Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHD8_LEIMA

TriTrypDb:

LmjF.10.0760 , LMJLV39_100013700 , LMJSD75_100014000

Length:

635

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHD8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	259	263	PF00656	0.668
CLV_NRD_NRD_1	28	30	PF00675	0.534
CLV_NRD_NRD_1	355	357	PF00675	0.582
CLV_NRD_NRD_1	387	389	PF00675	0.569
CLV_NRD_NRD_1	406	408	PF00675	0.329
CLV_NRD_NRD_1	41	43	PF00675	0.346
CLV_NRD_NRD_1	9	11	PF00675	0.471
CLV_PCSK_KEX2_1	355	357	PF00082	0.534
CLV_PCSK_KEX2_1	387	389	PF00082	0.569
CLV_PCSK_KEX2_1	406	408	PF00082	0.329
CLV_PCSK_KEX2_1	41	43	PF00082	0.383
CLV_PCSK_KEX2_1	9	11	PF00082	0.471
CLV_PCSK_SKI1_1	412	416	PF00082	0.477
CLV_PCSK_SKI1_1	459	463	PF00082	0.426
CLV_PCSK_SKI1_1	526	530	PF00082	0.369
DEG_COP1_1	315	325	PF00400	0.563
DEG_SCF_FBW7_2	55	62	PF00400	0.443
DEG_SPOP_SBC_1	173	177	PF00917	0.597
DOC_CDC14_PxL_1	509	517	PF14671	0.401
DOC_CKS1_1	390	395	PF01111	0.386
DOC_CYCLIN_yCln2_LP_2	515	521	PF00134	0.343
DOC_MAPK_DCC_7	487	496	PF00069	0.576
DOC_MAPK_gen_1	216	225	PF00069	0.507
DOC_MAPK_gen_1	596	605	PF00069	0.373
DOC_MAPK_MEF2A_6	487	496	PF00069	0.576
DOC_MAPK_MEF2A_6	526	533	PF00069	0.411
DOC_MAPK_NFAT4_5	526	534	PF00069	0.418
DOC_PP2B_LxvP_1	415	418	PF13499	0.558
DOC_PP2B_LxvP_1	515	518	PF13499	0.404
DOC_PP4_FxxP_1	414	417	PF00568	0.486
DOC_USP7_MATH_1	102	106	PF00917	0.530
DOC_USP7_MATH_1	321	325	PF00917	0.664
DOC_USP7_MATH_1	461	465	PF00917	0.557
DOC_USP7_MATH_1	501	505	PF00917	0.562
DOC_USP7_MATH_1	549	553	PF00917	0.386
DOC_USP7_MATH_1	560	564	PF00917	0.413
DOC_USP7_MATH_1	63	67	PF00917	0.569
DOC_USP7_MATH_1	91	95	PF00917	0.630
DOC_WW_Pin1_4	1	6	PF00397	0.542
DOC_WW_Pin1_4	245	250	PF00397	0.666
DOC_WW_Pin1_4	324	329	PF00397	0.557
DOC_WW_Pin1_4	389	394	PF00397	0.372
DOC_WW_Pin1_4	503	508	PF00397	0.617
DOC_WW_Pin1_4	55	60	PF00397	0.656
DOC_WW_Pin1_4	81	86	PF00397	0.471
LIG_14-3-3_CanoR_1	139	147	PF00244	0.656
LIG_14-3-3_CanoR_1	387	393	PF00244	0.550
LIG_14-3-3_CanoR_1	406	410	PF00244	0.316
LIG_14-3-3_CanoR_1	41	46	PF00244	0.433
LIG_14-3-3_CanoR_1	463	467	PF00244	0.500
LIG_14-3-3_CanoR_1	487	492	PF00244	0.530
LIG_14-3-3_CanoR_1	558	568	PF00244	0.450
LIG_14-3-3_CanoR_1	598	605	PF00244	0.365
LIG_Actin_WH2_2	339	357	PF00022	0.474
LIG_Actin_WH2_2	448	465	PF00022	0.365
LIG_APCC_ABBA_1	566	571	PF00400	0.395
LIG_BIR_III_4	614	618	PF00653	0.416
LIG_BRCT_BRCA1_1	335	339	PF00533	0.436
LIG_BRCT_BRCA1_1	43	47	PF00533	0.436
LIG_BRCT_BRCA1_1	535	539	PF00533	0.422
LIG_BRCT_BRCA1_1	83	87	PF00533	0.487
LIG_CtBP_PxDLS_1	249	253	PF00389	0.506
LIG_eIF4E_2	395	401	PF01652	0.447
LIG_FHA_1	15	21	PF00498	0.381
LIG_FHA_1	174	180	PF00498	0.639
LIG_FHA_1	185	191	PF00498	0.493
