Dihydroxyacetone kinase 1-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dihydroxyacetone kinase 1-like protein

Species:

Leishmania major

UniProt:

Q4QHH6_LEIMA

TriTrypDb:

LmjF.10.0420 , LMJLV39_100009500 , LMJSD75_100009600

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QHH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHH6

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	11
GO:0006066	alcohol metabolic process	3	11
GO:0006071	glycerol metabolic process	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	2
GO:0009987	cellular process	1	11
GO:0016052	carbohydrate catabolic process	4	2
GO:0016310	phosphorylation	5	11
GO:0019400	alditol metabolic process	4	11
GO:0019405	alditol catabolic process	5	2
GO:0019563	glycerol catabolic process	6	2
GO:0019751	polyol metabolic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044248	cellular catabolic process	3	2
GO:0044262	obsolete cellular carbohydrate metabolic process	3	11
GO:0044275	obsolete cellular carbohydrate catabolic process	4	2
GO:0044281	small molecule metabolic process	2	11
GO:0044282	small molecule catabolic process	3	2
GO:0046164	alcohol catabolic process	4	2
GO:0046174	polyol catabolic process	5	2
GO:0071704	organic substance metabolic process	2	11
GO:1901575	organic substance catabolic process	3	2
GO:1901615	organic hydroxy compound metabolic process	3	11
GO:1901616	organic hydroxy compound catabolic process	4	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	11
GO:0004371	glycerone kinase activity	5	11
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	411	415	PF00656	0.520
CLV_MEL_PAP_1	183	189	PF00089	0.391
CLV_NRD_NRD_1	154	156	PF00675	0.292
CLV_NRD_NRD_1	442	444	PF00675	0.312
CLV_NRD_NRD_1	506	508	PF00675	0.255
CLV_PCSK_KEX2_1	153	155	PF00082	0.294
CLV_PCSK_KEX2_1	442	444	PF00082	0.312
CLV_PCSK_KEX2_1	506	508	PF00082	0.258
CLV_PCSK_KEX2_1	98	100	PF00082	0.205
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.405
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.205
CLV_PCSK_SKI1_1	227	231	PF00082	0.368
CLV_PCSK_SKI1_1	268	272	PF00082	0.322
CLV_PCSK_SKI1_1	309	313	PF00082	0.273
CLV_PCSK_SKI1_1	397	401	PF00082	0.459
CLV_PCSK_SKI1_1	443	447	PF00082	0.314
CLV_PCSK_SKI1_1	48	52	PF00082	0.319
CLV_PCSK_SKI1_1	489	493	PF00082	0.239
DOC_ANK_TNKS_1	98	105	PF00023	0.205
DOC_CDC14_PxL_1	429	437	PF14671	0.444
DOC_MAPK_gen_1	506	515	PF00069	0.370
DOC_PP1_RVXF_1	328	335	PF00149	0.420
DOC_PP2B_PxIxI_1	104	110	PF00149	0.318
DOC_PP4_FxxP_1	230	233	PF00568	0.315
DOC_PP4_FxxP_1	348	351	PF00568	0.404
DOC_PP4_FxxP_1	81	84	PF00568	0.273
DOC_USP7_MATH_1	207	211	PF00917	0.421
DOC_USP7_MATH_1	254	258	PF00917	0.411
DOC_USP7_MATH_1	262	266	PF00917	0.159
