RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA-binding protein

Gene product:

RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain), putative

Species:

Leishmania major

UniProt:

Q4QHE5_LEIMA

TriTrypDb:

LmjF.10.0700 , LMJLV39_100013100 , LMJSD75_100013300

Length:

950

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005654	nucleoplasm	2	2
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QHE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHE5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.480
CLV_C14_Caspase3-7	179	183	PF00656	0.689
CLV_C14_Caspase3-7	188	192	PF00656	0.657
CLV_C14_Caspase3-7	258	262	PF00656	0.600
CLV_C14_Caspase3-7	300	304	PF00656	0.712
CLV_C14_Caspase3-7	591	595	PF00656	0.510
CLV_C14_Caspase3-7	816	820	PF00656	0.560
CLV_MEL_PAP_1	601	607	PF00089	0.464
CLV_NRD_NRD_1	125	127	PF00675	0.558
CLV_NRD_NRD_1	138	140	PF00675	0.617
CLV_NRD_NRD_1	142	144	PF00675	0.683
CLV_NRD_NRD_1	167	169	PF00675	0.745
CLV_NRD_NRD_1	195	197	PF00675	0.526
CLV_NRD_NRD_1	247	249	PF00675	0.727
CLV_NRD_NRD_1	272	274	PF00675	0.630
CLV_NRD_NRD_1	309	311	PF00675	0.667
CLV_NRD_NRD_1	42	44	PF00675	0.545
CLV_NRD_NRD_1	492	494	PF00675	0.556
CLV_NRD_NRD_1	807	809	PF00675	0.664
CLV_NRD_NRD_1	833	835	PF00675	0.621
CLV_NRD_NRD_1	896	898	PF00675	0.240
CLV_PCSK_KEX2_1	127	129	PF00082	0.557
CLV_PCSK_KEX2_1	142	144	PF00082	0.454
CLV_PCSK_KEX2_1	169	171	PF00082	0.687
CLV_PCSK_KEX2_1	195	197	PF00082	0.544
CLV_PCSK_KEX2_1	246	248	PF00082	0.729
CLV_PCSK_KEX2_1	272	274	PF00082	0.630
CLV_PCSK_KEX2_1	309	311	PF00082	0.689
CLV_PCSK_KEX2_1	42	44	PF00082	0.434
CLV_PCSK_KEX2_1	451	453	PF00082	0.541
CLV_PCSK_KEX2_1	492	494	PF00082	0.578
CLV_PCSK_KEX2_1	740	742	PF00082	0.521
CLV_PCSK_KEX2_1	807	809	PF00082	0.664
CLV_PCSK_KEX2_1	832	834	PF00082	0.619
CLV_PCSK_PC1ET2_1	127	129	PF00082	0.557
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.454
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.687
CLV_PCSK_PC1ET2_1	451	453	PF00082	0.535
CLV_PCSK_PC1ET2_1	740	742	PF00082	0.521
CLV_PCSK_PC7_1	488	494	PF00082	0.661
CLV_PCSK_SKI1_1	272	276	PF00082	0.583
CLV_PCSK_SKI1_1	43	47	PF00082	0.540
CLV_PCSK_SKI1_1	631	635	PF00082	0.348
CLV_PCSK_SKI1_1	640	644	PF00082	0.377
CLV_PCSK_SKI1_1	74	78	PF00082	0.491
CLV_PCSK_SKI1_1	741	745	PF00082	0.409
CLV_PCSK_SKI1_1	750	754	PF00082	0.344
