Putative folate/biopterin transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

folate/biopterin transporter, putative

Species:

Leishmania major

UniProt:

Q4QHH8_LEIMA

TriTrypDb:

LmjF.10.0390 , LMJLV39_100009300 , LMJSD75_100009400

Length:

732

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 70
NetGPI	no	yes: 0, no: 70

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0016020	membrane	2	71
GO:0110165	cellular anatomical entity	1	71
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

Q4QHH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHH8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	703	707	PF00656	0.796
CLV_MEL_PAP_1	476	482	PF00089	0.285
CLV_NRD_NRD_1	309	311	PF00675	0.372
CLV_NRD_NRD_1	36	38	PF00675	0.441
CLV_NRD_NRD_1	86	88	PF00675	0.452
CLV_PCSK_KEX2_1	171	173	PF00082	0.331
CLV_PCSK_KEX2_1	43	45	PF00082	0.485
CLV_PCSK_KEX2_1	557	559	PF00082	0.556
CLV_PCSK_KEX2_1	86	88	PF00082	0.486
CLV_PCSK_PC1ET2_1	171	173	PF00082	0.331
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.485
CLV_PCSK_PC1ET2_1	557	559	PF00082	0.556
CLV_PCSK_SKI1_1	154	158	PF00082	0.388
CLV_PCSK_SKI1_1	354	358	PF00082	0.383
DEG_APCC_DBOX_1	314	322	PF00400	0.460
DEG_Nend_Nbox_1	1	3	PF02207	0.689
DEG_SPOP_SBC_1	701	705	PF00917	0.631
DOC_CDC14_PxL_1	647	655	PF14671	0.366
DOC_CKS1_1	659	664	PF01111	0.467
DOC_CYCLIN_yCln2_LP_2	664	670	PF00134	0.412
DOC_MAPK_DCC_7	139	148	PF00069	0.417
DOC_MAPK_gen_1	139	148	PF00069	0.417
DOC_MAPK_gen_1	171	177	PF00069	0.540
DOC_MAPK_gen_1	295	305	PF00069	0.583
DOC_MAPK_gen_1	310	318	PF00069	0.575
DOC_MAPK_gen_1	557	565	PF00069	0.357
DOC_MAPK_gen_1	675	684	PF00069	0.622
DOC_MAPK_MEF2A_6	142	149	PF00069	0.499
DOC_MAPK_MEF2A_6	265	272	PF00069	0.363
DOC_MAPK_MEF2A_6	557	565	PF00069	0.391
DOC_PP2B_LxvP_1	2	5	PF13499	0.866
DOC_PP2B_LxvP_1	664	667	PF13499	0.399
DOC_PP2B_PxIxI_1	265	271	PF00149	0.322
DOC_USP7_MATH_1	11	15	PF00917	0.748
DOC_USP7_MATH_1	21	25	PF00917	0.708
DOC_USP7_MATH_1	237	241	PF00917	0.357
DOC_USP7_MATH_1	340	344	PF00917	0.594
DOC_USP7_MATH_1	599	603	PF00917	0.520
DOC_USP7_MATH_1	701	705	PF00917	0.670
DOC_WW_Pin1_4	141	146	PF00397	0.447
DOC_WW_Pin1_4	336	341	PF00397	0.624
DOC_WW_Pin1_4	658	663	PF00397	0.449
LIG_14-3-3_CanoR_1	295	305	PF00244	0.620
LIG_Actin_WH2_2	88	103	PF00022	0.660
LIG_APCC_ABBA_1	88	93	PF00400	0.672
LIG_APCC_ABBAyCdc20_2	87	93	PF00400	0.543
LIG_BIR_III_4	51	55	PF00653	0.870
LIG_Clathr_ClatBox_1	303	307	PF01394	0.482
LIG_EH1_1	537	545	PF00400	0.375
LIG_eIF4E_1	647	653	PF01652	0.265
LIG_FHA_1	106	112	PF00498	0.596
LIG_FHA_1	155	161	PF00498	0.604
LIG_FHA_1	246	252	PF00498	0.372
LIG_FHA_1	403	409	PF00498	0.625
LIG_FHA_1	420	426	PF00498	0.391
LIG_FHA_1	435	441	PF00498	0.293
LIG_FHA_1	519	525	PF00498	0.429
LIG_FHA_1	53	59	PF00498	0.712
LIG_FHA_1	535	541	PF00498	0.372
