ATP-dependent DNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QHG8_LEIMA

TriTrypDb:

LmjF.10.0483 , LMJLV39_100010400 , LMJSD75_100010500

Length:

564

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHG8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.751
CLV_C14_Caspase3-7	134	138	PF00656	0.464
CLV_C14_Caspase3-7	22	26	PF00656	0.748
CLV_C14_Caspase3-7	264	268	PF00656	0.849
CLV_NRD_NRD_1	148	150	PF00675	0.781
CLV_NRD_NRD_1	192	194	PF00675	0.878
CLV_NRD_NRD_1	29	31	PF00675	0.775
CLV_NRD_NRD_1	344	346	PF00675	0.857
CLV_NRD_NRD_1	418	420	PF00675	0.870
CLV_NRD_NRD_1	428	430	PF00675	0.693
CLV_NRD_NRD_1	549	551	PF00675	0.636
CLV_NRD_NRD_1	552	554	PF00675	0.620
CLV_NRD_NRD_1	89	91	PF00675	0.764
CLV_NRD_NRD_1	93	95	PF00675	0.713
CLV_PCSK_FUR_1	550	554	PF00082	0.657
CLV_PCSK_FUR_1	90	94	PF00082	0.766
CLV_PCSK_KEX2_1	148	150	PF00082	0.781
CLV_PCSK_KEX2_1	191	193	PF00082	0.885
CLV_PCSK_KEX2_1	29	31	PF00082	0.775
CLV_PCSK_KEX2_1	344	346	PF00082	0.857
CLV_PCSK_KEX2_1	418	420	PF00082	0.870
CLV_PCSK_KEX2_1	449	451	PF00082	0.871
CLV_PCSK_KEX2_1	549	551	PF00082	0.636
CLV_PCSK_KEX2_1	552	554	PF00082	0.620
CLV_PCSK_KEX2_1	89	91	PF00082	0.764
CLV_PCSK_KEX2_1	92	94	PF00082	0.732
CLV_PCSK_PC1ET2_1	449	451	PF00082	0.871
CLV_PCSK_PC7_1	89	95	PF00082	0.765
CLV_PCSK_SKI1_1	30	34	PF00082	0.768
CLV_PCSK_SKI1_1	526	530	PF00082	0.624
DEG_Nend_UBRbox_1	1	4	PF02207	0.776
DEG_SCF_FBW7_1	533	539	PF00400	0.692
DEG_SPOP_SBC_1	470	474	PF00917	0.853
DOC_CKS1_1	104	109	PF01111	0.750
DOC_CKS1_1	533	538	PF01111	0.693
DOC_CKS1_1	62	67	PF01111	0.777
DOC_CYCLIN_RxL_1	521	532	PF00134	0.636
DOC_CYCLIN_yCln2_LP_2	540	546	PF00134	0.632
DOC_MAPK_gen_1	344	351	PF00069	0.809
DOC_MAPK_gen_1	521	530	PF00069	0.633
DOC_MAPK_MEF2A_6	252	259	PF00069	0.707
DOC_PP2B_LxvP_1	307	310	PF13499	0.853
DOC_PP4_FxxP_1	317	320	PF00568	0.855
DOC_PP4_FxxP_1	439	442	PF00568	0.862
DOC_PP4_FxxP_1	96	99	PF00568	0.758
DOC_USP7_MATH_1	202	206	PF00917	0.841
DOC_USP7_MATH_1	318	322	PF00917	0.843
DOC_USP7_MATH_1	388	392	PF00917	0.690
DOC_USP7_MATH_1	456	460	PF00917	0.868
DOC_USP7_MATH_1	461	465	PF00917	0.793
DOC_USP7_MATH_1	470	474	PF00917	0.608
DOC_USP7_MATH_1	536	540	PF00917	0.685
DOC_WW_Pin1_4	103	108	PF00397	0.745
DOC_WW_Pin1_4	282	287	PF00397	0.856
DOC_WW_Pin1_4	407	412	PF00397	0.794
DOC_WW_Pin1_4	440	445	PF00397	0.842
DOC_WW_Pin1_4	532	537	PF00397	0.683
