Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QHD7_LEIMA

TriTrypDb:

LmjF.10.0770 , LMJLV39_100013800 , LMJSD75_100014100

Length:

566

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHD7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	59	63	PF00656	0.413
CLV_NRD_NRD_1	233	235	PF00675	0.573
CLV_NRD_NRD_1	292	294	PF00675	0.509
CLV_NRD_NRD_1	329	331	PF00675	0.611
CLV_NRD_NRD_1	461	463	PF00675	0.595
CLV_NRD_NRD_1	505	507	PF00675	0.571
CLV_NRD_NRD_1	75	77	PF00675	0.537
CLV_PCSK_FUR_1	461	465	PF00082	0.579
CLV_PCSK_KEX2_1	232	234	PF00082	0.602
CLV_PCSK_KEX2_1	242	244	PF00082	0.711
CLV_PCSK_KEX2_1	292	294	PF00082	0.509
CLV_PCSK_KEX2_1	329	331	PF00082	0.611
CLV_PCSK_KEX2_1	461	463	PF00082	0.574
CLV_PCSK_KEX2_1	505	507	PF00082	0.571
CLV_PCSK_KEX2_1	75	77	PF00082	0.537
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.545
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.690
CLV_PCSK_PC1ET2_1	463	465	PF00082	0.585
CLV_PCSK_PC7_1	229	235	PF00082	0.409
CLV_PCSK_SKI1_1	229	233	PF00082	0.401
CLV_PCSK_SKI1_1	317	321	PF00082	0.504
CLV_PCSK_SKI1_1	75	79	PF00082	0.442
CLV_Separin_Metazoa	458	462	PF03568	0.479
DEG_APCC_DBOX_1	533	541	PF00400	0.419
DEG_Kelch_actinfilin_1	342	346	PF01344	0.416
DEG_SCF_FBW7_1	401	406	PF00400	0.417
DOC_CKS1_1	268	273	PF01111	0.475
DOC_CYCLIN_RxL_1	311	324	PF00134	0.461
DOC_CYCLIN_yCln2_LP_2	401	407	PF00134	0.480
DOC_MAPK_DCC_7	81	90	PF00069	0.472
DOC_MAPK_gen_1	242	249	PF00069	0.494
DOC_MAPK_HePTP_8	78	90	PF00069	0.453
DOC_MAPK_MEF2A_6	12	21	PF00069	0.405
DOC_MAPK_MEF2A_6	152	160	PF00069	0.418
DOC_MAPK_MEF2A_6	81	90	PF00069	0.574
DOC_PP1_RVXF_1	203	210	PF00149	0.399
DOC_PP2B_LxvP_1	401	404	PF13499	0.597
DOC_USP7_MATH_1	188	192	PF00917	0.688
DOC_USP7_MATH_1	34	38	PF00917	0.637
DOC_WW_Pin1_4	111	116	PF00397	0.525
DOC_WW_Pin1_4	250	255	PF00397	0.586
DOC_WW_Pin1_4	267	272	PF00397	0.494
DOC_WW_Pin1_4	319	324	PF00397	0.517
DOC_WW_Pin1_4	399	404	PF00397	0.609
DOC_WW_Pin1_4	42	47	PF00397	0.753
DOC_WW_Pin1_4	54	59	PF00397	0.402
DOC_WW_Pin1_4	81	86	PF00397	0.523
DOC_WW_Pin1_4	93	98	PF00397	0.625
LIG_14-3-3_CanoR_1	152	160	PF00244	0.507
LIG_14-3-3_CanoR_1	16	22	PF00244	0.479
LIG_14-3-3_CanoR_1	203	208	PF00244	0.391
LIG_14-3-3_CanoR_1	243	249	PF00244	0.668
LIG_14-3-3_CanoR_1	292	301	PF00244	0.550
LIG_14-3-3_CanoR_1	505	515	PF00244	0.349
LIG_14-3-3_CanoR_1	89	97	PF00244	0.598
LIG_APCC_ABBA_1	538	543	PF00400	0.436
LIG_BIR_II_1	1	5	PF00653	0.480
