Putative endonuclease G

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endonuclease G, putative

Species:

Leishmania major

UniProt:

Q4QHF4_LEIMA

TriTrypDb:

LmjF.10.0610 , LMJLV39_100012200 , LMJSD75_100012300

Length:

502

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 9
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005743	mitochondrial inner membrane	5	2
GO:0016020	membrane	2	3
GO:0019866	organelle inner membrane	4	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QHF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHF4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000014	single-stranded DNA endodeoxyribonuclease activity	6	2
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004518	nuclease activity	4	12
GO:0004519	endonuclease activity	5	12
GO:0004520	DNA endonuclease activity	5	2
GO:0004521	RNA endonuclease activity	5	2
GO:0004536	DNA nuclease activity	4	2
GO:0004540	RNA nuclease activity	4	2
GO:0005488	binding	1	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	2
GO:0140098	catalytic activity, acting on RNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.509
CLV_C14_Caspase3-7	324	328	PF00656	0.467
CLV_NRD_NRD_1	123	125	PF00675	0.228
CLV_NRD_NRD_1	135	137	PF00675	0.228
CLV_NRD_NRD_1	142	144	PF00675	0.228
CLV_NRD_NRD_1	252	254	PF00675	0.263
CLV_PCSK_KEX2_1	123	125	PF00082	0.228
CLV_PCSK_KEX2_1	142	144	PF00082	0.228
CLV_PCSK_KEX2_1	28	30	PF00082	0.451
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.482
CLV_PCSK_SKI1_1	365	369	PF00082	0.233
DEG_APCC_DBOX_1	352	360	PF00400	0.399
DEG_Nend_Nbox_1	1	3	PF02207	0.154
DOC_CKS1_1	77	82	PF01111	0.570
DOC_CYCLIN_yCln2_LP_2	69	75	PF00134	0.604
DOC_MAPK_gen_1	253	261	PF00069	0.508
DOC_MAPK_gen_1	28	34	PF00069	0.655
DOC_MAPK_MEF2A_6	334	343	PF00069	0.515
DOC_PP4_FxxP_1	382	385	PF00568	0.428
DOC_USP7_MATH_1	150	154	PF00917	0.490
DOC_USP7_MATH_1	289	293	PF00917	0.528
DOC_USP7_MATH_1	322	326	PF00917	0.533
DOC_USP7_MATH_1	332	336	PF00917	0.320
DOC_USP7_MATH_1	358	362	PF00917	0.513
DOC_USP7_MATH_1	36	40	PF00917	0.701
DOC_USP7_MATH_1	433	437	PF00917	0.638
DOC_USP7_MATH_1	450	454	PF00917	0.456
DOC_USP7_MATH_1	46	50	PF00917	0.743
DOC_USP7_MATH_1	82	86	PF00917	0.645
DOC_WW_Pin1_4	143	148	PF00397	0.516
DOC_WW_Pin1_4	274	279	PF00397	0.513
DOC_WW_Pin1_4	76	81	PF00397	0.583
LIG_14-3-3_CanoR_1	38	48	PF00244	0.688
LIG_BIR_III_2	432	436	PF00653	0.622
LIG_BRCT_BRCA1_1	360	364	PF00533	0.513
LIG_BRCT_BRCA1_1	435	439	PF00533	0.622
LIG_Clathr_ClatBox_1	307	311	PF01394	0.515
LIG_FHA_1	104	110	PF00498	0.515
LIG_FHA_1	250	256	PF00498	0.450
LIG_FHA_1	28	34	PF00498	0.674
LIG_FHA_1	342	348	PF00498	0.494
LIG_FHA_2	282	288	PF00498	0.399
LIG_Integrin_RGD_1	64	66	PF01839	0.441
LIG_LIR_Apic_2	396	401	PF02991	0.454
LIG_LIR_Gen_1	244	251	PF02991	0.440
LIG_LIR_LC3C_4	30	34	PF02991	0.619
LIG_LIR_Nem_3	134	138	PF02991	0.554
LIG_LIR_Nem_3	17	22	PF02991	0.402
LIG_LIR_Nem_3	244	248	PF02991	0.440
LIG_LIR_Nem_3	361	367	PF02991	0.428
LIG_LIR_Nem_3	436	442	PF02991	0.554
LIG_NRP_CendR_1	501	502	PF00754	0.400
LIG_SH2_CRK	135	139	PF00017	0.513
LIG_SH2_CRK	398	402	PF00017	0.440
LIG_SH2_CRK	442	446	PF00017	0.524
LIG_SH2_CRK	461	465	PF00017	0.480
