Publication identifier(s): 31356625
GPI-anchored cell surface protease. Broad-spectrum ectoenzyme involved in pathogenesis. Heavily expanded family in all parazitic species.. Localization: Cell surface (experimental)
by homology
Contact email: albert.descoteaux@iaf.inrs.ca
Publication title: The host cell secretory pathway mediates the export of Leishmania virulence factors out of the parasitophorous vacuole
Publication 1st author(s): Amandine Isnard
Publication Identifier(s): 25826301
Host organism: -1
Interaction detection method(s): protease assay
Interaction type: physical association
Identification method participant A: monoclonal antibody western blot
Identification method participant B: monoclonal antibody western blot
ID(s) interactor A: P05627
ID(s) interactor B: P08148
Taxid interactor A: Mus musculus
Taxid interactor B: Leishmania major
Biological role(s) interactor A: enzyme
Biological role(s) interactor B: enzyme target
Experimental role(s) interactor A: neutral component
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 2 |
| Forrest at al. (procyclic) | no | yes: 4 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | yes | yes: 51 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 5 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | yes | yes: 41, no: 9 |
| NetGPI | no | yes: 0, no: 50 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005737 | cytoplasm | 2 | 5 |
| GO:0016020 | membrane | 2 | 51 |
| GO:0018995 | host cellular component | 2 | 5 |
| GO:0033643 | host cell part | 3 | 5 |
| GO:0033646 | host intracellular part | 4 | 5 |
| GO:0033647 | host intracellular organelle | 5 | 5 |
| GO:0033648 | host intracellular membrane-bounded organelle | 6 | 5 |
| GO:0042025 | host cell nucleus | 7 | 5 |
| GO:0110165 | cellular anatomical entity | 1 | 51 |
Related structures:
AlphaFold database: Q4QHG9
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006508 | proteolysis | 4 | 51 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 51 |
| GO:0007155 | cell adhesion | 2 | 51 |
| GO:0008152 | metabolic process | 1 | 51 |
| GO:0009966 | regulation of signal transduction | 4 | 5 |
| GO:0009987 | cellular process | 1 | 51 |
| GO:0010646 | regulation of cell communication | 4 | 5 |
| GO:0010749 | regulation of nitric oxide mediated signal transduction | 6 | 5 |
| GO:0019538 | protein metabolic process | 3 | 51 |
| GO:0023051 | regulation of signaling | 3 | 5 |
| GO:0035821 | modulation of process of another organism | 2 | 5 |
| GO:0043170 | macromolecule metabolic process | 3 | 51 |
| GO:0044003 | modulation by symbiont of host process | 3 | 5 |
| GO:0044068 | modulation by symbiont of host cellular process | 4 | 5 |
| GO:0044081 | modulation by symbiont of host nitric oxide-mediated signal transduction | 5 | 5 |
