GCV_T domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHG0_LEIMA

TriTrypDb:

LmjF.10.0550 , LMJLV39_100011500 , LMJSD75_100011600

Length:

431

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

Q4QHG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHG0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	329	331	PF00675	0.367
CLV_NRD_NRD_1	384	386	PF00675	0.529
CLV_NRD_NRD_1	420	422	PF00675	0.731
CLV_NRD_NRD_1	50	52	PF00675	0.549
CLV_NRD_NRD_1	63	65	PF00675	0.454
CLV_PCSK_KEX2_1	270	272	PF00082	0.551
CLV_PCSK_KEX2_1	420	422	PF00082	0.712
CLV_PCSK_KEX2_1	50	52	PF00082	0.595
CLV_PCSK_KEX2_1	63	65	PF00082	0.443
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.551
CLV_Separin_Metazoa	102	106	PF03568	0.348
DOC_MAPK_DCC_7	225	234	PF00069	0.417
DOC_MAPK_gen_1	201	210	PF00069	0.381
DOC_MAPK_MEF2A_6	17	26	PF00069	0.496
DOC_PP2B_LxvP_1	137	140	PF13499	0.373
DOC_USP7_MATH_1	284	288	PF00917	0.432
DOC_USP7_MATH_1	362	366	PF00917	0.616
DOC_USP7_MATH_2	231	237	PF00917	0.273
DOC_USP7_UBL2_3	270	274	PF12436	0.572
DOC_WW_Pin1_4	235	240	PF00397	0.459
DOC_WW_Pin1_4	413	418	PF00397	0.510
DOC_WW_Pin1_4	79	84	PF00397	0.453
LIG_14-3-3_CanoR_1	105	113	PF00244	0.426
LIG_14-3-3_CanoR_1	17	23	PF00244	0.694
LIG_14-3-3_CanoR_1	33	40	PF00244	0.667
LIG_14-3-3_CanoR_1	54	58	PF00244	0.631
LIG_Actin_WH2_2	19	35	PF00022	0.710
LIG_Actin_WH2_2	90	107	PF00022	0.427
LIG_BRCT_BRCA1_1	376	380	PF00533	0.558
LIG_EH_1	319	323	PF12763	0.412
LIG_FHA_1	125	131	PF00498	0.297
LIG_FHA_1	164	170	PF00498	0.545
LIG_FHA_1	188	194	PF00498	0.351
LIG_FHA_1	200	206	PF00498	0.302
LIG_FHA_1	209	215	PF00498	0.342
LIG_FHA_1	250	256	PF00498	0.435
LIG_FHA_1	39	45	PF00498	0.624
LIG_FHA_1	64	70	PF00498	0.483
LIG_FHA_1	73	79	PF00498	0.545
LIG_LIR_Apic_2	325	329	PF02991	0.380
LIG_LIR_Gen_1	287	297	PF02991	0.457
LIG_LIR_Nem_3	287	292	PF02991	0.387
LIG_Pex14_2	322	326	PF04695	0.385
LIG_PTB_Apo_2	125	132	PF02174	0.457
LIG_PTB_Apo_2	64	71	PF02174	0.391
LIG_PTB_Phospho_1	64	70	PF10480	0.414
LIG_SH2_CRK	299	303	PF00017	0.349
LIG_SH2_CRK	414	418	PF00017	0.609
LIG_SH2_CRK	65	69	PF00017	0.367
LIG_SH2_CRK	70	74	PF00017	0.328
LIG_SH2_GRB2like	355	358	PF00017	0.494
LIG_SH2_GRB2like	65	68	PF00017	0.385
LIG_SH2_SRC	355	358	PF00017	0.552
LIG_SH2_STAP1	122	126	PF00017	0.350
LIG_SH2_STAP1	65	69	PF00017	0.503
LIG_SH2_STAT5	297	300	PF00017	0.479
LIG_SH2_STAT5	65	68	PF00017	0.399
LIG_SH3_3	404	410	PF00018	0.683
LIG_SH3_3	423	429	PF00018	0.695
LIG_SH3_4	405	412	PF00018	0.715
LIG_SUMO_SIM_par_1	43	49	PF11976	0.711
LIG_TRAF2_1	84	87	PF00917	0.508
LIG_TRFH_1	70	74	PF08558	0.508
LIG_UBA3_1	137	143	PF00899	0.512
MOD_CDK_SPxxK_3	413	420	PF00069	0.487
MOD_CK1_1	206	212	PF00069	0.344
MOD_CK1_1	27	33	PF00069	0.671
MOD_CK1_1	287	293	PF00069	0.345
MOD_CK1_1	374	380	PF00069	0.607
MOD_CK1_1	53	59	PF00069	0.635
