ULP_PROTEASE domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHD4_LEIMA

TriTrypDb:

LmjF.10.0800 , LMJLV39_100014100 , LMJSD75_100014400

Length:

1085

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHD4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.529
CLV_C14_Caspase3-7	298	302	PF00656	0.684
CLV_C14_Caspase3-7	424	428	PF00656	0.658
CLV_C14_Caspase3-7	864	868	PF00656	0.573
CLV_NRD_NRD_1	1011	1013	PF00675	0.716
CLV_NRD_NRD_1	1029	1031	PF00675	0.582
CLV_NRD_NRD_1	1033	1035	PF00675	0.802
CLV_NRD_NRD_1	1081	1083	PF00675	0.667
CLV_NRD_NRD_1	190	192	PF00675	0.710
CLV_NRD_NRD_1	245	247	PF00675	0.636
CLV_NRD_NRD_1	362	364	PF00675	0.687
CLV_NRD_NRD_1	4	6	PF00675	0.536
CLV_NRD_NRD_1	748	750	PF00675	0.648
CLV_NRD_NRD_1	770	772	PF00675	0.701
CLV_NRD_NRD_1	987	989	PF00675	0.742
CLV_PCSK_FUR_1	1027	1031	PF00082	0.714
CLV_PCSK_FUR_1	1078	1082	PF00082	0.670
CLV_PCSK_KEX2_1	1011	1013	PF00082	0.716
CLV_PCSK_KEX2_1	102	104	PF00082	0.730
CLV_PCSK_KEX2_1	1029	1031	PF00082	0.658
CLV_PCSK_KEX2_1	1033	1035	PF00082	0.812
CLV_PCSK_KEX2_1	1077	1079	PF00082	0.805
CLV_PCSK_KEX2_1	1080	1082	PF00082	0.770
CLV_PCSK_KEX2_1	189	191	PF00082	0.666
CLV_PCSK_KEX2_1	245	247	PF00082	0.680
CLV_PCSK_KEX2_1	270	272	PF00082	0.677
CLV_PCSK_KEX2_1	362	364	PF00082	0.687
CLV_PCSK_KEX2_1	4	6	PF00082	0.562
CLV_PCSK_KEX2_1	463	465	PF00082	0.693
CLV_PCSK_KEX2_1	550	552	PF00082	0.556
CLV_PCSK_KEX2_1	769	771	PF00082	0.706
CLV_PCSK_KEX2_1	987	989	PF00082	0.740
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.730
CLV_PCSK_PC1ET2_1	1077	1079	PF00082	0.672
CLV_PCSK_PC1ET2_1	1080	1082	PF00082	0.644
CLV_PCSK_PC1ET2_1	270	272	PF00082	0.677
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.721
CLV_PCSK_PC1ET2_1	463	465	PF00082	0.693
CLV_PCSK_PC1ET2_1	550	552	PF00082	0.520
CLV_PCSK_PC7_1	1029	1035	PF00082	0.691
CLV_PCSK_PC7_1	266	272	PF00082	0.668
CLV_PCSK_PC7_1	766	772	PF00082	0.635
CLV_PCSK_SKI1_1	102	106	PF00082	0.639
CLV_PCSK_SKI1_1	141	145	PF00082	0.580
CLV_PCSK_SKI1_1	434	438	PF00082	0.514
CLV_PCSK_SKI1_1	533	537	PF00082	0.492
CLV_PCSK_SKI1_1	542	546	PF00082	0.564
CLV_PCSK_SKI1_1	60	64	PF00082	0.488
DEG_APCC_DBOX_1	362	370	PF00400	0.492
DEG_APCC_DBOX_1	650	658	PF00400	0.359
DEG_SCF_SKP2-CKS1_1	526	533	PF00560	0.466
DEG_SPOP_SBC_1	111	115	PF00917	0.553
DEG_SPOP_SBC_1	331	335	PF00917	0.686
DEG_SPOP_SBC_1	517	521	PF00917	0.580
DOC_CKS1_1	660	665	PF01111	0.477
DOC_CYCLIN_RxL_1	57	64	PF00134	0.424
DOC_CYCLIN_yCln2_LP_2	660	666	PF00134	0.420