LIG_BRCT_BRCA1_1	205	209	PF00533	0.434
LIG_BRCT_BRCA1_1	332	336	PF00533	0.569
LIG_CtBP_PxDLS_1	85	89	PF00389	0.455
LIG_DLG_GKlike_1	203	210	PF00625	0.399
LIG_FHA_1	18	24	PF00498	0.503
LIG_FHA_1	187	193	PF00498	0.622
LIG_FHA_1	223	229	PF00498	0.482
LIG_FHA_1	345	351	PF00498	0.447
LIG_FHA_1	355	361	PF00498	0.430
LIG_FHA_1	400	406	PF00498	0.429
LIG_FHA_1	427	433	PF00498	0.440
LIG_FHA_1	484	490	PF00498	0.463
LIG_FHA_1	518	524	PF00498	0.394
LIG_FHA_1	64	70	PF00498	0.443
LIG_FHA_2	123	129	PF00498	0.442
LIG_FHA_2	133	139	PF00498	0.462
LIG_Integrin_RGD_1	81	83	PF01839	0.480
LIG_LIR_Apic_2	177	183	PF02991	0.503
LIG_LIR_Gen_1	425	435	PF02991	0.399
LIG_LIR_Nem_3	298	304	PF02991	0.399
LIG_LIR_Nem_3	425	431	PF02991	0.400
LIG_Pex14_2	11	15	PF04695	0.482
LIG_Pex14_2	209	213	PF04695	0.409
LIG_SH2_CRK	180	184	PF00017	0.496
LIG_SH2_CRK	428	432	PF00017	0.405
LIG_SH2_CRK	556	560	PF00017	0.371
LIG_SH2_NCK_1	180	184	PF00017	0.496
LIG_SH2_STAP1	428	432	PF00017	0.390
LIG_SH2_STAP1	444	448	PF00017	0.280
LIG_SH2_STAT5	304	307	PF00017	0.348
LIG_SH2_STAT5	359	362	PF00017	0.421
LIG_SH2_STAT5	428	431	PF00017	0.381
LIG_SH3_3	320	326	PF00018	0.477
LIG_SH3_3	40	46	PF00018	0.567
LIG_SH3_3	408	414	PF00018	0.473
LIG_SH3_3	94	100	PF00018	0.636
LIG_SUMO_SIM_anti_2	518	526	PF11976	0.459
LIG_SUMO_SIM_par_1	19	26	PF11976	0.473
LIG_SUMO_SIM_par_1	342	347	PF11976	0.415
LIG_SUMO_SIM_par_1	485	492	PF11976	0.495
LIG_TRAF2_1	212	215	PF00917	0.340
LIG_TYR_ITIM	426	431	PF00017	0.402
LIG_UBA3_1	422	430	PF00899	0.399
LIG_UBA3_1	537	544	PF00899	0.434
LIG_WW_3	458	462	PF00397	0.479
MOD_CK1_1	191	197	PF00069	0.666
MOD_CK1_1	245	251	PF00069	0.519
MOD_CK1_1	255	261	PF00069	0.609
MOD_CK1_1	480	486	PF00069	0.537
MOD_CK1_1	93	99	PF00069	0.788
MOD_CK2_1	122	128	PF00069	0.428
MOD_CK2_1	151	157	PF00069	0.506
MOD_CK2_1	30	36	PF00069	0.647
MOD_CK2_1	319	325	PF00069	0.524
MOD_CK2_1	42	48	PF00069	0.609
MOD_Cter_Amidation	73	76	PF01082	0.406
MOD_GlcNHglycan	101	104	PF01048	0.761
MOD_GlcNHglycan	153	156	PF01048	0.602
MOD_GlcNHglycan	176	179	PF01048	0.623
MOD_GlcNHglycan	180	183	PF01048	0.601
MOD_GlcNHglycan	238	241	PF01048	0.553
MOD_GlcNHglycan	254	257	PF01048	0.699
MOD_GlcNHglycan	32	35	PF01048	0.621
MOD_GlcNHglycan	332	335	PF01048	0.800
MOD_GlcNHglycan	36	39	PF01048	0.626
MOD_GlcNHglycan	433	436	PF01048	0.449
MOD_GlcNHglycan	482	485	PF01048	0.692
MOD_GlcNHglycan	562	565	PF01048	0.531
MOD_GlcNHglycan	72	75	PF01048	0.489
MOD_GSK3_1	169	176	PF00069	0.673
MOD_GSK3_1	191	198	PF00069	0.661