LIG_SH2_STAP1	121	125	PF00017	0.440
LIG_SH2_STAP1	22	26	PF00017	0.705
LIG_SH2_STAT3	22	25	PF00017	0.690
LIG_SH2_STAT5	115	118	PF00017	0.497
LIG_SH2_STAT5	200	203	PF00017	0.464
LIG_SH2_STAT5	296	299	PF00017	0.525
LIG_SH3_3	141	147	PF00018	0.543
LIG_SH3_3	295	301	PF00018	0.435
LIG_SH3_3	30	36	PF00018	0.629
LIG_SH3_3	316	322	PF00018	0.466
LIG_SH3_3	354	360	PF00018	0.525
LIG_SH3_3	382	388	PF00018	0.428
LIG_SH3_3	70	76	PF00018	0.589
LIG_SUMO_SIM_par_1	355	361	PF11976	0.529
LIG_TYR_ITIM	133	138	PF00017	0.558
LIG_WW_3	75	79	PF00397	0.539
MOD_CK1_1	167	173	PF00069	0.558
MOD_CK1_1	198	204	PF00069	0.523
MOD_CK1_1	27	33	PF00069	0.676
MOD_CK1_1	39	45	PF00069	0.693
MOD_CK1_1	49	55	PF00069	0.756
MOD_CK1_1	59	65	PF00069	0.741
MOD_CK1_1	85	91	PF00069	0.546
MOD_CK2_1	102	108	PF00069	0.523
MOD_CK2_1	216	222	PF00069	0.442
MOD_CK2_1	281	287	PF00069	0.399
MOD_Cter_Amidation	140	143	PF01082	0.267
MOD_DYRK1A_RPxSP_1	143	147	PF00069	0.513
MOD_GlcNHglycan	291	294	PF01048	0.309
MOD_GlcNHglycan	324	327	PF01048	0.279
MOD_GlcNHglycan	328	331	PF01048	0.270
MOD_GlcNHglycan	334	337	PF01048	0.257
MOD_GlcNHglycan	435	438	PF01048	0.389
MOD_GlcNHglycan	466	469	PF01048	0.422
MOD_GlcNHglycan	51	54	PF01048	0.478
MOD_GSK3_1	14	21	PF00069	0.339
MOD_GSK3_1	174	181	PF00069	0.483
MOD_GSK3_1	195	202	PF00069	0.479
MOD_GSK3_1	249	256	PF00069	0.496
MOD_GSK3_1	322	329	PF00069	0.455
MOD_GSK3_1	341	348	PF00069	0.525
MOD_GSK3_1	36	43	PF00069	0.667
MOD_GSK3_1	52	59	PF00069	0.675
MOD_N-GLC_1	178	183	PF02516	0.341
MOD_N-GLC_1	281	286	PF02516	0.199
MOD_NEK2_1	14	19	PF00069	0.325
MOD_NEK2_1	223	228	PF00069	0.440
MOD_NEK2_1	40	45	PF00069	0.718
MOD_NEK2_1	417	422	PF00069	0.609
MOD_NEK2_1	464	469	PF00069	0.614
MOD_PIKK_1	21	27	PF00454	0.677
MOD_PIKK_1	216	222	PF00454	0.494
MOD_PIKK_1	56	62	PF00454	0.725
MOD_PK_1	257	263	PF00069	0.513
MOD_PKA_1	142	148	PF00069	0.513
MOD_PKA_1	253	259	PF00069	0.494
MOD_PKA_2	142	148	PF00069	0.513
MOD_PKA_2	352	358	PF00069	0.399
MOD_PKA_2	406	412	PF00069	0.464
MOD_PKA_2	433	439	PF00069	0.568
MOD_Plk_1	185	191	PF00069	0.450
MOD_Plk_1	223	229	PF00069	0.464
MOD_Plk_1	236	242	PF00069	0.384
MOD_Plk_1	257	263	PF00069	0.525
MOD_Plk_1	417	423	PF00069	0.587
MOD_Plk_4	352	358	PF00069	0.484
MOD_ProDKin_1	143	149	PF00069	0.516
MOD_ProDKin_1	274	280	PF00069	0.513
MOD_ProDKin_1	76	82	PF00069	0.587
TRG_DiLeu_BaLyEn_6	1	6	PF01217	0.267
TRG_ENDOCYTIC_2	135	138	PF00928	0.540
TRG_ENDOCYTIC_2	442	445	PF00928	0.503
TRG_ENDOCYTIC_2	461	464	PF00928	0.512
TRG_ER_diArg_1	123	125	PF00400	0.477
TRG_ER_diArg_1	142	144	PF00400	0.428
TRG_NES_CRM1_1	249	265	PF08389	0.525
TRG_Pf-PMV_PEXEL_1	253	258	PF00026	0.313

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK94	Leptomonas seymouri	62%	100%
A0A0S4JFH6	Bodo saltans	37%	100%
A0A1X0NQR8	Trypanosomatidae	39%	100%
A0A3Q8I8T5	Leishmania donovani	94%	99%
A0A422NX36	Trypanosoma rangeli	40%	100%
A4H653	Leishmania braziliensis	83%	100%
A4HUH3	Leishmania infantum	94%	99%
C9ZVJ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	99%
E9AN71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
Q0IH72	Xenopus laevis	26%	100%
Q502K1	Danio rerio	28%	100%
Q8C163	Mus musculus	25%	100%
Q9Y2C4	Homo sapiens	25%	100%
V5BJI6	Trypanosoma cruzi	40%	100%