Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHG2_LEIMA

TriTrypDb:

LmjF.10.0530 , LMJLV39_100011300 , LMJSD75_100011400

Length:

1144

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHG2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1100	1104	PF00656	0.552
CLV_C14_Caspase3-7	742	746	PF00656	0.657
CLV_NRD_NRD_1	109	111	PF00675	0.499
CLV_NRD_NRD_1	1136	1138	PF00675	0.554
CLV_NRD_NRD_1	245	247	PF00675	0.558
CLV_NRD_NRD_1	258	260	PF00675	0.547
CLV_NRD_NRD_1	380	382	PF00675	0.493
CLV_NRD_NRD_1	399	401	PF00675	0.525
CLV_NRD_NRD_1	470	472	PF00675	0.558
CLV_NRD_NRD_1	633	635	PF00675	0.600
CLV_NRD_NRD_1	657	659	PF00675	0.591
CLV_NRD_NRD_1	724	726	PF00675	0.494
CLV_NRD_NRD_1	732	734	PF00675	0.454
CLV_PCSK_KEX2_1	109	111	PF00082	0.499
CLV_PCSK_KEX2_1	115	117	PF00082	0.439
CLV_PCSK_KEX2_1	245	247	PF00082	0.505
CLV_PCSK_KEX2_1	258	260	PF00082	0.494
CLV_PCSK_KEX2_1	321	323	PF00082	0.491
CLV_PCSK_KEX2_1	398	400	PF00082	0.538
CLV_PCSK_KEX2_1	470	472	PF00082	0.558
CLV_PCSK_KEX2_1	578	580	PF00082	0.673
CLV_PCSK_KEX2_1	633	635	PF00082	0.600
CLV_PCSK_KEX2_1	657	659	PF00082	0.591
CLV_PCSK_KEX2_1	724	726	PF00082	0.494
CLV_PCSK_KEX2_1	732	734	PF00082	0.454
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.390
CLV_PCSK_PC1ET2_1	321	323	PF00082	0.491
CLV_PCSK_PC1ET2_1	578	580	PF00082	0.673
CLV_PCSK_PC7_1	574	580	PF00082	0.667
CLV_PCSK_PC7_1	629	635	PF00082	0.570
CLV_PCSK_SKI1_1	237	241	PF00082	0.433
CLV_PCSK_SKI1_1	305	309	PF00082	0.645
CLV_PCSK_SKI1_1	382	386	PF00082	0.416
CLV_PCSK_SKI1_1	623	627	PF00082	0.519
CLV_PCSK_SKI1_1	72	76	PF00082	0.753
CLV_PCSK_SKI1_1	782	786	PF00082	0.464
CLV_PCSK_SKI1_1	794	798	PF00082	0.519
CLV_PCSK_SKI1_1	810	814	PF00082	0.426
CLV_PCSK_SKI1_1	908	912	PF00082	0.555
CLV_Separin_Metazoa	106	110	PF03568	0.632
CLV_Separin_Metazoa	27	31	PF03568	0.586
CLV_Separin_Metazoa	50	54	PF03568	0.567
DEG_APCC_DBOX_1	236	244	PF00400	0.509
DEG_APCC_DBOX_1	692	700	PF00400	0.559
DEG_APCC_KENBOX_2	1006	1010	PF00400	0.630
DEG_APCC_KENBOX_2	222	226	PF00400	0.440
DEG_Nend_UBRbox_3	1	3	PF02207	0.690
DEG_SPOP_SBC_1	1012	1016	PF00917	0.602
DEG_SPOP_SBC_1	1053	1057	PF00917	0.597
DEG_SPOP_SBC_1	938	942	PF00917	0.519
DOC_CKS1_1	1081	1086	PF01111	0.758
DOC_CKS1_1	871	876	PF01111	0.624
DOC_CYCLIN_RxL_1	234	244	PF00134	0.541
DOC_CYCLIN_RxL_1	486	498	PF00134	0.548
DOC_MAPK_gen_1	417	424	PF00069	0.607
DOC_MAPK_MEF2A_6	417	424	PF00069	0.422
DOC_MAPK_RevD_3	384	400	PF00069	0.409
DOC_PP2B_LxvP_1	980	983	PF13499	0.712
DOC_PP4_FxxP_1	545	548	PF00568	0.575
