Fibronectin type-III domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FLA1-binding protein

Species:

Leishmania major

UniProt:

Q4QHF3_LEIMA

TriTrypDb:

LmjF.10.0620 , LMJLV39_100012300 , LMJSD75_100012400

Length:

757

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 3
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	12
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QHF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHF3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	317	321	PF00656	0.403
CLV_C14_Caspase3-7	610	614	PF00656	0.471
CLV_C14_Caspase3-7	615	619	PF00656	0.467
CLV_C14_Caspase3-7	72	76	PF00656	0.307
CLV_NRD_NRD_1	6	8	PF00675	0.739
CLV_NRD_NRD_1	689	691	PF00675	0.737
CLV_NRD_NRD_1	723	725	PF00675	0.439
CLV_PCSK_KEX2_1	6	8	PF00082	0.735
CLV_PCSK_KEX2_1	721	723	PF00082	0.425
CLV_PCSK_PC1ET2_1	721	723	PF00082	0.425
CLV_PCSK_SKI1_1	488	492	PF00082	0.559
CLV_PCSK_SKI1_1	724	728	PF00082	0.540
DEG_APCC_DBOX_1	721	729	PF00400	0.638
DEG_ODPH_VHL_1	238	249	PF01847	0.367
DEG_SPOP_SBC_1	230	234	PF00917	0.431
DEG_SPOP_SBC_1	27	31	PF00917	0.529
DEG_SPOP_SBC_1	283	287	PF00917	0.451
DOC_CKS1_1	439	444	PF01111	0.429
DOC_CYCLIN_yClb5_NLxxxL_5	468	477	PF00134	0.298
DOC_CYCLIN_yCln2_LP_2	491	497	PF00134	0.364
DOC_CYCLIN_yCln2_LP_2	517	523	PF00134	0.366
DOC_MAPK_MEF2A_6	12	21	PF00069	0.520
DOC_PP2B_LxvP_1	517	520	PF13499	0.325
DOC_PP2B_LxvP_1	639	642	PF13499	0.364
DOC_PP4_FxxP_1	237	240	PF00568	0.380
DOC_PP4_FxxP_1	462	465	PF00568	0.387
DOC_USP7_MATH_1	131	135	PF00917	0.470
DOC_USP7_MATH_1	230	234	PF00917	0.392
DOC_USP7_MATH_1	284	288	PF00917	0.406
DOC_USP7_MATH_1	437	441	PF00917	0.427
DOC_USP7_MATH_1	56	60	PF00917	0.359
DOC_USP7_MATH_1	701	705	PF00917	0.456
DOC_WW_Pin1_4	275	280	PF00397	0.340
DOC_WW_Pin1_4	321	326	PF00397	0.495
DOC_WW_Pin1_4	365	370	PF00397	0.442
DOC_WW_Pin1_4	406	411	PF00397	0.452
DOC_WW_Pin1_4	438	443	PF00397	0.423
DOC_WW_Pin1_4	535	540	PF00397	0.456
DOC_WW_Pin1_4	557	562	PF00397	0.468
LIG_14-3-3_CanoR_1	130	138	PF00244	0.489
LIG_14-3-3_CanoR_1	428	434	PF00244	0.472
LIG_14-3-3_CanoR_1	723	729	PF00244	0.768
LIG_14-3-3_CanoR_1	94	99	PF00244	0.368
LIG_BRCT_BRCA1_1	212	216	PF00533	0.343
LIG_BRCT_BRCA1_1	222	226	PF00533	0.304
LIG_BRCT_BRCA1_1	233	237	PF00533	0.260
LIG_BRCT_BRCA1_1	249	253	PF00533	0.429
LIG_BRCT_BRCA1_1	323	327	PF00533	0.354
LIG_BRCT_BRCA1_1	425	429	PF00533	0.375
LIG_BRCT_BRCA1_1	439	443	PF00533	0.262
LIG_BRCT_BRCA1_1	529	533	PF00533	0.540
LIG_BRCT_BRCA1_1	86	90	PF00533	0.396
LIG_deltaCOP1_diTrp_1	243	253	PF00928	0.315
LIG_deltaCOP1_diTrp_1	413	421	PF00928	0.391
LIG_EH_1	62	66	PF12763	0.354
LIG_FHA_1	137	143	PF00498	0.469