DOC_WW_Pin1_4	6	11	PF00397	0.751
DOC_WW_Pin1_4	61	66	PF00397	0.769
LIG_14-3-3_CanoR_1	331	337	PF00244	0.792
LIG_14-3-3_CanoR_1	344	350	PF00244	0.597
LIG_14-3-3_CanoR_1	378	383	PF00244	0.672
LIG_14-3-3_CanoR_1	460	466	PF00244	0.880
LIG_14-3-3_CanoR_1	471	480	PF00244	0.651
LIG_14-3-3_CanoR_1	502	509	PF00244	0.683
LIG_14-3-3_CanoR_1	93	99	PF00244	0.761
LIG_BIR_III_4	217	221	PF00653	0.845
LIG_BIR_III_4	421	425	PF00653	0.859
LIG_FHA_1	219	225	PF00498	0.842
LIG_FHA_1	296	302	PF00498	0.749
LIG_FHA_1	344	350	PF00498	0.825
LIG_FHA_1	41	47	PF00498	0.735
LIG_FHA_1	460	466	PF00498	0.880
LIG_FHA_2	129	135	PF00498	0.700
LIG_FHA_2	262	268	PF00498	0.835
LIG_Integrin_RGD_1	118	120	PF01839	0.757
LIG_LIR_Gen_1	130	140	PF02991	0.693
LIG_LIR_Gen_1	52	62	PF02991	0.670
LIG_LIR_Nem_3	130	135	PF02991	0.697
LIG_LIR_Nem_3	494	498	PF02991	0.625
LIG_LIR_Nem_3	52	57	PF02991	0.627
LIG_LIR_Nem_3	539	544	PF02991	0.644
LIG_Rb_pABgroove_1	254	262	PF01858	0.720
LIG_SH2_CRK	228	232	PF00017	0.848
LIG_SH2_GRB2like	228	231	PF00017	0.846
LIG_SH2_STAP1	132	136	PF00017	0.689
LIG_SH2_STAT5	176	179	PF00017	0.815
LIG_SH2_STAT5	546	549	PF00017	0.618
LIG_SH2_STAT5	80	83	PF00017	0.791
LIG_SH3_1	56	62	PF00018	0.699
LIG_SH3_1	67	73	PF00018	0.647
LIG_SH3_2	62	67	PF14604	0.777
LIG_SH3_3	307	313	PF00018	0.858
LIG_SH3_3	439	445	PF00018	0.847
LIG_SH3_3	530	536	PF00018	0.660
LIG_SH3_3	56	62	PF00018	0.699
LIG_SH3_3	67	73	PF00018	0.647
LIG_SUMO_SIM_par_1	42	48	PF11976	0.730
LIG_SUMO_SIM_par_1	526	532	PF11976	0.632
LIG_WRC_WIRS_1	492	497	PF05994	0.622
LIG_WW_3	308	312	PF00397	0.859
MOD_CDC14_SPxK_1	410	413	PF00782	0.821
MOD_CDK_SPK_2	6	11	PF00069	0.751
MOD_CDK_SPxK_1	407	413	PF00069	0.803
MOD_CDK_SPxK_1	61	67	PF00069	0.773
MOD_CDK_SPxxK_3	282	289	PF00069	0.855
MOD_CK1_1	157	163	PF00069	0.734
MOD_CK1_1	205	211	PF00069	0.840
MOD_CK1_1	321	327	PF00069	0.803
MOD_CK1_1	343	349	PF00069	0.834
MOD_CK1_1	397	403	PF00069	0.668
MOD_CK1_1	45	51	PF00069	0.696
MOD_CK1_1	459	465	PF00069	0.882
MOD_CK1_1	9	15	PF00069	0.747
MOD_CK2_1	531	537	PF00069	0.676
MOD_GlcNHglycan	152	155	PF01048	0.763
MOD_GlcNHglycan	25	28	PF01048	0.748
MOD_GlcNHglycan	261	264	PF01048	0.810
MOD_GlcNHglycan	320	323	PF01048	0.829
MOD_GlcNHglycan	37	40	PF01048	0.594
MOD_GlcNHglycan	433	436	PF01048	0.866
MOD_GlcNHglycan	473	476	PF01048	0.845
MOD_GSK3_1	110	117	PF00069	0.774