DOC_USP7_MATH_1	1001	1005	PF00917	0.599
DOC_USP7_MATH_1	1012	1016	PF00917	0.793
DOC_USP7_MATH_1	102	106	PF00917	0.590
DOC_USP7_MATH_1	1025	1029	PF00917	0.698
DOC_USP7_MATH_1	1053	1057	PF00917	0.648
DOC_USP7_MATH_1	1097	1101	PF00917	0.755
DOC_USP7_MATH_1	1106	1110	PF00917	0.760
DOC_USP7_MATH_1	18	22	PF00917	0.588
DOC_USP7_MATH_1	285	289	PF00917	0.506
DOC_USP7_MATH_1	452	456	PF00917	0.479
DOC_USP7_MATH_1	585	589	PF00917	0.756
DOC_USP7_MATH_1	656	660	PF00917	0.531
DOC_USP7_MATH_1	753	757	PF00917	0.651
DOC_USP7_MATH_1	819	823	PF00917	0.546
DOC_USP7_MATH_1	875	879	PF00917	0.701
DOC_USP7_MATH_1	939	943	PF00917	0.651
DOC_USP7_MATH_1	95	99	PF00917	0.661
DOC_USP7_MATH_1	950	954	PF00917	0.762
DOC_WW_Pin1_4	1080	1085	PF00397	0.729
DOC_WW_Pin1_4	1120	1125	PF00397	0.724
DOC_WW_Pin1_4	12	17	PF00397	0.604
DOC_WW_Pin1_4	158	163	PF00397	0.653
DOC_WW_Pin1_4	4	9	PF00397	0.625
DOC_WW_Pin1_4	521	526	PF00397	0.748
DOC_WW_Pin1_4	595	600	PF00397	0.634
DOC_WW_Pin1_4	870	875	PF00397	0.724
DOC_WW_Pin1_4	879	884	PF00397	0.665
DOC_WW_Pin1_4	978	983	PF00397	0.643
LIG_14-3-3_CanoR_1	17	23	PF00244	0.434
LIG_14-3-3_CanoR_1	227	233	PF00244	0.581
LIG_14-3-3_CanoR_1	268	273	PF00244	0.425
LIG_14-3-3_CanoR_1	356	362	PF00244	0.498
LIG_14-3-3_CanoR_1	369	375	PF00244	0.393
LIG_14-3-3_CanoR_1	38	47	PF00244	0.616
LIG_14-3-3_CanoR_1	419	425	PF00244	0.567
LIG_14-3-3_CanoR_1	617	626	PF00244	0.556
LIG_14-3-3_CanoR_1	657	661	PF00244	0.540
LIG_14-3-3_CanoR_1	670	675	PF00244	0.457
LIG_14-3-3_CanoR_1	683	692	PF00244	0.381
LIG_14-3-3_CanoR_1	693	697	PF00244	0.435
LIG_14-3-3_CanoR_1	761	769	PF00244	0.524
LIG_14-3-3_CanoR_1	782	791	PF00244	0.491
LIG_14-3-3_CanoR_1	827	835	PF00244	0.537
LIG_14-3-3_CanoR_1	850	855	PF00244	0.545
LIG_Actin_WH2_2	354	371	PF00022	0.462
LIG_APCC_ABBA_1	493	498	PF00400	0.550
LIG_APCC_ABBA_1	597	602	PF00400	0.603
LIG_BIR_III_2	973	977	PF00653	0.624
LIG_BRCT_BRCA1_1	1014	1018	PF00533	0.717
LIG_EVH1_1	1121	1125	PF00568	0.610
LIG_FHA_1	174	180	PF00498	0.612
LIG_FHA_1	46	52	PF00498	0.531
LIG_FHA_1	669	675	PF00498	0.484
LIG_FHA_1	684	690	PF00498	0.421
LIG_FHA_1	761	767	PF00498	0.558
LIG_FHA_1	787	793	PF00498	0.479
LIG_FHA_1	899	905	PF00498	0.705
LIG_FHA_1	986	992	PF00498	0.671
LIG_FHA_2	1137	1143	PF00498	0.547
LIG_FHA_2	219	225	PF00498	0.588
LIG_FHA_2	441	447	PF00498	0.550
LIG_FHA_2	521	527	PF00498	0.711
LIG_FHA_2	640	646	PF00498	0.533
LIG_FHA_2	692	698	PF00498	0.542
LIG_FHA_2	740	746	PF00498	0.568
LIG_LIR_Apic_2	543	548	PF02991	0.581
LIG_LIR_Gen_1	507	514	PF02991	0.413
LIG_LIR_Gen_1	602	612	PF02991	0.515
