Zinc binding dehydrogenase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc binding dehydrogenase-like protein

Species:

Leishmania major

UniProt:

Q4QHF9_LEIMA

TriTrypDb:

LmjF.10.0560 , LMJLV39_100011600 , LMJSD75_100011700

Length:

371

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QHF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHF9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0016491	oxidoreductase activity	2	16
GO:0003960	NADPH:quinone reductase activity	5	1
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	1
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	269	273	PF00656	0.311
CLV_NRD_NRD_1	110	112	PF00675	0.183
CLV_NRD_NRD_1	296	298	PF00675	0.334
CLV_PCSK_KEX2_1	296	298	PF00082	0.357
CLV_PCSK_KEX2_1	61	63	PF00082	0.366
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.366
CLV_PCSK_SKI1_1	111	115	PF00082	0.183
CLV_PCSK_SKI1_1	121	125	PF00082	0.313
CLV_PCSK_SKI1_1	187	191	PF00082	0.350
CLV_PCSK_SKI1_1	21	25	PF00082	0.600
CLV_PCSK_SKI1_1	353	357	PF00082	0.446
CLV_PCSK_SKI1_1	62	66	PF00082	0.452
CLV_PCSK_SKI1_1	80	84	PF00082	0.355
DEG_APCC_DBOX_1	315	323	PF00400	0.427
DOC_MAPK_gen_1	362	368	PF00069	0.398
DOC_PP1_RVXF_1	119	125	PF00149	0.313
DOC_PP1_RVXF_1	59	66	PF00149	0.478
DOC_USP7_MATH_1	185	189	PF00917	0.454
DOC_USP7_MATH_1	197	201	PF00917	0.362
DOC_USP7_MATH_1	67	71	PF00917	0.523
DOC_USP7_UBL2_3	21	25	PF12436	0.341
DOC_WW_Pin1_4	215	220	PF00397	0.389
LIG_14-3-3_CanoR_1	156	161	PF00244	0.341
LIG_14-3-3_CanoR_1	296	302	PF00244	0.333
LIG_14-3-3_CanoR_1	32	39	PF00244	0.444
LIG_Actin_WH2_2	102	119	PF00022	0.387
LIG_APCC_ABBA_1	341	346	PF00400	0.408
LIG_BIR_II_1	1	5	PF00653	0.640
LIG_BRCT_BRCA1_1	331	335	PF00533	0.440
LIG_deltaCOP1_diTrp_1	59	65	PF00928	0.477
LIG_FHA_1	170	176	PF00498	0.349
LIG_FHA_1	26	32	PF00498	0.406
LIG_FHA_1	269	275	PF00498	0.390
LIG_FHA_1	354	360	PF00498	0.526
LIG_LIR_Gen_1	138	147	PF02991	0.432
LIG_LIR_Gen_1	172	181	PF02991	0.339
LIG_LIR_Gen_1	300	309	PF02991	0.313
LIG_LIR_Nem_3	170	174	PF02991	0.338
LIG_LIR_Nem_3	256	261	PF02991	0.387
LIG_LIR_Nem_3	300	306	PF02991	0.313
LIG_LIR_Nem_3	59	63	PF02991	0.398
LIG_LYPXL_yS_3	94	97	PF13949	0.387
LIG_SH2_NCK_1	160	164	PF00017	0.344
LIG_SH2_PTP2	174	177	PF00017	0.328
LIG_SH2_PTP2	303	306	PF00017	0.313
LIG_SH2_SRC	160	163	PF00017	0.350
LIG_SH2_STAP1	160	164	PF00017	0.344
LIG_SH2_STAP1	51	55	PF00017	0.343
LIG_SH2_STAT5	174	177	PF00017	0.328
LIG_SH2_STAT5	212	215	PF00017	0.323
LIG_SH2_STAT5	224	227	PF00017	0.279
LIG_SH2_STAT5	258	261	PF00017	0.294
LIG_SH2_STAT5	303	306	PF00017	0.313
LIG_SH2_STAT5	321	324	PF00017	0.373
LIG_SH2_STAT5	96	99	PF00017	0.333
LIG_SH3_3	143	149	PF00018	0.468
LIG_SH3_3	16	22	PF00018	0.467
LIG_SH3_3	283	289	PF00018	0.387
LIG_SH3_3	33	39	PF00018	0.389
LIG_SH3_3	365	371	PF00018	0.451
LIG_SH3_3	60	66	PF00018	0.518
LIG_SH3_3	87	93	PF00018	0.325
LIG_SH3_4	21	28	PF00018	0.433
LIG_SUMO_SIM_anti_2	338	343	PF11976	0.405
LIG_TRAF2_1	159	162	PF00917	0.363
LIG_TYR_ITIM	301	306	PF00017	0.333
LIG_WW_1	89	92	PF00397	0.387
MOD_CK1_1	126	132	PF00069	0.432
MOD_CK1_1	34	40	PF00069	0.429