LIG_FHA_1	239	245	PF00498	0.397
LIG_FHA_1	276	282	PF00498	0.441
LIG_FHA_1	284	290	PF00498	0.366
LIG_FHA_1	336	342	PF00498	0.412
LIG_FHA_1	407	413	PF00498	0.375
LIG_FHA_1	418	424	PF00498	0.288
LIG_FHA_1	455	461	PF00498	0.396
LIG_FHA_1	472	478	PF00498	0.329
LIG_FHA_1	547	553	PF00498	0.395
LIG_FHA_1	635	641	PF00498	0.376
LIG_FHA_1	676	682	PF00498	0.433
LIG_FHA_1	692	698	PF00498	0.456
LIG_FHA_1	740	746	PF00498	0.740
LIG_FHA_1	77	83	PF00498	0.328
LIG_FHA_2	172	178	PF00498	0.306
LIG_FHA_2	259	265	PF00498	0.325
LIG_FHA_2	358	364	PF00498	0.484
LIG_FHA_2	608	614	PF00498	0.546
LIG_FHA_2	72	78	PF00498	0.449
LIG_LIR_Apic_2	234	240	PF02991	0.384
LIG_LIR_Gen_1	169	175	PF02991	0.336
LIG_LIR_Gen_1	213	222	PF02991	0.444
LIG_LIR_Gen_1	298	308	PF02991	0.480
LIG_LIR_Gen_1	562	573	PF02991	0.397
LIG_LIR_Gen_1	672	681	PF02991	0.380
LIG_LIR_Nem_3	121	127	PF02991	0.446
LIG_LIR_Nem_3	169	173	PF02991	0.346
LIG_LIR_Nem_3	188	194	PF02991	0.450
LIG_LIR_Nem_3	213	219	PF02991	0.365
LIG_LIR_Nem_3	223	229	PF02991	0.299
LIG_LIR_Nem_3	243	249	PF02991	0.356
LIG_LIR_Nem_3	298	304	PF02991	0.466
LIG_LIR_Nem_3	324	330	PF02991	0.433
LIG_LIR_Nem_3	368	373	PF02991	0.363
LIG_LIR_Nem_3	562	568	PF02991	0.363
LIG_LIR_Nem_3	672	677	PF02991	0.324
LIG_LIR_Nem_3	87	92	PF02991	0.366
LIG_LIR_Nem_3	96	101	PF02991	0.391
LIG_LYPXL_yS_3	493	496	PF13949	0.419
LIG_MLH1_MIPbox_1	529	533	PF16413	0.434
LIG_MLH1_MIPbox_1	86	90	PF16413	0.350
LIG_NRBOX	513	519	PF00104	0.405
LIG_Pex14_1	417	421	PF04695	0.343
LIG_Pex14_2	370	374	PF04695	0.354
LIG_PTB_Apo_2	424	431	PF02174	0.375
LIG_PTB_Apo_2	541	548	PF02174	0.359
LIG_PTB_Apo_2	603	610	PF02174	0.371
LIG_PTB_Phospho_1	603	609	PF10480	0.366
LIG_SH2_CRK	301	305	PF00017	0.390
LIG_SH2_CRK	565	569	PF00017	0.357
LIG_SH2_CRK	592	596	PF00017	0.362
LIG_SH2_GRB2like	453	456	PF00017	0.375
LIG_SH2_GRB2like	646	649	PF00017	0.418
LIG_SH2_NCK_1	301	305	PF00017	0.379
LIG_SH2_NCK_1	35	39	PF00017	0.390
LIG_SH2_NCK_1	390	394	PF00017	0.384
LIG_SH2_NCK_1	565	569	PF00017	0.357
LIG_SH2_NCK_1	592	596	PF00017	0.344
LIG_SH2_PTP2	402	405	PF00017	0.435
LIG_SH2_SRC	35	38	PF00017	0.401
LIG_SH2_STAP1	497	501	PF00017	0.362
LIG_SH2_STAP1	565	569	PF00017	0.371
LIG_SH2_STAP1	95	99	PF00017	0.351
LIG_SH2_STAT3	143	146	PF00017	0.387
LIG_SH2_STAT3	160	163	PF00017	0.411
LIG_SH2_STAT3	680	683	PF00017	0.300
LIG_SH2_STAT5	144	147	PF00017	0.292
LIG_SH2_STAT5	160	163	PF00017	0.295
LIG_SH2_STAT5	181	184	PF00017	0.317
LIG_SH2_STAT5	301	304	PF00017	0.461
LIG_SH2_STAT5	373	376	PF00017	0.433
LIG_SH2_STAT5	402	405	PF00017	0.404
LIG_SH2_STAT5	495	498	PF00017	0.406
LIG_SH2_STAT5	559	562	PF00017	0.382
LIG_SH2_STAT5	577	580	PF00017	0.250
LIG_SH2_STAT5	592	595	PF00017	0.335
