Zinc-binding dehydrogenase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc-binding dehydrogenase-like protein

Species:

Leishmania major

UniProt:

Q4QHF8_LEIMA

TriTrypDb:

LmjF.10.0570 , LMJLV39_100011700 , LMJSD75_100011800

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QHF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHF8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0016491	oxidoreductase activity	2	16
GO:0003960	NADPH:quinone reductase activity	5	1
GO:0016651	oxidoreductase activity, acting on NAD(P)H	3	1
GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	307	311	PF00656	0.392
CLV_NRD_NRD_1	112	114	PF00675	0.641
CLV_NRD_NRD_1	355	357	PF00675	0.382
CLV_NRD_NRD_1	439	441	PF00675	0.500
CLV_NRD_NRD_1	60	62	PF00675	0.381
CLV_PCSK_FUR_1	436	440	PF00082	0.590
CLV_PCSK_KEX2_1	112	114	PF00082	0.569
CLV_PCSK_KEX2_1	355	357	PF00082	0.406
CLV_PCSK_KEX2_1	438	440	PF00082	0.509
CLV_PCSK_KEX2_1	60	62	PF00082	0.483
CLV_PCSK_PC7_1	56	62	PF00082	0.352
CLV_PCSK_SKI1_1	169	173	PF00082	0.332
CLV_PCSK_SKI1_1	247	251	PF00082	0.315
CLV_PCSK_SKI1_1	42	46	PF00082	0.539
CLV_PCSK_SKI1_1	421	425	PF00082	0.340
DEG_APCC_DBOX_1	374	382	PF00400	0.418
DOC_MAPK_FxFP_2	122	125	PF00069	0.392
DOC_MAPK_gen_1	162	172	PF00069	0.471
DOC_MAPK_gen_1	436	444	PF00069	0.578
DOC_MAPK_JIP1_4	30	36	PF00069	0.523
DOC_PP1_RVXF_1	167	173	PF00149	0.342
DOC_PP1_RVXF_1	214	221	PF00149	0.416
DOC_PP4_FxxP_1	122	125	PF00568	0.392
DOC_USP7_MATH_1	142	146	PF00917	0.465
DOC_USP7_MATH_1	155	159	PF00917	0.716
DOC_USP7_MATH_1	25	29	PF00917	0.636
DOC_USP7_MATH_1	275	279	PF00917	0.261
DOC_WW_Pin1_4	276	281	PF00397	0.368
DOC_WW_Pin1_4	344	349	PF00397	0.360
DOC_WW_Pin1_4	99	104	PF00397	0.517
LIG_14-3-3_CanoR_1	283	289	PF00244	0.227
LIG_14-3-3_CanoR_1	355	361	PF00244	0.368
LIG_Actin_WH2_2	14	32	PF00022	0.540
LIG_eIF4E_1	312	318	PF01652	0.370
LIG_EVH1_2	120	124	PF00568	0.410
LIG_FHA_1	207	213	PF00498	0.568
LIG_FHA_1	230	236	PF00498	0.328
LIG_FHA_1	277	283	PF00498	0.224
LIG_FHA_1	341	347	PF00498	0.335
LIG_FHA_1	94	100	PF00498	0.538
LIG_FHA_2	295	301	PF00498	0.277
LIG_FHA_2	305	311	PF00498	0.147
LIG_FHA_2	427	433	PF00498	0.404
LIG_LIR_Apic_2	193	199	PF02991	0.427
LIG_LIR_Gen_1	232	241	PF02991	0.336
LIG_LIR_Gen_1	359	367	PF02991	0.358
LIG_LIR_Nem_3	183	187	PF02991	0.283
LIG_LIR_Nem_3	232	237	PF02991	0.317
LIG_LIR_Nem_3	359	365	PF02991	0.353
LIG_MYND_1	27	31	PF01753	0.624
LIG_NRBOX	341	347	PF00104	0.334
