LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Putative amino acid transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative amino acid transporter
Gene product:
amino acid permease 24, putative
Species:
Leishmania major
UniProt:
Q4QHE4_LEIMA
TriTrypDb:
LmjF.10.0710 , LMJLV39_100013200 , LMJSD75_100013500
Length:
488

Annotations

LeishMANIAdb annotations

Related to animal and plant proton-coupled amino acid transporters. The family has modestly expanded in kinetoplastid parazites.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 19
NetGPI no yes: 0, no: 19
Cellular components
Term Name Level Count
GO:0005774 vacuolar membrane 5 3
GO:0016020 membrane 2 19
GO:0031090 organelle membrane 3 3
GO:0098588 bounding membrane of organelle 4 3
GO:0110165 cellular anatomical entity 1 19

Expansion

Sequence features

Q4QHE4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHE4

Function

Biological processes
Term Name Level Count
GO:0003333 amino acid transmembrane transport 5 3
GO:0006810 transport 3 3
GO:0006865 amino acid transport 5 3
GO:0009987 cellular process 1 3
GO:0015849 organic acid transport 5 3
GO:0051179 localization 1 3
GO:0051234 establishment of localization 2 3
GO:0055085 transmembrane transport 2 3
GO:0071702 organic substance transport 4 3
GO:0071705 nitrogen compound transport 4 3
GO:1903825 organic acid transmembrane transport 3 3
GO:1905039 carboxylic acid transmembrane transport 4 3
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 3
GO:0005342 organic acid transmembrane transporter activity 3 3
GO:0015171 amino acid transmembrane transporter activity 5 3
GO:0015179 L-amino acid transmembrane transporter activity 6 3
GO:0022857 transmembrane transporter activity 2 3
GO:0046943 carboxylic acid transmembrane transporter activity 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 437 441 PF00656 0.622
CLV_C14_Caspase3-7 7 11 PF00656 0.728
CLV_NRD_NRD_1 24 26 PF00675 0.530
CLV_PCSK_KEX2_1 296 298 PF00082 0.351
CLV_PCSK_KEX2_1 462 464 PF00082 0.362
CLV_PCSK_PC1ET2_1 296 298 PF00082 0.351
CLV_PCSK_PC1ET2_1 462 464 PF00082 0.408
CLV_PCSK_SKI1_1 301 305 PF00082 0.303
CLV_PCSK_SKI1_1 347 351 PF00082 0.319
CLV_PCSK_SKI1_1 450 454 PF00082 0.342
CLV_PCSK_SKI1_1 88 92 PF00082 0.241
DEG_APCC_KENBOX_2 80 84 PF00400 0.620
DOC_MAPK_FxFP_2 356 359 PF00069 0.340
DOC_MAPK_gen_1 196 205 PF00069 0.306
DOC_MAPK_gen_1 376 385 PF00069 0.462
DOC_MAPK_gen_1 462 472 PF00069 0.478
DOC_MAPK_MEF2A_6 133 142 PF00069 0.360
DOC_MAPK_MEF2A_6 196 205 PF00069 0.318
DOC_MAPK_MEF2A_6 347 356 PF00069 0.340