CLV_PCSK_SKI1_1	881	885	PF00082	0.229
DEG_APCC_DBOX_1	367	375	PF00400	0.308
DEG_SPOP_SBC_1	294	298	PF00917	0.483
DEG_SPOP_SBC_1	479	483	PF00917	0.450
DOC_CYCLIN_RxL_1	2	12	PF00134	0.400
DOC_CYCLIN_RxL_1	582	591	PF00134	0.511
DOC_CYCLIN_RxL_1	737	747	PF00134	0.444
DOC_CYCLIN_RxL_1	865	877	PF00134	0.364
DOC_CYCLIN_yCln2_LP_2	390	396	PF00134	0.521
DOC_MAPK_gen_1	103	111	PF00069	0.488
DOC_MAPK_gen_1	195	203	PF00069	0.653
DOC_MAPK_gen_1	406	416	PF00069	0.429
DOC_MAPK_gen_1	575	584	PF00069	0.377
DOC_MAPK_gen_1	640	649	PF00069	0.384
DOC_MAPK_gen_1	71	81	PF00069	0.488
DOC_MAPK_MEF2A_6	103	111	PF00069	0.507
DOC_MAPK_MEF2A_6	113	122	PF00069	0.608
DOC_MAPK_MEF2A_6	28	35	PF00069	0.535
DOC_MAPK_MEF2A_6	71	79	PF00069	0.514
DOC_PP1_RVXF_1	629	635	PF00149	0.354
DOC_PP2B_LxvP_1	218	221	PF13499	0.733
DOC_PP2B_LxvP_1	7	10	PF13499	0.379
DOC_SPAK_OSR1_1	604	608	PF12202	0.485
DOC_USP7_MATH_1	150	154	PF00917	0.735
DOC_USP7_MATH_1	294	298	PF00917	0.659
DOC_USP7_MATH_1	363	367	PF00917	0.513
DOC_USP7_MATH_1	459	463	PF00917	0.574
DOC_USP7_MATH_1	479	483	PF00917	0.516
DOC_USP7_MATH_1	612	616	PF00917	0.381
DOC_USP7_MATH_1	678	682	PF00917	0.612
DOC_USP7_MATH_1	756	760	PF00917	0.466
DOC_USP7_MATH_1	852	856	PF00917	0.757
DOC_USP7_MATH_1	896	900	PF00917	0.440
DOC_USP7_UBL2_3	140	144	PF12436	0.627
DOC_USP7_UBL2_3	767	771	PF12436	0.476
DOC_USP7_UBL2_3	865	869	PF12436	0.272
DOC_WW_Pin1_4	221	226	PF00397	0.746
DOC_WW_Pin1_4	338	343	PF00397	0.574
DOC_WW_Pin1_4	798	803	PF00397	0.658
LIG_14-3-3_CanoR_1	204	213	PF00244	0.564
LIG_14-3-3_CanoR_1	364	371	PF00244	0.494
LIG_14-3-3_CanoR_1	415	423	PF00244	0.504
LIG_14-3-3_CanoR_1	440	448	PF00244	0.482
LIG_14-3-3_CanoR_1	577	584	PF00244	0.375
LIG_14-3-3_CanoR_1	623	627	PF00244	0.424
LIG_14-3-3_CanoR_1	636	640	PF00244	0.306
LIG_14-3-3_CanoR_1	750	756	PF00244	0.390
LIG_14-3-3_CanoR_1	85	93	PF00244	0.446
LIG_14-3-3_CanoR_1	897	903	PF00244	0.521
LIG_BIR_II_1	1	5	PF00653	0.405
LIG_BIR_III_2	726	730	PF00653	0.472
LIG_BRCT_BRCA1_1	480	484	PF00533	0.610
LIG_BRCT_BRCA1_1	898	902	PF00533	0.440
LIG_BRCT_BRCA1_1	98	102	PF00533	0.449
LIG_BRCT_BRCA1_2	480	486	PF00533	0.652
LIG_FHA_1	547	553	PF00498	0.360
LIG_FHA_1	578	584	PF00498	0.341
LIG_FHA_1	616	622	PF00498	0.402
LIG_FHA_1	642	648	PF00498	0.403
LIG_FHA_1	703	709	PF00498	0.330
LIG_FHA_1	784	790	PF00498	0.458
LIG_FHA_1	825	831	PF00498	0.714
