Putative folate/biopterin transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

folate/biopterin transporter, putative

Species:

Leishmania major

UniProt:

Q4QHH7_LEIMA

TriTrypDb:

LmjF.10.0400 , LMJLV39_100009400 , LMJSD75_100009500

Length:

713

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 70
NetGPI	no	yes: 0, no: 70

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0016020	membrane	2	71
GO:0110165	cellular anatomical entity	1	71
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

Q4QHH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHH7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	23	25	PF00675	0.438
CLV_NRD_NRD_1	263	265	PF00675	0.322
CLV_NRD_NRD_1	281	283	PF00675	0.344
CLV_NRD_NRD_1	709	711	PF00675	0.502
CLV_PCSK_KEX2_1	143	145	PF00082	0.302
CLV_PCSK_KEX2_1	543	545	PF00082	0.526
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.302
CLV_PCSK_PC1ET2_1	543	545	PF00082	0.526
CLV_PCSK_SKI1_1	126	130	PF00082	0.358
CLV_PCSK_SKI1_1	25	29	PF00082	0.425
CLV_PCSK_SKI1_1	285	289	PF00082	0.271
CLV_PCSK_SKI1_1	344	348	PF00082	0.377
CLV_PCSK_SKI1_1	668	672	PF00082	0.262
DEG_APCC_DBOX_1	284	292	PF00400	0.426
DEG_Nend_UBRbox_3	1	3	PF02207	0.610
DOC_CDC14_PxL_1	629	637	PF14671	0.332
DOC_CYCLIN_yCln2_LP_2	646	652	PF00134	0.395
DOC_MAPK_gen_1	143	149	PF00069	0.511
DOC_MAPK_gen_1	282	290	PF00069	0.550
DOC_MAPK_gen_1	300	309	PF00069	0.525
DOC_MAPK_gen_1	543	551	PF00069	0.328
DOC_MAPK_gen_1	656	665	PF00069	0.591
DOC_MAPK_MEF2A_6	237	244	PF00069	0.341
DOC_MAPK_MEF2A_6	282	290	PF00069	0.546
DOC_MAPK_MEF2A_6	543	551	PF00069	0.361
DOC_MAPK_MEF2A_6	73	80	PF00069	0.552
DOC_PP1_RVXF_1	519	525	PF00149	0.524
DOC_PP2B_LxvP_1	464	467	PF13499	0.381
DOC_PP2B_LxvP_1	646	649	PF13499	0.401
DOC_PP2B_LxvP_1	652	655	PF13499	0.237
DOC_PP4_FxxP_1	42	45	PF00568	0.595
DOC_USP7_MATH_1	209	213	PF00917	0.333
DOC_USP7_MATH_1	308	312	PF00917	0.533
DOC_USP7_MATH_1	321	325	PF00917	0.583
DOC_USP7_MATH_1	469	473	PF00917	0.332
DOC_USP7_MATH_1	585	589	PF00917	0.494
DOC_WW_Pin1_4	18	23	PF00397	0.725
DOC_WW_Pin1_4	31	36	PF00397	0.800
DOC_WW_Pin1_4	6	11	PF00397	0.707
DOC_WW_Pin1_4	621	626	PF00397	0.353
LIG_14-3-3_CanoR_1	521	525	PF00244	0.498
LIG_APCC_ABBA_1	60	65	PF00400	0.646
LIG_CSL_BTD_1	572	575	PF09270	0.404
LIG_EH1_1	523	531	PF00400	0.367
LIG_EVH1_2	625	629	PF00568	0.364
LIG_FHA_1	127	133	PF00498	0.569
LIG_FHA_1	320	326	PF00498	0.389
LIG_FHA_1	406	412	PF00498	0.353
