Rhomboid domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHE8_LEIMA

TriTrypDb:

LmjF.10.0670 , LMJLV39_100012800 , LMJSD75_100012900

Length:

326

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QHE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHE8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	37	39	PF00675	0.594
CLV_PCSK_KEX2_1	37	39	PF00082	0.594
CLV_PCSK_PC7_1	33	39	PF00082	0.412
CLV_PCSK_SKI1_1	33	37	PF00082	0.539
DOC_MAPK_FxFP_2	13	16	PF00069	0.740
DOC_MAPK_MEF2A_6	11	20	PF00069	0.765
DOC_PP2B_LxvP_1	41	44	PF13499	0.676
DOC_PP4_FxxP_1	13	16	PF00568	0.765
DOC_USP7_MATH_1	100	104	PF00917	0.816
DOC_USP7_UBL2_3	106	110	PF12436	0.711
DOC_WW_Pin1_4	20	25	PF00397	0.723
DOC_WW_Pin1_4	265	270	PF00397	0.321
DOC_WW_Pin1_4	27	32	PF00397	0.732
DOC_WW_Pin1_4	5	10	PF00397	0.761
LIG_14-3-3_CanoR_1	175	180	PF00244	0.404
LIG_14-3-3_CanoR_1	38	44	PF00244	0.712
LIG_BIR_II_1	1	5	PF00653	0.675
LIG_BIR_III_3	1	5	PF00653	0.675
LIG_Clathr_ClatBox_1	257	261	PF01394	0.438
LIG_CSL_BTD_1	6	9	PF09270	0.628
LIG_deltaCOP1_diTrp_1	160	168	PF00928	0.322
LIG_FHA_1	176	182	PF00498	0.388
LIG_FHA_1	20	26	PF00498	0.770
LIG_FHA_1	220	226	PF00498	0.324
LIG_FHA_2	72	78	PF00498	0.802
LIG_FHA_2	81	87	PF00498	0.722
LIG_LIR_Gen_1	127	136	PF02991	0.586
LIG_LIR_Gen_1	186	197	PF02991	0.326
LIG_LIR_Nem_3	127	132	PF02991	0.586
LIG_LIR_Nem_3	233	238	PF02991	0.444
LIG_LIR_Nem_3	261	267	PF02991	0.428
LIG_LIR_Nem_3	277	282	PF02991	0.529
LIG_Pex14_1	231	235	PF04695	0.385
LIG_PTB_Apo_2	231	238	PF02174	0.519
LIG_PTB_Phospho_1	231	237	PF10480	0.519
LIG_SH2_CRK	136	140	PF00017	0.557
LIG_SH2_GRB2like	129	132	PF00017	0.663
LIG_SH2_NCK_1	136	140	PF00017	0.460
LIG_SH2_STAP1	194	198	PF00017	0.438
LIG_SH2_STAP1	282	286	PF00017	0.516
LIG_SH2_STAT5	218	221	PF00017	0.306
LIG_SH2_STAT5	235	238	PF00017	0.328
LIG_SH2_STAT5	262	265	PF00017	0.298
LIG_SH2_STAT5	293	296	PF00017	0.547
LIG_SUMO_SIM_anti_2	268	275	PF11976	0.304
LIG_SUMO_SIM_par_1	268	275	PF11976	0.304
LIG_TRFH_1	265	269	PF08558	0.382
LIG_TYR_ITIM	52	57	PF00017	0.606
LIG_WRC_WIRS_1	181	186	PF05994	0.324
LIG_WRC_WIRS_1	273	278	PF05994	0.515
MOD_CDK_SPxK_1	27	33	PF00069	0.614
MOD_CDK_SPxK_1	5	11	PF00069	0.605
MOD_CK1_1	154	160	PF00069	0.438
MOD_CK1_1	183	189	PF00069	0.441
MOD_CK1_1	23	29	PF00069	0.763
MOD_CK1_1	271	277	PF00069	0.440
MOD_CK1_1	42	48	PF00069	0.587
MOD_CK1_1	82	88	PF00069	0.689
MOD_CK1_1	96	102	PF00069	0.816
MOD_CK2_1	154	160	PF00069	0.438
MOD_CK2_1	71	77	PF00069	0.735
MOD_CK2_1	80	86	PF00069	0.716
MOD_GlcNHglycan	225	228	PF01048	0.316
MOD_GlcNHglycan	276	279	PF01048	0.424
MOD_GlcNHglycan	41	44	PF01048	0.433
MOD_GlcNHglycan	95	98	PF01048	0.539
MOD_GSK3_1	152	159	PF00069	0.438
MOD_GSK3_1	19	26	PF00069	0.766
MOD_GSK3_1	219	226	PF00069	0.302
MOD_GSK3_1	268	275	PF00069	0.494
MOD_GSK3_1	27	34	PF00069	0.742
MOD_GSK3_1	296	303	PF00069	0.492
MOD_GSK3_1	78	85	PF00069	0.815
MOD_GSK3_1	96	103	PF00069	0.710
MOD_NEK2_1	152	157	PF00069	0.306
MOD_NEK2_1	180	185	PF00069	0.329
MOD_NEK2_1	190	195	PF00069	0.279
MOD_NEK2_1	198	203	PF00069	0.204
MOD_NEK2_1	230	235	PF00069	0.440
MOD_NEK2_1	300	305	PF00069	0.594
MOD_PIKK_1	45	51	PF00454	0.691
MOD_PKA_2	319	325	PF00069	0.634
MOD_PKA_2	39	45	PF00069	0.759
MOD_Plk_1	170	176	PF00069	0.350
MOD_Plk_4	180	186	PF00069	0.260
MOD_Plk_4	296	302	PF00069	0.510
MOD_Plk_4	42	48	PF00069	0.750
MOD_ProDKin_1	20	26	PF00069	0.723
MOD_ProDKin_1	265	271	PF00069	0.321
MOD_ProDKin_1	27	33	PF00069	0.733
MOD_ProDKin_1	5	11	PF00069	0.763
TRG_DiLeu_BaEn_4	160	166	PF01217	0.382
TRG_ENDOCYTIC_2	129	132	PF00928	0.603
TRG_ENDOCYTIC_2	136	139	PF00928	0.540
TRG_ENDOCYTIC_2	194	197	PF00928	0.438
TRG_ENDOCYTIC_2	264	267	PF00928	0.438
TRG_ENDOCYTIC_2	54	57	PF00928	0.685
TRG_ER_diArg_1	36	38	PF00400	0.762
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILE4	Leptomonas seymouri	58%	84%
A0A0S4ILW7	Bodo saltans	49%	93%
A0A1X0NQ98	Trypanosomatidae	60%	100%
A0A3S5IS56	Trypanosoma rangeli	57%	100%
A0A3S7WR67	Leishmania donovani	92%	100%
A4H659	Leishmania braziliensis	78%	85%
A4HUH9	Leishmania infantum	92%	100%
C9ZVK4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9AN77	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BP48	Trypanosoma cruzi	53%	100%