| GO:0044238 | primary metabolic process | 2 | 51 |
| GO:0044403 | biological process involved in symbiotic interaction | 2 | 5 |
| GO:0044419 | biological process involved in interspecies interaction between organisms | 1 | 5 |
| GO:0044501 | modulation of signal transduction in another organism | 3 | 5 |
| GO:0048583 | regulation of response to stimulus | 3 | 5 |
| GO:0050789 | regulation of biological process | 2 | 5 |
| GO:0050794 | regulation of cellular process | 3 | 5 |
| GO:0051701 | biological process involved in interaction with host | 3 | 5 |
| GO:0052027 | modulation by symbiont of host signal transduction pathway | 4 | 5 |
| GO:0065007 | biological regulation | 1 | 5 |
| GO:0071704 | organic substance metabolic process | 2 | 51 |
| GO:0075130 | modulation by symbiont of host protein kinase-mediated signal transduction | 5 | 5 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 51 |
| GO:1902531 | regulation of intracellular signal transduction | 5 | 5 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 51 |
| GO:0004175 | endopeptidase activity | 4 | 51 |
| GO:0004222 | metalloendopeptidase activity | 5 | 51 |
| GO:0005488 | binding | 1 | 51 |
| GO:0008047 | enzyme activator activity | 3 | 5 |
| GO:0008160 | protein tyrosine phosphatase activator activity | 6 | 5 |
| GO:0008233 | peptidase activity | 3 | 51 |
| GO:0008237 | metallopeptidase activity | 4 | 51 |
| GO:0016787 | hydrolase activity | 2 | 51 |
| GO:0019208 | phosphatase regulator activity | 3 | 5 |
| GO:0019211 | phosphatase activator activity | 4 | 5 |
| GO:0019888 | protein phosphatase regulator activity | 4 | 5 |
| GO:0030234 | enzyme regulator activity | 2 | 5 |
| GO:0043167 | ion binding | 2 | 51 |
| GO:0043169 | cation binding | 3 | 51 |
| GO:0046872 | metal ion binding | 4 | 51 |
| GO:0072542 | protein phosphatase activator activity | 5 | 5 |
| GO:0098772 | molecular function regulator activity | 1 | 5 |
| GO:0140096 | catalytic activity, acting on a protein | 2 | 51 |
| GO:0140677 | molecular function activator activity | 2 | 5 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_C14_Caspase3-7 | 232 | 236 | PF00656 | 0.257 |
| CLV_NRD_NRD_1 | 11 | 13 | PF00675 | 0.626 |
| CLV_NRD_NRD_1 | 582 | 584 | PF00675 | 0.624 |
| CLV_PCSK_KEX2_1 | 10 | 12 | PF00082 | 0.627 |
| CLV_PCSK_KEX2_1 | 152 | 154 | PF00082 | 0.603 |
| CLV_PCSK_KEX2_1 | 582 | 584 | PF00082 | 0.624 |
| CLV_PCSK_PC1ET2_1 | 152 | 154 | PF00082 | 0.592 |
| CLV_PCSK_SKI1_1 | 153 | 157 | PF00082 | 0.581 |
| CLV_PCSK_SKI1_1 | 260 | 264 | PF00082 | 0.588 |
| DEG_APCC_DBOX_1 | 539 | 547 | PF00400 | 0.353 |
| DEG_SPOP_SBC_1 | 3 | 7 | PF00917 | 0.647 |
| DOC_CYCLIN_yCln2_LP_2 | 118 | 124 | PF00134 | 0.314 |
| DOC_MAPK_gen_1 | 290 | 298 | PF00069 | 0.364 |
| DOC_PP1_RVXF_1 | 100 | 107 | PF00149 | 0.238 |
| DOC_PP4_FxxP_1 | 194 | 197 | PF00568 | 0.328 |
