Flagellar glycoprotein-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagellum adhesion protein 1

Species:

Leishmania major

UniProt:

Q4QHF2_LEIMA

TriTrypDb:

LmjF.10.0630 , LMJLV39_100012400 , LMJSD75_100012500

Length:

573

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 8, no: 1
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0016020	membrane	2	6
GO:0020016	ciliary pocket	2	2
GO:0031514	motile cilium	5	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

Q4QHF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHF2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.380
CLV_C14_Caspase3-7	70	74	PF00656	0.463
CLV_NRD_NRD_1	10	12	PF00675	0.804
CLV_NRD_NRD_1	123	125	PF00675	0.703
CLV_PCSK_KEX2_1	10	12	PF00082	0.778
CLV_PCSK_SKI1_1	479	483	PF00082	0.619
CLV_PCSK_SKI1_1	515	519	PF00082	0.698
DOC_CDC14_PxL_1	240	248	PF14671	0.350
DOC_CKS1_1	187	192	PF01111	0.460
DOC_CKS1_1	273	278	PF01111	0.517
DOC_MAPK_MEF2A_6	272	281	PF00069	0.353
DOC_PP2B_LxvP_1	215	218	PF13499	0.467
DOC_PP4_FxxP_1	426	429	PF00568	0.426
DOC_PP4_FxxP_1	465	468	PF00568	0.430
DOC_USP7_MATH_1	365	369	PF00917	0.580
DOC_USP7_MATH_1	44	48	PF00917	0.673
DOC_USP7_MATH_1	520	524	PF00917	0.496
DOC_USP7_MATH_1	538	542	PF00917	0.433
DOC_USP7_MATH_2	365	371	PF00917	0.552
DOC_USP7_UBL2_3	482	486	PF12436	0.396
DOC_WW_Pin1_4	18	23	PF00397	0.709
DOC_WW_Pin1_4	186	191	PF00397	0.407
DOC_WW_Pin1_4	219	224	PF00397	0.504
DOC_WW_Pin1_4	272	277	PF00397	0.485
DOC_WW_Pin1_4	309	314	PF00397	0.476
DOC_WW_Pin1_4	358	363	PF00397	0.381
DOC_WW_Pin1_4	480	485	PF00397	0.379
DOC_WW_Pin1_4	556	561	PF00397	0.547
DOC_WW_Pin1_4	9	14	PF00397	0.759
LIG_14-3-3_CanoR_1	147	152	PF00244	0.465
LIG_14-3-3_CanoR_1	342	350	PF00244	0.406
LIG_BIR_II_1	1	5	PF00653	0.729
LIG_BRCT_BRCA1_1	246	250	PF00533	0.407
LIG_BRCT_BRCA1_1	560	564	PF00533	0.688
LIG_EVH1_2	429	433	PF00568	0.373
LIG_FHA_1	172	178	PF00498	0.459
LIG_FHA_1	26	32	PF00498	0.651
LIG_FHA_1	327	333	PF00498	0.450
LIG_FHA_1	351	357	PF00498	0.373
LIG_FHA_1	457	463	PF00498	0.363
LIG_FHA_1	563	569	PF00498	0.757
LIG_FHA_2	161	167	PF00498	0.307
LIG_GBD_Chelix_1	160	168	PF00786	0.589
LIG_IBAR_NPY_1	232	234	PF08397	0.349
LIG_LIR_Apic_2	231	237	PF02991	0.451
LIG_LIR_Apic_2	262	266	PF02991	0.522
LIG_LIR_Apic_2	425	429	PF02991	0.459
LIG_LIR_Gen_1	209	218	PF02991	0.428
LIG_LIR_Gen_1	352	363	PF02991	0.480
LIG_LIR_Gen_1	403	413	PF02991	0.417
LIG_LIR_Gen_1	431	441	PF02991	0.384
LIG_LIR_Gen_1	55	66	PF02991	0.447
LIG_LIR_Gen_1	561	572	PF02991	0.698
