Putative deaminase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative deaminase

Gene product:

deaminase, putative

Species:

Leishmania major

UniProt:

Q4QHE1_LEIMA

TriTrypDb:

LmjF.10.0730 , LMJLV39_100013400 , LMJSD75_100013700

Length:

281

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QHE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHE1

Function

Biological processes
Term	Name	Level	Count
GO:0002097	tRNA wobble base modification	7	3
GO:0002100	tRNA wobble adenosine to inosine editing	8	3
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006382	adenosine to inosine editing	7	3
GO:0006396	RNA processing	6	3
GO:0006399	tRNA metabolic process	7	3
GO:0006400	tRNA modification	6	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008033	tRNA processing	8	3
GO:0008152	metabolic process	1	3
GO:0009451	RNA modification	5	3
GO:0009987	cellular process	1	3
GO:0016070	RNA metabolic process	5	3
GO:0016553	base conversion or substitution editing	6	3
GO:0034470	ncRNA processing	7	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0034660	ncRNA metabolic process	6	3
GO:0043170	macromolecule metabolic process	3	3
GO:0043412	macromolecule modification	4	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0046483	heterocycle metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:1901360	organic cyclic compound metabolic process	3	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004000	adenosine deaminase activity	4	3
GO:0008251	tRNA-specific adenosine deaminase activity	5	3
GO:0016787	hydrolase activity	2	9
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	3
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	4	3
GO:0019239	deaminase activity	3	3
GO:0052717	tRNA-specific adenosine-34 deaminase activity	6	2
GO:0005488	binding	1	2
GO:0008270	zinc ion binding	6	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0046914	transition metal ion binding	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	278	280	PF00675	0.575
CLV_PCSK_KEX2_1	276	278	PF00082	0.561
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.549
CLV_PCSK_SKI1_1	11	15	PF00082	0.233
CLV_PCSK_SKI1_1	44	48	PF00082	0.266
DEG_SCF_FBW7_1	140	147	PF00400	0.430
DOC_CKS1_1	141	146	PF01111	0.433
DOC_USP7_MATH_1	112	116	PF00917	0.475
DOC_USP7_MATH_1	145	149	PF00917	0.501
DOC_USP7_MATH_1	211	215	PF00917	0.590
DOC_USP7_MATH_1	222	226	PF00917	0.638
DOC_USP7_MATH_1	46	50	PF00917	0.451
DOC_USP7_UBL2_3	276	280	PF12436	0.554
DOC_WW_Pin1_4	136	141	PF00397	0.522
DOC_WW_Pin1_4	194	199	PF00397	0.518
DOC_WW_Pin1_4	225	230	PF00397	0.670
LIG_14-3-3_CanoR_1	136	140	PF00244	0.350
LIG_BIR_II_1	1	5	PF00653	0.442
LIG_FHA_1	141	147	PF00498	0.436
LIG_FHA_2	251	257	PF00498	0.412
LIG_LIR_Gen_1	39	47	PF02991	0.466
LIG_LIR_Gen_1	93	101	PF02991	0.392
LIG_LIR_Nem_3	151	155	PF02991	0.448