DOC_MAPK_MEF2A_6 376 385 PF00069 0.462
DOC_MAPK_MEF2A_6 386 393 PF00069 0.263
DOC_MAPK_MEF2A_6 463 472 PF00069 0.480
DOC_MAPK_NFAT4_5 386 394 PF00069 0.340
DOC_PP1_RVXF_1 345 351 PF00149 0.346
DOC_PP4_FxxP_1 103 106 PF00568 0.299
DOC_PP4_FxxP_1 356 359 PF00568 0.340
DOC_USP7_MATH_1 224 228 PF00917 0.318
DOC_USP7_MATH_1 230 234 PF00917 0.318
DOC_USP7_MATH_1 414 418 PF00917 0.392
DOC_WW_Pin1_4 337 342 PF00397 0.322
LIG_14-3-3_CanoR_1 23 29 PF00244 0.745
LIG_14-3-3_CanoR_1 3 13 PF00244 0.778
LIG_14-3-3_CanoR_1 443 447 PF00244 0.534
LIG_BIR_II_1 1 5 PF00653 0.749
LIG_BRCT_BRCA1_1 181 185 PF00533 0.363
LIG_EH1_1 113 121 PF00400 0.316
LIG_FHA_1 130 136 PF00498 0.397
LIG_FHA_1 224 230 PF00498 0.354
LIG_FHA_1 302 308 PF00498 0.484
LIG_FHA_1 318 324 PF00498 0.254
LIG_FHA_1 328 334 PF00498 0.246
LIG_FHA_1 355 361 PF00498 0.347
LIG_FHA_1 400 406 PF00498 0.325
LIG_FHA_1 479 485 PF00498 0.331
LIG_FHA_2 15 21 PF00498 0.706
LIG_FHA_2 186 192 PF00498 0.335
LIG_FHA_2 25 31 PF00498 0.753
LIG_FHA_2 5 11 PF00498 0.761
LIG_GBD_Chelix_1 115 123 PF00786 0.388
LIG_GBD_Chelix_1 311 319 PF00786 0.434
LIG_LIR_Apic_2 100 106 PF02991 0.318
LIG_LIR_Gen_1 148 157 PF02991 0.505
LIG_LIR_Gen_1 190 200 PF02991 0.245
LIG_LIR_Gen_1 233 244 PF02991 0.372
LIG_LIR_Gen_1 30 38 PF02991 0.724
LIG_LIR_Gen_1 60 68 PF02991 0.747
LIG_LIR_Gen_1 89 98 PF02991 0.357
LIG_LIR_Nem_3 148 153 PF02991 0.462
LIG_LIR_Nem_3 190 195 PF02991 0.252
LIG_LIR_Nem_3 198 203 PF02991 0.321
LIG_LIR_Nem_3 233 239 PF02991 0.377
LIG_LIR_Nem_3 30 35 PF02991 0.758
LIG_LIR_Nem_3 320 325 PF02991 0.368
LIG_LIR_Nem_3 379 383 PF02991 0.487
LIG_LIR_Nem_3 460 464 PF02991 0.537
LIG_LIR_Nem_3 89 94 PF02991 0.357
LIG_PALB2_WD40_1 265 273 PF16756 0.311
LIG_PDZ_Class_2 483 488 PF00595 0.483
LIG_Pex14_1 313 317 PF04695 0.364
LIG_Pex14_1 449 453 PF04695 0.582
LIG_Pex14_2 207 211 PF04695 0.367
LIG_PTB_Apo_2 350 357 PF02174 0.377
LIG_SH2_CRK 150 154 PF00017 0.483
LIG_SH2_CRK 181 185 PF00017 0.384
LIG_SH2_CRK 236 240 PF00017 0.412
LIG_SH2_PTP2 467 470 PF00017 0.437
LIG_SH2_STAP1 181 185 PF00017 0.348
LIG_SH2_STAP1 482 486 PF00017 0.321
LIG_SH2_STAT3 358 361 PF00017 0.318
LIG_SH2_STAT5 114 117 PF00017 0.337
LIG_SH2_STAT5 156 159 PF00017 0.485
LIG_SH2_STAT5 200 203 PF00017 0.340
LIG_SH2_STAT5 314 317 PF00017 0.316
LIG_SH2_STAT5 322 325 PF00017 0.334
LIG_SH2_STAT5 467 470 PF00017 0.308
LIG_SH2_STAT5 61 64 PF00017 0.754
LIG_SH3_3 433 439 PF00018 0.524
LIG_SH3_3 451 457 PF00018 0.617
LIG_SUMO_SIM_anti_2 217 224 PF11976 0.482
LIG_SUMO_SIM_anti_2 281 287 PF11976 0.364
LIG_SUMO_SIM_par_1 221 227 PF11976 0.491
