Related to divere Eukaryotic membrane-associated ubiquitin ligases (animal RNF180 or plant SPL1). If it has similar function, this protein is likely anchored to the ER. The topology must be in-out due to the RING finger being redox sensitive. The genes have duplicated in Leishmaniids.. Localization: ER (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 10 |
| NetGPI | no | yes: 0, no: 10 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0016020 | membrane | 2 | 5 |
| GO:0110165 | cellular anatomical entity | 1 | 5 |
Related structures:
AlphaFold database: Q4QHH4
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| DOC_PP4_FxxP_1 | 142 | 145 | PF00568 | 0.626 |
| DOC_USP7_MATH_1 | 13 | 17 | PF00917 | 0.340 |
| DOC_USP7_MATH_1 | 38 | 42 | PF00917 | 0.570 |
| DOC_USP7_MATH_1 | 52 | 56 | PF00917 | 0.620 |
| DOC_USP7_MATH_1 | 76 | 80 | PF00917 | 0.594 |
| LIG_14-3-3_CanoR_1 | 107 | 112 | PF00244 | 0.525 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.322 |
| LIG_BIR_III_3 | 1 | 5 | PF00653 | 0.322 |
| LIG_BRCT_BRCA1_1 | 109 | 113 | PF00533 | 0.507 |
| LIG_FHA_2 | 41 | 47 | PF00498 | 0.648 |
| LIG_LIR_Gen_1 | 110 | 119 | PF02991 | 0.523 |
| LIG_LIR_Nem_3 | 110 | 114 | PF02991 | 0.511 |
| LIG_LIR_Nem_3 | 16 | 22 | PF02991 | 0.664 |
| LIG_LIR_Nem_3 | 30 | 36 | PF02991 | 0.524 |
| LIG_Pex14_2 | 53 | 57 | PF04695 | 0.637 |
| LIG_SH2_CRK | 34 | 38 | PF00017 | 0.690 |
| LIG_SH2_STAT5 | 158 | 161 | PF00017 | 0.658 |
| LIG_SH2_STAT5 | 22 | 25 | PF00017 | 0.735 |
| LIG_SH2_STAT5 | 34 | 37 | PF00017 | 0.537 |
| LIG_SH3_3 | 143 | 149 | PF00018 | 0.678 |
| LIG_TRFH_1 | 34 | 38 | PF08558 | 0.707 |
| LIG_WW_3 | 36 | 40 | PF00397 | 0.587 |
| MOD_CK1_1 | 20 | 26 | PF00069 | 0.621 |
| MOD_CK1_1 | 56 | 62 | PF00069 | 0.579 |
| MOD_CK1_1 | 77 | 83 | PF00069 | 0.589 |
| MOD_CK2_1 | 40 | 46 | PF00069 | 0.594 |
| MOD_GlcNHglycan | 15 | 18 | PF01048 | 0.293 |
| MOD_GlcNHglycan | 5 | 8 | PF01048 | 0.437 |
| MOD_GlcNHglycan | 60 | 63 | PF01048 | 0.456 |
| MOD_GlcNHglycan | 91 | 94 | PF01048 | 0.514 |
| MOD_GSK3_1 | 13 | 20 | PF00069 | 0.322 |
| MOD_GSK3_1 | 40 | 47 | PF00069 | 0.597 |
| MOD_GSK3_1 | 52 | 59 | PF00069 | 0.563 |
| MOD_GSK3_1 | 77 | 84 | PF00069 | 0.603 |
| MOD_NEK2_1 | 3 | 8 | PF00069 | 0.515 |
| MOD_NEK2_1 | 53 | 58 | PF00069 | 0.638 |
| MOD_PIKK_1 | 20 | 26 | PF00454 | 0.718 |
| MOD_PKA_2 | 38 | 44 | PF00069 | 0.560 |
| MOD_PKA_2 | 67 | 73 | PF00069 | 0.684 |
| MOD_Plk_4 | 107 | 113 | PF00069 | 0.520 |
| MOD_Plk_4 | 17 | 23 | PF00069 | 0.671 |
| MOD_Plk_4 | 53 | 59 | PF00069 | 0.640 |
| MOD_SUMO_rev_2 | 134 | 138 | PF00179 | 0.573 |
| TRG_ENDOCYTIC_2 | 33 | 36 | PF00928 | 0.623 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1HT25 | Leptomonas seymouri | 39% | 100% |
| A0A3Q8I8R6 | Leishmania donovani | 92% | 100% |
| A0A3S7WR53 | Leishmania donovani | 45% | 100% |
| A4H623 | Leishmania braziliensis | 43% | 100% |
| A4HUF1 | Leishmania infantum | 45% | 100% |
| A4HUF2 | Leishmania infantum | 92% | 100% |
| E9AN50 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 44% | 100% |
| E9AN51 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 87% | 100% |
| Q4QHH5 | Leishmania major | 42% | 100% |