LIG_FHA_1	659	665	PF00498	0.452
LIG_FHA_2	307	313	PF00498	0.605
LIG_FHA_2	636	642	PF00498	0.262
LIG_GBD_Chelix_1	539	547	PF00786	0.509
LIG_GBD_Chelix_1	577	585	PF00786	0.538
LIG_LIR_Apic_2	386	392	PF02991	0.564
LIG_LIR_Apic_2	454	460	PF02991	0.452
LIG_LIR_Apic_2	491	495	PF02991	0.366
LIG_LIR_Apic_2	630	634	PF02991	0.336
LIG_LIR_Apic_2	67	73	PF02991	0.669
LIG_LIR_Gen_1	123	133	PF02991	0.574
LIG_LIR_Gen_1	162	169	PF02991	0.554
LIG_LIR_Gen_1	240	251	PF02991	0.538
LIG_LIR_Gen_1	504	513	PF02991	0.365
LIG_LIR_Gen_1	523	530	PF02991	0.428
LIG_LIR_Gen_1	604	614	PF02991	0.551
LIG_LIR_Nem_3	162	167	PF02991	0.529
LIG_LIR_Nem_3	170	176	PF02991	0.529
LIG_LIR_Nem_3	240	246	PF02991	0.327
LIG_LIR_Nem_3	280	286	PF02991	0.379
LIG_LIR_Nem_3	409	415	PF02991	0.533
LIG_LIR_Nem_3	453	459	PF02991	0.407
LIG_LIR_Nem_3	502	506	PF02991	0.335
LIG_LIR_Nem_3	523	528	PF02991	0.376
LIG_PDZ_Class_3	727	732	PF00595	0.647
LIG_Pex14_2	207	211	PF04695	0.400
LIG_Pex14_2	501	505	PF04695	0.345
LIG_Pex14_2	525	529	PF04695	0.406
LIG_PTB_Apo_2	497	504	PF02174	0.407
LIG_PTB_Apo_2	523	530	PF02174	0.474
LIG_PTB_Phospho_1	497	503	PF10480	0.440
LIG_SH2_CRK	140	144	PF00017	0.546
LIG_SH2_CRK	174	178	PF00017	0.410
LIG_SH2_CRK	189	193	PF00017	0.361
LIG_SH2_CRK	224	228	PF00017	0.549
LIG_SH2_CRK	389	393	PF00017	0.653
LIG_SH2_CRK	417	421	PF00017	0.380
LIG_SH2_CRK	492	496	PF00017	0.362
LIG_SH2_CRK	506	510	PF00017	0.337
LIG_SH2_CRK	631	635	PF00017	0.359
LIG_SH2_CRK	647	651	PF00017	0.392
LIG_SH2_GRB2like	488	491	PF00017	0.392
LIG_SH2_GRB2like	647	650	PF00017	0.385
LIG_SH2_NCK_1	372	376	PF00017	0.471
LIG_SH2_NCK_1	506	510	PF00017	0.335
LIG_SH2_PTP2	562	565	PF00017	0.434
LIG_SH2_PTP2	70	73	PF00017	0.661
LIG_SH2_SRC	372	375	PF00017	0.474
LIG_SH2_SRC	376	379	PF00017	0.462
LIG_SH2_SRC	70	73	PF00017	0.667
LIG_SH2_STAP1	122	126	PF00017	0.565
LIG_SH2_STAP1	169	173	PF00017	0.535
LIG_SH2_STAP1	224	228	PF00017	0.524
LIG_SH2_STAP1	372	376	PF00017	0.466
LIG_SH2_STAP1	417	421	PF00017	0.428
LIG_SH2_STAP1	607	611	PF00017	0.374
LIG_SH2_STAT5	110	113	PF00017	0.560
LIG_SH2_STAT5	169	172	PF00017	0.536
LIG_SH2_STAT5	284	287	PF00017	0.474
LIG_SH2_STAT5	471	474	PF00017	0.389
LIG_SH2_STAT5	488	491	PF00017	0.321
LIG_SH2_STAT5	503	506	PF00017	0.297
LIG_SH2_STAT5	534	537	PF00017	0.482
LIG_SH2_STAT5	562	565	PF00017	0.337
LIG_SH2_STAT5	571	574	PF00017	0.328
LIG_SH2_STAT5	70	73	PF00017	0.656
LIG_SH3_1	389	395	PF00018	0.620
LIG_SH3_3	15	21	PF00018	0.795
LIG_SH3_3	2	8	PF00018	0.782
LIG_SH3_3	389	395	PF00018	0.631
LIG_SH3_3	477	483	PF00018	0.394
LIG_SUMO_SIM_anti_2	552	557	PF11976	0.355
LIG_SUMO_SIM_anti_2	661	667	PF11976	0.489
LIG_SUMO_SIM_par_1	102	109	PF11976	0.444
LIG_SUMO_SIM_par_1	518	523	PF11976	0.270
LIG_SUMO_SIM_par_1	590	595	PF11976	0.363
LIG_TRFH_1	189	193	PF08558	0.396
LIG_TYR_ITIM	187	192	PF00017	0.416
LIG_TYR_ITSM	502	509	PF00017	0.439