LIG_LIR_Nem_3	1015	1021	PF02991	0.539
LIG_LIR_Nem_3	507	512	PF02991	0.399
LIG_LIR_Nem_3	602	607	PF02991	0.642
LIG_OCRL_FandH_1	603	615	PF00620	0.522
LIG_PCNA_yPIPBox_3	96	108	PF02747	0.454
LIG_PDZ_Class_3	1139	1144	PF00595	0.645
LIG_Pex14_1	839	843	PF04695	0.558
LIG_PTAP_UEV_1	1067	1072	PF05743	0.612
LIG_SH2_STAP1	685	689	PF00017	0.469
LIG_SH2_STAT5	685	688	PF00017	0.549
LIG_SH2_STAT5	772	775	PF00017	0.485
LIG_SH2_STAT5	791	794	PF00017	0.564
LIG_SH3_3	1024	1030	PF00018	0.685
LIG_SH3_3	1065	1071	PF00018	0.798
LIG_SH3_3	1075	1081	PF00018	0.740
LIG_SH3_3	1119	1125	PF00018	0.747
LIG_SH3_3	159	165	PF00018	0.658
LIG_SH3_3	456	462	PF00018	0.514
LIG_SH3_3	868	874	PF00018	0.537
LIG_SH3_3	91	97	PF00018	0.602
LIG_SH3_3	933	939	PF00018	0.721
LIG_SH3_3	957	963	PF00018	0.788
LIG_SH3_CIN85_PxpxPR_1	12	17	PF14604	0.490
LIG_SUMO_SIM_anti_2	21	27	PF11976	0.411
LIG_TRAF2_1	1056	1059	PF00917	0.735
LIG_TRAF2_1	1072	1075	PF00917	0.755
LIG_TRAF2_1	1113	1116	PF00917	0.624
LIG_TRAF2_1	1139	1142	PF00917	0.546
LIG_TRAF2_1	464	467	PF00917	0.577
LIG_TRAF2_1	651	654	PF00917	0.589
LIG_UBA3_1	215	223	PF00899	0.563
LIG_WRC_WIRS_1	195	200	PF05994	0.469
LIG_WRC_WIRS_1	907	912	PF05994	0.411
MOD_CDK_SPK_2	12	17	PF00069	0.490
MOD_CDK_SPxK_1	595	601	PF00069	0.615
MOD_CK1_1	1028	1034	PF00069	0.573
MOD_CK1_1	1063	1069	PF00069	0.816
MOD_CK1_1	1123	1129	PF00069	0.684
MOD_CK1_1	157	163	PF00069	0.544
MOD_CK1_1	331	337	PF00069	0.627
MOD_CK1_1	430	436	PF00069	0.583
MOD_CK1_1	529	535	PF00069	0.699
MOD_CK1_1	592	598	PF00069	0.676
MOD_CK1_1	603	609	PF00069	0.577
MOD_CK1_1	641	647	PF00069	0.583
MOD_CK1_1	687	693	PF00069	0.608
MOD_CK1_1	7	13	PF00069	0.738
MOD_CK1_1	739	745	PF00069	0.655
MOD_CK1_1	879	885	PF00069	0.643
MOD_CK1_1	937	943	PF00069	0.773
MOD_CK1_1	969	975	PF00069	0.824
MOD_CK1_1	999	1005	PF00069	0.621
MOD_CK2_1	1053	1059	PF00069	0.768
MOD_CK2_1	1069	1075	PF00069	0.529
MOD_CK2_1	1124	1130	PF00069	0.815
MOD_CK2_1	1136	1142	PF00069	0.589
MOD_CK2_1	197	203	PF00069	0.560
MOD_CK2_1	218	224	PF00069	0.511
MOD_CK2_1	430	436	PF00069	0.573
MOD_CK2_1	440	446	PF00069	0.569
MOD_CK2_1	520	526	PF00069	0.530
MOD_CK2_1	639	645	PF00069	0.523
MOD_CK2_1	691	697	PF00069	0.533
MOD_CK2_1	820	826	PF00069	0.503
MOD_Cter_Amidation	576	579	PF01082	0.673
MOD_GlcNHglycan	1022	1025	PF01048	0.692
MOD_GlcNHglycan	1027	1030	PF01048	0.684
MOD_GlcNHglycan	1061	1065	PF01048	0.733
MOD_GlcNHglycan	1068	1071	PF01048	0.646
MOD_GlcNHglycan	273	279	PF01048	0.524
MOD_GlcNHglycan	4	7	PF01048	0.754
MOD_GlcNHglycan	454	457	PF01048	0.524
