A_deaminase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QHD0_LEIMA

TriTrypDb:

LmjF.10.0840 , LMJLV39_100014500 , LMJSD75_100014800

Length:

728

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QHD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHD0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006152	purine nucleoside catabolic process	6	2
GO:0006154	adenosine catabolic process	8	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009058	biosynthetic process	2	2
GO:0009116	nucleoside metabolic process	4	2
GO:0009119	ribonucleoside metabolic process	5	2
GO:0009163	nucleoside biosynthetic process	5	2
GO:0009164	nucleoside catabolic process	5	2
GO:0009987	cellular process	1	2
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0019439	aromatic compound catabolic process	4	2
GO:0034404	nucleobase-containing small molecule biosynthetic process	4	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0034655	nucleobase-containing compound catabolic process	4	2
GO:0034656	nucleobase-containing small molecule catabolic process	4	2
GO:0042278	purine nucleoside metabolic process	5	2
GO:0042451	purine nucleoside biosynthetic process	6	2
GO:0042454	ribonucleoside catabolic process	6	2
GO:0042455	ribonucleoside biosynthetic process	6	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044270	cellular nitrogen compound catabolic process	4	2
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0044281	small molecule metabolic process	2	2
GO:0044282	small molecule catabolic process	3	2
GO:0044283	small molecule biosynthetic process	3	2
GO:0046085	adenosine metabolic process	7	2
GO:0046102	inosine metabolic process	7	2
GO:0046103	inosine biosynthetic process	8	2
GO:0046128	purine ribonucleoside metabolic process	6	2
GO:0046129	purine ribonucleoside biosynthetic process	7	2
GO:0046130	purine ribonucleoside catabolic process	7	2
GO:0046483	heterocycle metabolic process	3	2
GO:0046700	heterocycle catabolic process	4	2
GO:0055086	nucleobase-containing small molecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0072521	purine-containing compound metabolic process	4	2
GO:0072522	purine-containing compound biosynthetic process	5	2
GO:0072523	purine-containing compound catabolic process	5	2
GO:1901135	carbohydrate derivative metabolic process	3	2
GO:1901136	carbohydrate derivative catabolic process	4	2
GO:1901137	carbohydrate derivative biosynthetic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901361	organic cyclic compound catabolic process	4	2
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901566	organonitrogen compound biosynthetic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:1901576	organic substance biosynthetic process	3	2
GO:1901657	glycosyl compound metabolic process	4	2
GO:1901658	glycosyl compound catabolic process	5	2
GO:1901659	glycosyl compound biosynthetic process	5	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004000	adenosine deaminase activity	4	2
GO:0016787	hydrolase activity	2	11
