Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QHF0_LEIMA

TriTrypDb:

LmjF.10.0650 , LMJLV39_100012600 , LMJSD75_100012700

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHF0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	154	158	PF00656	0.559
CLV_NRD_NRD_1	112	114	PF00675	0.484
CLV_NRD_NRD_1	117	119	PF00675	0.523
CLV_NRD_NRD_1	169	171	PF00675	0.453
CLV_NRD_NRD_1	181	183	PF00675	0.573
CLV_NRD_NRD_1	191	193	PF00675	0.457
CLV_NRD_NRD_1	252	254	PF00675	0.595
CLV_NRD_NRD_1	257	259	PF00675	0.636
CLV_NRD_NRD_1	308	310	PF00675	0.483
CLV_NRD_NRD_1	316	318	PF00675	0.590
CLV_NRD_NRD_1	35	37	PF00675	0.483
CLV_NRD_NRD_1	78	80	PF00675	0.502
CLV_NRD_NRD_1	81	83	PF00675	0.458
CLV_NRD_NRD_1	84	86	PF00675	0.467
CLV_PCSK_FUR_1	115	119	PF00082	0.514
CLV_PCSK_FUR_1	314	318	PF00082	0.593
CLV_PCSK_FUR_1	79	83	PF00082	0.535
CLV_PCSK_KEX2_1	112	114	PF00082	0.485
CLV_PCSK_KEX2_1	117	119	PF00082	0.524
CLV_PCSK_KEX2_1	181	183	PF00082	0.571
CLV_PCSK_KEX2_1	191	193	PF00082	0.444
CLV_PCSK_KEX2_1	252	254	PF00082	0.556
CLV_PCSK_KEX2_1	308	310	PF00082	0.483
CLV_PCSK_KEX2_1	316	318	PF00082	0.590
CLV_PCSK_KEX2_1	35	37	PF00082	0.483
CLV_PCSK_KEX2_1	5	7	PF00082	0.736
CLV_PCSK_KEX2_1	78	80	PF00082	0.502
CLV_PCSK_KEX2_1	81	83	PF00082	0.458
CLV_PCSK_KEX2_1	84	86	PF00082	0.467
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.505
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.648
CLV_PCSK_PC7_1	113	119	PF00082	0.485
CLV_PCSK_SKI1_1	171	175	PF00082	0.500
CLV_PCSK_SKI1_1	182	186	PF00082	0.510
CLV_PCSK_SKI1_1	19	23	PF00082	0.570
CLV_PCSK_SKI1_1	232	236	PF00082	0.662
CLV_PCSK_SKI1_1	317	321	PF00082	0.585
CLV_PCSK_SKI1_1	35	39	PF00082	0.610
CLV_PCSK_SKI1_1	64	68	PF00082	0.515
DEG_APCC_DBOX_1	180	188	PF00400	0.440
DEG_Kelch_Keap1_1	207	212	PF01344	0.630
DEG_Nend_Nbox_1	1	3	PF02207	0.661
DOC_CYCLIN_RxL_1	178	186	PF00134	0.475
DOC_CYCLIN_yCln2_LP_2	123	129	PF00134	0.552
DOC_CYCLIN_yCln2_LP_2	374	377	PF00134	0.535
DOC_MAPK_gen_1	115	125	PF00069	0.433
DOC_MAPK_gen_1	178	187	PF00069	0.614
DOC_MAPK_MEF2A_6	118	127	PF00069	0.458
DOC_MAPK_RevD_3	65	79	PF00069	0.548
DOC_PP1_RVXF_1	220	227	PF00149	0.532
DOC_PP1_RVXF_1	333	339	PF00149	0.591
DOC_PP2B_LxvP_1	123	126	PF13499	0.568
DOC_PP2B_LxvP_1	203	206	PF13499	0.517
DOC_PP2B_LxvP_1	21	24	PF13499	0.543
DOC_PP2B_LxvP_1	354	357	PF13499	0.483
DOC_PP2B_LxvP_1	374	377	PF13499	0.390
DOC_PP4_FxxP_1	15	18	PF00568	0.586
DOC_WW_Pin1_4	204	209	PF00397	0.587
DOC_WW_Pin1_4	251	256	PF00397	0.747
LIG_14-3-3_CanoR_1	170	180	PF00244	0.392
LIG_14-3-3_CanoR_1	316	322	PF00244	0.647
LIG_APCC_ABBA_1	361	366	PF00400	0.517
LIG_CaM_IQ_9	185	200	PF13499	0.523
