Nucleolar protein 16

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ribosome biogenesis protein Nop16, putative

Species:

Leishmania major

UniProt:

Q4QHC8_LEIMA

TriTrypDb:

LmjF.10.0860 , LMJLV39_100014700 , LMJSD75_100015000

Length:

196

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QHC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHC8

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0022613	ribonucleoprotein complex biogenesis	4	2
GO:0042273	ribosomal large subunit biogenesis	5	2
GO:0044085	cellular component biogenesis	3	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	139	141	PF00675	0.317
CLV_NRD_NRD_1	29	31	PF00675	0.473
CLV_NRD_NRD_1	79	81	PF00675	0.468
CLV_NRD_NRD_1	89	91	PF00675	0.498
CLV_PCSK_KEX2_1	134	136	PF00082	0.410
CLV_PCSK_KEX2_1	28	30	PF00082	0.466
CLV_PCSK_KEX2_1	79	81	PF00082	0.524
CLV_PCSK_KEX2_1	89	91	PF00082	0.485
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.410
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.466
CLV_PCSK_PC1ET2_1	79	81	PF00082	0.585
CLV_PCSK_PC7_1	85	91	PF00082	0.515
CLV_PCSK_SKI1_1	103	107	PF00082	0.410
CLV_PCSK_SKI1_1	134	138	PF00082	0.410
CLV_PCSK_SKI1_1	164	168	PF00082	0.475
CLV_PCSK_SKI1_1	177	181	PF00082	0.468
CLV_PCSK_SKI1_1	80	84	PF00082	0.552
CLV_PCSK_SKI1_1	89	93	PF00082	0.568
DOC_MAPK_gen_1	9	18	PF00069	0.538
DOC_MAPK_RevD_3	66	80	PF00069	0.568
DOC_PP4_FxxP_1	185	188	PF00568	0.539
DOC_USP7_UBL2_3	24	28	PF12436	0.457
DOC_USP7_UBL2_3	5	9	PF12436	0.564
DOC_USP7_UBL2_3	79	83	PF12436	0.592
DOC_WW_Pin1_4	4	9	PF00397	0.560
LIG_14-3-3_CanoR_1	135	139	PF00244	0.342
LIG_14-3-3_CanoR_1	45	51	PF00244	0.544
LIG_Actin_WH2_2	175	193	PF00022	0.358
LIG_Clathr_ClatBox_1	179	183	PF01394	0.346
LIG_EH_1	142	146	PF12763	0.322
LIG_FHA_1	86	92	PF00498	0.576
LIG_LIR_Apic_2	183	188	PF02991	0.419
LIG_LIR_Gen_1	58	68	PF02991	0.547
LIG_LIR_Nem_3	58	64	PF02991	0.479
LIG_PCNA_PIPBox_1	153	162	PF02747	0.357
LIG_PCNA_yPIPBox_3	150	160	PF02747	0.279
LIG_Pex14_2	167	171	PF04695	0.404
LIG_PTAP_UEV_1	69	74	PF05743	0.427
LIG_SH2_STAT5	159	162	PF00017	0.375
LIG_SH2_STAT5	26	29	PF00017	0.455
LIG_SH2_STAT5	50	53	PF00017	0.430
LIG_SH3_3	67	73	PF00018	0.417
LIG_TRAF2_1	115	118	PF00917	0.349
MOD_CDK_SPK_2	4	9	PF00069	0.550
MOD_CDK_SPxxK_3	4	11	PF00069	0.550
MOD_CK2_1	112	118	PF00069	0.318
MOD_CK2_1	72	78	PF00069	0.563
MOD_Cter_Amidation	21	24	PF01082	0.470
MOD_GlcNHglycan	191	194	PF01048	0.616
MOD_GlcNHglycan	69	73	PF01048	0.444
MOD_GSK3_1	189	196	PF00069	0.464
MOD_GSK3_1	53	60	PF00069	0.490
MOD_GSK3_1	68	75	PF00069	0.523
MOD_N-GLC_1	53	58	PF02516	0.461
MOD_PIKK_1	44	50	PF00454	0.455
MOD_PKA_1	134	140	PF00069	0.410
MOD_PKA_2	134	140	PF00069	0.410
MOD_PKA_2	44	50	PF00069	0.549
MOD_Plk_1	57	63	PF00069	0.424
MOD_ProDKin_1	4	10	PF00069	0.560
MOD_SUMO_for_1	160	163	PF00179	0.498
MOD_SUMO_rev_2	102	110	PF00179	0.296
MOD_SUMO_rev_2	127	136	PF00179	0.365
MOD_SUMO_rev_2	173	179	PF00179	0.356
TRG_DiLeu_BaEn_4	93	99	PF01217	0.481
TRG_ER_diArg_1	29	31	PF00400	0.461
TRG_ER_diArg_1	89	91	PF00400	0.507
TRG_NLS_Bipartite_1	13	32	PF00514	0.484
TRG_NLS_MonoExtN_4	79	84	PF00514	0.583
TRG_Pf-PMV_PEXEL_1	150	155	PF00026	0.308

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY36	Leptomonas seymouri	91%	100%
A0A1X0NQN2	Trypanosomatidae	70%	100%
A0A3R7LG34	Trypanosoma rangeli	67%	100%
A0A3S7WR83	Leishmania donovani	98%	100%
A4H674	Leishmania braziliensis	93%	100%
A4HUJ8	Leishmania infantum	98%	100%
C9ZVM3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AN96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BJL8	Trypanosoma cruzi	66%	100%