MOD_CK2_1	132	138	PF00069	0.387
MOD_CK2_1	156	162	PF00069	0.433
MOD_Cter_Amidation	109	112	PF01082	0.183
MOD_GlcNHglycan	1	4	PF01048	0.666
MOD_GlcNHglycan	194	197	PF01048	0.388
MOD_GlcNHglycan	283	286	PF01048	0.355
MOD_GlcNHglycan	331	334	PF01048	0.450
MOD_GlcNHglycan	352	356	PF01048	0.465
MOD_GlcNHglycan	67	70	PF01048	0.557
MOD_GlcNHglycan	76	79	PF01048	0.393
MOD_GSK3_1	213	220	PF00069	0.337
MOD_NEK2_1	123	128	PF00069	0.368
MOD_NEK2_1	142	147	PF00069	0.256
MOD_NEK2_1	259	264	PF00069	0.347
MOD_NEK2_1	329	334	PF00069	0.409
MOD_NEK2_1	351	356	PF00069	0.533
MOD_NEK2_2	185	190	PF00069	0.390
MOD_PIKK_1	261	267	PF00454	0.453
MOD_PIKK_1	41	47	PF00454	0.459
MOD_PK_1	297	303	PF00069	0.357
MOD_PKA_1	111	117	PF00069	0.183
MOD_PKA_2	31	37	PF00069	0.354
MOD_Plk_1	142	148	PF00069	0.507
MOD_Plk_1	34	40	PF00069	0.446
MOD_Plk_2-3	266	272	PF00069	0.263
MOD_ProDKin_1	215	221	PF00069	0.389
MOD_SUMO_rev_2	54	63	PF00179	0.441
TRG_ENDOCYTIC_2	139	142	PF00928	0.370
TRG_ENDOCYTIC_2	174	177	PF00928	0.328
TRG_ENDOCYTIC_2	258	261	PF00928	0.387
TRG_ENDOCYTIC_2	303	306	PF00928	0.313
TRG_ENDOCYTIC_2	94	97	PF00928	0.441
TRG_ER_diArg_1	295	297	PF00400	0.357
TRG_ER_diArg_1	46	49	PF00400	0.306
TRG_Pf-PMV_PEXEL_1	320	324	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A089FS99	Fungal sp. (strain NRRL 50135)	31%	100%
A0A0N0P3I0	Leptomonas seymouri	26%	100%
A0A0N0P5I8	Leptomonas seymouri	73%	100%
A0A0N1I4X2	Leptomonas seymouri	41%	79%
A0A0S4ILS9	Bodo saltans	33%	100%
A0A1W5T1Y4	Penicillium oxalicum	26%	98%
A0A1X0NRR2	Trypanosomatidae	44%	76%
A0A2L0P0L5	Talaromyces wortmannii	25%	100%
A0A2Z5TIQ0	Aspergillus japonicus	29%	100%
A0A2Z5XAK4	Pyrenochaetopsis sp.	27%	100%
A0A3Q9U4Z5	Talaromyces variabilis	28%	100%
A0A3S7WR50	Leishmania donovani	99%	100%
A0A3S7WR58	Leishmania donovani	44%	78%
A0A4P8W733	Magnaporthe grisea	27%	100%
A1CLZ2	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	26%	100%
A1JHX8	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	26%	100%
A4H648	Leishmania braziliensis	88%	100%
A4H649	Leishmania braziliensis	44%	77%
A4HUG8	Leishmania infantum	99%	100%
A4HUG9	Leishmania infantum	44%	78%
A4TSC6	Yersinia pestis (strain Pestoides F)	27%	100%
A6WUG6	Shewanella baltica (strain OS185)	26%	100%
A7FCU5	Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)	26%	100%
A7RK30	Nematostella vectensis	26%	100%
A9R685	Yersinia pestis bv. Antiqua (strain Angola)	27%	100%
B1JQW2	Yersinia pseudotuberculosis serotype O:3 (strain YPIII)	26%	100%
B2JYP4	Yersinia pseudotuberculosis serotype IB (strain PB1/+)	26%	100%
B8NJH1	Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC 167)	25%	93%
C5E3S5	Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)	26%	100%
C9ZVI9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	86%
E9AN66	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AN67	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	78%
E9ATK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
G3JUI7	Cordyceps militaris (strain CM01)	24%	100%
G4MWB1	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	26%	100%
K4BW79	Solanum lycopersicum	32%	96%