MOD_CK2_1	253	259	PF00069	0.532
MOD_CK2_1	81	87	PF00069	0.521
MOD_GlcNHglycan	149	152	PF01048	0.537
MOD_GlcNHglycan	181	184	PF01048	0.341
MOD_GlcNHglycan	316	319	PF01048	0.543
MOD_GlcNHglycan	83	86	PF01048	0.510
MOD_GSK3_1	147	154	PF00069	0.405
MOD_GSK3_1	18	25	PF00069	0.680
MOD_GSK3_1	199	206	PF00069	0.452
MOD_GSK3_1	235	242	PF00069	0.558
MOD_GSK3_1	249	256	PF00069	0.510
MOD_GSK3_1	27	34	PF00069	0.679
MOD_GSK3_1	335	342	PF00069	0.479
MOD_GSK3_1	367	374	PF00069	0.581
MOD_GSK3_1	420	427	PF00069	0.668
MOD_GSK3_1	46	53	PF00069	0.630
MOD_GSK3_1	77	84	PF00069	0.514
MOD_N-GLC_1	10	15	PF02516	0.766
MOD_NEK2_1	104	109	PF00069	0.400
MOD_NEK2_1	186	191	PF00069	0.364
MOD_NEK2_1	208	213	PF00069	0.407
MOD_NEK2_1	22	27	PF00069	0.689
MOD_NEK2_1	28	33	PF00069	0.621
MOD_NEK2_1	314	319	PF00069	0.531
MOD_NEK2_1	332	337	PF00069	0.343
MOD_NEK2_1	38	43	PF00069	0.586
MOD_NEK2_1	57	62	PF00069	0.529
MOD_NEK2_2	284	289	PF00069	0.458
MOD_PIKK_1	104	110	PF00454	0.365
MOD_PIKK_1	72	78	PF00454	0.544
MOD_PKA_1	420	426	PF00069	0.732
MOD_PKA_1	50	56	PF00069	0.598
MOD_PKA_1	63	69	PF00069	0.433
MOD_PKA_2	104	110	PF00069	0.396
MOD_PKA_2	179	185	PF00069	0.494
MOD_PKA_2	32	38	PF00069	0.667
MOD_PKA_2	343	349	PF00069	0.449
MOD_PKA_2	420	426	PF00069	0.739
MOD_PKA_2	50	56	PF00069	0.637
MOD_PKA_2	63	69	PF00069	0.466
MOD_Plk_4	203	209	PF00069	0.466
MOD_Plk_4	284	290	PF00069	0.312
MOD_Plk_4	40	46	PF00069	0.736
MOD_Plk_4	420	426	PF00069	0.739
MOD_Plk_4	53	59	PF00069	0.479
MOD_ProDKin_1	235	241	PF00069	0.452
MOD_ProDKin_1	413	419	PF00069	0.500
MOD_ProDKin_1	79	85	PF00069	0.453
MOD_SUMO_for_1	280	283	PF00179	0.465
MOD_SUMO_rev_2	111	118	PF00179	0.465
TRG_ENDOCYTIC_2	122	125	PF00928	0.382
TRG_ENDOCYTIC_2	299	302	PF00928	0.370
TRG_ENDOCYTIC_2	65	68	PF00928	0.414
TRG_ER_diArg_1	2	5	PF00400	0.672
TRG_ER_diArg_1	62	64	PF00400	0.499
TRG_Pf-PMV_PEXEL_1	225	230	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Y0	Leptomonas seymouri	72%	100%
A0A0N1PDA3	Leptomonas seymouri	33%	100%
A0A0S4INL4	Bodo saltans	48%	100%
A0A0S4JAJ5	Bodo saltans	32%	100%
A0A1X0NQR5	Trypanosomatidae	65%	100%
A0A1X0P2H5	Trypanosomatidae	32%	100%
A0A3Q8IH71	Leishmania donovani	98%	100%
A0A3R7M1X1	Trypanosoma rangeli	64%	100%
A0A3R7MCA7	Trypanosoma rangeli	32%	100%
A0A3S7X6N8	Leishmania donovani	33%	100%
A4H647	Leishmania braziliensis	89%	100%
A4HLI1	Leishmania braziliensis	33%	100%
A4HUG7	Leishmania infantum	98%	100%
A4I8Z1	Leishmania infantum	33%	100%
C9ZVI8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	86%
D0A4Y9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AN65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
E9B3W0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q4Q464	Leishmania major	33%	100%
V5B205	Trypanosoma cruzi	65%	100%
V5BLV5	Trypanosoma cruzi	31%	100%