MOD_GSK3_1	150	157	PF00069	0.761
MOD_GSK3_1	290	297	PF00069	0.829
MOD_GSK3_1	318	325	PF00069	0.827
MOD_GSK3_1	336	343	PF00069	0.506
MOD_GSK3_1	45	52	PF00069	0.686
MOD_GSK3_1	456	463	PF00069	0.876
MOD_GSK3_1	465	472	PF00069	0.707
MOD_GSK3_1	532	539	PF00069	0.689
MOD_GSK3_1	80	87	PF00069	0.785
MOD_N-GLC_2	367	369	PF02516	0.631
MOD_N-GLC_2	484	486	PF02516	0.770
MOD_NEK2_1	110	115	PF00069	0.785
MOD_NEK2_1	169	174	PF00069	0.751
MOD_NEK2_1	259	264	PF00069	0.775
MOD_NEK2_1	376	381	PF00069	0.663
MOD_NEK2_1	49	54	PF00069	0.638
MOD_NEK2_1	508	513	PF00069	0.673
MOD_NEK2_2	220	225	PF00069	0.840
MOD_NEK2_2	536	541	PF00069	0.677
MOD_PIKK_1	351	357	PF00454	0.690
MOD_PIKK_1	376	382	PF00454	0.661
MOD_PIKK_1	84	90	PF00454	0.775
MOD_PK_1	345	351	PF00069	0.801
MOD_PKA_1	344	350	PF00069	0.825
MOD_PKA_2	272	278	PF00069	0.882
MOD_PKA_2	318	324	PF00069	0.833
MOD_PKA_2	330	336	PF00069	0.579
MOD_PKA_2	343	349	PF00069	0.606
MOD_PKA_2	459	465	PF00069	0.882
MOD_PKA_2	470	476	PF00069	0.658
MOD_PKA_2	501	507	PF00069	0.692
MOD_PKA_2	73	79	PF00069	0.790
MOD_PKB_1	458	466	PF00069	0.879
MOD_PKB_1	92	100	PF00069	0.756
MOD_Plk_1	397	403	PF00069	0.755
MOD_Plk_1	536	542	PF00069	0.677
MOD_Plk_4	157	163	PF00069	0.734
MOD_Plk_4	345	351	PF00069	0.801
MOD_Plk_4	49	55	PF00069	0.637
MOD_Plk_4	536	542	PF00069	0.677
MOD_ProDKin_1	103	109	PF00069	0.749
MOD_ProDKin_1	282	288	PF00069	0.854
MOD_ProDKin_1	407	413	PF00069	0.803
MOD_ProDKin_1	440	446	PF00069	0.844
MOD_ProDKin_1	532	538	PF00069	0.689
MOD_ProDKin_1	6	12	PF00069	0.749
MOD_ProDKin_1	61	67	PF00069	0.773
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.639
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.743
TRG_ENDOCYTIC_2	132	135	PF00928	0.692
TRG_ENDOCYTIC_2	228	231	PF00928	0.846
TRG_ER_diArg_1	102	105	PF00400	0.574
TRG_ER_diArg_1	191	193	PF00400	0.885
TRG_ER_diArg_1	28	30	PF00400	0.769
TRG_ER_diArg_1	313	316	PF00400	0.874
TRG_ER_diArg_1	389	392	PF00400	0.695
TRG_ER_diArg_1	417	419	PF00400	0.875
TRG_ER_diArg_1	549	552	PF00400	0.631
TRG_ER_diArg_1	72	75	PF00400	0.795
TRG_ER_diArg_1	89	92	PF00400	0.541
TRG_ER_diArg_1	93	95	PF00400	0.713
TRG_Pf-PMV_PEXEL_1	526	531	PF00026	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A6ZM04	YEAS7	34%	66%
P07271	YEAST	34%	66%
P38766	YEAST	33%	78%
Q580X6	TRYB2	45%	61%
Q59RQ0	CANAL	36%	62%
Q5AXT5	EMENI	38%	76%
Q7ZV90	DANRE	36%	88%
Q9UUA2	SCHPO	36%	70%