DOC_MAPK_DCC_7	607	616	PF00069	0.457
DOC_MAPK_gen_1	362	369	PF00069	0.652
DOC_MAPK_gen_1	607	616	PF00069	0.542
DOC_MAPK_MEF2A_6	607	616	PF00069	0.457
DOC_PIKK_1	671	679	PF02985	0.430
DOC_PIKK_1	880	888	PF02985	0.697
DOC_PP2B_LxvP_1	98	101	PF13499	0.773
DOC_USP7_MATH_1	1032	1036	PF00917	0.725
DOC_USP7_MATH_1	111	115	PF00917	0.753
DOC_USP7_MATH_1	197	201	PF00917	0.703
DOC_USP7_MATH_1	204	208	PF00917	0.586
DOC_USP7_MATH_1	247	251	PF00917	0.670
DOC_USP7_MATH_1	330	334	PF00917	0.622
DOC_USP7_MATH_1	500	504	PF00917	0.452
DOC_USP7_MATH_1	515	519	PF00917	0.561
DOC_USP7_MATH_1	563	567	PF00917	0.537
DOC_USP7_MATH_1	627	631	PF00917	0.564
DOC_USP7_MATH_1	764	768	PF00917	0.690
DOC_USP7_MATH_1	795	799	PF00917	0.758
DOC_USP7_MATH_1	861	865	PF00917	0.736
DOC_USP7_MATH_1	901	905	PF00917	0.794
DOC_USP7_MATH_1	910	914	PF00917	0.675
DOC_USP7_MATH_1	925	929	PF00917	0.649
DOC_USP7_MATH_1	937	941	PF00917	0.689
DOC_USP7_UBL2_3	1076	1080	PF12436	0.634
DOC_WW_Pin1_4	1004	1009	PF00397	0.653
DOC_WW_Pin1_4	112	117	PF00397	0.688
DOC_WW_Pin1_4	141	146	PF00397	0.566
DOC_WW_Pin1_4	249	254	PF00397	0.709
DOC_WW_Pin1_4	259	264	PF00397	0.698
DOC_WW_Pin1_4	339	344	PF00397	0.847
DOC_WW_Pin1_4	489	494	PF00397	0.510
DOC_WW_Pin1_4	527	532	PF00397	0.605
DOC_WW_Pin1_4	550	555	PF00397	0.460
DOC_WW_Pin1_4	659	664	PF00397	0.476
DOC_WW_Pin1_4	758	763	PF00397	0.766
DOC_WW_Pin1_4	805	810	PF00397	0.642
DOC_WW_Pin1_4	851	856	PF00397	0.681
DOC_WW_Pin1_4	926	931	PF00397	0.692
DOC_WW_Pin1_4	997	1002	PF00397	0.805
LIG_14-3-3_CanoR_1	103	110	PF00244	0.806
LIG_14-3-3_CanoR_1	1033	1042	PF00244	0.676
LIG_14-3-3_CanoR_1	196	204	PF00244	0.611
LIG_14-3-3_CanoR_1	266	273	PF00244	0.658
LIG_14-3-3_CanoR_1	38	44	PF00244	0.563
LIG_14-3-3_CanoR_1	52	62	PF00244	0.450
LIG_14-3-3_CanoR_1	638	645	PF00244	0.537
LIG_14-3-3_CanoR_1	74	83	PF00244	0.565
LIG_14-3-3_CanoR_1	803	811	PF00244	0.653
LIG_14-3-3_CanoR_1	902	910	PF00244	0.687
LIG_BIR_III_2	427	431	PF00653	0.535
LIG_BRCT_BRCA1_1	631	635	PF00533	0.601
LIG_EH_1	646	650	PF12763	0.491
LIG_EVH1_2	495	499	PF00568	0.433
LIG_FHA_1	333	339	PF00498	0.593
LIG_FHA_1	406	412	PF00498	0.515
LIG_FHA_1	57	63	PF00498	0.425
LIG_FHA_1	572	578	PF00498	0.452
LIG_FHA_1	638	644	PF00498	0.492
LIG_FHA_1	705	711	PF00498	0.548
LIG_FHA_1	77	83	PF00498	0.563
LIG_FHA_1	779	785	PF00498	0.653
LIG_FHA_1	85	91	PF00498	0.488
LIG_FHA_2	1043	1049	PF00498	0.561
LIG_FHA_2	135	141	PF00498	0.641
LIG_FHA_2	153	159	PF00498	0.572