LIG_FHA_1	890	896	PF00498	0.515
LIG_FHA_2	158	164	PF00498	0.761
LIG_FHA_2	186	192	PF00498	0.659
LIG_FHA_2	44	50	PF00498	0.570
LIG_FHA_2	714	720	PF00498	0.381
LIG_FHA_2	752	758	PF00498	0.394
LIG_FHA_2	874	880	PF00498	0.441
LIG_LIR_Gen_1	199	207	PF02991	0.663
LIG_LIR_Gen_1	503	509	PF02991	0.534
LIG_LIR_Gen_1	599	608	PF02991	0.439
LIG_LIR_Gen_1	882	890	PF02991	0.429
LIG_LIR_Nem_3	199	203	PF02991	0.657
LIG_LIR_Nem_3	599	605	PF02991	0.351
LIG_LIR_Nem_3	638	642	PF02991	0.393
LIG_LIR_Nem_3	650	654	PF02991	0.400
LIG_LIR_Nem_3	882	887	PF02991	0.429
LIG_MLH1_MIPbox_1	98	102	PF16413	0.478
LIG_Pex14_1	504	508	PF04695	0.438
LIG_Pex14_2	97	101	PF04695	0.453
LIG_PTB_Apo_2	370	377	PF02174	0.440
LIG_PTB_Apo_2	707	714	PF02174	0.345
LIG_PTB_Apo_2	867	874	PF02174	0.429
LIG_PTB_Apo_2	95	102	PF02174	0.501
LIG_PTB_Phospho_1	370	376	PF10480	0.472
LIG_REV1ctd_RIR_1	99	107	PF16727	0.463
LIG_SH2_GRB2like	508	511	PF00017	0.444
LIG_SH2_GRB2like	96	99	PF00017	0.497
LIG_SH2_NCK_1	624	628	PF00017	0.466
LIG_SH2_STAP1	704	708	PF00017	0.448
LIG_SH2_STAT5	376	379	PF00017	0.472
LIG_SH2_STAT5	547	550	PF00017	0.388
LIG_SH2_STAT5	624	627	PF00017	0.342
LIG_SH2_STAT5	704	707	PF00017	0.418
LIG_SH2_STAT5	763	766	PF00017	0.368
LIG_SH2_STAT5	96	99	PF00017	0.393
LIG_SH3_3	394	400	PF00018	0.437
LIG_SH3_3	890	896	PF00018	0.429
LIG_SUMO_SIM_par_1	31	37	PF11976	0.516
LIG_TRAF2_1	268	271	PF00917	0.610
LIG_TRAF2_1	358	361	PF00917	0.536
LIG_TRAF2_1	378	381	PF00917	0.505
LIG_TRAF2_1	443	446	PF00917	0.543
LIG_TYR_ITIM	943	948	PF00017	0.380
MOD_CDC14_SPxK_1	341	344	PF00782	0.515
MOD_CDK_SPxK_1	338	344	PF00069	0.519
MOD_CDK_SPxxK_3	338	345	PF00069	0.521
MOD_CK1_1	153	159	PF00069	0.651
MOD_CK1_1	205	211	PF00069	0.625
MOD_CK1_1	297	303	PF00069	0.621
MOD_CK1_1	338	344	PF00069	0.627
MOD_CK1_1	578	584	PF00069	0.350
MOD_CK1_1	615	621	PF00069	0.437
MOD_CK1_1	693	699	PF00069	0.717
MOD_CK1_1	783	789	PF00069	0.421
MOD_CK1_1	822	828	PF00069	0.609
MOD_CK1_1	885	891	PF00069	0.316
MOD_CK2_1	157	163	PF00069	0.751
MOD_CK2_1	414	420	PF00069	0.393
MOD_CK2_1	439	445	PF00069	0.440
MOD_CK2_1	713	719	PF00069	0.393
MOD_CK2_1	901	907	PF00069	0.285
MOD_CK2_1	917	923	PF00069	0.239
MOD_Cter_Amidation	342	345	PF01082	0.552
MOD_GlcNHglycan	144	147	PF01048	0.687
MOD_GlcNHglycan	152	155	PF01048	0.645
MOD_GlcNHglycan	258	261	PF01048	0.764