LIG_LIR_Nem_3	135	141	PF02991	0.480
LIG_LIR_Nem_3	209	214	PF02991	0.428
LIG_LIR_Nem_3	280	284	PF02991	0.470
LIG_LIR_Nem_3	344	350	PF02991	0.365
LIG_LIR_Nem_3	352	358	PF02991	0.355
LIG_LIR_Nem_3	431	436	PF02991	0.403
LIG_LIR_Nem_3	55	61	PF02991	0.416
LIG_LIR_Nem_3	561	567	PF02991	0.689
LIG_MYND_1	317	321	PF01753	0.438
LIG_NRBOX	326	332	PF00104	0.307
LIG_Pex14_2	422	426	PF04695	0.346
LIG_PTB_Apo_2	109	116	PF02174	0.328
LIG_PTB_Apo_2	152	159	PF02174	0.430
LIG_PTB_Apo_2	205	212	PF02174	0.373
LIG_PTB_Apo_2	229	236	PF02174	0.328
LIG_PTB_Phospho_1	109	115	PF10480	0.332
LIG_PTB_Phospho_1	205	211	PF10480	0.369
LIG_REV1ctd_RIR_1	337	346	PF16727	0.464
LIG_SH2_CRK	211	215	PF00017	0.418
LIG_SH2_CRK	58	62	PF00017	0.435
LIG_SH2_CRK	81	85	PF00017	0.472
LIG_SH2_PTP2	263	266	PF00017	0.480
LIG_SH2_SRC	216	219	PF00017	0.394
LIG_SH2_STAT5	115	118	PF00017	0.417
LIG_SH2_STAT5	159	162	PF00017	0.334
LIG_SH2_STAT5	216	219	PF00017	0.474
LIG_SH2_STAT5	234	237	PF00017	0.319
LIG_SH2_STAT5	259	262	PF00017	0.409
LIG_SH2_STAT5	263	266	PF00017	0.493
LIG_SH2_STAT5	296	299	PF00017	0.428
LIG_SH2_STAT5	348	351	PF00017	0.365
LIG_SH2_STAT5	475	478	PF00017	0.424
LIG_SH3_3	270	276	PF00018	0.493
LIG_SH3_3	359	365	PF00018	0.463
LIG_SH3_3	424	430	PF00018	0.389
LIG_SH3_3	565	571	PF00018	0.747
LIG_SH3_3	69	75	PF00018	0.349
LIG_SUMO_SIM_anti_2	459	465	PF11976	0.424
LIG_SUMO_SIM_par_1	274	280	PF11976	0.371
LIG_SUMO_SIM_par_1	323	329	PF11976	0.430
LIG_SUMO_SIM_par_1	553	559	PF11976	0.519
LIG_TYR_ITSM	207	214	PF00017	0.375
LIG_TYR_ITSM	53	60	PF00017	0.422
MOD_CDC14_SPxK_1	483	486	PF00782	0.417
MOD_CDK_SPxK_1	480	486	PF00069	0.422
MOD_CDK_SPxxK_3	9	16	PF00069	0.563
MOD_CK1_1	196	202	PF00069	0.458
MOD_CK1_1	219	225	PF00069	0.463
MOD_CK1_1	312	318	PF00069	0.428
MOD_CK1_1	368	374	PF00069	0.585
MOD_CK1_1	494	500	PF00069	0.461
MOD_CK2_1	370	376	PF00069	0.513
MOD_GlcNHglycan	102	105	PF01048	0.622
MOD_GlcNHglycan	132	135	PF01048	0.564
MOD_GlcNHglycan	358	361	PF01048	0.685
MOD_GlcNHglycan	370	373	PF01048	0.659
MOD_GlcNHglycan	379	382	PF01048	0.694
MOD_GlcNHglycan	443	446	PF01048	0.635
MOD_GlcNHglycan	497	500	PF01048	0.689
MOD_GlcNHglycan	522	525	PF01048	0.742
MOD_GlcNHglycan	528	531	PF01048	0.739
MOD_GlcNHglycan	63	66	PF01048	0.645
MOD_GlcNHglycan	75	78	PF01048	0.591
MOD_GSK3_1	143	150	PF00069	0.507
MOD_GSK3_1	171	178	PF00069	0.460
MOD_GSK3_1	189	196	PF00069	0.442
MOD_GSK3_1	200	207	PF00069	0.458
MOD_GSK3_1	267	274	PF00069	0.469
MOD_GSK3_1	295	302	PF00069	0.381
MOD_GSK3_1	303	310	PF00069	0.279