LIG_UBA3_1	146	154	PF00899	0.320
LIG_UBA3_1	187	195	PF00899	0.393
LIG_UBA3_1	303	311	PF00899	0.556
LIG_UBA3_1	524	531	PF00899	0.450
LIG_UBA3_1	670	675	PF00899	0.270
LIG_Vh1_VBS_1	415	433	PF01044	0.442
MOD_CK1_1	658	664	PF00069	0.280
MOD_CK1_1	704	710	PF00069	0.647
MOD_CK2_1	306	312	PF00069	0.467
MOD_CK2_1	33	39	PF00069	0.697
MOD_Cter_Amidation	335	338	PF01082	0.505
MOD_GlcNHglycan	196	200	PF01048	0.394
MOD_GlcNHglycan	22	26	PF01048	0.730
MOD_GlcNHglycan	272	275	PF01048	0.406
MOD_GlcNHglycan	514	517	PF01048	0.398
MOD_GSK3_1	102	109	PF00069	0.338
MOD_GSK3_1	247	254	PF00069	0.354
MOD_GSK3_1	266	273	PF00069	0.476
MOD_GSK3_1	3	10	PF00069	0.702
MOD_GSK3_1	336	343	PF00069	0.456
MOD_GSK3_1	402	409	PF00069	0.515
MOD_GSK3_1	415	422	PF00069	0.409
MOD_GSK3_1	446	453	PF00069	0.309
MOD_GSK3_1	501	508	PF00069	0.414
MOD_GSK3_1	534	541	PF00069	0.399
MOD_GSK3_1	612	619	PF00069	0.410
MOD_GSK3_1	700	707	PF00069	0.662
MOD_N-GLC_1	499	504	PF02516	0.390
MOD_NEK2_1	106	111	PF00069	0.492
MOD_NEK2_1	149	154	PF00069	0.411
MOD_NEK2_1	167	172	PF00069	0.317
MOD_NEK2_1	175	180	PF00069	0.372
MOD_NEK2_1	247	252	PF00069	0.361
MOD_NEK2_1	306	311	PF00069	0.445
MOD_NEK2_1	415	420	PF00069	0.407
MOD_NEK2_1	434	439	PF00069	0.333
MOD_NEK2_1	501	506	PF00069	0.397
MOD_NEK2_1	538	543	PF00069	0.401
MOD_NEK2_1	616	621	PF00069	0.390
MOD_NEK2_1	655	660	PF00069	0.483
MOD_NEK2_2	266	271	PF00069	0.503
MOD_OFUCOSY	203	210	PF10250	0.247
MOD_PIKK_1	13	19	PF00454	0.568
MOD_PIKK_1	217	223	PF00454	0.361
MOD_PIKK_1	635	641	PF00454	0.542
MOD_PK_1	474	480	PF00069	0.423
MOD_PKA_2	599	605	PF00069	0.369
MOD_Plk_1	122	128	PF00069	0.428
MOD_Plk_1	499	505	PF00069	0.408
MOD_Plk_4	106	112	PF00069	0.334
MOD_Plk_4	23	29	PF00069	0.655
MOD_Plk_4	237	243	PF00069	0.380
MOD_Plk_4	247	253	PF00069	0.371
MOD_Plk_4	415	421	PF00069	0.390
MOD_Plk_4	452	458	PF00069	0.429
MOD_Plk_4	501	507	PF00069	0.498
MOD_Plk_4	520	526	PF00069	0.241
MOD_Plk_4	534	540	PF00069	0.380
MOD_Plk_4	601	607	PF00069	0.416
MOD_Plk_4	666	672	PF00069	0.416
MOD_Plk_4	74	80	PF00069	0.553
MOD_ProDKin_1	141	147	PF00069	0.261
MOD_ProDKin_1	336	342	PF00069	0.509
MOD_ProDKin_1	658	664	PF00069	0.449
MOD_SUMO_for_1	42	45	PF00179	0.587
MOD_SUMO_rev_2	680	689	PF00179	0.442
TRG_DiLeu_BaEn_2	299	305	PF01217	0.350
TRG_DiLeu_BaLyEn_6	648	653	PF01217	0.415
TRG_DiLeu_BaLyEn_6	659	664	PF01217	0.355
TRG_ENDOCYTIC_2	126	129	PF00928	0.387
TRG_ENDOCYTIC_2	140	143	PF00928	0.360
TRG_ENDOCYTIC_2	174	177	PF00928	0.387
TRG_ENDOCYTIC_2	189	192	PF00928	0.375
TRG_ENDOCYTIC_2	224	227	PF00928	0.379
TRG_ENDOCYTIC_2	417	420	PF00928	0.382
TRG_ENDOCYTIC_2	506	509	PF00928	0.391
TRG_ENDOCYTIC_2	562	565	PF00928	0.516
TRG_ENDOCYTIC_2	607	610	PF00928	0.375
TRG_ENDOCYTIC_2	647	650	PF00928	0.459
TRG_ER_diArg_1	86	88	PF00400	0.623
TRG_Pf-PMV_PEXEL_1	295	300	PF00026	0.523