MOD_GlcNHglycan	290	293	PF01048	0.612
MOD_GlcNHglycan	299	302	PF01048	0.591
MOD_GlcNHglycan	337	340	PF01048	0.602
MOD_GlcNHglycan	417	420	PF01048	0.408
MOD_GlcNHglycan	441	444	PF01048	0.381
MOD_GlcNHglycan	473	476	PF01048	0.675
MOD_GlcNHglycan	609	613	PF01048	0.377
MOD_GlcNHglycan	614	617	PF01048	0.355
MOD_GlcNHglycan	664	667	PF01048	0.634
MOD_GlcNHglycan	680	683	PF01048	0.501
MOD_GlcNHglycan	693	696	PF01048	0.518
MOD_GlcNHglycan	836	839	PF01048	0.632
MOD_GlcNHglycan	844	847	PF01048	0.735
MOD_GlcNHglycan	850	853	PF01048	0.761
MOD_GlcNHglycan	86	89	PF01048	0.420
MOD_GlcNHglycan	884	887	PF01048	0.314
MOD_GSK3_1	150	157	PF00069	0.760
MOD_GSK3_1	185	192	PF00069	0.704
MOD_GSK3_1	205	212	PF00069	0.553
MOD_GSK3_1	293	300	PF00069	0.570
MOD_GSK3_1	329	336	PF00069	0.725
MOD_GSK3_1	573	580	PF00069	0.522
MOD_GSK3_1	608	615	PF00069	0.372
MOD_GSK3_1	674	681	PF00069	0.597
MOD_GSK3_1	687	694	PF00069	0.529
MOD_GSK3_1	702	709	PF00069	0.335
MOD_GSK3_1	776	783	PF00069	0.425
MOD_GSK3_1	798	805	PF00069	0.688
MOD_GSK3_1	842	849	PF00069	0.754
MOD_GSK3_1	885	892	PF00069	0.291
MOD_GSK3_1	896	903	PF00069	0.288
MOD_GSK3_1	927	934	PF00069	0.301
MOD_GSK3_1	97	104	PF00069	0.431
MOD_N-GLC_1	578	583	PF02516	0.369
MOD_N-GLC_1	819	824	PF02516	0.668
MOD_N-GLC_1	97	102	PF02516	0.410
MOD_N-GLC_2	11	13	PF02516	0.508
MOD_NEK2_1	155	160	PF00069	0.715
MOD_NEK2_1	189	194	PF00069	0.615
MOD_NEK2_1	22	27	PF00069	0.461
MOD_NEK2_1	293	298	PF00069	0.540
MOD_NEK2_1	386	391	PF00069	0.272
MOD_NEK2_1	439	444	PF00069	0.385
MOD_NEK2_1	460	465	PF00069	0.590
MOD_NEK2_1	478	483	PF00069	0.662
MOD_NEK2_1	573	578	PF00069	0.575
MOD_NEK2_1	608	613	PF00069	0.351
MOD_NEK2_1	622	627	PF00069	0.342
MOD_NEK2_1	641	646	PF00069	0.420
MOD_NEK2_1	674	679	PF00069	0.587
MOD_NEK2_1	702	707	PF00069	0.355
MOD_NEK2_1	84	89	PF00069	0.437
MOD_NEK2_1	931	936	PF00069	0.288
MOD_NEK2_1	97	102	PF00069	0.295
MOD_NEK2_2	480	485	PF00069	0.444
MOD_NEK2_2	927	932	PF00069	0.308
MOD_PIKK_1	240	246	PF00454	0.692
MOD_PIKK_1	352	358	PF00454	0.584
MOD_PIKK_1	567	573	PF00454	0.590
MOD_PK_1	60	66	PF00069	0.727
MOD_PKA_1	142	148	PF00069	0.559
MOD_PKA_2	102	108	PF00069	0.508
MOD_PKA_2	142	148	PF00069	0.504
MOD_PKA_2	253	259	PF00069	0.647
MOD_PKA_2	363	369	PF00069	0.439
MOD_PKA_2	414	420	PF00069	0.369
MOD_PKA_2	439	445	PF00069	0.395
MOD_PKA_2	622	628	PF00069	0.382
MOD_PKA_2	635	641	PF00069	0.331
