Chromatin assembly factor 1 subunit A

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

chromatin assembly factor 1 subunit A, putative

Species:

Leishmania major

UniProt:

Q4QHF7_LEIMA

TriTrypDb:

LmjF.10.0580 , LMJLV39_100011800 , LMJSD75_100011900

Length:

807

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4QHF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHF7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	174	178	PF00656	0.452
CLV_C14_Caspase3-7	196	200	PF00656	0.515
CLV_C14_Caspase3-7	451	455	PF00656	0.432
CLV_C14_Caspase3-7	459	463	PF00656	0.564
CLV_C14_Caspase3-7	473	477	PF00656	0.605
CLV_C14_Caspase3-7	723	727	PF00656	0.594
CLV_C14_Caspase3-7	796	800	PF00656	0.652
CLV_MEL_PAP_1	657	663	PF00089	0.610
CLV_NRD_NRD_1	150	152	PF00675	0.598
CLV_NRD_NRD_1	162	164	PF00675	0.454
CLV_NRD_NRD_1	178	180	PF00675	0.380
CLV_NRD_NRD_1	190	192	PF00675	0.426
CLV_NRD_NRD_1	200	202	PF00675	0.503
CLV_NRD_NRD_1	267	269	PF00675	0.607
CLV_NRD_NRD_1	295	297	PF00675	0.669
CLV_NRD_NRD_1	35	37	PF00675	0.332
CLV_NRD_NRD_1	419	421	PF00675	0.304
CLV_NRD_NRD_1	482	484	PF00675	0.505
CLV_NRD_NRD_1	491	493	PF00675	0.509
CLV_NRD_NRD_1	584	586	PF00675	0.547
CLV_NRD_NRD_1	633	635	PF00675	0.511
CLV_NRD_NRD_1	638	640	PF00675	0.502
CLV_NRD_NRD_1	664	666	PF00675	0.781
CLV_NRD_NRD_1	684	686	PF00675	0.552
CLV_PCSK_FUR_1	151	155	PF00082	0.411
CLV_PCSK_FUR_1	489	493	PF00082	0.504
CLV_PCSK_KEX2_1	150	152	PF00082	0.532
CLV_PCSK_KEX2_1	153	155	PF00082	0.516
CLV_PCSK_KEX2_1	161	163	PF00082	0.649
CLV_PCSK_KEX2_1	190	192	PF00082	0.575
CLV_PCSK_KEX2_1	256	258	PF00082	0.564
CLV_PCSK_KEX2_1	267	269	PF00082	0.583
CLV_PCSK_KEX2_1	295	297	PF00082	0.669
CLV_PCSK_KEX2_1	35	37	PF00082	0.356
CLV_PCSK_KEX2_1	419	421	PF00082	0.304
CLV_PCSK_KEX2_1	491	493	PF00082	0.517
CLV_PCSK_KEX2_1	571	573	PF00082	0.579
CLV_PCSK_KEX2_1	584	586	PF00082	0.477
CLV_PCSK_KEX2_1	633	635	PF00082	0.520
CLV_PCSK_KEX2_1	638	640	PF00082	0.528
CLV_PCSK_KEX2_1	686	688	PF00082	0.537
CLV_PCSK_KEX2_1	786	788	PF00082	0.655
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.415
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.548
CLV_PCSK_PC1ET2_1	571	573	PF00082	0.565
CLV_PCSK_PC1ET2_1	686	688	PF00082	0.537
CLV_PCSK_PC1ET2_1	786	788	PF00082	0.655
CLV_PCSK_PC7_1	415	421	PF00082	0.304
CLV_PCSK_PC7_1	634	640	PF00082	0.567
CLV_PCSK_SKI1_1	150	154	PF00082	0.560
CLV_PCSK_SKI1_1	162	166	PF00082	0.496
CLV_PCSK_SKI1_1	190	194	PF00082	0.579
CLV_PCSK_SKI1_1	216	220	PF00082	0.607
CLV_PCSK_SKI1_1	349	353	PF00082	0.563
CLV_PCSK_SKI1_1	585	589	PF00082	0.601
CLV_PCSK_SKI1_1	765	769	PF00082	0.614
DEG_COP1_1	694	705	PF00400	0.538
