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	48%	100%
A0A0N1HY49	Leptomonas seymouri	45%	100%
A0A0N1HZ06	Leptomonas seymouri	37%	100%
A0A0N1IHL1	Leptomonas seymouri	37%	99%
A0A0N1PAY4	Leptomonas seymouri	46%	80%
A0A0N1PB77	Leptomonas seymouri	35%	100%
A0A0N1PBZ2	Leptomonas seymouri	67%	100%
A0A0N1PCC1	Leptomonas seymouri	41%	100%
A0A381MBI0	Leishmania infantum	43%	100%
A0A3Q8I8X7	Leishmania donovani	44%	100%
A0A3Q8IAZ0	Leishmania donovani	88%	100%
A0A3Q8IH50	Leishmania donovani	58%	98%
A0A3Q8IVN0	Leishmania donovani	37%	100%
A0A3R7M4J1	Trypanosoma rangeli	41%	100%
A0A3S5H5P4	Leishmania donovani	43%	100%
A0A3S5H5V2	Leishmania donovani	43%	100%
A0A3S5H6F6	Leishmania donovani	91%	100%
A0A3S5H763	Leishmania donovani	51%	100%
A0A3S7WR10	Leishmania donovani	42%	95%
A0A3S7WR14	Leishmania donovani	79%	100%
A0A3S7WR15	Leishmania donovani	68%	83%
A0A3S7WR24	Leishmania donovani	92%	100%
A4H4T8	Leishmania braziliensis	43%	100%
A4H5Y4	Leishmania braziliensis	44%	100%
A4H617	Leishmania braziliensis	78%	100%
A4H618	Leishmania braziliensis	78%	100%
A4H619	Leishmania braziliensis	80%	100%
A4H620	Leishmania braziliensis	56%	100%
A4H6C3	Leishmania braziliensis	42%	100%
A4HNH7	Leishmania braziliensis	36%	100%
A4HSS2	Leishmania infantum	43%	100%
A4HUE4	Leishmania infantum	41%	95%
A4HUE5	Leishmania infantum	71%	100%
A4HUE6	Leishmania infantum	79%	100%
A4HUE7	Leishmania infantum	89%	100%
A4HUE8	Leishmania infantum	93%	100%
A4HUF4	Leishmania infantum	91%	100%
A4HUF5	Leishmania infantum	56%	100%
A4HYA9	Leishmania infantum	51%	100%
A4IC33	Leishmania infantum	36%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9AG72	Leishmania infantum	43%	100%
E9AI40	Leishmania braziliensis	72%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	95%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	99%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
Q4QDC4	Leishmania major	51%	100%
Q4QH81	Leishmania major	44%	100%
Q4QHH7	Leishmania major	59%	100%
Q4QHH8	Leishmania major	96%	100%
Q4QHI0	Leishmania major	90%	100%
Q4QHI1	Leishmania major	87%	100%
Q4QHI2	Leishmania major	78%	100%
Q4QIU9	Leishmania major	44%	100%
Q4QJ48	Leishmania major	43%	100%
Q7KIP2	Leishmania major	37%	100%