Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QHE7_LEIMA

TriTrypDb:

LmjF.10.0680 , LMJLV39_100012900 , LMJSD75_100013000

Length:

375

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHE7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.624
CLV_NRD_NRD_1	167	169	PF00675	0.625
CLV_NRD_NRD_1	175	177	PF00675	0.701
CLV_NRD_NRD_1	18	20	PF00675	0.629
CLV_NRD_NRD_1	266	268	PF00675	0.768
CLV_NRD_NRD_1	322	324	PF00675	0.847
CLV_NRD_NRD_1	36	38	PF00675	0.543
CLV_NRD_NRD_1	64	66	PF00675	0.662
CLV_PCSK_KEX2_1	175	177	PF00082	0.751
CLV_PCSK_KEX2_1	266	268	PF00082	0.768
CLV_PCSK_KEX2_1	322	324	PF00082	0.847
CLV_PCSK_KEX2_1	36	38	PF00082	0.638
CLV_PCSK_KEX2_1	367	369	PF00082	0.624
CLV_PCSK_KEX2_1	54	56	PF00082	0.632
CLV_PCSK_KEX2_1	64	66	PF00082	0.562
CLV_PCSK_PC1ET2_1	367	369	PF00082	0.624
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.710
CLV_PCSK_PC7_1	32	38	PF00082	0.613
CLV_PCSK_SKI1_1	168	172	PF00082	0.708
CLV_PCSK_SKI1_1	36	40	PF00082	0.588
CLV_PCSK_SKI1_1	68	72	PF00082	0.718
DEG_Nend_UBRbox_1	1	4	PF02207	0.773
DEG_SCF_FBW7_1	107	113	PF00400	0.616
DEG_SPOP_SBC_1	344	348	PF00917	0.810
DOC_CKS1_1	107	112	PF01111	0.613
DOC_MAPK_gen_1	162	172	PF00069	0.695
DOC_MAPK_gen_1	64	72	PF00069	0.711
DOC_PP2B_LxvP_1	275	278	PF13499	0.788
DOC_PP2B_LxvP_1	28	31	PF13499	0.600
DOC_USP7_MATH_1	103	107	PF00917	0.814
DOC_USP7_MATH_1	110	114	PF00917	0.708
DOC_USP7_MATH_1	141	145	PF00917	0.766
DOC_USP7_MATH_1	174	178	PF00917	0.694
DOC_USP7_MATH_1	180	184	PF00917	0.735
DOC_USP7_MATH_1	187	191	PF00917	0.631
DOC_USP7_MATH_1	278	282	PF00917	0.822
DOC_USP7_MATH_1	324	328	PF00917	0.803
DOC_USP7_MATH_1	344	348	PF00917	0.763
DOC_USP7_MATH_1	48	52	PF00917	0.526
DOC_USP7_MATH_1	9	13	PF00917	0.667
DOC_WW_Pin1_4	106	111	PF00397	0.646
DOC_WW_Pin1_4	176	181	PF00397	0.719
DOC_WW_Pin1_4	276	281	PF00397	0.782
DOC_WW_Pin1_4	313	318	PF00397	0.787
DOC_WW_Pin1_4	355	360	PF00397	0.827
DOC_WW_Pin1_4	7	12	PF00397	0.617
DOC_WW_Pin1_4	96	101	PF00397	0.798
LIG_14-3-3_CanoR_1	175	179	PF00244	0.716
LIG_14-3-3_CanoR_1	188	193	PF00244	0.621
LIG_14-3-3_CanoR_1	2	8	PF00244	0.768
LIG_14-3-3_CanoR_1	266	275	PF00244	0.829
LIG_14-3-3_CanoR_1	328	336	PF00244	0.776
LIG_14-3-3_CanoR_1	349	357	PF00244	0.691
LIG_14-3-3_CanoR_1	87	96	PF00244	0.812
LIG_Actin_WH2_2	49	66	PF00022	0.656
LIG_BIR_III_2	5	9	PF00653	0.620
LIG_EVH1_1	30	34	PF00568	0.803
LIG_EVH1_2	34	38	PF00568	0.591
LIG_FHA_1	48	54	PF00498	0.533
LIG_FHA_2	193	199	PF00498	0.815
LIG_LIR_Apic_2	147	151	PF02991	0.701
LIG_LIR_Gen_1	99	107	PF02991	0.760
LIG_LIR_Nem_3	99	104	PF02991	0.759
LIG_MYND_1	361	365	PF01753	0.637
LIG_NRBOX	251	257	PF00104	0.703
LIG_SH3_2	31	36	PF14604	0.810
LIG_SH3_2	357	362	PF14604	0.628
LIG_SH3_3	104	110	PF00018	0.608
LIG_SH3_3	28	34	PF00018	0.804
LIG_SH3_3	351	357	PF00018	0.832