| DOC_PP4_FxxP_1 | 272 | 275 | PF00568 | 0.237 |
| DOC_PP4_FxxP_1 | 294 | 297 | PF00568 | 0.317 |
| DOC_PP4_FxxP_1 | 440 | 443 | PF00568 | 0.298 |
| DOC_USP7_MATH_1 | 346 | 350 | PF00917 | 0.237 |
| DOC_USP7_MATH_1 | 446 | 450 | PF00917 | 0.225 |
| DOC_USP7_MATH_1 | 473 | 477 | PF00917 | 0.281 |
| DOC_WW_Pin1_4 | 533 | 538 | PF00397 | 0.436 |
| LIG_14-3-3_CanoR_1 | 110 | 118 | PF00244 | 0.413 |
| LIG_14-3-3_CanoR_1 | 281 | 287 | PF00244 | 0.243 |
| LIG_14-3-3_CanoR_1 | 419 | 423 | PF00244 | 0.337 |
| LIG_14-3-3_CanoR_1 | 469 | 477 | PF00244 | 0.276 |
| LIG_14-3-3_CanoR_1 | 520 | 525 | PF00244 | 0.418 |
| LIG_14-3-3_CanoR_1 | 56 | 62 | PF00244 | 0.404 |
| LIG_14-3-3_CanoR_1 | 586 | 594 | PF00244 | 0.600 |
| LIG_Actin_WH2_2 | 97 | 112 | PF00022 | 0.238 |
| LIG_APCC_ABBA_1 | 165 | 170 | PF00400 | 0.432 |
| LIG_APCC_ABBA_1 | 458 | 463 | PF00400 | 0.303 |
| LIG_APCC_ABBA_1 | 480 | 485 | PF00400 | 0.436 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.711 |
| LIG_BRCT_BRCA1_1 | 272 | 276 | PF00533 | 0.357 |
| LIG_BRCT_BRCA1_1 | 546 | 550 | PF00533 | 0.436 |
| LIG_FHA_1 | 113 | 119 | PF00498 | 0.353 |
| LIG_FHA_1 | 167 | 173 | PF00498 | 0.318 |
| LIG_FHA_1 | 182 | 188 | PF00498 | 0.325 |
| LIG_FHA_1 | 206 | 212 | PF00498 | 0.337 |
| LIG_FHA_1 | 257 | 263 | PF00498 | 0.378 |
| LIG_FHA_1 | 27 | 33 | PF00498 | 0.531 |
| LIG_FHA_1 | 356 | 362 | PF00498 | 0.388 |
| LIG_FHA_1 | 415 | 421 | PF00498 | 0.330 |
| LIG_FHA_1 | 497 | 503 | PF00498 | 0.257 |
| LIG_FHA_1 | 519 | 525 | PF00498 | 0.417 |
| LIG_FHA_1 | 534 | 540 | PF00498 | 0.264 |
| LIG_FHA_1 | 588 | 594 | PF00498 | 0.580 |
| LIG_FHA_2 | 141 | 147 | PF00498 | 0.357 |
| LIG_FHA_2 | 230 | 236 | PF00498 | 0.256 |
| LIG_GBD_Chelix_1 | 594 | 602 | PF00786 | 0.555 |
| LIG_LIR_Apic_2 | 193 | 197 | PF02991 | 0.418 |
| LIG_LIR_Gen_1 | 252 | 262 | PF02991 | 0.385 |
| LIG_LIR_Gen_1 | 316 | 324 | PF02991 | 0.430 |
| LIG_LIR_Nem_3 | 103 | 109 | PF02991 | 0.320 |
| LIG_LIR_Nem_3 | 208 | 213 | PF02991 | 0.364 |
| LIG_LIR_Nem_3 | 252 | 257 | PF02991 | 0.362 |
| LIG_LIR_Nem_3 | 449 | 454 | PF02991 | 0.403 |
| LIG_LIR_Nem_3 | 505 | 509 | PF02991 | 0.342 |
| LIG_MYND_1 | 431 | 435 | PF01753 | 0.265 |
| LIG_PDZ_Class_2 | 597 | 602 | PF00595 | 0.547 |
| LIG_Pex14_1 | 401 | 405 | PF04695 | 0.425 |
| LIG_Pex14_2 | 272 | 276 | PF04695 | 0.370 |
| LIG_PTB_Apo_2 | 204 | 211 | PF02174 | 0.421 |
| LIG_SH2_CRK | 254 | 258 | PF00017 | 0.381 |
| LIG_SH2_CRK | 354 | 358 | PF00017 | 0.436 |
| LIG_SH2_CRK | 454 | 458 | PF00017 | 0.310 |
| LIG_SH2_CRK | 506 | 510 | PF00017 | 0.398 |
| LIG_SH2_GRB2like | 532 | 535 | PF00017 | 0.317 |
| LIG_SH2_NCK_1 | 461 | 465 | PF00017 | 0.240 |
| LIG_SH2_PTP2 | 561 | 564 | PF00017 | 0.432 |
| LIG_SH2_PTP2 | 78 | 81 | PF00017 | 0.321 |
| LIG_SH2_SRC | 561 | 564 | PF00017 | 0.432 |