DOC_USP7_MATH_1	457	461	PF00917	0.486
DOC_USP7_MATH_1	478	482	PF00917	0.564
DOC_USP7_MATH_1	493	497	PF00917	0.414
DOC_USP7_MATH_1	583	587	PF00917	0.484
DOC_USP7_MATH_1	61	65	PF00917	0.383
DOC_USP7_MATH_1	87	91	PF00917	0.318
DOC_USP7_UBL2_3	149	153	PF12436	0.305
DOC_USP7_UBL2_3	565	569	PF12436	0.520
DOC_WW_Pin1_4	378	383	PF00397	0.514
DOC_WW_Pin1_4	528	533	PF00397	0.452
DOC_WW_Pin1_4	80	85	PF00397	0.273
LIG_14-3-3_CanoR_1	173	178	PF00244	0.349
LIG_14-3-3_CanoR_1	309	315	PF00244	0.273
LIG_14-3-3_CanoR_1	442	448	PF00244	0.569
LIG_APCC_ABBA_1	221	226	PF00400	0.273
LIG_BIR_II_1	1	5	PF00653	0.550
LIG_Clathr_ClatBox_1	323	327	PF01394	0.388
LIG_Clathr_ClatBox_1	398	402	PF01394	0.442
LIG_DLG_GKlike_1	173	180	PF00625	0.399
LIG_FHA_1	146	152	PF00498	0.330
LIG_FHA_1	214	220	PF00498	0.378
LIG_FHA_1	258	264	PF00498	0.449
LIG_FHA_1	277	283	PF00498	0.267
LIG_FHA_1	320	326	PF00498	0.399
LIG_FHA_1	336	342	PF00498	0.425
LIG_FHA_1	34	40	PF00498	0.273
LIG_FHA_1	442	448	PF00498	0.486
LIG_FHA_1	45	51	PF00498	0.273
LIG_FHA_1	529	535	PF00498	0.528
LIG_FHA_1	547	553	PF00498	0.429
LIG_FHA_1	84	90	PF00498	0.338
LIG_FHA_2	278	284	PF00498	0.292
LIG_FHA_2	310	316	PF00498	0.273
LIG_FHA_2	509	515	PF00498	0.430
LIG_FHA_2	528	534	PF00498	0.430
LIG_Integrin_RGD_1	507	509	PF01839	0.258
LIG_LIR_Apic_2	79	84	PF02991	0.318
LIG_LIR_Gen_1	444	453	PF02991	0.462
LIG_LIR_LC3C_4	575	578	PF02991	0.444
LIG_LIR_Nem_3	402	408	PF02991	0.400
LIG_LIR_Nem_3	444	448	PF02991	0.449
LIG_Pex14_2	230	234	PF04695	0.305
LIG_PTB_Apo_2	117	124	PF02174	0.292
LIG_PTB_Phospho_1	117	123	PF10480	0.388
LIG_SH2_CRK	164	168	PF00017	0.292
LIG_SH2_CRK	464	468	PF00017	0.520
LIG_SH2_GRB2like	404	407	PF00017	0.337
LIG_SH2_STAT5	404	407	PF00017	0.324
LIG_SH2_STAT5	434	437	PF00017	0.486
LIG_SH2_STAT5	95	98	PF00017	0.273
LIG_SH3_1	99	105	PF00018	0.221
LIG_SH3_3	201	207	PF00018	0.400
LIG_SH3_3	355	361	PF00018	0.502
LIG_SH3_3	430	436	PF00018	0.444
LIG_SH3_3	99	105	PF00018	0.318
LIG_SUMO_SIM_anti_2	320	325	PF11976	0.351
LIG_SUMO_SIM_anti_2	424	430	PF11976	0.417
LIG_SUMO_SIM_anti_2	47	53	PF11976	0.351
LIG_SUMO_SIM_anti_2	511	517	PF11976	0.430
LIG_SUMO_SIM_par_1	320	329	PF11976	0.391
LIG_SUMO_SIM_par_1	511	517	PF11976	0.430
LIG_TRAF2_1	368	371	PF00917	0.413
LIG_TYR_ITIM	162	167	PF00017	0.292
LIG_UBA3_1	107	112	PF00899	0.351
MOD_CK1_1	197	203	PF00069	0.273
MOD_CK1_1	257	263	PF00069	0.445
MOD_CK1_1	354	360	PF00069	0.567
MOD_CK1_1	83	89	PF00069	0.318
MOD_CK2_1	277	283	PF00069	0.292
MOD_CK2_1	527	533	PF00069	0.462
MOD_CK2_1	54	60	PF00069	0.334
MOD_Cter_Amidation	567	570	PF01082	0.320
MOD_GlcNHglycan	1	4	PF01048	0.592
MOD_GlcNHglycan	213	216	PF01048	0.386
MOD_GlcNHglycan	256	259	PF01048	0.252
MOD_GlcNHglycan	306	309	PF01048	0.399
