MAGE domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHF6_LEIMA

TriTrypDb:

LmjF.10.0590 , LMJLV39_100011900 , LMJSD75_100012000

Length:

267

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QHF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHF6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	72	76	PF00656	0.592
CLV_NRD_NRD_1	46	48	PF00675	0.535
CLV_PCSK_SKI1_1	143	147	PF00082	0.417
CLV_PCSK_SKI1_1	20	24	PF00082	0.755
CLV_PCSK_SKI1_1	232	236	PF00082	0.596
CLV_PCSK_SKI1_1	48	52	PF00082	0.577
DEG_APCC_DBOX_1	138	146	PF00400	0.375
DEG_SPOP_SBC_1	177	181	PF00917	0.396
DEG_SPOP_SBC_1	68	72	PF00917	0.472
DOC_CYCLIN_RxL_1	139	148	PF00134	0.377
DOC_MAPK_gen_1	139	147	PF00069	0.400
DOC_MAPK_gen_1	78	87	PF00069	0.427
DOC_MAPK_MEF2A_6	141	149	PF00069	0.389
DOC_MAPK_MEF2A_6	89	98	PF00069	0.285
DOC_PP1_RVXF_1	78	85	PF00149	0.577
DOC_PP1_RVXF_1	87	93	PF00149	0.383
DOC_PP2B_LxvP_1	40	43	PF13499	0.453
DOC_USP7_MATH_1	111	115	PF00917	0.550
DOC_USP7_MATH_1	5	9	PF00917	0.631
DOC_USP7_MATH_1	57	61	PF00917	0.470
DOC_USP7_MATH_1	68	72	PF00917	0.650
DOC_USP7_UBL2_3	15	19	PF12436	0.585
DOC_USP7_UBL2_3	44	48	PF12436	0.412
DOC_USP7_UBL2_3	6	10	PF12436	0.702
LIG_14-3-3_CanoR_1	172	177	PF00244	0.401
LIG_14-3-3_CanoR_1	80	85	PF00244	0.418
LIG_14-3-3_CanoR_1	89	95	PF00244	0.308
LIG_BIR_II_1	1	5	PF00653	0.656
LIG_FHA_1	142	148	PF00498	0.443
LIG_FHA_1	150	156	PF00498	0.366
LIG_FHA_1	224	230	PF00498	0.520
LIG_FHA_1	37	43	PF00498	0.504
LIG_FHA_2	179	185	PF00498	0.496
LIG_FHA_2	233	239	PF00498	0.441
LIG_LIR_Gen_1	187	195	PF02991	0.398
LIG_LIR_Gen_1	83	91	PF02991	0.374
LIG_LIR_Nem_3	187	192	PF02991	0.399
LIG_LIR_Nem_3	241	246	PF02991	0.457
LIG_LIR_Nem_3	83	87	PF02991	0.388
LIG_NRBOX	141	147	PF00104	0.426
LIG_NRBOX	216	222	PF00104	0.454
LIG_Pex14_2	189	193	PF04695	0.403
LIG_Pex14_2	259	263	PF04695	0.470
LIG_SH2_STAT3	157	160	PF00017	0.472
LIG_SH2_STAT3	32	35	PF00017	0.502
LIG_SH2_STAT5	243	246	PF00017	0.448
LIG_SH2_STAT5	41	44	PF00017	0.496
LIG_SH3_2	167	172	PF14604	0.484
LIG_SH3_3	127	133	PF00018	0.618
LIG_SH3_3	164	170	PF00018	0.424
LIG_SH3_3	22	28	PF00018	0.566
LIG_SH3_4	6	13	PF00018	0.617
LIG_SUMO_SIM_par_1	143	148	PF11976	0.370
MOD_CK2_1	176	182	PF00069	0.548
MOD_CK2_1	232	238	PF00069	0.516
MOD_Cter_Amidation	12	15	PF01082	0.635
MOD_GlcNHglycan	120	124	PF01048	0.632
MOD_GlcNHglycan	59	62	PF01048	0.370
MOD_GSK3_1	111	118	PF00069	0.587
MOD_GSK3_1	149	156	PF00069	0.497
MOD_GSK3_1	172	179	PF00069	0.524
MOD_GSK3_1	228	235	PF00069	0.693
MOD_GSK3_1	63	70	PF00069	0.491
MOD_NEK2_1	149	154	PF00069	0.488
MOD_NEK2_1	36	41	PF00069	0.505
MOD_NEK2_1	63	68	PF00069	0.405
MOD_PIKK_1	111	117	PF00454	0.585
MOD_PIKK_1	5	11	PF00454	0.634
MOD_PIKK_1	69	75	PF00454	0.557
MOD_PK_1	172	178	PF00069	0.445
MOD_PKA_2	171	177	PF00069	0.484
MOD_PKB_1	78	86	PF00069	0.437
MOD_Plk_1	36	42	PF00069	0.621
MOD_Plk_4	172	178	PF00069	0.448
MOD_Plk_4	36	42	PF00069	0.621
TRG_ENDOCYTIC_2	243	246	PF00928	0.448
TRG_NLS_MonoExtC_3	46	52	PF00514	0.395
TRG_NLS_MonoExtN_4	44	51	PF00514	0.404
TRG_Pf-PMV_PEXEL_1	143	148	PF00026	0.370
TRG_Pf-PMV_PEXEL_1	232	236	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKR2	Leptomonas seymouri	44%	100%
A0A3Q8I8T9	Leishmania donovani	94%	100%
A0A3R7KUI1	Trypanosoma rangeli	26%	87%
A4H651	Leishmania braziliensis	68%	100%
A4HUH1	Leishmania infantum	93%	100%
E9AI41	Leishmania braziliensis	73%	100%
E9AN69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5B6H6	Trypanosoma cruzi	25%	86%