LIG_deltaCOP1_diTrp_1	366	372	PF00928	0.518
LIG_FHA_1	103	109	PF00498	0.487
LIG_FHA_1	157	163	PF00498	0.498
LIG_FHA_1	208	214	PF00498	0.570
LIG_FHA_1	252	258	PF00498	0.638
LIG_FHA_1	26	32	PF00498	0.508
LIG_FHA_1	70	76	PF00498	0.484
LIG_FHA_2	318	324	PF00498	0.571
LIG_GBD_Chelix_1	341	349	PF00786	0.515
LIG_LIR_Apic_2	12	18	PF02991	0.600
LIG_LIR_Gen_1	337	345	PF02991	0.623
LIG_LIR_Gen_1	346	355	PF02991	0.488
LIG_LIR_Nem_3	337	341	PF02991	0.634
LIG_LIR_Nem_3	344	350	PF02991	0.486
LIG_LIR_Nem_3	351	356	PF02991	0.439
LIG_LIR_Nem_3	370	375	PF02991	0.655
LIG_MYND_1	14	18	PF01753	0.590
LIG_NRBOX	183	189	PF00104	0.515
LIG_PTB_Apo_2	307	314	PF02174	0.556
LIG_PTB_Phospho_1	307	313	PF10480	0.548
LIG_SH2_CRK	221	225	PF00017	0.533
LIG_SH2_NCK_1	347	351	PF00017	0.492
LIG_SH2_STAT3	303	306	PF00017	0.500
LIG_SH2_STAT5	303	306	PF00017	0.436
LIG_SH2_STAT5	353	356	PF00017	0.465
LIG_SUMO_SIM_anti_2	183	190	PF11976	0.518
LIG_SUMO_SIM_par_1	201	207	PF11976	0.537
LIG_SUMO_SIM_par_1	63	70	PF11976	0.496
LIG_TRFH_1	372	376	PF08558	0.557
LIG_TYR_ITIM	345	350	PF00017	0.479
LIG_UBA3_1	162	171	PF00899	0.515
LIG_UBA3_1	184	193	PF00899	0.537
MOD_CDK_SPxxK_3	251	258	PF00069	0.585
MOD_CK1_1	164	170	PF00069	0.492
MOD_CK1_1	207	213	PF00069	0.565
MOD_CK1_1	90	96	PF00069	0.481
MOD_Cter_Amidation	33	36	PF01082	0.479
MOD_GlcNHglycan	127	130	PF01048	0.581
MOD_GlcNHglycan	149	152	PF01048	0.705
MOD_GlcNHglycan	282	285	PF01048	0.602
MOD_GSK3_1	121	128	PF00069	0.547
MOD_GSK3_1	157	164	PF00069	0.474
MOD_GSK3_1	239	246	PF00069	0.662
MOD_NEK2_1	102	107	PF00069	0.480
MOD_NEK2_1	69	74	PF00069	0.482
MOD_PIKK_1	157	163	PF00454	0.429
MOD_PIKK_1	90	96	PF00454	0.400
MOD_PK_1	121	127	PF00069	0.476
MOD_PKA_1	35	41	PF00069	0.478
MOD_PKA_2	239	245	PF00069	0.611
MOD_PKA_2	35	41	PF00069	0.559
MOD_PKA_2	90	96	PF00069	0.522
MOD_Plk_1	121	127	PF00069	0.476
MOD_Plk_4	183	189	PF00069	0.493
MOD_ProDKin_1	204	210	PF00069	0.588
MOD_ProDKin_1	251	257	PF00069	0.747
TRG_DiLeu_BaEn_1	12	17	PF01217	0.608
TRG_DiLeu_BaEn_1	183	188	PF01217	0.510
TRG_ENDOCYTIC_2	221	224	PF00928	0.541
TRG_ENDOCYTIC_2	347	350	PF00928	0.464
TRG_ENDOCYTIC_2	353	356	PF00928	0.423
TRG_ER_diArg_1	111	113	PF00400	0.494
TRG_ER_diArg_1	114	117	PF00400	0.511
TRG_ER_diArg_1	180	182	PF00400	0.470
TRG_ER_diArg_1	313	316	PF00400	0.574
TRG_ER_diArg_1	78	81	PF00400	0.535
TRG_ER_diArg_1	82	85	PF00400	0.499
TRG_Pf-PMV_PEXEL_1	258	263	PF00026	0.614

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5X7	Leptomonas seymouri	35%	96%
A0A3S7WR94	Leishmania donovani	92%	100%
A4H657	Leishmania braziliensis	75%	100%
A4HUH7	Leishmania infantum	93%	100%
E9AN75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%