MOD_GlcNHglycan	353	356	PF01048	0.599
MOD_GlcNHglycan	418	421	PF01048	0.244
MOD_GlcNHglycan	423	426	PF01048	0.244
MOD_GlcNHglycan	459	462	PF01048	0.230
MOD_GlcNHglycan	480	483	PF01048	0.321
MOD_GlcNHglycan	501	505	PF01048	0.261
MOD_GlcNHglycan	56	59	PF01048	0.320
MOD_GlcNHglycan	63	66	PF01048	0.271
MOD_GlcNHglycan	72	75	PF01048	0.179
MOD_GlcNHglycan	89	92	PF01048	0.292
MOD_GSK3_1	145	152	PF00069	0.205
MOD_GSK3_1	190	197	PF00069	0.280
MOD_GSK3_1	207	214	PF00069	0.212
MOD_GSK3_1	254	261	PF00069	0.316
MOD_GSK3_1	378	385	PF00069	0.584
MOD_GSK3_1	76	83	PF00069	0.299
MOD_NEK2_1	282	287	PF00069	0.399
MOD_NEK2_1	319	324	PF00069	0.292
MOD_NEK2_1	335	340	PF00069	0.437
MOD_NEK2_1	441	446	PF00069	0.476
MOD_NEK2_1	456	461	PF00069	0.454
MOD_NEK2_1	556	561	PF00069	0.492
MOD_PIKK_1	175	181	PF00454	0.355
MOD_PKA_2	185	191	PF00069	0.292
MOD_PKA_2	441	447	PF00069	0.565
MOD_Plk_1	282	288	PF00069	0.442
MOD_Plk_1	508	514	PF00069	0.430
MOD_Plk_1	546	552	PF00069	0.488
MOD_Plk_4	11	17	PF00069	0.466
MOD_Plk_4	134	140	PF00069	0.400
MOD_Plk_4	207	213	PF00069	0.367
MOD_Plk_4	236	242	PF00069	0.312
MOD_Plk_4	298	304	PF00069	0.388
MOD_Plk_4	319	325	PF00069	0.399
MOD_Plk_4	76	82	PF00069	0.399
MOD_ProDKin_1	378	384	PF00069	0.515
MOD_ProDKin_1	528	534	PF00069	0.452
MOD_ProDKin_1	80	86	PF00069	0.273
MOD_SUMO_rev_2	559	567	PF00179	0.512
TRG_ENDOCYTIC_2	164	167	PF00928	0.292
TRG_ENDOCYTIC_2	464	467	PF00928	0.444
TRG_ER_diArg_1	441	443	PF00400	0.512
TRG_ER_diArg_1	558	561	PF00400	0.444
TRG_NES_CRM1_1	315	329	PF08389	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0Z1	Leptomonas seymouri	75%	100%
A0A0S4IPA3	Bodo saltans	43%	96%
A0A1X0P659	Trypanosomatidae	55%	100%
A0A3S5H6F7	Leishmania donovani	95%	100%
A0A422NR38	Trypanosoma rangeli	56%	100%
A0QXE4	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	31%	100%
A0R758	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	32%	100%
A4H621	Leishmania braziliensis	83%	90%
A4HUE9	Leishmania infantum	95%	100%
E9AN48	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
F1RKQ4	Sus scrofa	35%	100%
O04059	Solanum lycopersicum	34%	99%
O13902	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
O60017	Pichia angusta	32%	97%
O74192	Komagataella pastoris	31%	97%
O74215	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	30%	100%
P43550	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P45510	Citrobacter freundii	33%	100%
P54838	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q3LXA3	Homo sapiens	33%	100%
Q4KLZ6	Rattus norvegicus	33%	100%
Q55EE0	Dictyostelium discoideum	28%	91%
Q58DK4	Bos taurus	33%	100%
Q6D8V6	Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)	31%	100%
Q8VC30	Mus musculus	34%	100%
V5C2U9	Trypanosoma cruzi	53%	100%