LIG_FHA_1	421	427	PF00498	0.246
LIG_FHA_1	459	465	PF00498	0.387
LIG_FHA_1	521	527	PF00498	0.498
LIG_FHA_1	649	655	PF00498	0.427
LIG_FHA_1	691	697	PF00498	0.576
LIG_FHA_1	701	707	PF00498	0.557
LIG_LIR_Apic_2	39	45	PF02991	0.646
LIG_LIR_Apic_2	440	446	PF02991	0.407
LIG_LIR_Gen_1	134	141	PF02991	0.532
LIG_LIR_Gen_1	193	204	PF02991	0.522
LIG_LIR_Gen_1	212	223	PF02991	0.467
LIG_LIR_Gen_1	461	470	PF02991	0.351
LIG_LIR_Gen_1	490	499	PF02991	0.322
LIG_LIR_Gen_1	535	542	PF02991	0.349
LIG_LIR_Gen_1	590	599	PF02991	0.519
LIG_LIR_LC3C_4	353	358	PF02991	0.393
LIG_LIR_Nem_3	134	139	PF02991	0.505
LIG_LIR_Nem_3	142	148	PF02991	0.504
LIG_LIR_Nem_3	193	199	PF02991	0.531
LIG_LIR_Nem_3	212	218	PF02991	0.359
LIG_LIR_Nem_3	252	258	PF02991	0.352
LIG_LIR_Nem_3	368	374	PF02991	0.560
LIG_LIR_Nem_3	440	445	PF02991	0.447
LIG_LIR_Nem_3	461	466	PF02991	0.396
LIG_LIR_Nem_3	488	492	PF02991	0.302
LIG_LIR_Nem_3	535	540	PF02991	0.351
LIG_Pex14_1	213	217	PF04695	0.381
LIG_Pex14_2	256	260	PF04695	0.298
LIG_Pex14_2	487	491	PF04695	0.311
LIG_Pex14_2	511	515	PF04695	0.379
LIG_SH2_CRK	146	150	PF00017	0.376
LIG_SH2_CRK	161	165	PF00017	0.341
LIG_SH2_CRK	196	200	PF00017	0.527
LIG_SH2_CRK	403	407	PF00017	0.359
LIG_SH2_CRK	492	496	PF00017	0.312
LIG_SH2_NCK_1	492	496	PF00017	0.315
LIG_SH2_PTP2	548	551	PF00017	0.402
LIG_SH2_STAP1	141	145	PF00017	0.510
LIG_SH2_STAP1	196	200	PF00017	0.495
LIG_SH2_STAP1	403	407	PF00017	0.400
LIG_SH2_STAP1	593	597	PF00017	0.355
LIG_SH2_STAT3	95	98	PF00017	0.417
LIG_SH2_STAT5	141	144	PF00017	0.508
LIG_SH2_STAT5	371	374	PF00017	0.584
LIG_SH2_STAT5	457	460	PF00017	0.361
LIG_SH2_STAT5	463	466	PF00017	0.354
LIG_SH2_STAT5	474	477	PF00017	0.294
LIG_SH2_STAT5	489	492	PF00017	0.303
LIG_SH2_STAT5	513	516	PF00017	0.459
LIG_SH2_STAT5	548	551	PF00017	0.310
LIG_SH2_STAT5	557	560	PF00017	0.297
LIG_SH2_STAT5	82	85	PF00017	0.525
LIG_SH3_3	162	168	PF00018	0.306
LIG_SH3_3	373	379	PF00018	0.601
LIG_SH3_3	479	485	PF00018	0.289
LIG_SH3_3	49	55	PF00018	0.578
LIG_SH3_3	7	13	PF00018	0.780
LIG_SUMO_SIM_par_1	304	311	PF11976	0.388
LIG_SUMO_SIM_par_1	575	581	PF11976	0.344
LIG_TRAF2_1	346	349	PF00917	0.389
LIG_TRFH_1	161	165	PF08558	0.368
LIG_TYR_ITIM	159	164	PF00017	0.393
LIG_TYR_ITSM	488	495	PF00017	0.410
LIG_UBA3_1	383	391	PF00899	0.392
LIG_UBA3_1	536	543	PF00899	0.330
LIG_Vh1_VBS_1	401	419	PF01044	0.414
LIG_Vh1_VBS_1	491	509	PF01044	0.393
LIG_WRC_WIRS_1	470	475	PF05994	0.344
