Archaic_translocase_outer_membrane_12_kDa_subunit_-_putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Archaic translocase of outer membrane 12 kDa subunit, putative

Species:

Leishmania major

UniProt:

Q4QHC0_LEIMA

TriTrypDb:

LmjF.10.0945 , LMJLV39_100016300 , LMJSD75_100016500

Length:

107

Annotations

LeishMANIAdb annotations

A very simple single-pass membrane protein restricted to Kinetoplastids. Might be mitochondrial.. A transit peptide cannot be excluded in the sequence.. Localization: Mitochondrial (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0005741	mitochondrial outer membrane	5	2
GO:0005742	mitochondrial outer membrane translocase complex	4	2
GO:0016020	membrane	2	5
GO:0019867	outer membrane	3	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0031968	organelle outer membrane	4	2
GO:0032991	protein-containing complex	1	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098588	bounding membrane of organelle	4	2
GO:0098796	membrane protein complex	2	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:0098799	outer mitochondrial membrane protein complex	3	2
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QHC0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QHC0

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	2
GO:0006626	protein targeting to mitochondrion	5	2
GO:0006810	transport	3	2
GO:0006839	mitochondrial transport	4	2
GO:0006886	intracellular protein transport	4	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0030150	protein import into mitochondrial matrix	4	2
GO:0033036	macromolecule localization	2	2
GO:0033365	protein localization to organelle	5	2
GO:0044743	protein transmembrane import into intracellular organelle	4	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0055085	transmembrane transport	2	2
GO:0065002	intracellular protein transmembrane transport	4	2
GO:0070585	protein localization to mitochondrion	6	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071806	protein transmembrane transport	3	2
GO:0072594	establishment of protein localization to organelle	4	2
GO:0072655	establishment of protein localization to mitochondrion	5	2
GO:1990542	mitochondrial transmembrane transport	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	92	94	PF00675	0.621
CLV_PCSK_KEX2_1	91	93	PF00082	0.609
DEG_APCC_DBOX_1	58	66	PF00400	0.377
DEG_Nend_Nbox_1	1	3	PF02207	0.707
DOC_PP4_FxxP_1	38	41	PF00568	0.329
DOC_USP7_UBL2_3	25	29	PF12436	0.640
LIG_14-3-3_CanoR_1	91	100	PF00244	0.477
LIG_BRCT_BRCA1_1	56	60	PF00533	0.471
LIG_LIR_Apic_2	37	41	PF02991	0.329
LIG_LIR_Nem_3	77	83	PF02991	0.446
LIG_Pex14_2	60	64	PF04695	0.381
LIG_RPA_C_Fungi	88	100	PF08784	0.612
LIG_SH2_NCK_1	102	106	PF00017	0.598
LIG_SH2_SRC	83	86	PF00017	0.551
LIG_SH2_STAT5	27	30	PF00017	0.475
LIG_SH2_STAT5	3	6	PF00017	0.498
LIG_SH2_STAT5	35	38	PF00017	0.292
LIG_SH2_STAT5	66	69	PF00017	0.594
MOD_CK2_1	5	11	PF00069	0.599
MOD_CK2_1	95	101	PF00069	0.603
MOD_GlcNHglycan	86	89	PF01048	0.553
MOD_GlcNHglycan	97	100	PF01048	0.299
MOD_GSK3_1	79	86	PF00069	0.652
MOD_GSK3_1	91	98	PF00069	0.585
MOD_NEK2_1	23	28	PF00069	0.463
MOD_NEK2_1	65	70	PF00069	0.524
MOD_NEK2_2	66	71	PF00069	0.608
MOD_PKA_1	91	97	PF00069	0.577
MOD_PKA_2	91	97	PF00069	0.616
MOD_Plk_4	23	29	PF00069	0.548
MOD_SUMO_rev_2	72	81	PF00179	0.529
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.441
TRG_ENDOCYTIC_2	35	38	PF00928	0.322
TRG_ER_diArg_1	91	93	PF00400	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVG0	Leptomonas seymouri	77%	100%
A0A0S4JL52	Bodo saltans	42%	100%
A0A1X0NS16	Trypanosomatidae	51%	100%
A0A3S7WR90	Leishmania donovani	95%	100%
A0A422NCR7	Trypanosoma rangeli	52%	100%
A4HUK7	Leishmania infantum	95%	100%
C9ZVN4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9ANA4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%