LIG_SUMO_SIM_par_1 303 308 PF11976 0.403
LIG_TYR_ITIM 179 184 PF00017 0.346
LIG_TYR_ITIM 234 239 PF00017 0.412
LIG_TYR_ITSM 146 153 PF00017 0.529
LIG_WRC_WIRS_1 105 110 PF05994 0.346
MOD_CK1_1 145 151 PF00069 0.506
MOD_CK1_1 328 334 PF00069 0.323
MOD_CK1_1 6 12 PF00069 0.740
MOD_CK2_1 14 20 PF00069 0.693
MOD_CK2_1 185 191 PF00069 0.335
MOD_CK2_1 24 30 PF00069 0.753
MOD_CK2_1 31 37 PF00069 0.728
MOD_CK2_1 6 12 PF00069 0.737
MOD_GlcNHglycan 363 366 PF01048 0.358
MOD_GlcNHglycan 402 405 PF01048 0.512
MOD_GlcNHglycan 88 91 PF01048 0.296
MOD_GSK3_1 142 149 PF00069 0.545
MOD_GSK3_1 214 221 PF00069 0.357
MOD_GSK3_1 224 231 PF00069 0.322
MOD_GSK3_1 301 308 PF00069 0.507
MOD_GSK3_1 325 332 PF00069 0.315
MOD_GSK3_1 337 344 PF00069 0.251
MOD_GSK3_1 400 407 PF00069 0.443
MOD_GSK3_1 480 487 PF00069 0.378
MOD_N-GLC_1 142 147 PF02516 0.354
MOD_N-GLC_1 218 223 PF02516 0.273
MOD_NEK2_1 179 184 PF00069 0.343
MOD_NEK2_1 195 200 PF00069 0.210
MOD_NEK2_1 201 206 PF00069 0.306
MOD_NEK2_1 223 228 PF00069 0.311
MOD_NEK2_1 242 247 PF00069 0.338
MOD_NEK2_1 305 310 PF00069 0.403
MOD_NEK2_1 317 322 PF00069 0.282
MOD_NEK2_1 329 334 PF00069 0.216
MOD_NEK2_1 354 359 PF00069 0.340
MOD_NEK2_1 381 386 PF00069 0.498
MOD_NEK2_2 230 235 PF00069 0.440
MOD_NEK2_2 342 347 PF00069 0.314
MOD_NEK2_2 457 462 PF00069 0.625
MOD_OFUCOSY 210 215 PF10250 0.378
MOD_PIKK_1 14 20 PF00454 0.714
MOD_PIKK_1 148 154 PF00454 0.510
MOD_PIKK_1 179 185 PF00454 0.343
MOD_PIKK_1 247 253 PF00454 0.332
MOD_PIKK_1 291 297 PF00454 0.518
MOD_PKA_2 24 30 PF00069 0.730
MOD_PKA_2 442 448 PF00069 0.527
MOD_Plk_1 129 135 PF00069 0.340
MOD_Plk_1 145 151 PF00069 0.479
MOD_Plk_1 218 224 PF00069 0.473
MOD_Plk_4 104 110 PF00069 0.315
MOD_Plk_4 114 120 PF00069 0.315
MOD_Plk_4 201 207 PF00069 0.332
MOD_Plk_4 218 224 PF00069 0.395
MOD_Plk_4 230 236 PF00069 0.310
MOD_Plk_4 24 30 PF00069 0.746
MOD_Plk_4 242 248 PF00069 0.270
MOD_Plk_4 301 307 PF00069 0.477
MOD_Plk_4 329 335 PF00069 0.249
MOD_Plk_4 404 410 PF00069 0.274
MOD_Plk_4 423 429 PF00069 0.187
MOD_ProDKin_1 337 343 PF00069 0.322
MOD_SUMO_rev_2 50 59 PF00179 0.778
TRG_DiLeu_BaLyEn_6 130 135 PF01217 0.367
TRG_DiLeu_BaLyEn_6 383 388 PF01217 0.410
TRG_ENDOCYTIC_2 150 153 PF00928 0.447
TRG_ENDOCYTIC_2 181 184 PF00928 0.355
TRG_ENDOCYTIC_2 200 203 PF00928 0.193
TRG_ENDOCYTIC_2 236 239 PF00928 0.371
TRG_ENDOCYTIC_2 314 317 PF00928 0.319
TRG_ENDOCYTIC_2 467 470 PF00928 0.329
TRG_ENDOCYTIC_2 61 64 PF00928 0.754
TRG_NLS_Bipartite_1 450 466 PF00514 0.610
TRG_Pf-PMV_PEXEL_1 133 137 PF00026 0.434
TRG_Pf-PMV_PEXEL_1 26 30 PF00026 0.539