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	2
GO:0016814	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines	4	2
GO:0019239	deaminase activity	3	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.506
CLV_C14_Caspase3-7	406	410	PF00656	0.524
CLV_C14_Caspase3-7	605	609	PF00656	0.568
CLV_NRD_NRD_1	171	173	PF00675	0.458
CLV_NRD_NRD_1	175	177	PF00675	0.487
CLV_NRD_NRD_1	273	275	PF00675	0.500
CLV_NRD_NRD_1	340	342	PF00675	0.562
CLV_NRD_NRD_1	368	370	PF00675	0.386
CLV_NRD_NRD_1	401	403	PF00675	0.445
CLV_NRD_NRD_1	501	503	PF00675	0.646
CLV_NRD_NRD_1	532	534	PF00675	0.427
CLV_NRD_NRD_1	95	97	PF00675	0.500
CLV_PCSK_FUR_1	499	503	PF00082	0.508
CLV_PCSK_KEX2_1	171	173	PF00082	0.458
CLV_PCSK_KEX2_1	175	177	PF00082	0.487
CLV_PCSK_KEX2_1	272	274	PF00082	0.477
CLV_PCSK_KEX2_1	340	342	PF00082	0.562
CLV_PCSK_KEX2_1	368	370	PF00082	0.413
CLV_PCSK_KEX2_1	401	403	PF00082	0.408
CLV_PCSK_KEX2_1	499	501	PF00082	0.612
CLV_PCSK_KEX2_1	532	534	PF00082	0.426
CLV_PCSK_KEX2_1	94	96	PF00082	0.572
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.572
CLV_PCSK_PC7_1	167	173	PF00082	0.450
CLV_PCSK_SKI1_1	133	137	PF00082	0.361
CLV_PCSK_SKI1_1	274	278	PF00082	0.417
CLV_PCSK_SKI1_1	282	286	PF00082	0.388
CLV_PCSK_SKI1_1	291	295	PF00082	0.273
CLV_PCSK_SKI1_1	298	302	PF00082	0.367
CLV_PCSK_SKI1_1	570	574	PF00082	0.355
CLV_PCSK_SKI1_1	579	583	PF00082	0.335
DEG_APCC_DBOX_1	273	281	PF00400	0.465
DEG_APCC_DBOX_1	627	635	PF00400	0.334
DEG_Nend_UBRbox_2	1	3	PF02207	0.623
DEG_SCF_FBW7_1	702	709	PF00400	0.456
DOC_CDC14_PxL_1	33	41	PF14671	0.365
DOC_CYCLIN_RxL_1	287	295	PF00134	0.385
DOC_CYCLIN_RxL_1	576	585	PF00134	0.371
DOC_CYCLIN_yCln2_LP_2	637	643	PF00134	0.428
DOC_MAPK_DCC_7	6	14	PF00069	0.579
DOC_MAPK_HePTP_8	284	296	PF00069	0.310
DOC_MAPK_MEF2A_6	287	296	PF00069	0.305
DOC_PP1_RVXF_1	36	42	PF00149	0.322
DOC_PP2B_LxvP_1	260	263	PF13499	0.395
DOC_PP2B_LxvP_1	437	440	PF13499	0.420
DOC_PP2B_LxvP_1	637	640	PF13499	0.331
DOC_PP4_FxxP_1	448	451	PF00568	0.474
DOC_PP4_FxxP_1	635	638	PF00568	0.289
DOC_USP7_MATH_1	104	108	PF00917	0.685
DOC_USP7_MATH_1	215	219	PF00917	0.402
DOC_USP7_MATH_1	263	267	PF00917	0.472
DOC_USP7_MATH_1	357	361	PF00917	0.574
DOC_USP7_MATH_1	541	545	PF00917	0.694
DOC_USP7_MATH_1	604	608	PF00917	0.451
DOC_USP7_MATH_1	655	659	PF00917	0.648
DOC_USP7_MATH_1	661	665	PF00917	0.554
DOC_USP7_MATH_1	706	710	PF00917	0.518
DOC_WW_Pin1_4	113	118	PF00397	0.470
DOC_WW_Pin1_4	347	352	PF00397	0.606
DOC_WW_Pin1_4	355	360	PF00397	0.536
DOC_WW_Pin1_4	691	696	PF00397	0.465
DOC_WW_Pin1_4	702	707	PF00397	0.386
LIG_14-3-3_CanoR_1	163	167	PF00244	0.331
LIG_14-3-3_CanoR_1	171	175	PF00244	0.393
LIG_14-3-3_CanoR_1	282	287	PF00244	0.457
LIG_14-3-3_CanoR_1	291	297	PF00244	0.357
LIG_14-3-3_CanoR_1	298	306	PF00244	0.370
LIG_14-3-3_CanoR_1	414	421	PF00244	0.358
LIG_14-3-3_CanoR_1	6	10	PF00244	0.550
LIG_14-3-3_CanoR_1	628	638	PF00244	0.290
LIG_14-3-3_CanoR_1	686	692	PF00244	0.360
LIG_Actin_WH2_2	155	173	PF00022	0.346
LIG_BIR_III_4	505	509	PF00653	0.507
LIG_BIR_III_4	548	552	PF00653	0.495