LIG_SH2_NCK_1	187	191	PF00017	0.413
LIG_SH2_NCK_1	296	300	PF00017	0.348
LIG_SH2_NCK_1	445	449	PF00017	0.584
LIG_SH2_PTP2	19	22	PF00017	0.554
LIG_SH2_PTP2	234	237	PF00017	0.307
LIG_SH2_PTP2	362	365	PF00017	0.355
LIG_SH2_SRC	272	275	PF00017	0.273
LIG_SH2_STAP1	308	312	PF00017	0.273
LIG_SH2_STAP1	65	69	PF00017	0.482
LIG_SH2_STAT5	126	129	PF00017	0.360
LIG_SH2_STAT5	19	22	PF00017	0.656
LIG_SH2_STAT5	234	237	PF00017	0.330
LIG_SH2_STAT5	268	271	PF00017	0.310
LIG_SH2_STAT5	272	275	PF00017	0.310
LIG_SH2_STAT5	284	287	PF00017	0.316
LIG_SH2_STAT5	292	295	PF00017	0.332
LIG_SH2_STAT5	296	299	PF00017	0.332
LIG_SH2_STAT5	308	311	PF00017	0.347
LIG_SH2_STAT5	316	319	PF00017	0.254
LIG_SH2_STAT5	362	365	PF00017	0.355
LIG_SH2_STAT5	389	392	PF00017	0.498
LIG_SH3_1	19	25	PF00018	0.548
LIG_SH3_2	118	123	PF14604	0.447
LIG_SH3_3	10	16	PF00018	0.749
LIG_SH3_3	115	121	PF00018	0.549
LIG_SH3_3	19	25	PF00018	0.546
LIG_SH3_3	199	205	PF00018	0.591
LIG_SH3_3	70	76	PF00018	0.417
LIG_SH3_3	97	103	PF00018	0.654
LIG_SUMO_SIM_anti_2	408	415	PF11976	0.392
LIG_TRAF2_1	429	432	PF00917	0.379
LIG_TYR_ITIM	360	365	PF00017	0.371
LIG_WW_1	16	19	PF00397	0.552
MOD_CDK_SPK_2	344	349	PF00069	0.227
MOD_CDK_SPxxK_3	276	283	PF00069	0.273
MOD_CK1_1	108	114	PF00069	0.723
MOD_CK1_1	180	186	PF00069	0.475
MOD_CK1_1	252	258	PF00069	0.275
MOD_CK1_1	276	282	PF00069	0.254
MOD_CK1_1	347	353	PF00069	0.376
MOD_CK1_1	37	43	PF00069	0.512
MOD_CK1_1	7	13	PF00069	0.636
MOD_CK2_1	142	148	PF00069	0.621
MOD_CK2_1	426	432	PF00069	0.337
MOD_CK2_1	64	70	PF00069	0.590
MOD_CK2_1	98	104	PF00069	0.495
MOD_GlcNHglycan	10	13	PF01048	0.656
MOD_GlcNHglycan	107	110	PF01048	0.639
MOD_GlcNHglycan	145	148	PF01048	0.506
MOD_GlcNHglycan	150	154	PF01048	0.525
MOD_GlcNHglycan	157	160	PF01048	0.448
MOD_GlcNHglycan	179	182	PF01048	0.418
MOD_GlcNHglycan	251	254	PF01048	0.332
MOD_GlcNHglycan	259	262	PF01048	0.321
MOD_GlcNHglycan	35	39	PF01048	0.591
MOD_GlcNHglycan	414	417	PF01048	0.473
MOD_GSK3_1	104	111	PF00069	0.599
MOD_GSK3_1	25	32	PF00069	0.655
MOD_GSK3_1	3	10	PF00069	0.677
MOD_GSK3_1	340	347	PF00069	0.398
MOD_GSK3_1	422	429	PF00069	0.522
MOD_GSK3_1	467	474	PF00069	0.626
MOD_N-GLC_1	4	9	PF02516	0.554
MOD_N-GLC_1	54	59	PF02516	0.359
MOD_NEK2_1	177	182	PF00069	0.423
MOD_NEK2_1	34	39	PF00069	0.569
MOD_NEK2_1	373	378	PF00069	0.405
MOD_NEK2_1	412	417	PF00069	0.567
MOD_PIKK_1	242	248	PF00454	0.340
MOD_PIKK_1	373	379	PF00454	0.436