MOD_GSK3_1	241	248	PF00069	0.544
MOD_GSK3_1	30	37	PF00069	0.720
MOD_GSK3_1	344	351	PF00069	0.516
MOD_GSK3_1	38	45	PF00069	0.783
MOD_GSK3_1	399	406	PF00069	0.501
MOD_GSK3_1	422	429	PF00069	0.401
MOD_GSK3_1	483	490	PF00069	0.493
MOD_GSK3_1	506	513	PF00069	0.360
MOD_LATS_1	328	334	PF00433	0.580
MOD_N-GLC_1	23	28	PF02516	0.472
MOD_N-GLC_1	480	485	PF02516	0.518
MOD_NEK2_1	1	6	PF00069	0.572
MOD_NEK2_1	169	174	PF00069	0.416
MOD_NEK2_1	294	299	PF00069	0.447
MOD_NEK2_1	349	354	PF00069	0.417
MOD_NEK2_1	422	427	PF00069	0.401
MOD_NEK2_1	477	482	PF00069	0.464
MOD_NEK2_1	70	75	PF00069	0.425
MOD_PIKK_1	1	7	PF00454	0.539
MOD_PIKK_1	344	350	PF00454	0.443
MOD_PIKK_1	38	44	PF00454	0.621
MOD_PK_1	195	201	PF00069	0.490
MOD_PK_1	511	517	PF00069	0.295
MOD_PKA_1	242	248	PF00069	0.509
MOD_PKA_2	151	157	PF00069	0.553
MOD_PKA_2	194	200	PF00069	0.459
MOD_PKA_2	242	248	PF00069	0.509
MOD_PKA_2	510	516	PF00069	0.362
MOD_PKB_1	330	338	PF00069	0.523
MOD_Plk_1	169	175	PF00069	0.537
MOD_Plk_1	195	201	PF00069	0.699
MOD_Plk_1	23	29	PF00069	0.486
MOD_Plk_1	245	251	PF00069	0.520
MOD_Plk_1	469	475	PF00069	0.530
MOD_Plk_4	296	302	PF00069	0.437
MOD_Plk_4	469	475	PF00069	0.530
MOD_Plk_4	511	517	PF00069	0.311
MOD_ProDKin_1	111	117	PF00069	0.521
MOD_ProDKin_1	250	256	PF00069	0.584
MOD_ProDKin_1	267	273	PF00069	0.485
MOD_ProDKin_1	319	325	PF00069	0.524
MOD_ProDKin_1	399	405	PF00069	0.593
MOD_ProDKin_1	42	48	PF00069	0.751
MOD_ProDKin_1	54	60	PF00069	0.393
MOD_ProDKin_1	81	87	PF00069	0.536
MOD_ProDKin_1	93	99	PF00069	0.622
TRG_DiLeu_BaEn_1	519	524	PF01217	0.381
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.400
TRG_ENDOCYTIC_2	428	431	PF00928	0.408
TRG_ER_diArg_1	291	293	PF00400	0.509
TRG_ER_diArg_1	329	332	PF00400	0.600
TRG_ER_diArg_1	460	462	PF00400	0.564
TRG_ER_diArg_1	504	506	PF00400	0.360
TRG_ER_diArg_1	75	77	PF00400	0.434
TRG_NLS_MonoExtN_4	229	236	PF00514	0.418
TRG_Pf-PMV_PEXEL_1	312	316	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	453	457	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZQ1	Leptomonas seymouri	37%	82%
A0A0N1PDV8	Leptomonas seymouri	28%	97%
A0A3S5H6G6	Leishmania donovani	88%	100%
A0A3S7WR70	Leishmania donovani	30%	88%
A4H664	Leishmania braziliensis	29%	87%
A4HUI8	Leishmania infantum	31%	88%
A4HUI9	Leishmania infantum	88%	86%
E9AN86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	90%
E9AN87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QHD8	Leishmania major	29%	89%