LIG_FHA_1	2	8	PF00498	0.544
LIG_FHA_1	440	446	PF00498	0.396
LIG_FHA_1	586	592	PF00498	0.381
LIG_FHA_2	284	290	PF00498	0.505
LIG_FHA_2	29	35	PF00498	0.537
LIG_FHA_2	99	105	PF00498	0.607
LIG_IBAR_NPY_1	255	257	PF08397	0.494
LIG_Integrin_RGD_1	226	228	PF01839	0.526
LIG_LIR_Apic_2	392	398	PF02991	0.435
LIG_LIR_Gen_1	377	386	PF02991	0.369
LIG_LIR_Gen_1	44	55	PF02991	0.459
LIG_LIR_Gen_1	449	458	PF02991	0.411
LIG_LIR_Nem_3	377	383	PF02991	0.398
LIG_LIR_Nem_3	44	50	PF02991	0.426
LIG_LIR_Nem_3	449	455	PF02991	0.395
LIG_LIR_Nem_3	81	86	PF02991	0.419
LIG_MLH1_MIPbox_1	83	87	PF16413	0.487
LIG_MYND_1	250	254	PF01753	0.530
LIG_PTB_Apo_2	408	415	PF02174	0.352
LIG_RPA_C_Fungi	377	389	PF08784	0.396
LIG_SH2_CRK	45	49	PF00017	0.399
LIG_SH2_NCK_1	600	604	PF00017	0.384
LIG_SH2_SRC	569	572	PF00017	0.402
LIG_SH2_STAP1	45	49	PF00017	0.364
LIG_SH2_STAT3	120	123	PF00017	0.451
LIG_SH2_STAT3	232	235	PF00017	0.540
LIG_SH2_STAT5	120	123	PF00017	0.442
LIG_SH2_STAT5	232	235	PF00017	0.531
LIG_SH2_STAT5	257	260	PF00017	0.530
LIG_SH2_STAT5	454	457	PF00017	0.408
LIG_SH2_STAT5	600	603	PF00017	0.385
LIG_SH2_STAT5	86	89	PF00017	0.461
LIG_SH3_1	10	16	PF00018	0.412
LIG_SH3_1	532	538	PF00018	0.414
LIG_SH3_3	10	16	PF00018	0.470
LIG_SH3_3	361	367	PF00018	0.565
LIG_SH3_3	45	51	PF00018	0.439
LIG_SH3_3	507	513	PF00018	0.532
LIG_SH3_3	532	538	PF00018	0.414
LIG_SH3_3	629	635	PF00018	0.533
LIG_SH3_3	69	75	PF00018	0.467
LIG_SUMO_SIM_anti_2	262	268	PF11976	0.403
LIG_SUMO_SIM_anti_2	508	513	PF11976	0.492
LIG_SUMO_SIM_anti_2	588	594	PF11976	0.452
LIG_SUMO_SIM_par_1	131	136	PF11976	0.430
LIG_SUMO_SIM_par_1	582	588	PF11976	0.354
MOD_CK1_1	146	152	PF00069	0.701
MOD_CK1_1	166	172	PF00069	0.581
MOD_CK1_1	24	30	PF00069	0.570
MOD_CK1_1	248	254	PF00069	0.655
MOD_CK1_1	324	330	PF00069	0.668
MOD_CK1_1	368	374	PF00069	0.425
MOD_CK1_1	505	511	PF00069	0.498
MOD_CK1_1	559	565	PF00069	0.511
MOD_CK2_1	139	145	PF00069	0.629
MOD_CK2_1	28	34	PF00069	0.535
MOD_CK2_1	283	289	PF00069	0.593
MOD_CK2_1	368	374	PF00069	0.463
MOD_CK2_1	444	450	PF00069	0.383
MOD_CK2_1	549	555	PF00069	0.438
MOD_CK2_1	98	104	PF00069	0.604
MOD_GlcNHglycan	103	107	PF01048	0.595
MOD_GlcNHglycan	168	171	PF01048	0.563
MOD_GlcNHglycan	198	201	PF01048	0.498
MOD_GlcNHglycan	245	248	PF01048	0.772
MOD_GlcNHglycan	26	29	PF01048	0.574
MOD_GlcNHglycan	323	326	PF01048	0.603
MOD_GlcNHglycan	361	364	PF01048	0.531
MOD_GlcNHglycan	426	429	PF01048	0.633
MOD_GlcNHglycan	433	436	PF01048	0.555
MOD_GlcNHglycan	446	449	PF01048	0.271
MOD_GlcNHglycan	499	502	PF01048	0.582
MOD_GlcNHglycan	526	529	PF01048	0.465
MOD_GlcNHglycan	551	554	PF01048	0.499
MOD_GlcNHglycan	558	561	PF01048	0.453
MOD_GlcNHglycan	605	608	PF01048	0.329