MOD_CDK_SPK_2	6	11	PF00069	0.524
MOD_CDK_SPxK_1	18	24	PF00069	0.534
MOD_CDK_SPxxK_3	18	25	PF00069	0.693
MOD_CK1_1	410	416	PF00069	0.353
MOD_CK1_1	516	522	PF00069	0.372
MOD_CK1_1	620	626	PF00069	0.321
MOD_CK1_1	9	15	PF00069	0.603
MOD_CK2_1	691	697	PF00069	0.468
MOD_GlcNHglycan	169	172	PF01048	0.348
MOD_GlcNHglycan	244	247	PF01048	0.393
MOD_GlcNHglycan	300	303	PF01048	0.366
MOD_GlcNHglycan	310	313	PF01048	0.347
MOD_GlcNHglycan	314	317	PF01048	0.329
MOD_GlcNHglycan	6	9	PF01048	0.717
MOD_GSK3_1	117	124	PF00069	0.415
MOD_GSK3_1	294	301	PF00069	0.395
MOD_GSK3_1	308	315	PF00069	0.441
MOD_GSK3_1	401	408	PF00069	0.371
MOD_GSK3_1	487	494	PF00069	0.376
MOD_GSK3_1	516	523	PF00069	0.379
MOD_GSK3_1	602	609	PF00069	0.391
MOD_GSK3_1	617	624	PF00069	0.340
MOD_N-GLC_1	627	632	PF02516	0.205
MOD_N-GLC_1	691	696	PF02516	0.655
MOD_NEK2_1	100	105	PF00069	0.308
MOD_NEK2_1	121	126	PF00069	0.382
MOD_NEK2_1	139	144	PF00069	0.289
MOD_NEK2_1	147	152	PF00069	0.345
MOD_NEK2_1	179	184	PF00069	0.352
MOD_NEK2_1	401	406	PF00069	0.381
MOD_NEK2_1	407	412	PF00069	0.366
MOD_NEK2_1	420	425	PF00069	0.385
MOD_NEK2_1	458	463	PF00069	0.484
MOD_NEK2_1	487	492	PF00069	0.363
MOD_NEK2_1	524	529	PF00069	0.375
MOD_NEK2_1	602	607	PF00069	0.372
MOD_NEK2_2	321	326	PF00069	0.188
MOD_NEK2_2	469	474	PF00069	0.347
MOD_OFUCOSY	409	416	PF10250	0.404
MOD_PKA_2	520	526	PF00069	0.366
MOD_PKA_2	585	591	PF00069	0.348
MOD_Plk_1	294	300	PF00069	0.415
MOD_Plk_1	45	51	PF00069	0.358
MOD_Plk_1	691	697	PF00069	0.621
MOD_Plk_4	209	215	PF00069	0.351
MOD_Plk_4	401	407	PF00069	0.354
MOD_Plk_4	415	421	PF00069	0.318
MOD_Plk_4	438	444	PF00069	0.388
MOD_Plk_4	458	464	PF00069	0.381
MOD_Plk_4	46	52	PF00069	0.533
MOD_Plk_4	469	475	PF00069	0.338
MOD_Plk_4	487	493	PF00069	0.394
MOD_Plk_4	525	531	PF00069	0.314
MOD_Plk_4	532	538	PF00069	0.324
MOD_Plk_4	587	593	PF00069	0.371
MOD_Plk_4	648	654	PF00069	0.375
MOD_ProDKin_1	18	24	PF00069	0.665
MOD_ProDKin_1	31	37	PF00069	0.766
MOD_ProDKin_1	6	12	PF00069	0.638
MOD_ProDKin_1	621	627	PF00069	0.423
MOD_SUMO_rev_2	3	7	PF00179	0.503
MOD_SUMO_rev_2	661	670	PF00179	0.414
MOD_SUMO_rev_2	705	713	PF00179	0.468
TRG_DiLeu_BaEn_2	37	43	PF01217	0.429
TRG_DiLeu_BaEn_4	361	367	PF01217	0.203
TRG_DiLeu_BaLyEn_6	641	646	PF01217	0.336
TRG_ENDOCYTIC_2	146	149	PF00928	0.360
TRG_ENDOCYTIC_2	161	164	PF00928	0.347
TRG_ENDOCYTIC_2	196	199	PF00928	0.351
TRG_ENDOCYTIC_2	278	281	PF00928	0.453
TRG_ENDOCYTIC_2	403	406	PF00928	0.360