| LIG_SH2_STAP1 | 254 | 258 | PF00017 | 0.389 |
| LIG_SH2_STAP1 | 522 | 526 | PF00017 | 0.415 |
| LIG_SH2_STAT3 | 522 | 525 | PF00017 | 0.421 |
| LIG_SH2_STAT5 | 213 | 216 | PF00017 | 0.385 |
| LIG_SH2_STAT5 | 319 | 322 | PF00017 | 0.316 |
| LIG_SH2_STAT5 | 354 | 357 | PF00017 | 0.359 |
| LIG_SH2_STAT5 | 439 | 442 | PF00017 | 0.418 |
| LIG_SH2_STAT5 | 454 | 457 | PF00017 | 0.379 |
| LIG_SH2_STAT5 | 532 | 535 | PF00017 | 0.368 |
| LIG_SH2_STAT5 | 555 | 558 | PF00017 | 0.432 |
| LIG_SH2_STAT5 | 561 | 564 | PF00017 | 0.366 |
| LIG_SH2_STAT5 | 78 | 81 | PF00017 | 0.402 |
| LIG_SH3_3 | 428 | 434 | PF00018 | 0.274 |
| LIG_SH3_3 | 454 | 460 | PF00018 | 0.295 |
| LIG_SH3_3 | 71 | 77 | PF00018 | 0.317 |
| LIG_Sin3_3 | 589 | 596 | PF02671 | 0.560 |
| LIG_SUMO_SIM_par_1 | 28 | 34 | PF11976 | 0.528 |
| LIG_TRAF2_1 | 218 | 221 | PF00917 | 0.302 |
| LIG_TYR_ITIM | 459 | 464 | PF00017 | 0.231 |
| LIG_TYR_ITIM | 76 | 81 | PF00017 | 0.321 |
| MOD_CDK_SPxxK_3 | 533 | 540 | PF00069 | 0.376 |
| MOD_CK1_1 | 2 | 8 | PF00069 | 0.677 |
| MOD_CK1_1 | 216 | 222 | PF00069 | 0.426 |
| MOD_CK1_1 | 327 | 333 | PF00069 | 0.308 |
| MOD_CK1_1 | 418 | 424 | PF00069 | 0.300 |
| MOD_CK1_1 | 462 | 468 | PF00069 | 0.249 |
| MOD_CK1_1 | 544 | 550 | PF00069 | 0.340 |
| MOD_CK1_1 | 96 | 102 | PF00069 | 0.328 |
| MOD_CK2_1 | 370 | 376 | PF00069 | 0.436 |
| MOD_Cter_Amidation | 580 | 583 | PF01082 | 0.623 |
| MOD_GlcNHglycan | 272 | 275 | PF01048 | 0.455 |
| MOD_GlcNHglycan | 326 | 329 | PF01048 | 0.515 |
| MOD_GlcNHglycan | 348 | 351 | PF01048 | 0.484 |
| MOD_GlcNHglycan | 448 | 451 | PF01048 | 0.533 |
| MOD_GlcNHglycan | 71 | 74 | PF01048 | 0.606 |
| MOD_GlcNHglycan | 95 | 98 | PF01048 | 0.506 |
| MOD_GSK3_1 | 112 | 119 | PF00069 | 0.313 |
| MOD_GSK3_1 | 199 | 206 | PF00069 | 0.429 |
| MOD_GSK3_1 | 225 | 232 | PF00069 | 0.243 |
| MOD_GSK3_1 | 256 | 263 | PF00069 | 0.352 |
| MOD_GSK3_1 | 414 | 421 | PF00069 | 0.329 |
| MOD_GSK3_1 | 464 | 471 | PF00069 | 0.266 |
| MOD_GSK3_1 | 514 | 521 | PF00069 | 0.323 |
| MOD_GSK3_1 | 526 | 533 | PF00069 | 0.294 |
| MOD_N-GLC_1 | 299 | 304 | PF02516 | 0.509 |
| MOD_N-GLC_1 | 396 | 401 | PF02516 | 0.582 |
| MOD_N-GLC_1 | 406 | 411 | PF02516 | 0.499 |
| MOD_N-GLC_1 | 533 | 538 | PF02516 | 0.520 |
| MOD_N-GLC_2 | 391 | 393 | PF02516 | 0.497 |
| MOD_NEK2_1 | 270 | 275 | PF00069 | 0.384 |
| MOD_PIKK_1 | 396 | 402 | PF00454 | 0.353 |
| MOD_PIKK_1 | 464 | 470 | PF00454 | 0.231 |
| MOD_PK_1 | 520 | 526 | PF00069 | 0.346 |
| MOD_PKA_2 | 418 | 424 | PF00069 | 0.336 |
| MOD_PKA_2 | 468 | 474 | PF00069 | 0.264 |
| MOD_PKA_2 | 57 | 63 | PF00069 | 0.317 |
| MOD_Plk_1 | 396 | 402 | PF00069 | 0.373 |
| MOD_Plk_1 | 541 | 547 | PF00069 | 0.327 |
| MOD_Plk_4 | 473 | 479 | PF00069 | 0.248 |
| MOD_ProDKin_1 | 533 | 539 | PF00069 | 0.436 |
| MOD_SUMO_rev_2 | 189 | 197 | PF00179 | 0.328 |