MOD_GlcNHglycan	88	91	PF01048	0.633
MOD_GSK3_1	131	138	PF00069	0.496
MOD_GSK3_1	139	146	PF00069	0.692
MOD_GSK3_1	162	169	PF00069	0.708
MOD_GSK3_1	173	180	PF00069	0.550
MOD_GSK3_1	201	208	PF00069	0.605
MOD_GSK3_1	212	219	PF00069	0.556
MOD_GSK3_1	24	31	PF00069	0.567
MOD_GSK3_1	439	446	PF00069	0.524
MOD_GSK3_1	497	504	PF00069	0.613
MOD_GSK3_1	549	556	PF00069	0.467
MOD_GSK3_1	81	88	PF00069	0.471
MOD_GSK3_1	98	105	PF00069	0.503
MOD_LATS_1	160	166	PF00433	0.665
MOD_N-GLC_1	24	29	PF02516	0.586
MOD_N-GLC_1	603	608	PF02516	0.399
MOD_NEK2_1	109	114	PF00069	0.542
MOD_NEK2_1	131	136	PF00069	0.444
MOD_NEK2_1	21	26	PF00069	0.567
MOD_NEK2_1	269	274	PF00069	0.506
MOD_NEK2_1	43	48	PF00069	0.365
MOD_NEK2_1	462	467	PF00069	0.619
MOD_NEK2_1	524	529	PF00069	0.387
MOD_NEK2_2	553	558	PF00069	0.453
MOD_PIKK_1	111	117	PF00454	0.456
MOD_PIKK_1	147	153	PF00454	0.694
MOD_PIKK_1	154	160	PF00454	0.677
MOD_PIKK_1	208	214	PF00454	0.730
MOD_PIKK_1	439	445	PF00454	0.400
MOD_PK_1	487	493	PF00069	0.530
MOD_PKA_1	29	35	PF00069	0.537
MOD_PKA_1	41	47	PF00069	0.301
MOD_PKA_2	138	144	PF00069	0.605
MOD_PKA_2	196	202	PF00069	0.474
MOD_PKA_2	28	34	PF00069	0.695
MOD_PKA_2	405	411	PF00069	0.490
MOD_PKA_2	41	47	PF00069	0.429
MOD_PKA_2	462	468	PF00069	0.500
MOD_PKB_1	596	604	PF00069	0.376
MOD_Plk_1	109	115	PF00069	0.379
MOD_Plk_1	603	609	PF00069	0.536
MOD_Plk_4	116	122	PF00069	0.449
MOD_Plk_4	168	174	PF00069	0.603
MOD_Plk_4	342	348	PF00069	0.484
MOD_Plk_4	391	397	PF00069	0.486
MOD_Plk_4	43	49	PF00069	0.429
MOD_Plk_4	505	511	PF00069	0.493
MOD_Plk_4	64	70	PF00069	0.395
MOD_Plk_4	73	79	PF00069	0.457
MOD_ProDKin_1	1	7	PF00069	0.528
MOD_ProDKin_1	245	251	PF00069	0.667
MOD_ProDKin_1	324	330	PF00069	0.552
MOD_ProDKin_1	389	395	PF00069	0.377
MOD_ProDKin_1	503	509	PF00069	0.599
MOD_ProDKin_1	55	61	PF00069	0.647
MOD_ProDKin_1	81	87	PF00069	0.473
TRG_AP2beta_CARGO_1	377	387	PF09066	0.371
TRG_ENDOCYTIC_2	257	260	PF00928	0.521
TRG_ENDOCYTIC_2	45	48	PF00928	0.399
TRG_ENDOCYTIC_2	600	603	PF00928	0.385
TRG_ER_diArg_1	274	277	PF00400	0.485
TRG_ER_diArg_1	354	356	PF00400	0.507
TRG_ER_diArg_1	386	388	PF00400	0.565
TRG_ER_diArg_1	40	42	PF00400	0.414
TRG_ER_diArg_1	595	598	PF00400	0.415
TRG_ER_diArg_1	8	10	PF00400	0.480
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	541	545	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZQ1	Leptomonas seymouri	30%	92%
A0A0N1PDV8	Leptomonas seymouri	45%	100%
A0A3S5H6G6	Leishmania donovani	32%	100%
A0A3S7WR70	Leishmania donovani	89%	99%
A4H664	Leishmania braziliensis	66%	98%
A4HUI8	Leishmania infantum	89%	99%
E9AN86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
E9AN87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
Q4QHD7	Leishmania major	29%	100%