Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHG3_LEIMA

TriTrypDb:

LmjF.10.0520 , LMJLV39_100011200 , LMJSD75_100011300

Length:

907

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHG3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	397	401	PF00656	0.772
CLV_C14_Caspase3-7	842	846	PF00656	0.743
CLV_NRD_NRD_1	13	15	PF00675	0.626
CLV_NRD_NRD_1	131	133	PF00675	0.623
CLV_NRD_NRD_1	202	204	PF00675	0.650
CLV_NRD_NRD_1	214	216	PF00675	0.576
CLV_NRD_NRD_1	287	289	PF00675	0.648
CLV_NRD_NRD_1	29	31	PF00675	0.447
CLV_NRD_NRD_1	332	334	PF00675	0.604
CLV_NRD_NRD_1	362	364	PF00675	0.626
CLV_NRD_NRD_1	387	389	PF00675	0.793
CLV_NRD_NRD_1	398	400	PF00675	0.673
CLV_NRD_NRD_1	454	456	PF00675	0.702
CLV_NRD_NRD_1	465	467	PF00675	0.506
CLV_NRD_NRD_1	53	55	PF00675	0.567
CLV_NRD_NRD_1	654	656	PF00675	0.542
CLV_NRD_NRD_1	694	696	PF00675	0.696
CLV_NRD_NRD_1	731	733	PF00675	0.627
CLV_NRD_NRD_1	903	905	PF00675	0.709
CLV_NRD_NRD_1	92	94	PF00675	0.556
CLV_PCSK_FUR_1	462	466	PF00082	0.546
CLV_PCSK_FUR_1	901	905	PF00082	0.705
CLV_PCSK_KEX2_1	13	15	PF00082	0.626
CLV_PCSK_KEX2_1	131	133	PF00082	0.623
CLV_PCSK_KEX2_1	204	206	PF00082	0.697
CLV_PCSK_KEX2_1	287	289	PF00082	0.648
CLV_PCSK_KEX2_1	29	31	PF00082	0.447
CLV_PCSK_KEX2_1	332	334	PF00082	0.656
CLV_PCSK_KEX2_1	362	364	PF00082	0.634
CLV_PCSK_KEX2_1	387	389	PF00082	0.793
CLV_PCSK_KEX2_1	398	400	PF00082	0.673
CLV_PCSK_KEX2_1	464	466	PF00082	0.548
CLV_PCSK_KEX2_1	53	55	PF00082	0.567
CLV_PCSK_KEX2_1	654	656	PF00082	0.562
CLV_PCSK_KEX2_1	681	683	PF00082	0.693
CLV_PCSK_KEX2_1	694	696	PF00082	0.559
CLV_PCSK_KEX2_1	731	733	PF00082	0.559
CLV_PCSK_KEX2_1	903	905	PF00082	0.709
CLV_PCSK_KEX2_1	92	94	PF00082	0.556
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.751
CLV_PCSK_PC1ET2_1	681	683	PF00082	0.693
CLV_PCSK_SKI1_1	159	163	PF00082	0.635
CLV_PCSK_SKI1_1	296	300	PF00082	0.521
CLV_PCSK_SKI1_1	3	7	PF00082	0.559
CLV_PCSK_SKI1_1	430	434	PF00082	0.683
CLV_PCSK_SKI1_1	532	536	PF00082	0.610
CLV_PCSK_SKI1_1	580	584	PF00082	0.511
CLV_PCSK_SKI1_1	682	686	PF00082	0.578
CLV_PCSK_SKI1_1	708	712	PF00082	0.683
CLV_PCSK_SKI1_1	780	784	PF00082	0.615
CLV_PCSK_SKI1_1	80	84	PF00082	0.508
CLV_Separin_Metazoa	26	30	PF03568	0.464
CLV_Separin_Metazoa	343	347	PF03568	0.495
DEG_APCC_DBOX_1	113	121	PF00400	0.485
DEG_APCC_DBOX_1	2	10	PF00400	0.660
DEG_APCC_DBOX_1	657	665	PF00400	0.638
DEG_APCC_DBOX_1	681	689	PF00400	0.597