LIG_LIR_Nem_3	241	246	PF02991	0.526
LIG_LIR_Nem_3	39	45	PF02991	0.466
LIG_LIR_Nem_3	93	97	PF02991	0.392
LIG_Pex14_1	242	246	PF04695	0.514
LIG_PTB_Apo_2	179	186	PF02174	0.347
LIG_REV1ctd_RIR_1	175	182	PF16727	0.510
LIG_SH2_CRK	170	174	PF00017	0.413
LIG_SH2_CRK	42	46	PF00017	0.433
LIG_SH2_NCK_1	170	174	PF00017	0.510
LIG_SH2_PTP2	155	158	PF00017	0.415
LIG_SH2_STAP1	42	46	PF00017	0.433
LIG_SH2_STAT5	152	155	PF00017	0.415
LIG_SH2_STAT5	246	249	PF00017	0.412
LIG_SH2_STAT5	42	45	PF00017	0.366
LIG_SH2_STAT5	5	8	PF00017	0.316
LIG_SH3_1	267	273	PF00018	0.589
LIG_SH3_3	138	144	PF00018	0.507
LIG_SH3_3	205	211	PF00018	0.585
LIG_SH3_3	267	273	PF00018	0.589
LIG_SUMO_SIM_anti_2	256	262	PF11976	0.368
LIG_TRAF2_1	20	23	PF00917	0.510
LIG_TYR_ITIM	153	158	PF00017	0.415
LIG_TYR_ITIM	168	173	PF00017	0.415
LIG_WRC_WIRS_1	6	11	PF05994	0.183
MOD_CDK_SPK_2	194	199	PF00069	0.308
MOD_CK1_1	116	122	PF00069	0.456
MOD_CK1_1	139	145	PF00069	0.463
MOD_CK1_1	214	220	PF00069	0.618
MOD_CK1_1	225	231	PF00069	0.694
MOD_CK2_1	119	125	PF00069	0.375
MOD_CK2_1	227	233	PF00069	0.605
MOD_CK2_1	250	256	PF00069	0.421
MOD_GlcNHglycan	109	113	PF01048	0.330
MOD_GlcNHglycan	212	216	PF01048	0.575
MOD_GSK3_1	108	115	PF00069	0.474
MOD_GSK3_1	135	142	PF00069	0.527
MOD_GSK3_1	221	228	PF00069	0.667
MOD_GSK3_1	47	54	PF00069	0.451
MOD_N-GLC_1	187	192	PF02516	0.357
MOD_N-GLC_1	37	42	PF02516	0.307
MOD_N-GLC_1	79	84	PF02516	0.215
MOD_NEK2_1	221	226	PF00069	0.561
MOD_NEK2_1	69	74	PF00069	0.466
MOD_NEK2_2	37	42	PF00069	0.492
MOD_OFUCOSY	66	73	PF10250	0.233
MOD_PIKK_1	206	212	PF00454	0.672
MOD_PKA_2	135	141	PF00069	0.433
MOD_PKB_1	77	85	PF00069	0.428
MOD_Plk_1	37	43	PF00069	0.504
MOD_Plk_4	187	193	PF00069	0.355
MOD_Plk_4	37	43	PF00069	0.507
MOD_Plk_4	5	11	PF00069	0.315
MOD_ProDKin_1	136	142	PF00069	0.522
MOD_ProDKin_1	194	200	PF00069	0.526
MOD_ProDKin_1	225	231	PF00069	0.669
TRG_DiLeu_BaEn_1	256	261	PF01217	0.380
TRG_ENDOCYTIC_2	155	158	PF00928	0.415
TRG_ENDOCYTIC_2	170	173	PF00928	0.415
TRG_ENDOCYTIC_2	42	45	PF00928	0.466
TRG_ER_diArg_1	277	279	PF00400	0.597
TRG_NLS_MonoCore_2	275	280	PF00514	0.573
TRG_NLS_MonoExtC_3	275	280	PF00514	0.548
TRG_NLS_MonoExtN_4	273	280	PF00514	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6V2	Leptomonas seymouri	47%	86%
A0A1X0NRT1	Trypanosomatidae	49%	100%
A0A3S7WR79	Leishmania donovani	89%	100%
A0A422NWX1	Trypanosoma rangeli	44%	100%
A4H663	Leishmania braziliensis	74%	100%
A4HUI5	Leishmania infantum	89%	100%
C9ZVK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AN83	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
O94642	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	72%
P47058	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
Q5E9J7	Bos taurus	27%	100%
Q5RIV4	Danio rerio	28%	100%
Q6P6J0	Mus musculus	28%	100%
Q7Z6V5	Homo sapiens	27%	100%
V5DKK8	Trypanosoma cruzi	44%	100%