MOD_GSK3_1	366	373	PF00069	0.526
MOD_GSK3_1	396	403	PF00069	0.419
MOD_GSK3_1	428	435	PF00069	0.480
MOD_GSK3_1	448	455	PF00069	0.385
MOD_GSK3_1	491	498	PF00069	0.421
MOD_GSK3_1	5	12	PF00069	0.592
MOD_GSK3_1	509	516	PF00069	0.420
MOD_GSK3_1	558	565	PF00069	0.601
MOD_N-GLC_1	171	176	PF02516	0.691
MOD_N-GLC_1	227	232	PF02516	0.669
MOD_N-GLC_1	252	257	PF02516	0.607
MOD_N-GLC_1	299	304	PF02516	0.667
MOD_N-GLC_1	396	401	PF02516	0.654
MOD_N-GLC_1	441	446	PF02516	0.592
MOD_N-GLC_1	448	453	PF02516	0.586
MOD_N-GLC_1	495	500	PF02516	0.653
MOD_N-GLC_1	508	513	PF02516	0.661
MOD_NEK2_1	100	105	PF00069	0.474
MOD_NEK2_1	193	198	PF00069	0.445
MOD_NEK2_1	25	30	PF00069	0.658
MOD_NEK2_1	252	257	PF00069	0.384
MOD_NEK2_1	295	300	PF00069	0.447
MOD_NEK2_1	307	312	PF00069	0.339
MOD_NEK2_1	350	355	PF00069	0.458
MOD_NEK2_1	356	361	PF00069	0.403
MOD_NEK2_1	37	42	PF00069	0.619
MOD_NEK2_1	491	496	PF00069	0.368
MOD_PIKK_1	265	271	PF00454	0.386
MOD_PIKK_1	350	356	PF00454	0.400
MOD_PIKK_1	400	406	PF00454	0.402
MOD_PIKK_1	473	479	PF00454	0.491
MOD_PIKK_1	485	491	PF00454	0.369
MOD_PKA_2	341	347	PF00069	0.477
MOD_Plk_1	199	205	PF00069	0.323
MOD_Plk_1	252	258	PF00069	0.393
MOD_Plk_1	396	402	PF00069	0.448
MOD_Plk_1	441	447	PF00069	0.380
MOD_Plk_4	177	183	PF00069	0.401
MOD_Plk_4	193	199	PF00069	0.334
MOD_Plk_4	200	206	PF00069	0.422
MOD_Plk_4	210	216	PF00069	0.361
MOD_Plk_4	315	321	PF00069	0.494
MOD_Plk_4	326	332	PF00069	0.376
MOD_Plk_4	343	349	PF00069	0.293
MOD_Plk_4	432	438	PF00069	0.504
MOD_Plk_4	456	462	PF00069	0.402
MOD_Plk_4	52	58	PF00069	0.447
MOD_Plk_4	539	545	PF00069	0.364
MOD_ProDKin_1	18	24	PF00069	0.704
MOD_ProDKin_1	186	192	PF00069	0.406
MOD_ProDKin_1	219	225	PF00069	0.502
MOD_ProDKin_1	272	278	PF00069	0.492
MOD_ProDKin_1	309	315	PF00069	0.478
MOD_ProDKin_1	358	364	PF00069	0.392
MOD_ProDKin_1	480	486	PF00069	0.382
MOD_ProDKin_1	556	562	PF00069	0.549
MOD_ProDKin_1	9	15	PF00069	0.759
TRG_ENDOCYTIC_2	211	214	PF00928	0.406
TRG_ENDOCYTIC_2	406	409	PF00928	0.390
TRG_ENDOCYTIC_2	57	60	PF00928	0.395
TRG_ENDOCYTIC_2	81	84	PF00928	0.458
TRG_ER_diArg_1	15	18	PF00400	0.680

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NRY9	Trypanosomatidae	31%	100%
A0A3S7WR66	Leishmania donovani	84%	95%
A0A422NWX8	Trypanosoma rangeli	30%	99%
A4H655	Leishmania braziliensis	72%	100%
A4HUH5	Leishmania infantum	85%	97%
C9ZVK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AN73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	95%
V5BP43	Trypanosoma cruzi	29%	99%