LIG_FHA_2	236	242	PF00498	0.682
LIG_FHA_2	356	362	PF00498	0.551
LIG_FHA_2	422	428	PF00498	0.532
LIG_FHA_2	648	654	PF00498	0.490
LIG_FHA_2	774	780	PF00498	0.555
LIG_GSK3_LRP6_1	1004	1009	PF00069	0.575
LIG_Integrin_RGD_1	398	400	PF01839	0.466
LIG_LIR_Apic_2	381	386	PF02991	0.568
LIG_LIR_Gen_1	506	517	PF02991	0.605
LIG_LIR_Gen_1	879	888	PF02991	0.628
LIG_LIR_Nem_3	438	443	PF02991	0.668
LIG_LIR_Nem_3	506	512	PF02991	0.663
LIG_LIR_Nem_3	549	555	PF02991	0.601
LIG_LIR_Nem_3	64	70	PF02991	0.541
LIG_LIR_Nem_3	671	676	PF02991	0.591
LIG_LIR_Nem_3	879	885	PF02991	0.628
LIG_NRBOX	16	22	PF00104	0.542
LIG_PTAP_UEV_1	276	281	PF05743	0.696
LIG_REV1ctd_RIR_1	542	552	PF16727	0.416
LIG_SH2_CRK	472	476	PF00017	0.533
LIG_SH2_CRK	497	501	PF00017	0.474
LIG_SH2_CRK	619	623	PF00017	0.409
LIG_SH2_CRK	67	71	PF00017	0.565
LIG_SH2_NCK_1	882	886	PF00017	0.613
LIG_SH2_SRC	383	386	PF00017	0.564
LIG_SH2_SRC	882	885	PF00017	0.613
LIG_SH2_STAT5	118	121	PF00017	0.622
LIG_SH2_STAT5	383	386	PF00017	0.548
LIG_SH2_STAT5	579	582	PF00017	0.492
LIG_SH2_STAT5	58	61	PF00017	0.423
LIG_SH3_1	551	557	PF00018	0.466
LIG_SH3_1	998	1004	PF00018	0.584
LIG_SH3_2	744	749	PF14604	0.693
LIG_SH3_3	1000	1006	PF00018	0.652
LIG_SH3_3	166	172	PF00018	0.630
LIG_SH3_3	274	280	PF00018	0.725
LIG_SH3_3	334	340	PF00018	0.706
LIG_SH3_3	347	353	PF00018	0.783
LIG_SH3_3	490	496	PF00018	0.493
LIG_SH3_3	551	557	PF00018	0.514
LIG_SH3_3	588	594	PF00018	0.465
LIG_SH3_3	738	744	PF00018	0.681
LIG_SH3_3	927	933	PF00018	0.807
LIG_SH3_3	972	978	PF00018	0.674
LIG_SH3_3	993	999	PF00018	0.780
LIG_SUMO_SIM_anti_2	15	21	PF11976	0.478
LIG_SUMO_SIM_anti_2	400	408	PF11976	0.544
LIG_SUMO_SIM_anti_2	483	490	PF11976	0.601
LIG_SUMO_SIM_par_1	400	408	PF11976	0.544
LIG_SUMO_SIM_par_1	483	490	PF11976	0.541
LIG_SUMO_SIM_par_1	639	646	PF11976	0.462
LIG_TRAF2_1	211	214	PF00917	0.688
LIG_TRAF2_1	238	241	PF00917	0.588
LIG_TRAF2_1	320	323	PF00917	0.645
LIG_TRAF2_1	449	452	PF00917	0.572
LIG_TRAF2_1	481	484	PF00917	0.554
LIG_TRAF2_1	650	653	PF00917	0.504
LIG_TRAF2_1	776	779	PF00917	0.555
LIG_TRAF2_1	870	873	PF00917	0.702
LIG_TRAF2_1	952	955	PF00917	0.650
LIG_TRAF2_1	961	964	PF00917	0.677
LIG_TYR_ITIM	470	475	PF00017	0.531
LIG_TYR_ITIM	617	622	PF00017	0.439
MOD_CDC14_SPxK_1	553	556	PF00782	0.536
MOD_CDC14_SPxK_1	763	766	PF00782	0.623
MOD_CDK_SPK_2	851	856	PF00069	0.664
MOD_CDK_SPxK_1	527	533	PF00069	0.458
MOD_CDK_SPxK_1	550	556	PF00069	0.464
MOD_CDK_SPxK_1	760	766	PF00069	0.622
