TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHD2_LEIMA

TriTrypDb:

LmjF.10.0820 , LMJLV39_100014300 , LMJSD75_100014600

Length:

400

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHD2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHD2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.599
CLV_NRD_NRD_1	28	30	PF00675	0.591
CLV_NRD_NRD_1	310	312	PF00675	0.424
CLV_NRD_NRD_1	395	397	PF00675	0.692
CLV_PCSK_KEX2_1	125	127	PF00082	0.579
CLV_PCSK_KEX2_1	16	18	PF00082	0.550
CLV_PCSK_KEX2_1	163	165	PF00082	0.534
CLV_PCSK_KEX2_1	221	223	PF00082	0.580
CLV_PCSK_KEX2_1	27	29	PF00082	0.599
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.609
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.553
CLV_PCSK_PC1ET2_1	221	223	PF00082	0.580
CLV_PCSK_SKI1_1	149	153	PF00082	0.650
CLV_PCSK_SKI1_1	290	294	PF00082	0.408
CLV_PCSK_SKI1_1	311	315	PF00082	0.533
CLV_PCSK_SKI1_1	349	353	PF00082	0.435
CLV_PCSK_SKI1_1	361	365	PF00082	0.415
CLV_PCSK_SKI1_1	90	94	PF00082	0.688
DEG_APCC_DBOX_1	310	318	PF00400	0.519
DEG_APCC_DBOX_1	360	368	PF00400	0.445
DEG_SCF_FBW7_1	1	7	PF00400	0.649
DOC_CKS1_1	1	6	PF01111	0.654
DOC_CKS1_1	386	391	PF01111	0.567
DOC_CKS1_1	70	75	PF01111	0.577
DOC_CYCLIN_RxL_1	94	104	PF00134	0.687
DOC_MAPK_gen_1	309	319	PF00069	0.474
DOC_MAPK_gen_1	78	86	PF00069	0.589
DOC_MAPK_MEF2A_6	261	270	PF00069	0.377
DOC_PP1_RVXF_1	147	153	PF00149	0.648
DOC_PP1_RVXF_1	338	345	PF00149	0.413
DOC_PP2B_LxvP_1	181	184	PF13499	0.664
DOC_PP4_FxxP_1	109	112	PF00568	0.567
DOC_PP4_FxxP_1	127	130	PF00568	0.620
DOC_PP4_FxxP_1	168	171	PF00568	0.550
DOC_PP4_FxxP_1	70	73	PF00568	0.619
DOC_USP7_MATH_1	21	25	PF00917	0.612
DOC_USP7_MATH_1	288	292	PF00917	0.376
DOC_USP7_MATH_1	294	298	PF00917	0.381
DOC_USP7_MATH_1	347	351	PF00917	0.551
DOC_WW_Pin1_4	385	390	PF00397	0.577
DOC_WW_Pin1_4	4	9	PF00397	0.637
DOC_WW_Pin1_4	69	74	PF00397	0.616
DOC_WW_Pin1_4	91	96	PF00397	0.636
LIG_14-3-3_CanoR_1	349	354	PF00244	0.441
LIG_14-3-3_CterR_2	396	400	PF00244	0.703
LIG_Actin_WH2_2	77	92	PF00022	0.683
LIG_APCC_ABBA_1	278	283	PF00400	0.410
LIG_APCC_ABBAyCdc20_2	277	283	PF00400	0.409
LIG_BRCT_BRCA1_1	258	262	PF00533	0.550
LIG_BRCT_BRCA1_1	294	298	PF00533	0.487
LIG_BRCT_BRCA1_2	258	264	PF00533	0.539
LIG_CSL_BTD_1	57	60	PF09270	0.671
LIG_CtBP_PxDLS_1	255	261	PF00389	0.564
LIG_CtBP_PxDLS_1	98	102	PF00389	0.578
LIG_deltaCOP1_diTrp_1	55	65	PF00928	0.609
LIG_EVH1_2	129	133	PF00568	0.557