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6H0 Leptomonas seymouri 71% 100%
A0A0N0P8T9 Leptomonas seymouri 21% 98%
A0A0N1PCP5 Leptomonas seymouri 70% 100%
A0A1X0NHS6 Trypanosomatidae 46% 100%
A0A1X0NRL3 Trypanosomatidae 23% 100%
A0A1X0NYI3 Trypanosomatidae 22% 98%
A0A1X0NZK6 Trypanosomatidae 49% 100%
A0A1X0P7Z8 Trypanosomatidae 32% 78%
A0A381MBS1 Leishmania infantum 93% 100%
A0A3Q8IB21 Leishmania donovani 94% 100%
A0A3Q8IFZ0 Leishmania donovani 22% 95%
A0A3S5H6G5 Leishmania donovani 94% 100%
A0A3S5H6T4 Leishmania donovani 23% 96%
A0A3S5ISG3 Trypanosoma rangeli 24% 99%
A0A3S7WQ39 Leishmania donovani 21% 100%
A0A422MW74 Trypanosoma rangeli 21% 95%
A0A422MZQ8 Trypanosoma rangeli 35% 82%
A4H565 Leishmania braziliensis 21% 99%
A4H662 Leishmania braziliensis 78% 100%
A4HNZ6 Leishmania braziliensis 31% 100%
A4HTE2 Leishmania infantum 21% 99%
A4HUI4 Leishmania infantum 94% 100%
A4I6K0 Leishmania infantum 22% 95%
C9ZW15 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
D0A2X2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 85%
E9AN82 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
E9AYW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 23% 98%
F4ILY9 Arabidopsis thaliana 24% 100%
P36062 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 21% 71%
Q10074 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 23% 74%
Q495M3 Homo sapiens 20% 100%
Q495N2 Homo sapiens 21% 100%
Q4KL91 Xenopus laevis 21% 93%
Q4Q6M8 Leishmania major 23% 95%
Q4QHE2 Leishmania major 100% 100%
Q4QIH0 Leishmania major 23% 99%
Q4V8B1 Rattus norvegicus 22% 100%
Q6YBV0 Homo sapiens 21% 97%
Q7Z2H8 Homo sapiens 21% 100%
Q811P0 Mus musculus 22% 100%
Q8BHK3 Mus musculus 21% 100%
Q8CH36 Mus musculus 22% 98%
Q8K415 Rattus norvegicus 21% 100%
Q8K4D3 Mus musculus 23% 100%
Q924A5 Rattus norvegicus 22% 100%
Q9SS86 Arabidopsis thaliana 20% 100%
Q9SVG0 Arabidopsis thaliana 24% 100%
Q9VT04 Drosophila melanogaster 20% 100%
Q9W056 Drosophila melanogaster 24% 100%
V5BHF0 Trypanosoma cruzi 44% 100%
V5BJY7 Trypanosoma cruzi 34% 82%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS