DFRP_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHD5_LEIMA

TriTrypDb:

LmjF.10.0790 , LMJLV39_100014000 , LMJSD75_100014300

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QHD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHD5

Function

Biological processes
Term	Name	Level	Count
GO:0002181	cytoplasmic translation	5	2
GO:0006412	translation	4	2
GO:0006518	peptide metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	2
GO:0043043	peptide biosynthetic process	5	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043603	amide metabolic process	3	2
GO:0043604	amide biosynthetic process	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	207	211	PF00656	0.583
CLV_NRD_NRD_1	154	156	PF00675	0.311
CLV_NRD_NRD_1	169	171	PF00675	0.171
CLV_NRD_NRD_1	47	49	PF00675	0.509
CLV_NRD_NRD_1	57	59	PF00675	0.468
CLV_NRD_NRD_1	82	84	PF00675	0.617
CLV_PCSK_FUR_1	167	171	PF00082	0.318
CLV_PCSK_FUR_1	83	87	PF00082	0.560
CLV_PCSK_KEX2_1	156	158	PF00082	0.249
CLV_PCSK_KEX2_1	169	171	PF00082	0.215
CLV_PCSK_KEX2_1	57	59	PF00082	0.504
CLV_PCSK_KEX2_1	64	66	PF00082	0.504
CLV_PCSK_KEX2_1	85	87	PF00082	0.570
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.256
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.519
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.570
CLV_PCSK_SKI1_1	169	173	PF00082	0.269
CLV_PCSK_SKI1_1	58	62	PF00082	0.477
DEG_APCC_DBOX_1	137	145	PF00400	0.438
DEG_APCC_DBOX_1	202	210	PF00400	0.701
DEG_SCF_FBW7_2	141	146	PF00400	0.438
DOC_USP7_UBL2_3	3	7	PF12436	0.476
DOC_WW_Pin1_4	139	144	PF00397	0.450
LIG_14-3-3_CanoR_1	48	55	PF00244	0.643
LIG_deltaCOP1_diTrp_1	182	191	PF00928	0.438
LIG_FHA_1	15	21	PF00498	0.438
LIG_LIR_Gen_1	112	121	PF02991	0.476
LIG_LIR_Nem_3	112	117	PF02991	0.469
LIG_SH2_STAT3	32	35	PF00017	0.544
LIG_SH2_STAT5	107	110	PF00017	0.472
LIG_SH2_STAT5	32	35	PF00017	0.432
LIG_TRAF2_1	60	63	PF00917	0.471
MOD_CK2_1	47	53	PF00069	0.613
MOD_CMANNOS	181	184	PF00535	0.238
MOD_GlcNHglycan	172	175	PF01048	0.338
MOD_N-GLC_1	23	28	PF02516	0.448
MOD_PIKK_1	47	53	PF00454	0.582
MOD_PKA_2	24	30	PF00069	0.365
MOD_PKA_2	47	53	PF00069	0.648
MOD_Plk_1	14	20	PF00069	0.434
MOD_Plk_1	145	151	PF00069	0.438
MOD_ProDKin_1	139	145	PF00069	0.450
MOD_SUMO_for_1	60	63	PF00179	0.565
MOD_SUMO_rev_2	10	18	PF00179	0.432
MOD_SUMO_rev_2	120	128	PF00179	0.393
MOD_SUMO_rev_2	173	178	PF00179	0.522
MOD_SUMO_rev_2	41	50	PF00179	0.626
TRG_DiLeu_BaEn_4	204	210	PF01217	0.586
TRG_ER_diArg_1	167	170	PF00400	0.482
TRG_NES_CRM1_1	182	195	PF08389	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7Z1	Leptomonas seymouri	82%	100%
A0A1X0NQY5	Trypanosomatidae	63%	93%
A0A3Q8I8U9	Leishmania donovani	99%	100%
A0A3R7M6G6	Trypanosoma rangeli	66%	99%
A4H667	Leishmania braziliensis	90%	100%
A4HUJ1	Leishmania infantum	99%	100%
C9ZVL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	98%
E9AN89	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q9USV4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	76%