O13309	Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545)	27%	100%
O23939	Fragaria vesca	32%	100%
O58389	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	24%	100%
O94564	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
O97764	Bos taurus	31%	100%
P00331	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P07246	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	23%	99%
P11415	Cavia porcellus	31%	100%
P20369	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	25%	100%
P28304	Escherichia coli (strain K12)	27%	100%
P38113	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	100%
P40783	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	26%	100%
P42865	Leishmania amazonensis	28%	100%
P43903	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	26%	100%
P47199	Mus musculus	30%	100%
P49383	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	26%	100%
P63475	Staphylococcus aureus (strain Mu50 / ATCC 700699)	28%	100%
P99173	Staphylococcus aureus (strain N315)	28%	100%
Q08257	Homo sapiens	28%	100%
Q0CS94	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	30%	100%
Q0MVN8	Sus scrofa	29%	100%
Q0VC50	Bos taurus	25%	94%
Q1C278	Yersinia pestis bv. Antiqua (strain Antiqua)	27%	100%
Q1CD13	Yersinia pestis bv. Antiqua (strain Nepal516)	27%	100%
Q24K16	Bos taurus	28%	98%
Q28452	Lama guanicoe	29%	100%
Q28GQ2	Xenopus tropicalis	26%	100%
Q3IHW0	Pseudoalteromonas translucida (strain TAC 125)	25%	100%
Q3IZ91	Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.)	24%	86%
Q3S2U1	Monascus pilosus	24%	100%
Q4Q0Z7	Leishmania major	26%	100%
Q4QHF8	Leishmania major	42%	100%
Q53865	Streptomyces collinus	26%	83%
Q53FA7	Homo sapiens	23%	100%
Q54II4	Dictyostelium discoideum	24%	100%
Q54YT4	Dictyostelium discoideum	26%	100%
Q59I44	Burkholderia sp.	27%	100%
Q5AUW6	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	25%	100%
Q5HE19	Staphylococcus aureus (strain COL)	25%	100%
Q5R4S7	Pongo abelii	29%	100%
Q66GC5	Yersinia pseudotuberculosis serotype I (strain IP32953)	26%	100%
Q6AYT0	Rattus norvegicus	31%	100%
Q6G7C8	Staphylococcus aureus (strain MSSA476)	25%	100%
Q6GEP3	Staphylococcus aureus (strain MRSA252)	28%	100%
Q6XQ67	Saccharomyces pastorianus	26%	100%
Q7T3C7	Danio rerio	25%	96%
Q82LU9	Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)	26%	83%
Q84V25	Fragaria ananassa	35%	100%
Q8BGC4	Mus musculus	26%	98%
Q8J0F9	Penicillium citrinum	24%	100%
Q8LCU7	Arabidopsis thaliana	26%	99%
Q8NVD1	Staphylococcus aureus (strain MW2)	25%	100%
Q8WWV3	Homo sapiens	26%	94%
Q8ZJN2	Yersinia pestis	27%	100%
Q921W4	Mus musculus	27%	100%
Q924D0	Mus musculus	26%	94%
Q941I0	Fragaria ananassa	32%	100%
Q96XE0	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	23%	100%
Q9P4C2	Kluyveromyces marxianus	26%	100%
Q9P7F4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	100%
Q9UYX0	Pyrococcus abyssi (strain GE5 / Orsay)	25%	100%
Q9ZUC1	Arabidopsis thaliana	31%	96%
S0DQ98	Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)	30%	100%
S0EJ18	Gibberella fujikuroi (strain CBS 195.34 / IMI 58289 / NRRL A-6831)	26%	100%
V5ALK9	Trypanosoma cruzi	45%	82%