DEG_APCC_DBOX_1	783	791	PF00400	0.636
DEG_COP1_1	479	490	PF00400	0.659
DEG_Nend_Nbox_1	1	3	PF02207	0.591
DEG_SPOP_SBC_1	441	445	PF00917	0.660
DEG_SPOP_SBC_1	809	813	PF00917	0.600
DEG_SPOP_SBC_1	846	850	PF00917	0.660
DOC_CKS1_1	597	602	PF01111	0.678
DOC_CKS1_1	675	680	PF01111	0.485
DOC_CYCLIN_RxL_1	427	437	PF00134	0.690
DOC_CYCLIN_RxL_1	705	714	PF00134	0.686
DOC_CYCLIN_yCln2_LP_2	746	752	PF00134	0.625
DOC_CYCLIN_yCln2_LP_2	803	809	PF00134	0.716
DOC_CYCLIN_yCln2_LP_2	826	832	PF00134	0.730
DOC_MAPK_gen_1	428	435	PF00069	0.686
DOC_MAPK_gen_1	654	664	PF00069	0.548
DOC_MAPK_gen_1	681	689	PF00069	0.675
DOC_MAPK_MEF2A_6	681	689	PF00069	0.553
DOC_MAPK_MEF2A_6	822	830	PF00069	0.816
DOC_MAPK_MEF2A_6	93	102	PF00069	0.651
DOC_MAPK_NFAT4_5	682	690	PF00069	0.577
DOC_PP1_RVXF_1	530	537	PF00149	0.482
DOC_PP2B_LxvP_1	433	436	PF13499	0.750
DOC_PP2B_LxvP_1	826	829	PF13499	0.735
DOC_PP2B_LxvP_1	830	833	PF13499	0.666
DOC_PP4_FxxP_1	689	692	PF00568	0.581
DOC_PP4_FxxP_1	713	716	PF00568	0.618
DOC_USP7_MATH_1	146	150	PF00917	0.760
DOC_USP7_MATH_1	170	174	PF00917	0.667
DOC_USP7_MATH_1	310	314	PF00917	0.587
DOC_USP7_MATH_1	389	393	PF00917	0.805
DOC_USP7_MATH_1	39	43	PF00917	0.557
DOC_USP7_MATH_1	394	398	PF00917	0.859
DOC_USP7_MATH_1	441	445	PF00917	0.709
DOC_USP7_MATH_1	486	490	PF00917	0.641
DOC_USP7_MATH_1	495	499	PF00917	0.472
DOC_USP7_MATH_1	513	517	PF00917	0.494
DOC_USP7_MATH_1	592	596	PF00917	0.720
DOC_USP7_MATH_1	810	814	PF00917	0.797
DOC_USP7_MATH_1	844	848	PF00917	0.757
DOC_USP7_MATH_2	374	380	PF00917	0.658
DOC_USP7_UBL2_3	216	220	PF12436	0.745
DOC_WW_Pin1_4	115	120	PF00397	0.515
DOC_WW_Pin1_4	370	375	PF00397	0.836
DOC_WW_Pin1_4	412	417	PF00397	0.864
DOC_WW_Pin1_4	480	485	PF00397	0.704
DOC_WW_Pin1_4	490	495	PF00397	0.698
DOC_WW_Pin1_4	596	601	PF00397	0.683
DOC_WW_Pin1_4	62	67	PF00397	0.769
DOC_WW_Pin1_4	668	673	PF00397	0.619
DOC_WW_Pin1_4	674	679	PF00397	0.572
DOC_WW_Pin1_4	745	750	PF00397	0.605
DOC_WW_Pin1_4	872	877	PF00397	0.724
DOC_WW_Pin1_4	902	907	PF00397	0.724
DOC_WW_Pin1_4	94	99	PF00397	0.670
LIG_14-3-3_CanoR_1	147	153	PF00244	0.757
LIG_14-3-3_CanoR_1	29	39	PF00244	0.569
LIG_14-3-3_CanoR_1	346	354	PF00244	0.478
LIG_14-3-3_CanoR_1	366	374	PF00244	0.662
LIG_14-3-3_CanoR_1	388	394	PF00244	0.830
LIG_14-3-3_CanoR_1	419	424	PF00244	0.753
LIG_14-3-3_CanoR_1	434	440	PF00244	0.645
LIG_14-3-3_CanoR_1	540	545	PF00244	0.502
LIG_14-3-3_CanoR_1	791	798	PF00244	0.690