MOD_GlcNHglycan	540	543	PF01048	0.637
MOD_GlcNHglycan	587	590	PF01048	0.774
MOD_GlcNHglycan	686	689	PF01048	0.589
MOD_GlcNHglycan	755	758	PF01048	0.687
MOD_GlcNHglycan	814	818	PF01048	0.563
MOD_GlcNHglycan	828	831	PF01048	0.441
MOD_GlcNHglycan	878	881	PF01048	0.681
MOD_GlcNHglycan	887	890	PF01048	0.714
MOD_GlcNHglycan	936	939	PF01048	0.765
MOD_GlcNHglycan	941	944	PF01048	0.750
MOD_GSK3_1	1025	1032	PF00069	0.656
MOD_GSK3_1	1076	1083	PF00069	0.657
MOD_GSK3_1	1102	1109	PF00069	0.756
MOD_GSK3_1	1120	1127	PF00069	0.709
MOD_GSK3_1	154	161	PF00069	0.552
MOD_GSK3_1	187	194	PF00069	0.504
MOD_GSK3_1	198	205	PF00069	0.485
MOD_GSK3_1	305	312	PF00069	0.650
MOD_GSK3_1	327	334	PF00069	0.667
MOD_GSK3_1	585	592	PF00069	0.803
MOD_GSK3_1	665	672	PF00069	0.517
MOD_GSK3_1	683	690	PF00069	0.396
MOD_GSK3_1	739	746	PF00069	0.554
MOD_GSK3_1	778	785	PF00069	0.520
MOD_GSK3_1	875	882	PF00069	0.647
MOD_GSK3_1	894	901	PF00069	0.663
MOD_GSK3_1	934	941	PF00069	0.773
MOD_GSK3_1	962	969	PF00069	0.790
MOD_GSK3_1	981	988	PF00069	0.724
MOD_GSK3_1	996	1003	PF00069	0.807
MOD_N-GLC_1	228	233	PF02516	0.490
MOD_N-GLC_1	31	36	PF02516	0.428
MOD_N-GLC_1	529	534	PF02516	0.613
MOD_N-GLC_1	585	590	PF02516	0.616
MOD_N-GLC_1	883	888	PF02516	0.739
MOD_NEK2_1	1	6	PF00069	0.688
MOD_NEK2_1	154	159	PF00069	0.622
MOD_NEK2_1	368	373	PF00069	0.501
MOD_NEK2_1	420	425	PF00069	0.429
MOD_NEK2_1	618	623	PF00069	0.566
MOD_NEK2_1	639	644	PF00069	0.517
MOD_NEK2_1	691	696	PF00069	0.498
MOD_NEK2_1	813	818	PF00069	0.504
MOD_NEK2_1	900	905	PF00069	0.611
MOD_NEK2_2	218	223	PF00069	0.436
MOD_NEK2_2	440	445	PF00069	0.580
MOD_PIKK_1	1054	1060	PF00454	0.650
MOD_PIKK_1	1106	1112	PF00454	0.705
MOD_PIKK_1	305	311	PF00454	0.528
MOD_PIKK_1	368	374	PF00454	0.463
MOD_PIKK_1	45	51	PF00454	0.596
MOD_PIKK_1	611	617	PF00454	0.499
MOD_PIKK_1	67	73	PF00454	0.542
MOD_PIKK_1	782	788	PF00454	0.498
MOD_PK_1	850	856	PF00069	0.575
MOD_PKA_1	1137	1143	PF00069	0.547
MOD_PKA_1	578	584	PF00069	0.621
MOD_PKA_2	1136	1142	PF00069	0.582
MOD_PKA_2	173	179	PF00069	0.431
MOD_PKA_2	368	374	PF00069	0.452
MOD_PKA_2	45	51	PF00069	0.581
MOD_PKA_2	512	518	PF00069	0.698
MOD_PKA_2	578	584	PF00069	0.665
MOD_PKA_2	600	606	PF00069	0.576
MOD_PKA_2	656	662	PF00069	0.545
MOD_PKA_2	669	675	PF00069	0.440
MOD_PKA_2	692	698	PF00069	0.494
MOD_PKA_2	760	766	PF00069	0.586
MOD_PKA_2	826	832	PF00069	0.465
MOD_PKA_2	95	101	PF00069	0.546
MOD_PKB_1	266	274	PF00069	0.413
MOD_Plk_1	1032	1038	PF00069	0.620
MOD_Plk_1	154	160	PF00069	0.626
MOD_Plk_1	202	208	PF00069	0.363