TRG_ENDOCYTIC_2	457	460	PF00928	0.365
TRG_ENDOCYTIC_2	463	466	PF00928	0.367
TRG_ENDOCYTIC_2	492	495	PF00928	0.358
TRG_ENDOCYTIC_2	548	551	PF00928	0.485
TRG_ENDOCYTIC_2	593	596	PF00928	0.359
TRG_NES_CRM1_1	465	479	PF08389	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	50%	100%
A0A0N1HY49	Leptomonas seymouri	53%	100%
A0A0N1HZ06	Leptomonas seymouri	41%	100%
A0A0N1IHL1	Leptomonas seymouri	44%	100%
A0A0N1PAY4	Leptomonas seymouri	49%	81%
A0A0N1PB77	Leptomonas seymouri	38%	100%
A0A0N1PBZ2	Leptomonas seymouri	60%	100%
A0A0N1PCC1	Leptomonas seymouri	45%	100%
A0A0S4INN8	Bodo saltans	31%	100%
A0A381MBI0	Leishmania infantum	46%	100%
A0A3Q8I8X7	Leishmania donovani	46%	100%
A0A3Q8IAZ0	Leishmania donovani	60%	100%
A0A3Q8IH50	Leishmania donovani	91%	99%
A0A3Q8IVN0	Leishmania donovani	39%	100%
A0A3R7M4J1	Trypanosoma rangeli	43%	100%
A0A3S5H5P4	Leishmania donovani	49%	100%
A0A3S5H5V2	Leishmania donovani	46%	100%
A0A3S5H6F6	Leishmania donovani	59%	100%
A0A3S5H763	Leishmania donovani	62%	100%
A0A3S7WR10	Leishmania donovani	48%	96%
A0A3S7WR14	Leishmania donovani	59%	100%
A0A3S7WR15	Leishmania donovani	57%	84%
A0A3S7WR24	Leishmania donovani	57%	100%
A4H4T8	Leishmania braziliensis	45%	100%
A4H5Y4	Leishmania braziliensis	47%	100%
A4H617	Leishmania braziliensis	58%	100%
A4H618	Leishmania braziliensis	57%	100%
A4H619	Leishmania braziliensis	57%	100%
A4H620	Leishmania braziliensis	80%	100%
A4H6C3	Leishmania braziliensis	47%	100%
A4HNH7	Leishmania braziliensis	37%	100%
A4HSS2	Leishmania infantum	49%	100%
A4HUE4	Leishmania infantum	49%	96%
A4HUE5	Leishmania infantum	57%	100%
A4HUE6	Leishmania infantum	59%	100%
A4HUE7	Leishmania infantum	60%	100%
A4HUE8	Leishmania infantum	57%	100%
A4HUF4	Leishmania infantum	59%	100%
A4HUF5	Leishmania infantum	93%	100%
A4HYA9	Leishmania infantum	62%	100%
A4IC33	Leishmania infantum	39%	100%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
E9AG72	Leishmania infantum	46%	100%
E9AI40	Leishmania braziliensis	58%	100%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	96%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
Q4QDC4	Leishmania major	61%	100%
Q4QH81	Leishmania major	46%	100%
Q4QHH8	Leishmania major	60%	97%
Q4QHH9	Leishmania major	59%	100%
Q4QHI0	Leishmania major	59%	100%
Q4QHI1	Leishmania major	61%	100%
Q4QHI2	Leishmania major	59%	100%
Q4QIU9	Leishmania major	44%	100%
Q4QJ48	Leishmania major	50%	100%
Q7KIP2	Leishmania major	38%	96%