LIG_deltaCOP1_diTrp_1	441	448	PF00928	0.358
LIG_deltaCOP1_diTrp_1	677	684	PF00928	0.483
LIG_deltaCOP1_diTrp_1	715	723	PF00928	0.334
LIG_FHA_1	207	213	PF00498	0.343
LIG_FHA_1	371	377	PF00498	0.326
LIG_FHA_1	414	420	PF00498	0.450
LIG_FHA_1	516	522	PF00498	0.539
LIG_FHA_1	555	561	PF00498	0.490
LIG_FHA_1	614	620	PF00498	0.361
LIG_FHA_1	697	703	PF00498	0.625
LIG_FHA_2	114	120	PF00498	0.475
LIG_FHA_2	124	130	PF00498	0.324
LIG_FHA_2	149	155	PF00498	0.320
LIG_FHA_2	189	195	PF00498	0.377
LIG_FHA_2	375	381	PF00498	0.299
LIG_FHA_2	5	11	PF00498	0.468
LIG_FHA_2	603	609	PF00498	0.655
LIG_GBD_Chelix_1	158	166	PF00786	0.450
LIG_HCF-1_HBM_1	2	5	PF13415	0.364
LIG_LIR_Apic_2	632	638	PF02991	0.320
LIG_LIR_Gen_1	126	135	PF02991	0.336
LIG_LIR_Gen_1	683	692	PF02991	0.480
LIG_LIR_Gen_1	715	723	PF02991	0.459
LIG_LIR_Nem_3	126	131	PF02991	0.355
LIG_LIR_Nem_3	253	259	PF02991	0.363
LIG_LIR_Nem_3	278	284	PF02991	0.349
LIG_LIR_Nem_3	441	446	PF02991	0.310
LIG_LIR_Nem_3	510	515	PF02991	0.483
LIG_LIR_Nem_3	680	684	PF02991	0.471
LIG_LIR_Nem_3	715	719	PF02991	0.403
LIG_LIR_Nem_3	720	726	PF02991	0.409
LIG_NRBOX	484	490	PF00104	0.490
LIG_NRBOX	56	62	PF00104	0.399
LIG_Pex14_1	248	252	PF04695	0.322
LIG_PTB_Apo_2	134	141	PF02174	0.290
LIG_PTB_Apo_2	559	566	PF02174	0.324
LIG_SH2_CRK	256	260	PF00017	0.388
LIG_SH2_NCK_1	252	256	PF00017	0.449
LIG_SH2_NCK_1	652	656	PF00017	0.622
LIG_SH2_STAP1	252	256	PF00017	0.449
LIG_SH2_STAT5	123	126	PF00017	0.343
LIG_SH2_STAT5	188	191	PF00017	0.316
LIG_SH2_STAT5	275	278	PF00017	0.396
LIG_SH3_3	180	186	PF00018	0.304
LIG_SH3_3	348	354	PF00018	0.612
LIG_SH3_3	356	362	PF00018	0.512
LIG_SH3_3	537	543	PF00018	0.557
LIG_SUMO_SIM_anti_2	154	161	PF11976	0.393
LIG_SUMO_SIM_par_1	10	16	PF11976	0.467
LIG_SUMO_SIM_par_1	203	209	PF11976	0.433
LIG_TRAF2_1	152	155	PF00917	0.326
LIG_TRAF2_1	179	182	PF00917	0.628
MOD_CDK_SPxxK_3	113	120	PF00069	0.468
MOD_CK1_1	325	331	PF00069	0.456
MOD_CK1_1	350	356	PF00069	0.673
MOD_CK1_1	360	366	PF00069	0.447
MOD_CK1_1	564	570	PF00069	0.294
MOD_CK1_1	653	659	PF00069	0.634
MOD_CK1_1	709	715	PF00069	0.440
MOD_CK2_1	113	119	PF00069	0.552
MOD_CK2_1	148	154	PF00069	0.299
MOD_CK2_1	188	194	PF00069	0.381
MOD_CK2_1	4	10	PF00069	0.548
MOD_CK2_1	491	497	PF00069	0.591
MOD_CK2_1	501	507	PF00069	0.478
MOD_CK2_1	691	697	PF00069	0.535
MOD_CK2_1	709	715	PF00069	0.237
MOD_CMANNOS	678	681	PF00535	0.488
MOD_GlcNHglycan	106	109	PF01048	0.588
MOD_GlcNHglycan	151	154	PF01048	0.301
MOD_GlcNHglycan	200	203	PF01048	0.479
MOD_GlcNHglycan	217	220	PF01048	0.525
MOD_GlcNHglycan	342	345	PF01048	0.630
MOD_GlcNHglycan	380	384	PF01048	0.309
MOD_GlcNHglycan	454	457	PF01048	0.465
MOD_GlcNHglycan	49	52	PF01048	0.445
MOD_GlcNHglycan	509	512	PF01048	0.523
MOD_GlcNHglycan	542	546	PF01048	0.746
MOD_GlcNHglycan	657	660	PF01048	0.507
MOD_GlcNHglycan	663	666	PF01048	0.436
MOD_GlcNHglycan	74	77	PF01048	0.671
MOD_GSK3_1	188	195	PF00069	0.370
MOD_GSK3_1	211	218	PF00069	0.422
MOD_GSK3_1	346	353	PF00069	0.690
MOD_GSK3_1	357	364	PF00069	0.552
MOD_GSK3_1	370	377	PF00069	0.233
MOD_GSK3_1	413	420	PF00069	0.369