| TRG_ENDOCYTIC_2 | 254 | 257 | PF00928 | 0.393 |
| TRG_ENDOCYTIC_2 | 319 | 322 | PF00928 | 0.325 |
| TRG_ENDOCYTIC_2 | 354 | 357 | PF00928 | 0.436 |
| TRG_ENDOCYTIC_2 | 454 | 457 | PF00928 | 0.352 |
| TRG_ENDOCYTIC_2 | 461 | 464 | PF00928 | 0.305 |
| TRG_ENDOCYTIC_2 | 506 | 509 | PF00928 | 0.324 |
| TRG_ENDOCYTIC_2 | 561 | 564 | PF00928 | 0.432 |
| TRG_ENDOCYTIC_2 | 78 | 81 | PF00928 | 0.321 |
| TRG_ER_diArg_1 | 10 | 12 | PF00400 | 0.626 |
| TRG_NES_CRM1_1 | 185 | 198 | PF08389 | 0.235 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1IL11 | Leptomonas seymouri | 37% | 92% |
| A0A0S4IN60 | Bodo saltans | 29% | 67% |
| A0A0S4IS53 | Bodo saltans | 34% | 100% |
| A0A0S4IYM3 | Bodo saltans | 29% | 83% |
| A0A1L8HYT7 | Xenopus laevis | 24% | 84% |
| A0A1X0NDG7 | Trypanosomatidae | 31% | 92% |
| A0A1X0NDJ3 | Trypanosomatidae | 29% | 83% |
| A0A1X0NDK2 | Trypanosomatidae | 32% | 100% |
| A0A1X0NDK7 | Trypanosomatidae | 30% | 84% |
| A0A1X0NDK9 | Trypanosomatidae | 29% | 100% |
| A0A1X0NDM7 | Trypanosomatidae | 29% | 93% |
| A0A1X0NDU8 | Trypanosomatidae | 29% | 90% |
| A0A1X0NE71 | Trypanosomatidae | 29% | 100% |
| A0A1X0NER9 | Trypanosomatidae | 32% | 94% |
| A0A1X0NET7 | Trypanosomatidae | 34% | 100% |
| A0A1X0NEX7 | Trypanosomatidae | 31% | 92% |
| A0A1X0NEZ6 | Trypanosomatidae | 31% | 92% |
| A0A1X0NF32 | Trypanosomatidae | 30% | 100% |
| A0A1X0NF41 | Trypanosomatidae | 30% | 98% |
| A0A1X0NFJ0 | Trypanosomatidae | 30% | 100% |
| A0A1X0NFK3 | Trypanosomatidae | 29% | 90% |
| A0A1X0NFS0 | Trypanosomatidae | 30% | 69% |
| A0A1X0NFU4 | Trypanosomatidae | 30% | 74% |
| A0A1X0NFZ9 | Trypanosomatidae | 31% | 100% |
| A0A1X0NG20 | Trypanosomatidae | 31% | 97% |
| A0A1X0NGP3 | Trypanosomatidae | 31% | 70% |
| A0A1X0NGY3 | Trypanosomatidae | 30% | 78% |
| A0A1X0NGZ3 | Trypanosomatidae | 31% | 100% |
| A0A1X0NH86 | Trypanosomatidae | 31% | 68% |
| A0A1X0NHP6 | Trypanosomatidae | 30% | 100% |
| A0A1X0NHQ6 | Trypanosomatidae | 30% | 100% |
| A0A1X0NI38 | Trypanosomatidae | 28% | 68% |
| A0A1X0NI74 | Trypanosomatidae | 30% | 80% |
| A0A1X0NII4 | Trypanosomatidae | 28% | 71% |
| A0A1X0NIZ3 | Trypanosomatidae | 32% | 100% |
| A0A1X0NJS3 | Trypanosomatidae | 31% | 92% |
| A0A1X0NJU4 | Trypanosomatidae | 31% | 70% |
| A0A1X0NK66 | Trypanosomatidae | 31% | 91% |
| A0A1X0NKJ8 | Trypanosomatidae | 28% | 81% |
| A0A1X0NKW9 | Trypanosomatidae | 31% | 100% |
| A0A1X0NME2 | Trypanosomatidae | 31% | 96% |
| A0A1X0NMK3 | Trypanosomatidae | 27% | 100% |
| A0A1X0NMK7 | Trypanosomatidae | 35% | 100% |
| A0A1X0NMV0 | Trypanosomatidae | 30% | 82% |
| A0A1X0NN43 | Trypanosomatidae | 30% | 84% |
| A0A1X0NNK8 | Trypanosomatidae | 29% | 91% |
| A0A1X0NP64 | Trypanosomatidae | 30% | 68% |
| A0A1X0NPW0 | Trypanosomatidae | 29% | 94% |
| A0A1X0NQM4 | Trypanosomatidae | 33% | 100% |
| A0A1X0NQN3 | Trypanosomatidae | 36% | 100% |