LIG_14-3-3_CanoR_1	822	827	PF00244	0.784
LIG_14-3-3_CanoR_1	879	889	PF00244	0.740
LIG_Actin_WH2_2	768	786	PF00022	0.633
LIG_ActinCP_TwfCPI_2	713	721	PF01115	0.620
LIG_BRCT_BRCA1_1	221	225	PF00533	0.620
LIG_BRCT_BRCA1_1	689	693	PF00533	0.698
LIG_CSL_BTD_1	438	441	PF09270	0.773
LIG_DCNL_PONY_1	1	4	PF03556	0.682
LIG_deltaCOP1_diTrp_1	238	244	PF00928	0.607
LIG_eIF4E_1	339	345	PF01652	0.637
LIG_FHA_1	120	126	PF00498	0.494
LIG_FHA_1	240	246	PF00498	0.453
LIG_FHA_1	249	255	PF00498	0.468
LIG_FHA_1	420	426	PF00498	0.787
LIG_FHA_1	477	483	PF00498	0.671
LIG_FHA_1	519	525	PF00498	0.601
LIG_FHA_1	565	571	PF00498	0.483
LIG_FHA_1	675	681	PF00498	0.684
LIG_FHA_1	724	730	PF00498	0.801
LIG_FHA_1	742	748	PF00498	0.487
LIG_FHA_1	757	763	PF00498	0.605
LIG_FHA_1	821	827	PF00498	0.824
LIG_FHA_1	833	839	PF00498	0.565
LIG_FHA_1	895	901	PF00498	0.737
LIG_FHA_1	97	103	PF00498	0.644
LIG_FHA_2	224	230	PF00498	0.622
LIG_FHA_2	68	74	PF00498	0.692
LIG_FHA_2	712	718	PF00498	0.732
LIG_FHA_2	774	780	PF00498	0.696
LIG_FHA_2	792	798	PF00498	0.564
LIG_FHA_2	99	105	PF00498	0.617
LIG_GBD_Chelix_1	109	117	PF00786	0.490
LIG_LIR_Apic_2	335	341	PF02991	0.644
LIG_LIR_Apic_2	686	692	PF02991	0.625
LIG_LIR_Gen_1	238	245	PF02991	0.450
LIG_LIR_Gen_1	505	515	PF02991	0.478
LIG_LIR_Nem_3	238	244	PF02991	0.505
LIG_LIR_Nem_3	505	511	PF02991	0.484
LIG_PCNA_yPIPBox_3	621	632	PF02747	0.473
LIG_Pex14_2	689	693	PF04695	0.582
LIG_SH2_CRK	659	663	PF00017	0.531
LIG_SH2_STAT3	339	342	PF00017	0.665
LIG_SH2_STAT3	899	902	PF00017	0.755
LIG_SH2_STAT5	470	473	PF00017	0.516
LIG_SH2_STAT5	899	902	PF00017	0.755
LIG_SH3_3	383	389	PF00018	0.811
LIG_SH3_3	421	427	PF00018	0.699
LIG_SH3_3	479	485	PF00018	0.695
LIG_SH3_3	558	564	PF00018	0.554
LIG_SH3_3	594	600	PF00018	0.690
LIG_SUMO_SIM_anti_2	259	266	PF11976	0.562
LIG_SUMO_SIM_par_1	310	316	PF11976	0.526
LIG_SUMO_SIM_par_1	352	358	PF11976	0.625
LIG_SUMO_SIM_par_1	96	104	PF11976	0.641
LIG_TRAF2_1	316	319	PF00917	0.658
LIG_TRAF2_1	786	789	PF00917	0.677
LIG_TRAF2_1	882	885	PF00917	0.703
LIG_UBA3_1	152	159	PF00899	0.717
MOD_CDK_SPK_2	872	877	PF00069	0.724
MOD_CDK_SPxxK_3	412	419	PF00069	0.777
MOD_CDK_SPxxK_3	674	681	PF00069	0.694
MOD_CDK_SPxxK_3	872	879	PF00069	0.725
MOD_CK1_1	219	225	PF00069	0.642
MOD_CK1_1	313	319	PF00069	0.558
MOD_CK1_1	34	40	PF00069	0.581
MOD_CK1_1	365	371	PF00069	0.709
MOD_CK1_1	406	412	PF00069	0.811
MOD_CK1_1	443	449	PF00069	0.699