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	47%	100%
A0A0N1HY49	Leptomonas seymouri	44%	100%
A0A0N1HZ06	Leptomonas seymouri	36%	100%
A0A0N1IHL1	Leptomonas seymouri	37%	100%
A0A0N1PAY4	Leptomonas seymouri	46%	83%
A0A0N1PB77	Leptomonas seymouri	34%	100%
A0A0N1PBZ2	Leptomonas seymouri	66%	100%
A0A0N1PCC1	Leptomonas seymouri	41%	100%
A0A381MBI0	Leishmania infantum	43%	100%
A0A3Q8I8X7	Leishmania donovani	44%	100%
A0A3Q8IAZ0	Leishmania donovani	91%	100%
A0A3Q8IH50	Leishmania donovani	58%	100%
A0A3Q8IVN0	Leishmania donovani	37%	100%
A0A3R7M4J1	Trypanosoma rangeli	40%	100%
A0A3S5H5P4	Leishmania donovani	43%	100%
A0A3S5H5V2	Leishmania donovani	44%	100%
A0A3S5H6F6	Leishmania donovani	92%	100%
A0A3S5H763	Leishmania donovani	51%	100%
A0A3S7WR10	Leishmania donovani	42%	98%
A0A3S7WR14	Leishmania donovani	79%	100%
A0A3S7WR15	Leishmania donovani	68%	86%
A0A3S7WR24	Leishmania donovani	91%	100%
A4H4T8	Leishmania braziliensis	43%	100%
A4H5Y4	Leishmania braziliensis	44%	100%
A4H617	Leishmania braziliensis	78%	100%
A4H618	Leishmania braziliensis	79%	100%
A4H619	Leishmania braziliensis	81%	100%
A4H620	Leishmania braziliensis	55%	100%
A4H6C3	Leishmania braziliensis	43%	100%
A4HNH7	Leishmania braziliensis	36%	100%
A4HSS2	Leishmania infantum	43%	100%
A4HUE4	Leishmania infantum	42%	98%
A4HUE5	Leishmania infantum	71%	100%
A4HUE6	Leishmania infantum	79%	100%
A4HUE7	Leishmania infantum	90%	100%
A4HUE8	Leishmania infantum	91%	100%
A4HUF4	Leishmania infantum	91%	100%
A4HUF5	Leishmania infantum	57%	100%
A4HYA9	Leishmania infantum	51%	100%
A4IC33	Leishmania infantum	36%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AG72	Leishmania infantum	44%	100%
E9AI40	Leishmania braziliensis	72%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	98%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	100%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
Q4QDC4	Leishmania major	51%	100%
Q4QH81	Leishmania major	44%	100%
Q4QHH7	Leishmania major	60%	100%
Q4QHH9	Leishmania major	96%	100%
Q4QHI0	Leishmania major	91%	100%
Q4QHI1	Leishmania major	87%	100%
Q4QHI2	Leishmania major	78%	100%
Q4QIU9	Leishmania major	44%	100%
Q4QJ48	Leishmania major	43%	100%
Q7KIP2	Leishmania major	36%	100%