| A0A1X0NQU4 | Trypanosomatidae | 35% | 93% |
| A0A1X0NQW6 | Trypanosomatidae | 33% | 100% |
| A0A1X0NRF3 | Trypanosomatidae | 32% | 90% |
| A0A1X0NRY8 | Trypanosomatidae | 35% | 100% |
| A0A1X0NU16 | Trypanosomatidae | 37% | 100% |
| A0A1X0NUR2 | Trypanosomatidae | 32% | 82% |
| A0A1X0NV28 | Trypanosomatidae | 37% | 100% |
| A0A1X0NVC3 | Trypanosomatidae | 33% | 88% |
| A0A1X0NVE0 | Trypanosomatidae | 29% | 77% |
| A0A1X0NW07 | Trypanosomatidae | 26% | 96% |
| A0A1X0NX94 | Trypanosomatidae | 30% | 93% |
| A0A1X0NX98 | Trypanosomatidae | 31% | 75% |
| A0A1X0NXB6 | Trypanosomatidae | 29% | 85% |
| A0A1X0NXH6 | Trypanosomatidae | 32% | 82% |
| A0A1X0NXQ4 | Trypanosomatidae | 28% | 89% |
| A0A1X0NXR7 | Trypanosomatidae | 33% | 80% |
| A0A1X0NY94 | Trypanosomatidae | 36% | 100% |
| A0A1X0NYE3 | Trypanosomatidae | 29% | 96% |
| A0A1X0NYE7 | Trypanosomatidae | 31% | 100% |
| A0A1X0NYN2 | Trypanosomatidae | 35% | 100% |
| A0A1X0NYN4 | Trypanosomatidae | 27% | 85% |
| A0A1X0NYS5 | Trypanosomatidae | 33% | 100% |
| A0A1X0NYZ2 | Trypanosomatidae | 39% | 100% |
| A0A1X0NZ46 | Trypanosomatidae | 27% | 100% |
| A0A1X0NZ63 | Trypanosomatidae | 30% | 94% |
| A0A1X0NZN6 | Trypanosomatidae | 28% | 92% |
| A0A1X0P055 | Trypanosomatidae | 36% | 100% |
| A0A1X0P154 | Trypanosomatidae | 27% | 100% |
| A0A1X0P331 | Trypanosomatidae | 34% | 100% |
| A0A1X0P3K0 | Trypanosomatidae | 29% | 83% |
| A0A1X0P3S2 | Trypanosomatidae | 27% | 100% |
| A0A1X0P4L8 | Trypanosomatidae | 31% | 100% |
| A0A1X0P4Y5 | Trypanosomatidae | 27% | 94% |
| A0A1X0P544 | Trypanosomatidae | 30% | 94% |
| A0A1X0P5J0 | Trypanosomatidae | 32% | 88% |
| A0A1X0P7K5 | Trypanosomatidae | 31% | 68% |
| A0A1X0P7R3 | Trypanosomatidae | 36% | 100% |
| A0A1X0P8B4 | Trypanosomatidae | 31% | 100% |
| A0A1X0P9Z4 | Trypanosomatidae | 31% | 100% |
| A0A1X0PB04 | Trypanosomatidae | 31% | 100% |
| A0A3Q8I8N3 | Leishmania donovani | 81% | 100% |
| A0A3Q8I8P8 | Leishmania donovani | 84% | 100% |
| A0A3Q8I8S6 | Leishmania donovani | 80% | 94% |
| A0A3Q8I8S9 | Leishmania donovani | 84% | 100% |
| A0A3Q8IAZ8 | Leishmania donovani | 81% | 100% |
| A0A3Q8IC35 | Leishmania donovani | 81% | 100% |
| A0A3Q8IC44 | Leishmania donovani | 80% | 100% |
| A0A3Q8IH61 | Leishmania donovani | 82% | 100% |
| A0A3Q8IIN4 | Leishmania donovani | 38% | 95% |
| A0A3R7JT49 | Trypanosoma rangeli | 35% | 71% |
| A0A3R7JTB6 | Trypanosoma rangeli | 33% | 86% |
| A0A3R7JUS0 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7JV87 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7K7T9 | Trypanosoma rangeli | 36% | 100% |
| A0A3R7K9S1 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7KB14 | Trypanosoma rangeli | 35% | 69% |
| A0A3R7KLR6 | Trypanosoma rangeli | 32% | 94% |
| A0A3R7KMY2 | Trypanosoma rangeli | 34% | 90% |