LIG_SH2_STAT5	609	612	PF00017	0.414
LIG_SH2_STAT5	680	683	PF00017	0.397
LIG_SH2_STAT5	88	91	PF00017	0.402
LIG_SH2_STAT5	98	101	PF00017	0.420
LIG_SH3_3	436	442	PF00018	0.409
LIG_SH3_3	639	645	PF00018	0.482
LIG_SH3_3	650	656	PF00018	0.300
LIG_SH3_3	725	731	PF00018	0.671
LIG_SUMO_SIM_anti_2	699	704	PF11976	0.307
LIG_SUMO_SIM_par_1	218	225	PF11976	0.494
LIG_SUMO_SIM_par_1	381	386	PF11976	0.373
LIG_SUMO_SIM_par_1	474	480	PF11976	0.293
LIG_SUMO_SIM_par_1	741	749	PF11976	0.766
LIG_TRAF2_1	594	597	PF00917	0.423
LIG_TRAF2_1	746	749	PF00917	0.766
LIG_TYR_ITIM	299	304	PF00017	0.389
LIG_TYR_ITIM	491	496	PF00017	0.426
LIG_TYR_ITIM	590	595	PF00017	0.357
MOD_CK1_1	203	209	PF00069	0.453
MOD_CK1_1	270	276	PF00069	0.416
MOD_CK1_1	291	297	PF00069	0.426
MOD_CK1_1	321	327	PF00069	0.447
MOD_CK1_1	357	363	PF00069	0.428
MOD_CK1_1	431	437	PF00069	0.398
MOD_CK1_1	612	618	PF00069	0.605
MOD_CK1_1	634	640	PF00069	0.354
MOD_CK2_1	302	308	PF00069	0.468
MOD_CK2_1	405	411	PF00069	0.341
MOD_CK2_1	71	77	PF00069	0.412
MOD_CK2_1	743	749	PF00069	0.701
MOD_GlcNHglycan	202	205	PF01048	0.566
MOD_GlcNHglycan	233	236	PF01048	0.620
MOD_GlcNHglycan	249	252	PF01048	0.549
MOD_GlcNHglycan	256	259	PF01048	0.530
MOD_GlcNHglycan	286	289	PF01048	0.604
MOD_GlcNHglycan	294	297	PF01048	0.639
MOD_GlcNHglycan	304	307	PF01048	0.588
MOD_GlcNHglycan	434	437	PF01048	0.608
MOD_GlcNHglycan	529	532	PF01048	0.738
MOD_GlcNHglycan	703	706	PF01048	0.460
MOD_GlcNHglycan	8	11	PF01048	0.653
MOD_GSK3_1	196	203	PF00069	0.370
MOD_GSK3_1	206	213	PF00069	0.340
MOD_GSK3_1	254	261	PF00069	0.394
MOD_GSK3_1	262	269	PF00069	0.333
MOD_GSK3_1	284	291	PF00069	0.345
MOD_GSK3_1	295	302	PF00069	0.408
MOD_GSK3_1	314	321	PF00069	0.483
MOD_GSK3_1	337	344	PF00069	0.327
MOD_GSK3_1	357	364	PF00069	0.465
MOD_GSK3_1	412	419	PF00069	0.379
MOD_GSK3_1	428	435	PF00069	0.382
MOD_GSK3_1	605	612	PF00069	0.489
MOD_GSK3_1	682	689	PF00069	0.430
MOD_GSK3_1	739	746	PF00069	0.787
MOD_GSK3_1	84	91	PF00069	0.358
MOD_N-GLC_1	131	136	PF02516	0.652
MOD_N-GLC_1	247	252	PF02516	0.580
MOD_N-GLC_1	357	362	PF02516	0.618
MOD_N-GLC_1	376	381	PF02516	0.560
MOD_N-GLC_1	405	410	PF02516	0.612
MOD_N-GLC_1	454	459	PF02516	0.579
MOD_N-GLC_1	471	476	PF02516	0.472
MOD_N-GLC_1	502	507	PF02516	0.623
MOD_N-GLC_1	510	515	PF02516	0.565
MOD_N-GLC_1	527	532	PF02516	0.631
MOD_N-GLC_1	534	539	PF02516	0.556
MOD_N-GLC_1	547	552	PF02516	0.453
MOD_N-GLC_1	634	639	PF02516	0.547
MOD_N-GLC_1	661	666	PF02516	0.511
MOD_N-GLC_1	675	680	PF02516	0.552
MOD_NEK2_1	137	142	PF00069	0.387
MOD_NEK2_1	229	234	PF00069	0.332
MOD_NEK2_1	247	252	PF00069	0.403
MOD_NEK2_1	262	267	PF00069	0.292
MOD_NEK2_1	282	287	PF00069	0.295