MOD_CDK_SPxxK_3	1004	1011	PF00069	0.646
MOD_CDK_SPxxK_3	259	266	PF00069	0.697
MOD_CK1_1	503	509	PF00069	0.552
MOD_CK1_1	518	524	PF00069	0.473
MOD_CK1_1	56	62	PF00069	0.482
MOD_CK1_1	571	577	PF00069	0.454
MOD_CK1_1	630	636	PF00069	0.626
MOD_CK1_1	639	645	PF00069	0.406
MOD_CK1_1	68	74	PF00069	0.560
MOD_CK1_1	687	693	PF00069	0.531
MOD_CK1_1	760	766	PF00069	0.615
MOD_CK1_1	805	811	PF00069	0.609
MOD_CK1_1	904	910	PF00069	0.791
MOD_CK2_1	1042	1048	PF00069	0.558
MOD_CK2_1	134	140	PF00069	0.641
MOD_CK2_1	152	158	PF00069	0.564
MOD_CK2_1	235	241	PF00069	0.579
MOD_CK2_1	355	361	PF00069	0.502
MOD_CK2_1	647	653	PF00069	0.430
MOD_CK2_1	773	779	PF00069	0.587
MOD_CK2_1	867	873	PF00069	0.802
MOD_CK2_1	958	964	PF00069	0.666
MOD_Cter_Amidation	985	988	PF01082	0.702
MOD_GlcNHglycan	124	127	PF01048	0.714
MOD_GlcNHglycan	161	165	PF01048	0.661
MOD_GlcNHglycan	175	178	PF01048	0.652
MOD_GlcNHglycan	521	524	PF01048	0.707
MOD_GlcNHglycan	55	58	PF01048	0.633
MOD_GlcNHglycan	560	564	PF01048	0.480
MOD_GlcNHglycan	570	573	PF01048	0.414
MOD_GlcNHglycan	684	689	PF01048	0.497
MOD_GlcNHglycan	804	807	PF01048	0.684
MOD_GlcNHglycan	869	872	PF01048	0.696
MOD_GlcNHglycan	903	906	PF01048	0.681
MOD_GlcNHglycan	910	913	PF01048	0.680
MOD_GSK3_1	249	256	PF00069	0.668
MOD_GSK3_1	326	333	PF00069	0.662
MOD_GSK3_1	435	442	PF00069	0.548
MOD_GSK3_1	515	522	PF00069	0.703
MOD_GSK3_1	559	566	PF00069	0.633
MOD_GSK3_1	639	646	PF00069	0.476
MOD_GSK3_1	683	690	PF00069	0.498
MOD_GSK3_1	702	709	PF00069	0.422
MOD_GSK3_1	760	767	PF00069	0.660
MOD_GSK3_1	805	812	PF00069	0.667
MOD_GSK3_1	850	857	PF00069	0.709
MOD_GSK3_1	901	908	PF00069	0.794
MOD_N-GLC_1	122	127	PF02516	0.546
MOD_NEK2_1	110	115	PF00069	0.599
MOD_NEK2_1	134	139	PF00069	0.640
MOD_NEK2_1	173	178	PF00069	0.561
MOD_NEK2_1	416	421	PF00069	0.453
MOD_NEK2_1	471	476	PF00069	0.527
MOD_NEK2_1	570	575	PF00069	0.417
MOD_NEK2_1	577	582	PF00069	0.429
MOD_NEK2_1	621	626	PF00069	0.461
MOD_NEK2_1	636	641	PF00069	0.588
MOD_NEK2_1	702	707	PF00069	0.635
MOD_NEK2_2	578	583	PF00069	0.340
MOD_PIKK_1	74	80	PF00454	0.532
MOD_PIKK_1	932	938	PF00454	0.596
MOD_PK_1	463	469	PF00069	0.531
MOD_PKA_1	102	108	PF00069	0.668
MOD_PKA_1	1033	1039	PF00069	0.812
MOD_PKA_1	463	469	PF00069	0.531
MOD_PKA_2	102	108	PF00069	0.803
MOD_PKA_2	1032	1038	PF00069	0.669
MOD_PKA_2	241	247	PF00069	0.772
MOD_PKA_2	265	271	PF00069	0.580
MOD_PKA_2	463	469	PF00069	0.531
MOD_PKA_2	568	574	PF00069	0.446
MOD_PKA_2	637	643	PF00069	0.552
MOD_PKA_2	68	74	PF00069	0.458