MOD_Plk_1	228	234	PF00069	0.540
MOD_Plk_1	253	259	PF00069	0.601
MOD_Plk_1	30	36	PF00069	0.530
MOD_Plk_1	529	535	PF00069	0.714
MOD_Plk_1	593	599	PF00069	0.685
MOD_Plk_1	786	792	PF00069	0.511
MOD_Plk_1	893	899	PF00069	0.691
MOD_Plk_4	194	200	PF00069	0.520
MOD_Plk_4	202	208	PF00069	0.426
MOD_Plk_4	454	460	PF00069	0.521
MOD_Plk_4	600	606	PF00069	0.555
MOD_Plk_4	687	693	PF00069	0.480
MOD_Plk_4	787	793	PF00069	0.564
MOD_Plk_4	850	856	PF00069	0.515
MOD_Plk_4	857	863	PF00069	0.575
MOD_Plk_4	95	101	PF00069	0.693
MOD_Plk_4	981	987	PF00069	0.630
MOD_ProDKin_1	1080	1086	PF00069	0.731
MOD_ProDKin_1	1120	1126	PF00069	0.726
MOD_ProDKin_1	12	18	PF00069	0.598
MOD_ProDKin_1	158	164	PF00069	0.652
MOD_ProDKin_1	4	10	PF00069	0.628
MOD_ProDKin_1	521	527	PF00069	0.749
MOD_ProDKin_1	595	601	PF00069	0.633
MOD_ProDKin_1	870	876	PF00069	0.732
MOD_ProDKin_1	879	885	PF00069	0.666
MOD_ProDKin_1	978	984	PF00069	0.644
MOD_SUMO_for_1	475	478	PF00179	0.439
MOD_SUMO_rev_2	1130	1140	PF00179	0.644
MOD_SUMO_rev_2	255	265	PF00179	0.553
MOD_SUMO_rev_2	397	406	PF00179	0.495
MOD_SUMO_rev_2	836	841	PF00179	0.447
TRG_DiLeu_BaEn_1	143	148	PF01217	0.571
TRG_DiLeu_BaEn_1	175	180	PF01217	0.503
TRG_DiLeu_BaEn_1	416	421	PF01217	0.553
TRG_DiLeu_BaEn_2	504	510	PF01217	0.380
TRG_DiLeu_BaEn_4	260	266	PF01217	0.496
TRG_DiLeu_BaEn_4	313	319	PF01217	0.544
TRG_DiLeu_BaEn_4	401	407	PF01217	0.447
TRG_DiLeu_BaLyEn_6	614	619	PF01217	0.541
TRG_DiLeu_LyEn_5	416	421	PF01217	0.553
TRG_ENDOCYTIC_2	843	846	PF00928	0.559
TRG_ER_diArg_1	108	110	PF00400	0.499
TRG_ER_diArg_1	257	259	PF00400	0.426
TRG_ER_diArg_1	398	400	PF00400	0.538
TRG_ER_diArg_1	469	471	PF00400	0.566
TRG_ER_diArg_1	633	635	PF00400	0.601
TRG_ER_diArg_1	731	733	PF00400	0.567
TRG_NLS_MonoExtC_3	320	326	PF00514	0.492
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	263	267	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.650
TRG_Pf-PMV_PEXEL_1	352	357	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	442	446	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	623	627	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	865	869	PF00026	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5I9	Leptomonas seymouri	55%	100%
A0A1X0NQ72	Trypanosomatidae	28%	100%
A0A3R7KN13	Trypanosoma rangeli	30%	100%
A0A3S7WR55	Leishmania donovani	92%	99%
A4H645	Leishmania braziliensis	79%	98%
A4HUG5	Leishmania infantum	92%	99%
C9ZVI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AN63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
V5BB18	Trypanosoma cruzi	29%	100%