MOD_PKA_2	84	90	PF00069	0.491
MOD_PKA_2	896	902	PF00069	0.288
MOD_PKB_1	832	840	PF00069	0.579
MOD_Plk_1	578	584	PF00069	0.367
MOD_Plk_1	608	614	PF00069	0.349
MOD_Plk_1	756	762	PF00069	0.383
MOD_Plk_1	97	103	PF00069	0.416
MOD_Plk_2-3	917	923	PF00069	0.272
MOD_Plk_4	386	392	PF00069	0.308
MOD_Plk_4	503	509	PF00069	0.441
MOD_Plk_4	578	584	PF00069	0.350
MOD_Plk_4	702	708	PF00069	0.395
MOD_Plk_4	97	103	PF00069	0.345
MOD_ProDKin_1	221	227	PF00069	0.748
MOD_ProDKin_1	338	344	PF00069	0.576
MOD_ProDKin_1	798	804	PF00069	0.660
MOD_SUMO_for_1	107	110	PF00179	0.440
MOD_SUMO_rev_2	173	183	PF00179	0.662
MOD_SUMO_rev_2	230	237	PF00179	0.710
MOD_SUMO_rev_2	297	307	PF00179	0.699
TRG_AP2beta_CARGO_1	882	891	PF09066	0.308
TRG_DiLeu_BaEn_2	718	724	PF01217	0.455
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.544
TRG_DiLeu_BaLyEn_6	434	439	PF01217	0.272
TRG_ENDOCYTIC_2	639	642	PF00928	0.370
TRG_ENDOCYTIC_2	704	707	PF00928	0.443
TRG_ENDOCYTIC_2	945	948	PF00928	0.378
TRG_ER_diArg_1	125	128	PF00400	0.425
TRG_ER_diArg_1	195	198	PF00400	0.557
TRG_ER_diArg_1	246	248	PF00400	0.729
TRG_ER_diArg_1	3	6	PF00400	0.352
TRG_ER_diArg_1	368	371	PF00400	0.277
TRG_ER_diArg_1	41	43	PF00400	0.539
TRG_ER_diArg_1	832	834	PF00400	0.739
TRG_NES_CRM1_1	110	124	PF08389	0.591
TRG_NES_CRM1_1	597	609	PF08389	0.469
TRG_NLS_Bipartite_1	126	146	PF00514	0.448
TRG_NLS_MonoExtC_3	167	172	PF00514	0.729
TRG_NLS_MonoExtN_4	139	146	PF00514	0.471
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.596
TRG_Pf-PMV_PEXEL_1	273	278	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	939	944	PF00026	0.359

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY42	Leptomonas seymouri	67%	100%
A0A0S4J8G6	Bodo saltans	40%	100%
A0A1X0NQT4	Trypanosomatidae	48%	100%
A0A3Q8I7R0	Leishmania donovani	92%	100%
A0A3R7NQE9	Trypanosoma rangeli	48%	100%
A4H661	Leishmania braziliensis	80%	100%
A4HUI2	Leishmania infantum	92%	100%
C9ZVK7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AN80	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q06106	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%
Q4WJT7	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	25%	100%
Q5BGA9	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	100%
Q7SG09	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	25%	100%
V5B419	Trypanosoma cruzi	50%	100%