MOD_PIKK_1	454	460	PF00454	0.436
MOD_PK_1	356	362	PF00069	0.392
MOD_PKA_1	112	118	PF00069	0.587
MOD_PKA_2	112	118	PF00069	0.624
MOD_Plk_1	54	60	PF00069	0.519
MOD_Plk_2-3	304	310	PF00069	0.242
MOD_ProDKin_1	276	282	PF00069	0.368
MOD_ProDKin_1	344	350	PF00069	0.360
MOD_ProDKin_1	99	105	PF00069	0.520
TRG_DiLeu_BaEn_2	398	404	PF01217	0.440
TRG_DiLeu_BaLyEn_6	213	218	PF01217	0.513
TRG_ENDOCYTIC_2	187	190	PF00928	0.348
TRG_ENDOCYTIC_2	234	237	PF00928	0.325
TRG_ENDOCYTIC_2	268	271	PF00928	0.254
TRG_ENDOCYTIC_2	362	365	PF00928	0.355
TRG_ER_diArg_1	354	356	PF00400	0.414
TRG_ER_diArg_1	436	439	PF00400	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3I0	Leptomonas seymouri	23%	100%
A0A0N0P5I8	Leptomonas seymouri	45%	100%
A0A0N1I4X2	Leptomonas seymouri	70%	100%
A0A0N1I9E8	Leptomonas seymouri	24%	100%
A0A0N1PDX1	Leptomonas seymouri	24%	100%
A0A0S4ILS9	Bodo saltans	27%	100%
A0A0S4JMB1	Bodo saltans	28%	100%
A0A1X0NRR2	Trypanosomatidae	49%	98%
A0A1X0NZZ5	Trypanosomatidae	23%	100%
A0A3Q8ICJ5	Leishmania donovani	24%	100%
A0A3Q8IRG0	Leishmania donovani	28%	100%
A0A3S7WR50	Leishmania donovani	43%	100%
A0A3S7WR58	Leishmania donovani	95%	100%
A4H648	Leishmania braziliensis	44%	100%
A4H649	Leishmania braziliensis	84%	100%
A4HUG8	Leishmania infantum	43%	100%
A4HUG9	Leishmania infantum	95%	100%
A4I0D8	Leishmania infantum	24%	100%
A4IE56	Leishmania infantum	28%	100%
C9ZVI9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
D7UPN2	Alternaria alternata	27%	100%
E9AN66	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AN67	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
E9ATK1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AWA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
K4BW79	Solanum lycopersicum	27%	100%
P12311	Geobacillus stearothermophilus	25%	100%
Q0VC50	Bos taurus	25%	100%
Q4Q0Z7	Leishmania major	27%	100%
Q4QB77	Leishmania major	24%	100%
Q4QHF9	Leishmania major	42%	100%
Q4W4Z2	Caenorhabditis elegans	26%	100%
Q7T3C7	Danio rerio	23%	100%
Q8BGC4	Mus musculus	23%	100%
Q8H0M1	Spinacia oleracea	26%	100%
Q8JFV8	Danio rerio	26%	99%
Q8KQL2	Enterococcus avium	23%	100%
Q8WWV3	Homo sapiens	25%	100%
Q924D0	Mus musculus	26%	100%
Q99536	Homo sapiens	26%	100%
Q9AYU1	Triphysaria versicolor	24%	100%
Q9P4C2	Kluyveromyces marxianus	26%	100%
Q9SV68	Arabidopsis thaliana	25%	100%
Q9ZUC1	Arabidopsis thaliana	28%	100%
V5ALK9	Trypanosoma cruzi	46%	100%
V5B1P3	Trypanosoma cruzi	28%	100%