MOD_CK1_1	480	486	PF00069	0.733
MOD_CK1_1	517	523	PF00069	0.655
MOD_CK1_1	847	853	PF00069	0.794
MOD_CK1_1	96	102	PF00069	0.577
MOD_CK2_1	20	26	PF00069	0.558
MOD_CK2_1	313	319	PF00069	0.636
MOD_CK2_1	328	334	PF00069	0.515
MOD_CK2_1	370	376	PF00069	0.804
MOD_CK2_1	67	73	PF00069	0.743
MOD_CK2_1	711	717	PF00069	0.721
MOD_CK2_1	773	779	PF00069	0.631
MOD_CK2_1	791	797	PF00069	0.664
MOD_CK2_1	808	814	PF00069	0.808
MOD_GlcNHglycan	141	144	PF01048	0.753
MOD_GlcNHglycan	207	210	PF01048	0.686
MOD_GlcNHglycan	270	273	PF01048	0.651
MOD_GlcNHglycan	368	371	PF01048	0.753
MOD_GlcNHglycan	580	583	PF01048	0.588
MOD_GlcNHglycan	594	597	PF01048	0.507
MOD_GlcNHglycan	689	692	PF01048	0.698
MOD_GlcNHglycan	767	770	PF01048	0.779
MOD_GlcNHglycan	776	779	PF01048	0.681
MOD_GlcNHglycan	784	787	PF01048	0.431
MOD_GlcNHglycan	842	845	PF01048	0.722
MOD_GlcNHglycan	861	864	PF01048	0.824
MOD_GSK3_1	115	122	PF00069	0.606
MOD_GSK3_1	134	141	PF00069	0.624
MOD_GSK3_1	219	226	PF00069	0.572
MOD_GSK3_1	263	270	PF00069	0.482
MOD_GSK3_1	287	294	PF00069	0.729
MOD_GSK3_1	30	37	PF00069	0.569
MOD_GSK3_1	328	335	PF00069	0.646
MOD_GSK3_1	362	369	PF00069	0.709
MOD_GSK3_1	389	396	PF00069	0.739
MOD_GSK3_1	401	408	PF00069	0.758
MOD_GSK3_1	415	422	PF00069	0.775
MOD_GSK3_1	476	483	PF00069	0.599
MOD_GSK3_1	486	493	PF00069	0.623
MOD_GSK3_1	513	520	PF00069	0.560
MOD_GSK3_1	588	595	PF00069	0.686
MOD_GSK3_1	633	640	PF00069	0.665
MOD_GSK3_1	642	649	PF00069	0.592
MOD_GSK3_1	741	748	PF00069	0.641
MOD_GSK3_1	828	835	PF00069	0.706
MOD_GSK3_1	840	847	PF00069	0.697
MOD_GSK3_1	888	895	PF00069	0.726
MOD_GSK3_1	94	101	PF00069	0.657
MOD_NEK2_1	155	160	PF00069	0.625
MOD_NEK2_1	263	268	PF00069	0.459
MOD_NEK2_1	282	287	PF00069	0.534
MOD_NEK2_1	31	36	PF00069	0.563
MOD_NEK2_1	405	410	PF00069	0.847
MOD_NEK2_1	476	481	PF00069	0.653
MOD_NEK2_1	578	583	PF00069	0.481
MOD_NEK2_1	602	607	PF00069	0.633
MOD_NEK2_1	631	636	PF00069	0.493
MOD_NEK2_1	687	692	PF00069	0.645
MOD_NEK2_1	711	716	PF00069	0.611
MOD_NEK2_1	782	787	PF00069	0.717
MOD_NEK2_2	616	621	PF00069	0.532
MOD_NEK2_2	624	629	PF00069	0.540
MOD_NEK2_2	67	72	PF00069	0.696
MOD_PIKK_1	119	125	PF00454	0.504
MOD_PIKK_1	313	319	PF00454	0.614
MOD_PIKK_1	345	351	PF00454	0.575
MOD_PIKK_1	564	570	PF00454	0.490
MOD_PIKK_1	633	639	PF00454	0.658
MOD_PIKK_1	723	729	PF00454	0.737
MOD_PIKK_1	791	797	PF00454	0.766
MOD_PKA_1	203	209	PF00069	0.748
MOD_PKA_1	287	293	PF00069	0.733
