Peptidylprolyl isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FKBP-type peptidyl-prolyl cis-trans isomerase, putative

Species:

Leishmania major

UniProt:

Q4QHC5_LEIMA

TriTrypDb:

LmjF.10.0890 , LMJLV39_100015100 , LMJSD75_100015300

Length:

159

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QHC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHC5

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	2
GO:0006457	protein folding	2	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018208	peptidyl-proline modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0061077	chaperone-mediated protein folding	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	7
GO:0003824	catalytic activity	1	7
GO:0016853	isomerase activity	2	7
GO:0016859	cis-trans isomerase activity	3	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	145	147	PF00675	0.469
CLV_PCSK_SKI1_1	130	134	PF00082	0.301
CLV_PCSK_SKI1_1	32	36	PF00082	0.380
DEG_Nend_UBRbox_3	1	3	PF02207	0.508
DOC_SPAK_OSR1_1	30	34	PF12202	0.364
DOC_USP7_UBL2_3	32	36	PF12436	0.390
DOC_WW_Pin1_4	42	47	PF00397	0.427
DOC_WW_Pin1_4	76	81	PF00397	0.324
LIG_CtBP_PxDLS_1	105	109	PF00389	0.301
LIG_FHA_1	86	92	PF00498	0.309
LIG_FHA_2	153	159	PF00498	0.371
LIG_LIR_Apic_2	101	106	PF02991	0.301
LIG_LIR_Gen_1	153	159	PF02991	0.412
LIG_LIR_Nem_3	153	159	PF02991	0.412
LIG_LIR_Nem_3	98	103	PF02991	0.301
LIG_SH2_SRC	103	106	PF00017	0.301
LIG_SH2_STAT5	103	106	PF00017	0.301
LIG_SH3_3	115	121	PF00018	0.301
LIG_SH3_3	99	105	PF00018	0.301
LIG_UBA3_1	131	139	PF00899	0.460
MOD_CK1_1	42	48	PF00069	0.301
MOD_CK2_1	152	158	PF00069	0.340
MOD_GlcNHglycan	26	29	PF01048	0.386
MOD_GSK3_1	42	49	PF00069	0.333
MOD_GSK3_1	74	81	PF00069	0.371
MOD_N-GLC_1	46	51	PF02516	0.301
MOD_NEK2_1	152	157	PF00069	0.374
MOD_NEK2_1	37	42	PF00069	0.378
MOD_PIKK_1	78	84	PF00454	0.324
MOD_Plk_1	66	72	PF00069	0.301
MOD_ProDKin_1	42	48	PF00069	0.320
MOD_ProDKin_1	76	82	PF00069	0.324
MOD_SUMO_rev_2	15	20	PF00179	0.469
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.279
TRG_ENDOCYTIC_2	156	159	PF00928	0.403
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTT4	Leptomonas seymouri	74%	100%
A0A0N1PEA6	Leptomonas seymouri	38%	100%
A0A1X0P7N1	Trypanosomatidae	48%	75%
A0A3Q8IB31	Leishmania donovani	94%	100%
A0A3Q8ICF9	Leishmania donovani	38%	100%
A0A3R7LCV9	Trypanosoma rangeli	39%	100%
A0A3S5H764	Leishmania donovani	30%	79%
A0A3S5H813	Leishmania donovani	38%	100%
A0A3S5IR72	Trypanosoma rangeli	43%	79%
A4H677	Leishmania braziliensis	83%	100%
A4HA48	Leishmania braziliensis	32%	78%
A4HNN1	Leishmania braziliensis	37%	100%
A4HUK1	Leishmania infantum	94%	100%
A4HYB4	Leishmania infantum	29%	79%
A4I002	Leishmania infantum	38%	100%
A4ICW4	Leishmania infantum	38%	100%
A5IGB8	Legionella pneumophila (strain Corby)	46%	68%
D0A0P0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	81%
E9AN99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AS47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	78%
E9ASE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9AVX5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
O54998	Mus musculus	36%	73%
P0A9L3	Escherichia coli (strain K12)	44%	77%
P0A9L4	Shigella flexneri	44%	77%
P0C1J5	Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880)	42%	76%
P30417	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	36%	70%
P32472	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	100%
P51752	Coxiella burnetii (strain RSA 493 / Nine Mile phase I)	49%	69%
P53605	Legionella longbeachae	48%	68%
Q09734	Trypanosoma cruzi	45%	81%
Q2U316	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	36%	100%
Q38935	Arabidopsis thaliana	37%	100%
Q38936	Arabidopsis thaliana	39%	98%
Q41649	Vicia faba	37%	100%
Q4HZB8	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	37%	100%
Q4IN00	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	41%	82%
Q4Q255	Leishmania major	39%	100%
Q4QBK4	Leishmania major	38%	100%
Q4QDB9	Leishmania major	28%	100%
Q5ZXE0	Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)	46%	68%
Q6BP84	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	41%	100%
Q6CGG3	Yarrowia lipolytica (strain CLIB 122 / E 150)	39%	100%
Q6FSC1	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	46%	100%
Q6M981	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	35%	100%
Q70YI1	Legionella pneumophila	46%	68%
Q9M2S7	Arabidopsis thaliana	34%	84%
V5BA38	Trypanosoma cruzi	38%	100%