LIG_SH3_3	5	11	PF00018	0.618
LIG_SH3_3	79	85	PF00018	0.790
LIG_SH3_CIN85_PxpxPR_1	31	36	PF14604	0.810
LIG_SH3_CIN85_PxpxPR_1	357	362	PF14604	0.628
LIG_TRAF2_1	237	240	PF00917	0.710
LIG_WW_3	33	37	PF00397	0.814
LIG_WW_3	359	363	PF00397	0.629
MOD_CDC14_SPxK_1	316	319	PF00782	0.785
MOD_CDK_SPK_2	313	318	PF00069	0.637
MOD_CDK_SPxK_1	313	319	PF00069	0.788
MOD_CDK_SPxxK_3	355	362	PF00069	0.629
MOD_CK1_1	106	112	PF00069	0.751
MOD_CK1_1	144	150	PF00069	0.715
MOD_CK1_1	179	185	PF00069	0.782
MOD_CK1_1	302	308	PF00069	0.793
MOD_CK1_1	329	335	PF00069	0.609
MOD_CK1_1	348	354	PF00069	0.667
MOD_CK1_1	355	361	PF00069	0.671
MOD_CK2_1	110	116	PF00069	0.828
MOD_CK2_1	192	198	PF00069	0.679
MOD_CK2_1	77	83	PF00069	0.728
MOD_DYRK1A_RPxSP_1	176	180	PF00069	0.713
MOD_DYRK1A_RPxSP_1	7	11	PF00069	0.616
MOD_GlcNHglycan	11	14	PF01048	0.663
MOD_GlcNHglycan	112	115	PF01048	0.763
MOD_GlcNHglycan	116	119	PF01048	0.709
MOD_GlcNHglycan	328	331	PF01048	0.823
MOD_GlcNHglycan	354	357	PF01048	0.693
MOD_GlcNHglycan	91	95	PF01048	0.663
MOD_GSK3_1	105	112	PF00069	0.672
MOD_GSK3_1	124	131	PF00069	0.532
MOD_GSK3_1	140	147	PF00069	0.573
MOD_GSK3_1	176	183	PF00069	0.774
MOD_GSK3_1	188	195	PF00069	0.606
MOD_GSK3_1	261	268	PF00069	0.749
MOD_GSK3_1	293	300	PF00069	0.838
MOD_GSK3_1	302	309	PF00069	0.711
MOD_GSK3_1	344	351	PF00069	0.665
MOD_GSK3_1	90	97	PF00069	0.681
MOD_N-GLC_1	293	298	PF02516	0.759
MOD_N-GLC_1	302	307	PF02516	0.792
MOD_NEK2_1	192	197	PF00069	0.653
MOD_NEK2_1	238	243	PF00069	0.679
MOD_NEK2_1	256	261	PF00069	0.460
MOD_NEK2_1	310	315	PF00069	0.790
MOD_NEK2_1	77	82	PF00069	0.774
MOD_NEK2_2	128	133	PF00069	0.630
MOD_NEK2_2	231	236	PF00069	0.528
MOD_PIKK_1	141	147	PF00454	0.755
MOD_PIKK_1	21	27	PF00454	0.813
MOD_PIKK_1	244	250	PF00454	0.681
MOD_PKA_1	266	272	PF00069	0.776
MOD_PKA_2	1	7	PF00069	0.773
MOD_PKA_2	174	180	PF00069	0.750
MOD_PKA_2	187	193	PF00069	0.587
MOD_PKA_2	265	271	PF00069	0.819
MOD_PKA_2	348	354	PF00069	0.685
MOD_Plk_1	302	308	PF00069	0.843
MOD_Plk_4	144	150	PF00069	0.715
MOD_Plk_4	188	194	PF00069	0.801
MOD_Plk_4	256	262	PF00069	0.738
MOD_Plk_4	302	308	PF00069	0.843
MOD_ProDKin_1	106	112	PF00069	0.648
MOD_ProDKin_1	176	182	PF00069	0.720
MOD_ProDKin_1	276	282	PF00069	0.780
MOD_ProDKin_1	313	319	PF00069	0.788
MOD_ProDKin_1	355	361	PF00069	0.827
MOD_ProDKin_1	7	13	PF00069	0.617
MOD_ProDKin_1	96	102	PF00069	0.800
MOD_SUMO_rev_2	51	56	PF00179	0.540
TRG_ER_diArg_1	155	158	PF00400	0.495
TRG_ER_diArg_1	321	323	PF00400	0.699
TRG_ER_diArg_1	35	37	PF00400	0.617
TRG_ER_diArg_1	63	65	PF00400	0.659
TRG_NES_CRM1_1	62	73	PF08389	0.666
TRG_Pf-PMV_PEXEL_1	54	58	PF00026	0.707

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IC56	Leishmania donovani	83%	74%
A4HUI0	Leishmania infantum	83%	74%
E9AN78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	74%