RING-type domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania major

UniProt:

Q4QHH5_LEIMA

TriTrypDb:

LmjF.10.0430 , LMJLV39_100009700 , LMJSD75_100009800

Length:

161

Annotations

LeishMANIAdb annotations

Related to divere Eukaryotic membrane-associated ubiquitin ligases (animal RNF180 or plant SPL1). If it has similar function, this protein is likely anchored to the ER. The topology must be in-out due to the RING finger being redox sensitive. The genes have duplicated in Leishmaniids.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QHH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHH5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.298
CLV_NRD_NRD_1	149	151	PF00675	0.397
CLV_NRD_NRD_1	90	92	PF00675	0.418
CLV_NRD_NRD_1	93	95	PF00675	0.350
CLV_PCSK_FUR_1	91	95	PF00082	0.415
CLV_PCSK_KEX2_1	103	105	PF00082	0.302
CLV_PCSK_KEX2_1	90	92	PF00082	0.414
CLV_PCSK_KEX2_1	93	95	PF00082	0.348
CLV_PCSK_SKI1_1	106	110	PF00082	0.301
DOC_MAPK_gen_1	103	110	PF00069	0.477
DOC_MAPK_gen_1	150	158	PF00069	0.600
DOC_MAPK_gen_1	90	98	PF00069	0.605
DOC_PP2B_LxvP_1	51	54	PF13499	0.590
DOC_PP4_FxxP_1	138	141	PF00568	0.568
LIG_14-3-3_CanoR_1	150	155	PF00244	0.534
LIG_BRCT_BRCA1_1	72	76	PF00533	0.527
LIG_eIF4E_1	129	135	PF01652	0.594
LIG_FHA_2	126	132	PF00498	0.537
LIG_FHA_2	79	85	PF00498	0.593
LIG_IRF3_LxIS_1	9	16	PF10401	0.382
LIG_LIR_Apic_2	46	52	PF02991	0.599
LIG_LIR_Nem_3	132	138	PF02991	0.587
LIG_LIR_Nem_3	45	51	PF02991	0.516
LIG_Pex14_2	27	31	PF04695	0.540
LIG_SH2_CRK	49	53	PF00017	0.657
LIG_SH2_STAP1	129	133	PF00017	0.586
LIG_SH2_STAT5	154	157	PF00017	0.651
LIG_SH2_STAT5	32	35	PF00017	0.734
LIG_SH3_3	139	145	PF00018	0.663
LIG_TRAF2_1	128	131	PF00917	0.542
LIG_TRAF2_1	64	67	PF00917	0.584
LIG_TRFH_1	49	53	PF08558	0.674
MOD_CK1_1	16	22	PF00069	0.415
MOD_CK2_1	125	131	PF00069	0.530
MOD_Cter_Amidation	88	91	PF01082	0.432
MOD_GlcNHglycan	6	9	PF01048	0.690
MOD_GlcNHglycan	87	90	PF01048	0.466
MOD_GSK3_1	125	132	PF00069	0.535
MOD_GSK3_1	85	92	PF00069	0.655
MOD_NEK2_1	13	18	PF00069	0.515
MOD_PIKK_1	30	36	PF00454	0.732
MOD_PKA_1	150	156	PF00069	0.532
MOD_PKA_2	89	95	PF00069	0.613
MOD_Plk_1	129	135	PF00069	0.548
MOD_Plk_1	70	76	PF00069	0.521
MOD_Plk_4	129	135	PF00069	0.594
MOD_Plk_4	150	156	PF00069	0.532
MOD_Plk_4	16	22	PF00069	0.374
TRG_ENDOCYTIC_2	48	51	PF00928	0.565
TRG_ER_diArg_1	103	106	PF00400	0.495
TRG_ER_diArg_1	90	93	PF00400	0.613

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT25	Leptomonas seymouri	37%	99%
A0A3Q8I8R6	Leishmania donovani	41%	98%
A0A3S7WR53	Leishmania donovani	95%	100%
A4H623	Leishmania braziliensis	78%	100%
A4HUF1	Leishmania infantum	96%	100%
A4HUF2	Leishmania infantum	42%	98%
E9AN50	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9AN51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	98%
Q4QHH4	Leishmania major	42%	94%