MOD_GSK3_1	45	52	PF00069	0.363
MOD_GSK3_1	452	459	PF00069	0.367
MOD_GSK3_1	467	474	PF00069	0.356
MOD_GSK3_1	491	498	PF00069	0.518
MOD_GSK3_1	687	694	PF00069	0.450
MOD_GSK3_1	696	703	PF00069	0.584
MOD_N-GLC_1	282	287	PF02516	0.525
MOD_N-GLC_1	345	350	PF02516	0.726
MOD_N-GLC_1	45	50	PF02516	0.281
MOD_N-GLC_1	452	457	PF02516	0.378
MOD_N-GLC_1	535	540	PF02516	0.507
MOD_N-GLC_1	561	566	PF02516	0.316
MOD_NEK2_1	138	143	PF00069	0.308
MOD_NEK2_1	148	153	PF00069	0.269
MOD_NEK2_1	170	175	PF00069	0.426
MOD_NEK2_1	292	297	PF00069	0.327
MOD_NEK2_1	370	375	PF00069	0.389
MOD_NEK2_1	379	384	PF00069	0.350
MOD_NEK2_1	4	9	PF00069	0.543
MOD_NEK2_1	45	50	PF00069	0.299
MOD_NEK2_1	466	471	PF00069	0.338
MOD_NEK2_1	491	496	PF00069	0.619
MOD_NEK2_1	573	578	PF00069	0.330
MOD_NEK2_1	582	587	PF00069	0.333
MOD_NEK2_1	629	634	PF00069	0.351
MOD_NEK2_2	123	128	PF00069	0.360
MOD_NEK2_2	417	422	PF00069	0.483
MOD_NEK2_2	561	566	PF00069	0.344
MOD_PIKK_1	227	233	PF00454	0.452
MOD_PIKK_1	312	318	PF00454	0.473
MOD_PIKK_1	582	588	PF00454	0.464
MOD_PIKK_1	629	635	PF00454	0.348
MOD_PIKK_1	88	94	PF00454	0.573
MOD_PKA_1	340	346	PF00069	0.568
MOD_PKA_1	501	507	PF00069	0.521
MOD_PKA_2	162	168	PF00069	0.339
MOD_PKA_2	170	176	PF00069	0.396
MOD_PKA_2	309	315	PF00069	0.475
MOD_PKA_2	340	346	PF00069	0.718
MOD_PKA_2	370	376	PF00069	0.330
MOD_PKA_2	413	419	PF00069	0.361
MOD_PKA_2	5	11	PF00069	0.581
MOD_PKA_2	501	507	PF00069	0.703
MOD_PKA_2	595	601	PF00069	0.548
MOD_PKA_2	627	633	PF00069	0.293
MOD_PKA_2	709	715	PF00069	0.542
MOD_PKB_1	499	507	PF00069	0.530
MOD_Plk_1	264	270	PF00069	0.587
MOD_Plk_1	282	288	PF00069	0.260
MOD_Plk_1	452	458	PF00069	0.385
MOD_Plk_1	535	541	PF00069	0.511
MOD_Plk_1	561	567	PF00069	0.326
MOD_Plk_4	188	194	PF00069	0.317
MOD_Plk_4	255	261	PF00069	0.371
MOD_Plk_4	28	34	PF00069	0.371
MOD_Plk_4	49	55	PF00069	0.428
MOD_Plk_4	680	686	PF00069	0.523
MOD_ProDKin_1	113	119	PF00069	0.466
MOD_ProDKin_1	347	353	PF00069	0.608
MOD_ProDKin_1	355	361	PF00069	0.526
MOD_ProDKin_1	691	697	PF00069	0.479
MOD_ProDKin_1	702	708	PF00069	0.370
MOD_SUMO_rev_2	544	554	PF00179	0.493
TRG_DiLeu_BaEn_2	433	439	PF01217	0.303
TRG_DiLeu_BaLyEn_6	288	293	PF01217	0.335
TRG_DiLeu_BaLyEn_6	56	61	PF01217	0.362
TRG_ENDOCYTIC_2	132	135	PF00928	0.327
TRG_ENDOCYTIC_2	252	255	PF00928	0.353
TRG_ENDOCYTIC_2	256	259	PF00928	0.349
TRG_ENDOCYTIC_2	390	393	PF00928	0.485
TRG_ER_diArg_1	170	172	PF00400	0.446
TRG_ER_diArg_1	174	176	PF00400	0.446
TRG_ER_diArg_1	272	274	PF00400	0.406
TRG_ER_diArg_1	368	371	PF00400	0.399
TRG_ER_diArg_1	499	502	PF00400	0.528
TRG_ER_diArg_1	531	533	PF00400	0.433
TRG_Pf-PMV_PEXEL_1	368	372	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6F9	Leptomonas seymouri	48%	98%
A0A1X0NRU3	Trypanosomatidae	33%	99%
A0A3S5IS54	Trypanosoma rangeli	36%	100%
A0A3S7WR98	Leishmania donovani	92%	99%
A4H672	Leishmania braziliensis	74%	100%
A4HUJ6	Leishmania infantum	92%	99%
C9ZVM1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AN94	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BTS5	Trypanosoma cruzi	37%	100%