DEG_Nend_Nbox_1	1	3	PF02207	0.423
DEG_SCF_FBW7_1	732	738	PF00400	0.653
DEG_SCF_SKP2-CKS1_1	319	326	PF00560	0.489
DEG_SPOP_SBC_1	448	452	PF00917	0.360
DEG_SPOP_SBC_1	81	85	PF00917	0.634
DOC_CKS1_1	732	737	PF01111	0.652
DOC_CYCLIN_RxL_1	638	648	PF00134	0.608
DOC_MAPK_gen_1	638	645	PF00069	0.599
DOC_MAPK_MEF2A_6	615	623	PF00069	0.564
DOC_MAPK_MEF2A_6	90	97	PF00069	0.508
DOC_PP1_RVXF_1	26	32	PF00149	0.325
DOC_PP2B_LxvP_1	313	316	PF13499	0.644
DOC_USP7_MATH_1	130	134	PF00917	0.634
DOC_USP7_MATH_1	298	302	PF00917	0.668
DOC_USP7_MATH_1	361	365	PF00917	0.585
DOC_USP7_MATH_1	366	370	PF00917	0.556
DOC_USP7_MATH_1	386	390	PF00917	0.522
DOC_USP7_MATH_1	448	452	PF00917	0.302
DOC_USP7_MATH_1	460	464	PF00917	0.564
DOC_USP7_MATH_1	547	551	PF00917	0.583
DOC_USP7_MATH_1	600	604	PF00917	0.571
DOC_USP7_MATH_1	659	663	PF00917	0.629
DOC_USP7_MATH_1	719	723	PF00917	0.694
DOC_USP7_MATH_1	75	79	PF00917	0.662
DOC_USP7_MATH_1	774	778	PF00917	0.691
DOC_USP7_MATH_1	81	85	PF00917	0.659
DOC_USP7_MATH_1	88	92	PF00917	0.594
DOC_USP7_UBL2_3	216	220	PF12436	0.546
DOC_USP7_UBL2_3	771	775	PF12436	0.644
DOC_WW_Pin1_4	136	141	PF00397	0.702
DOC_WW_Pin1_4	247	252	PF00397	0.609
DOC_WW_Pin1_4	320	325	PF00397	0.556
DOC_WW_Pin1_4	648	653	PF00397	0.634
DOC_WW_Pin1_4	666	671	PF00397	0.534
DOC_WW_Pin1_4	731	736	PF00397	0.654
DOC_WW_Pin1_4	745	750	PF00397	0.536
DOC_WW_Pin1_4	770	775	PF00397	0.605
DOC_WW_Pin1_4	89	94	PF00397	0.560
LIG_14-3-3_CanoR_1	28	34	PF00244	0.324
LIG_14-3-3_CanoR_1	638	644	PF00244	0.604
LIG_14-3-3_CanoR_1	660	667	PF00244	0.674
LIG_Actin_WH2_2	34	51	PF00022	0.370
LIG_Actin_WH2_2	406	421	PF00022	0.371
LIG_BRCT_BRCA1_1	506	510	PF00533	0.523
LIG_CSL_BTD_1	649	652	PF09270	0.613
LIG_FHA_1	106	112	PF00498	0.604
LIG_FHA_1	278	284	PF00498	0.616
LIG_FHA_1	4	10	PF00498	0.363
LIG_FHA_1	605	611	PF00498	0.533
LIG_FHA_1	673	679	PF00498	0.649
LIG_FHA_1	762	768	PF00498	0.685
LIG_FHA_2	120	126	PF00498	0.611
LIG_FHA_2	194	200	PF00498	0.537
LIG_FHA_2	41	47	PF00498	0.403
LIG_FHA_2	457	463	PF00498	0.574
LIG_FHA_2	586	592	PF00498	0.711
LIG_FHA_2	695	701	PF00498	0.646
LIG_FHA_2	711	717	PF00498	0.727
LIG_FHA_2	732	738	PF00498	0.702
LIG_LIR_Apic_2	14	19	PF02991	0.356
LIG_LIR_Apic_2	505	509	PF02991	0.595
LIG_LIR_Gen_1	333	340	PF02991	0.583
LIG_LIR_Gen_1	364	375	PF02991	0.584
LIG_LIR_Gen_1	396	405	PF02991	0.360
LIG_LIR_Gen_1	436	445	PF02991	0.333
LIG_LIR_Nem_3	230	235	PF02991	0.590
LIG_LIR_Nem_3	364	370	PF02991	0.537
LIG_LIR_Nem_3	373	379	PF02991	0.506
LIG_LIR_Nem_3	396	400	PF02991	0.360
LIG_LIR_Nem_3	507	513	PF02991	0.520
LIG_LIR_Nem_3	527	532	PF02991	0.385
LIG_LIR_Nem_3	655	661	PF02991	0.647