MOD_PKA_2	795	801	PF00069	0.795
MOD_PKA_2	802	808	PF00069	0.634
MOD_PKA_2	841	847	PF00069	0.607
MOD_PKA_2	901	907	PF00069	0.691
MOD_PKB_1	72	80	PF00069	0.616
MOD_Plk_1	122	128	PF00069	0.529
MOD_Plk_1	702	708	PF00069	0.658
MOD_Plk_1	778	784	PF00069	0.696
MOD_Plk_1	958	964	PF00069	0.579
MOD_Plk_2-3	451	457	PF00069	0.575
MOD_Plk_2-3	958	964	PF00069	0.579
MOD_Plk_4	435	441	PF00069	0.513
MOD_Plk_4	471	477	PF00069	0.524
MOD_Plk_4	563	569	PF00069	0.432
MOD_Plk_4	687	693	PF00069	0.539
MOD_ProDKin_1	1004	1010	PF00069	0.601
MOD_ProDKin_1	112	118	PF00069	0.690
MOD_ProDKin_1	141	147	PF00069	0.568
MOD_ProDKin_1	249	255	PF00069	0.707
MOD_ProDKin_1	259	265	PF00069	0.675
MOD_ProDKin_1	339	345	PF00069	0.849
MOD_ProDKin_1	489	495	PF00069	0.497
MOD_ProDKin_1	527	533	PF00069	0.600
MOD_ProDKin_1	550	556	PF00069	0.464
MOD_ProDKin_1	659	665	PF00069	0.483
MOD_ProDKin_1	758	764	PF00069	0.763
MOD_ProDKin_1	805	811	PF00069	0.639
MOD_ProDKin_1	851	857	PF00069	0.681
MOD_ProDKin_1	926	932	PF00069	0.685
MOD_ProDKin_1	997	1003	PF00069	0.804
MOD_SUMO_rev_2	780	790	PF00179	0.564
TRG_DiLeu_BaEn_4	232	238	PF01217	0.574
TRG_DiLeu_BaEn_4	652	658	PF01217	0.482
TRG_DiLeu_BaEn_4	883	889	PF01217	0.700
TRG_ENDOCYTIC_2	472	475	PF00928	0.533
TRG_ENDOCYTIC_2	541	544	PF00928	0.604
TRG_ENDOCYTIC_2	552	555	PF00928	0.497
TRG_ENDOCYTIC_2	579	582	PF00928	0.442
TRG_ENDOCYTIC_2	619	622	PF00928	0.444
TRG_ENDOCYTIC_2	67	70	PF00928	0.494
TRG_ENDOCYTIC_2	673	676	PF00928	0.417
TRG_ENDOCYTIC_2	882	885	PF00928	0.613
TRG_ER_diArg_1	1010	1012	PF00400	0.851
TRG_ER_diArg_1	1026	1029	PF00400	0.574
TRG_ER_diArg_1	1081	1083	PF00400	0.642
TRG_ER_diArg_1	189	191	PF00400	0.712
TRG_ER_diArg_1	193	196	PF00400	0.664
TRG_ER_diArg_1	245	247	PF00400	0.571
TRG_ER_diArg_1	35	38	PF00400	0.513
TRG_ER_diArg_1	769	771	PF00400	0.706
TRG_NES_CRM1_1	364	376	PF08389	0.441
TRG_NLS_MonoCore_2	1076	1081	PF00514	0.653
TRG_NLS_MonoExtC_3	1075	1080	PF00514	0.671
TRG_NLS_MonoExtC_3	3	8	PF00514	0.583
TRG_NLS_MonoExtN_4	1076	1081	PF00514	0.696
TRG_NLS_MonoExtN_4	4	9	PF00514	0.571
TRG_NLS_MonoExtN_4	746	753	PF00514	0.705
TRG_Pf-PMV_PEXEL_1	478	483	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	674	678	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I8U5	Leishmania donovani	89%	100%
A4H668	Leishmania braziliensis	68%	86%
A4HUJ2	Leishmania infantum	89%	85%
C9ZVL7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AN90	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%