MOD_NEK2_1	375	380	PF00069	0.479
MOD_NEK2_1	429	434	PF00069	0.428
MOD_NEK2_1	443	448	PF00069	0.387
MOD_NEK2_1	527	532	PF00069	0.482
MOD_NEK2_1	533	538	PF00069	0.447
MOD_NEK2_1	547	552	PF00069	0.261
MOD_NEK2_1	663	668	PF00069	0.363
MOD_NEK2_2	125	130	PF00069	0.398
MOD_PIKK_1	159	165	PF00454	0.440
MOD_PKA_1	6	12	PF00069	0.542
MOD_PKA_2	118	124	PF00069	0.411
MOD_PKA_2	270	276	PF00069	0.471
MOD_PKA_2	6	12	PF00069	0.617
MOD_PKA_2	93	99	PF00069	0.325
MOD_PKB_1	722	730	PF00069	0.750
MOD_Plk_1	171	177	PF00069	0.360
MOD_Plk_1	357	363	PF00069	0.414
MOD_Plk_1	375	381	PF00069	0.381
MOD_Plk_1	412	418	PF00069	0.385
MOD_Plk_1	502	508	PF00069	0.415
MOD_Plk_1	510	516	PF00069	0.332
MOD_Plk_1	547	553	PF00069	0.390
MOD_Plk_1	661	667	PF00069	0.337
MOD_Plk_1	76	82	PF00069	0.453
MOD_Plk_2-3	413	419	PF00069	0.431
MOD_Plk_2-3	744	750	PF00069	0.721
MOD_Plk_4	138	144	PF00069	0.368
MOD_Plk_4	154	160	PF00069	0.300
MOD_Plk_4	196	202	PF00069	0.347
MOD_Plk_4	258	264	PF00069	0.362
MOD_Plk_4	299	305	PF00069	0.348
MOD_Plk_4	337	343	PF00069	0.386
MOD_Plk_4	346	352	PF00069	0.376
MOD_Plk_4	376	382	PF00069	0.388
MOD_Plk_4	510	516	PF00069	0.431
MOD_Plk_4	547	553	PF00069	0.371
MOD_Plk_4	724	730	PF00069	0.769
MOD_Plk_4	77	83	PF00069	0.359
MOD_Plk_4	84	90	PF00069	0.361
MOD_Plk_4	94	100	PF00069	0.269
MOD_ProDKin_1	275	281	PF00069	0.328
MOD_ProDKin_1	321	327	PF00069	0.488
MOD_ProDKin_1	365	371	PF00069	0.438
MOD_ProDKin_1	406	412	PF00069	0.447
MOD_ProDKin_1	438	444	PF00069	0.427
MOD_ProDKin_1	535	541	PF00069	0.453
MOD_ProDKin_1	557	563	PF00069	0.466
MOD_SUMO_rev_2	305	311	PF00179	0.482
TRG_DiLeu_BaEn_1	215	220	PF01217	0.338
TRG_DiLeu_BaEn_1	277	282	PF01217	0.298
TRG_DiLeu_BaEn_1	77	82	PF01217	0.409
TRG_DiLeu_BaLyEn_6	379	384	PF01217	0.340
TRG_ENDOCYTIC_2	301	304	PF00928	0.490
TRG_ENDOCYTIC_2	390	393	PF00928	0.432
TRG_ENDOCYTIC_2	402	405	PF00928	0.460
TRG_ENDOCYTIC_2	493	496	PF00928	0.371
TRG_ENDOCYTIC_2	565	568	PF00928	0.443
TRG_ENDOCYTIC_2	592	595	PF00928	0.459
TRG_ENDOCYTIC_2	98	101	PF00928	0.427
TRG_ER_diArg_1	5	7	PF00400	0.545
TRG_ER_diArg_1	722	724	PF00400	0.631
TRG_NLS_MonoCore_2	720	725	PF00514	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWL9	Leptomonas seymouri	40%	100%
A0A1X0NRS2	Trypanosomatidae	29%	100%
A0A3Q8I8Q8	Leishmania donovani	91%	100%
A0A422NWY1	Trypanosoma rangeli	29%	100%
A4H654	Leishmania braziliensis	74%	100%
A4HUH4	Leishmania infantum	91%	100%
C9ZQ00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	93%
C9ZVJ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZVJ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AN72	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
V5B409	Trypanosoma cruzi	26%	100%