MOD_PKA_1	332	338	PF00069	0.520
MOD_PKA_1	362	368	PF00069	0.634
MOD_PKA_2	146	152	PF00069	0.769
MOD_PKA_2	204	210	PF00069	0.754
MOD_PKA_2	287	293	PF00069	0.704
MOD_PKA_2	332	338	PF00069	0.573
MOD_PKA_2	345	351	PF00069	0.528
MOD_PKA_2	362	368	PF00069	0.489
MOD_PKA_2	394	400	PF00069	0.835
MOD_PKA_2	454	460	PF00069	0.639
MOD_PKA_2	880	886	PF00069	0.751
MOD_PKB_1	201	209	PF00069	0.634
MOD_Plk_1	197	203	PF00069	0.480
MOD_Plk_1	741	747	PF00069	0.712
MOD_Plk_2-3	20	26	PF00069	0.523
MOD_Plk_4	177	183	PF00069	0.566
MOD_Plk_4	332	338	PF00069	0.542
MOD_Plk_4	435	441	PF00069	0.608
MOD_Plk_4	566	572	PF00069	0.474
MOD_ProDKin_1	115	121	PF00069	0.509
MOD_ProDKin_1	370	376	PF00069	0.839
MOD_ProDKin_1	412	418	PF00069	0.863
MOD_ProDKin_1	480	486	PF00069	0.705
MOD_ProDKin_1	490	496	PF00069	0.686
MOD_ProDKin_1	596	602	PF00069	0.680
MOD_ProDKin_1	62	68	PF00069	0.767
MOD_ProDKin_1	668	674	PF00069	0.622
MOD_ProDKin_1	745	751	PF00069	0.609
MOD_ProDKin_1	872	878	PF00069	0.725
MOD_ProDKin_1	94	100	PF00069	0.659
TRG_DiLeu_BaEn_1	549	554	PF01217	0.489
TRG_DiLeu_BaEn_1	742	747	PF01217	0.592
TRG_DiLeu_BaEn_1	884	889	PF01217	0.646
TRG_DiLeu_BaLyEn_6	349	354	PF01217	0.521
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.490
TRG_ENDOCYTIC_2	659	662	PF00928	0.531
TRG_ER_diArg_1	13	15	PF00400	0.617
TRG_ER_diArg_1	131	133	PF00400	0.623
TRG_ER_diArg_1	202	205	PF00400	0.582
TRG_ER_diArg_1	28	30	PF00400	0.452
TRG_ER_diArg_1	286	288	PF00400	0.660
TRG_ER_diArg_1	386	388	PF00400	0.793
TRG_ER_diArg_1	462	465	PF00400	0.646
TRG_ER_diArg_1	693	695	PF00400	0.668
TRG_ER_diArg_1	730	732	PF00400	0.539
TRG_ER_diArg_1	876	879	PF00400	0.845
TRG_ER_diArg_1	900	903	PF00400	0.764
TRG_ER_diArg_1	91	93	PF00400	0.550
TRG_NES_CRM1_1	174	186	PF08389	0.580
TRG_NES_CRM1_1	342	355	PF08389	0.533
TRG_NLS_MonoExtN_4	201	207	PF00514	0.643
TRG_Pf-PMV_PEXEL_1	13	17	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	3	7	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	542	546	PF00026	0.653
TRG_Pf-PMV_PEXEL_1	682	686	PF00026	0.678
TRG_Pf-PMV_PEXEL_1	86	90	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	898	902	PF00026	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE49	Leptomonas seymouri	45%	94%
A0A3S7WR65	Leishmania donovani	94%	100%
A4H644	Leishmania braziliensis	77%	100%
A4HUG4	Leishmania infantum	94%	100%
E9AN62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%