LIG_PCNA_yPIPBox_3	223	235	PF02747	0.495
LIG_Pex14_2	376	380	PF04695	0.597
LIG_PTB_Apo_2	424	431	PF02174	0.300
LIG_PTB_Phospho_1	424	430	PF10480	0.300
LIG_RPA_C_Fungi	634	646	PF08784	0.593
LIG_SH2_CRK	506	510	PF00017	0.583
LIG_SH2_STAT5	16	19	PF00017	0.376
LIG_SH2_STAT5	23	26	PF00017	0.339
LIG_SH2_STAT5	318	321	PF00017	0.610
LIG_SH2_STAT5	393	396	PF00017	0.300
LIG_SH2_STAT5	536	539	PF00017	0.525
LIG_SH3_1	646	652	PF00018	0.610
LIG_SH3_3	360	366	PF00018	0.603
LIG_SH3_3	508	514	PF00018	0.580
LIG_SH3_3	646	652	PF00018	0.611
LIG_SH3_3	664	670	PF00018	0.718
LIG_SH3_3	69	75	PF00018	0.597
LIG_SH3_3	729	735	PF00018	0.648
LIG_SH3_3	744	750	PF00018	0.522
LIG_SUMO_SIM_anti_2	57	65	PF11976	0.501
LIG_SUMO_SIM_par_1	764	770	PF11976	0.577
LIG_TRAF2_1	122	125	PF00917	0.602
LIG_TRAF2_1	139	142	PF00917	0.376
LIG_TRAF2_1	276	279	PF00917	0.515
LIG_TRAF2_1	564	567	PF00917	0.517
LIG_TRAF2_1	738	741	PF00917	0.697
LIG_TRAF2_1	788	791	PF00917	0.625
LIG_TRFH_1	15	19	PF08558	0.358
LIG_UBA3_1	231	240	PF00899	0.638
LIG_UBA3_1	62	67	PF00899	0.630
LIG_WRC_WIRS_1	12	17	PF05994	0.352
LIG_WRC_WIRS_1	367	372	PF05994	0.580
LIG_WW_1	315	318	PF00397	0.618
MOD_CDK_SPK_2	770	775	PF00069	0.605
MOD_CDK_SPxK_1	320	326	PF00069	0.487
MOD_CDK_SPxxK_3	136	143	PF00069	0.588
MOD_CK1_1	450	456	PF00069	0.306
MOD_CK1_1	463	469	PF00069	0.593
MOD_CK1_1	603	609	PF00069	0.569
MOD_CK1_1	65	71	PF00069	0.522
MOD_CK1_1	748	754	PF00069	0.689
MOD_CK1_1	83	89	PF00069	0.690
MOD_CK2_1	111	117	PF00069	0.636
MOD_CK2_1	119	125	PF00069	0.516
MOD_CK2_1	136	142	PF00069	0.424
MOD_CK2_1	271	277	PF00069	0.605
MOD_CK2_1	40	46	PF00069	0.376
MOD_CK2_1	464	470	PF00069	0.709
MOD_CK2_1	555	561	PF00069	0.642
MOD_CK2_1	585	591	PF00069	0.718
MOD_CK2_1	731	737	PF00069	0.726
MOD_CK2_1	748	754	PF00069	0.649
MOD_CK2_1	81	87	PF00069	0.742
MOD_CK2_1	88	94	PF00069	0.708
MOD_Cter_Amidation	683	686	PF01082	0.556
MOD_GlcNHglycan	119	122	PF01048	0.675
MOD_GlcNHglycan	433	436	PF01048	0.300
MOD_GlcNHglycan	506	509	PF01048	0.528
MOD_GlcNHglycan	549	552	PF01048	0.600
MOD_GlcNHglycan	563	566	PF01048	0.548
MOD_GlcNHglycan	715	720	PF01048	0.640
MOD_GlcNHglycan	751	754	PF01048	0.803
MOD_GlcNHglycan	776	779	PF01048	0.693
MOD_GSK3_1	105	112	PF00069	0.593
MOD_GSK3_1	273	280	PF00069	0.627
MOD_GSK3_1	448	455	PF00069	0.324
MOD_GSK3_1	456	463	PF00069	0.594
MOD_GSK3_1	474	481	PF00069	0.545
MOD_GSK3_1	594	601	PF00069	0.576
MOD_GSK3_1	672	679	PF00069	0.787
MOD_GSK3_1	715	722	PF00069	0.772
MOD_GSK3_1	731	738	PF00069	0.754
MOD_GSK3_1	745	752	PF00069	0.637
MOD_GSK3_1	761	768	PF00069	0.716
MOD_GSK3_1	770	777	PF00069	0.646
MOD_GSK3_1	799	806	PF00069	0.652