| A0A3R7LFC4 | Trypanosoma rangeli | 35% | 89% |
| A0A3R7LFZ4 | Trypanosoma rangeli | 35% | 100% |
| A0A3R7LWG1 | Trypanosoma rangeli | 33% | 100% |
| A0A3R7LX11 | Trypanosoma rangeli | 35% | 100% |
| A0A3R7M1R8 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7M574 | Trypanosoma rangeli | 34% | 94% |
| A0A3R7M5K4 | Trypanosoma rangeli | 36% | 100% |
| A0A3R7M7N6 | Trypanosoma rangeli | 35% | 88% |
| A0A3R7MTS2 | Trypanosoma rangeli | 35% | 100% |
| A0A3R7MW36 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7MXF4 | Trypanosoma rangeli | 37% | 98% |
| A0A3R7N1W7 | Trypanosoma rangeli | 35% | 100% |
| A0A3R7N289 | Trypanosoma rangeli | 35% | 83% |
| A0A3R7NTI8 | Trypanosoma rangeli | 35% | 100% |
| A0A3R7R2J4 | Trypanosoma rangeli | 34% | 93% |
| A0A3R7R5R1 | Trypanosoma rangeli | 34% | 100% |
| A0A3R7R818 | Trypanosoma rangeli | 32% | 100% |
| A0A3S5H6G0 | Leishmania donovani | 84% | 100% |
| A0A3S5IQY2 | Trypanosoma rangeli | 36% | 100% |
| A0A3S7WR43 | Leishmania donovani | 81% | 100% |
| A0A3S7WR46 | Leishmania donovani | 84% | 100% |
| A0A3S7WR60 | Leishmania donovani | 84% | 100% |
| A0A3S7X192 | Leishmania donovani | 39% | 100% |
| A0A422MP17 | Trypanosoma rangeli | 36% | 100% |
| A0A422MRQ6 | Trypanosoma rangeli | 37% | 80% |
| A0A422MU95 | Trypanosoma rangeli | 34% | 100% |
| A0A422MVF5 | Trypanosoma rangeli | 34% | 100% |
| A0A422MVS3 | Trypanosoma rangeli | 36% | 100% |
| A0A422MW99 | Trypanosoma rangeli | 32% | 81% |
| A0A422MZ47 | Trypanosoma rangeli | 37% | 100% |
| A0A422MZG4 | Trypanosoma rangeli | 37% | 100% |
| A0A422N361 | Trypanosoma rangeli | 33% | 100% |
| A0A422N7Q6 | Trypanosoma rangeli | 36% | 93% |
| A0A422NDS2 | Trypanosoma rangeli | 31% | 100% |
| A0A422NDT3 | Trypanosoma rangeli | 32% | 100% |
| A0A422NP82 | Trypanosoma rangeli | 37% | 100% |
| A4H626 | Leishmania braziliensis | 57% | 100% |
| A4H627 | Leishmania braziliensis | 59% | 100% |
| A4H630 | Leishmania braziliensis | 63% | 97% |
| A4H631 | Leishmania braziliensis | 58% | 100% |
| A4H632 | Leishmania braziliensis | 63% | 100% |
| A4H633 | Leishmania braziliensis | 59% | 100% |
| A4H634 | Leishmania braziliensis | 64% | 98% |
| A4H635 | Leishmania braziliensis | 64% | 97% |
| A4H636 | Leishmania braziliensis | 60% | 100% |
| A4H637 | Leishmania braziliensis | 64% | 97% |
| A4H638 | Leishmania braziliensis | 70% | 100% |
| A4H639 | Leishmania braziliensis | 65% | 99% |
| A4H640 | Leishmania braziliensis | 63% | 97% |
| A4H6D3 | Leishmania braziliensis | 60% | 100% |
| A4H6D5 | Leishmania braziliensis | 61% | 85% |
| A4H6D7 | Leishmania braziliensis | 59% | 100% |
| A4H6D8 | Leishmania braziliensis | 58% | 100% |
| A4H6D9 | Leishmania braziliensis | 58% | 100% |
| A4H6E0 | Leishmania braziliensis | 59% | 85% |
| A4H6E1 | Leishmania braziliensis | 59% | 100% |