LIG_FHA_1	337	343	PF00498	0.412
LIG_FHA_2	118	124	PF00498	0.693
LIG_FHA_2	171	177	PF00498	0.614
LIG_FHA_2	70	76	PF00498	0.572
LIG_LIR_Apic_2	106	112	PF02991	0.564
LIG_LIR_Apic_2	124	130	PF02991	0.624
LIG_LIR_Apic_2	166	171	PF02991	0.550
LIG_LIR_Apic_2	54	60	PF02991	0.669
LIG_LIR_Gen_1	259	270	PF02991	0.526
LIG_LIR_Nem_3	197	201	PF02991	0.524
LIG_LIR_Nem_3	259	265	PF02991	0.543
LIG_Pex14_2	70	74	PF04695	0.620
LIG_PTB_Apo_2	108	115	PF02174	0.610
LIG_SH2_STAT5	273	276	PF00017	0.451
LIG_SH3_3	125	131	PF00018	0.591
LIG_SH3_3	383	389	PF00018	0.509
LIG_SH3_3	89	95	PF00018	0.582
LIG_SUMO_SIM_par_1	96	102	PF11976	0.580
LIG_TRAF2_1	120	123	PF00917	0.693
LIG_TRAF2_1	157	160	PF00917	0.634
LIG_TRAF2_1	372	375	PF00917	0.534
LIG_TRAF2_1	40	43	PF00917	0.758
LIG_WRC_WIRS_1	328	333	PF05994	0.530
MOD_CDC14_SPxK_1	94	97	PF00782	0.635
MOD_CDK_SPxK_1	91	97	PF00069	0.637
MOD_CK1_1	297	303	PF00069	0.496
MOD_CK2_1	117	123	PF00069	0.694
MOD_GlcNHglycan	257	261	PF01048	0.572
MOD_GlcNHglycan	349	352	PF01048	0.544
MOD_GlcNHglycan	65	68	PF01048	0.659
MOD_GSK3_1	117	124	PF00069	0.671
MOD_GSK3_1	288	295	PF00069	0.483
MOD_LATS_1	325	331	PF00433	0.391
MOD_N-GLC_1	347	352	PF02516	0.502
MOD_N-GLC_1	63	68	PF02516	0.613
MOD_NEK2_1	121	126	PF00069	0.617
MOD_NEK2_1	145	150	PF00069	0.654
MOD_NEK2_1	266	271	PF00069	0.452
MOD_NEK2_1	292	297	PF00069	0.484
MOD_PKA_2	32	38	PF00069	0.581
MOD_Plk_1	117	123	PF00069	0.420
MOD_Plk_1	99	105	PF00069	0.559
MOD_Plk_2-3	49	55	PF00069	0.709
MOD_Plk_4	294	300	PF00069	0.446
MOD_Plk_4	349	355	PF00069	0.419
MOD_ProDKin_1	385	391	PF00069	0.577
MOD_ProDKin_1	4	10	PF00069	0.635
MOD_ProDKin_1	69	75	PF00069	0.613
MOD_ProDKin_1	91	97	PF00069	0.637
MOD_SUMO_for_1	305	308	PF00179	0.494
MOD_SUMO_rev_2	141	151	PF00179	0.658
MOD_SUMO_rev_2	159	165	PF00179	0.465
MOD_SUMO_rev_2	215	223	PF00179	0.475
MOD_SUMO_rev_2	82	92	PF00179	0.570
TRG_DiLeu_BaEn_2	196	202	PF01217	0.525
TRG_DiLeu_BaEn_3	122	128	PF01217	0.700
TRG_ER_diArg_1	125	127	PF00400	0.599
TRG_ER_diArg_1	26	29	PF00400	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCU6	Leptomonas seymouri	88%	79%
A0A0S4JP89	Bodo saltans	62%	87%
A0A1X0NQD3	Trypanosomatidae	78%	83%
A0A3S7WR96	Leishmania donovani	99%	100%
A4H670	Leishmania braziliensis	96%	100%
A4HUJ4	Leishmania infantum	99%	100%
C9ZVL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	78%	86%
E9AN92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
V5B434	Trypanosoma cruzi	78%	81%