MOD_N-GLC_1	227	232	PF02516	0.488
MOD_N-GLC_1	283	288	PF02516	0.675
MOD_N-GLC_1	497	502	PF02516	0.572
MOD_N-GLC_2	328	330	PF02516	0.480
MOD_NEK2_1	111	116	PF00069	0.724
MOD_NEK2_1	234	239	PF00069	0.642
MOD_NEK2_1	29	34	PF00069	0.343
MOD_NEK2_1	62	67	PF00069	0.517
MOD_PIKK_1	478	484	PF00454	0.536
MOD_PIKK_1	604	610	PF00454	0.416
MOD_PKA_2	423	429	PF00069	0.391
MOD_PKA_2	659	665	PF00069	0.622
MOD_PKB_1	495	503	PF00069	0.560
MOD_Plk_1	227	233	PF00069	0.488
MOD_Plk_1	277	283	PF00069	0.650
MOD_Plk_1	307	313	PF00069	0.621
MOD_Plk_1	628	634	PF00069	0.535
MOD_Plk_1	703	709	PF00069	0.691
MOD_Plk_2-3	474	480	PF00069	0.541
MOD_Plk_2-3	694	700	PF00069	0.641
MOD_Plk_4	227	233	PF00069	0.585
MOD_Plk_4	278	284	PF00069	0.646
MOD_Plk_4	308	314	PF00069	0.642
MOD_Plk_4	594	600	PF00069	0.580
MOD_Plk_4	756	762	PF00069	0.690
MOD_ProDKin_1	136	142	PF00069	0.695
MOD_ProDKin_1	247	253	PF00069	0.608
MOD_ProDKin_1	320	326	PF00069	0.554
MOD_ProDKin_1	648	654	PF00069	0.625
MOD_ProDKin_1	666	672	PF00069	0.539
MOD_ProDKin_1	731	737	PF00069	0.656
MOD_ProDKin_1	745	751	PF00069	0.541
MOD_ProDKin_1	770	776	PF00069	0.606
MOD_ProDKin_1	89	95	PF00069	0.560
MOD_SUMO_for_1	152	155	PF00179	0.570
MOD_SUMO_for_1	164	167	PF00179	0.502
MOD_SUMO_for_1	172	175	PF00179	0.460
MOD_SUMO_for_1	239	242	PF00179	0.641
MOD_SUMO_for_1	755	758	PF00179	0.687
MOD_SUMO_rev_2	139	146	PF00179	0.488
MOD_SUMO_rev_2	184	189	PF00179	0.458
MOD_SUMO_rev_2	586	595	PF00179	0.573
MOD_SUMO_rev_2	748	757	PF00179	0.691
TRG_DiLeu_BaEn_1	167	172	PF01217	0.523
TRG_DiLeu_BaEn_1	308	313	PF01217	0.622
TRG_DiLeu_BaEn_1	58	63	PF01217	0.478
TRG_DiLeu_BaEn_2	524	530	PF01217	0.474
TRG_DiLeu_BaEn_4	308	314	PF01217	0.622
TRG_ENDOCYTIC_2	30	33	PF00928	0.345
TRG_ENDOCYTIC_2	367	370	PF00928	0.575
TRG_ENDOCYTIC_2	397	400	PF00928	0.360
TRG_ER_diArg_1	161	163	PF00400	0.549
TRG_ER_diArg_1	190	192	PF00400	0.527
TRG_ER_diArg_1	266	268	PF00400	0.588
TRG_ER_diArg_1	35	37	PF00400	0.332
TRG_ER_diArg_1	418	420	PF00400	0.304
TRG_ER_diArg_1	489	492	PF00400	0.516
TRG_ER_diArg_1	632	634	PF00400	0.599
TRG_ER_diArg_1	638	641	PF00400	0.591
TRG_NLS_MonoCore_2	664	669	PF00514	0.629
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	349	354	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	483	487	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	574	578	PF00026	0.585

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6G0	Leptomonas seymouri	55%	100%
A0A1X0NRX9	Trypanosomatidae	34%	99%
A0A3S5H6G3	Leishmania donovani	93%	100%
A4H650	Leishmania braziliensis	77%	100%
A4HUH0	Leishmania infantum	93%	100%
E9AN68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%