| A4H6E2 | Leishmania braziliensis | 59% | 100% |
| A4H6E3 | Leishmania braziliensis | 61% | 100% |
| A4H6E4 | Leishmania braziliensis | 59% | 100% |
| A4H6E5 | Leishmania braziliensis | 71% | 100% |
| A4HJI2 | Leishmania braziliensis | 36% | 93% |
| A4HUF6 | Leishmania infantum | 81% | 100% |
| A4HUF8 | Leishmania infantum | 85% | 100% |
| A4HUF9 | Leishmania infantum | 81% | 94% |
| A4HUG0 | Leishmania infantum | 83% | 79% |
| A4I6X5 | Leishmania infantum | 38% | 95% |
| C9ZUT5 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 38% | 100% |
| D0A1R8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 32% | 100% |
| D0A7S8 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 31% | 89% |
| D0A855 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 36% | 98% |
| E9AHH5 | Leishmania infantum | 37% | 100% |
| E9AN53 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 76% | 92% |
| E9AN54 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 80% | 100% |
| E9AN55 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 76% | 93% |
| E9AN56 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 76% | 93% |
| E9AN57 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 80% | 100% |
| E9AZL8 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 39% | 100% |
| E9B1Z9 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 37% | 95% |
| O62446 | Caenorhabditis elegans | 24% | 91% |
| P08148 | Leishmania major | 98% | 100% |
| P15706 | Leishmania chagasi | 85% | 100% |
| P23223 | Leishmania donovani | 81% | 100% |
| P43150 | Leishmania mexicana | 74% | 93% |
| Q00689 | Leishmania guyanensis | 65% | 97% |
| Q06031 | Crithidia fasciculata | 54% | 92% |
| Q27673 | Leishmania amazonensis | 79% | 100% |
| Q29AK2 | Drosophila pseudoobscura pseudoobscura | 22% | 88% |
| Q4Q662 | Leishmania major | 38% | 100% |
| Q4Q8L3 | Leishmania major | 40% | 100% |
| Q4QHH0 | Leishmania major | 92% | 93% |
| Q4QHH1 | Leishmania major | 98% | 100% |
| Q4QHH2 | Leishmania major | 98% | 100% |
| Q61YG1 | Caenorhabditis briggsae | 24% | 91% |
| Q6LA77 | Leishmania infantum | 85% | 100% |
| Q8BMN4 | Mus musculus | 24% | 88% |
| Q8MNZ1 | Leishmania tropica | 83% | 92% |
| Q9VH19 | Drosophila melanogaster | 23% | 88% |
| V5A303 | Trypanosoma cruzi | 38% | 100% |
| V5A359 | Trypanosoma cruzi | 39% | 100% |
| V5A488 | Trypanosoma cruzi | 33% | 75% |
| V5AII7 | Trypanosoma cruzi | 39% | 100% |
| V5APQ4 | Trypanosoma cruzi | 34% | 76% |
| V5AX72 | Trypanosoma cruzi | 34% | 82% |
| V5B5M0 | Trypanosoma cruzi | 34% | 82% |
| V5B9W5 | Trypanosoma cruzi | 30% | 89% |
| V5BAL3 | Trypanosoma cruzi | 38% | 100% |
| V5BAN1 | Trypanosoma cruzi | 36% | 77% |
| V5BD39 | Trypanosoma cruzi | 39% | 100% |
| V5BLT3 | Trypanosoma cruzi | 32% | 96% |
| V5CI97 | Trypanosoma cruzi | 32% | 94% |
| V5D358 | Trypanosoma cruzi | 35% | 71% |